New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies

Journal of Medicinal Chemistry

Volumn 52, Issue 23, 2009, Pages 7512-7527

  La Regina, Giuseppe ^a   Sarkar, Taradas ^c   Bai, Ruoli ^c   Edler, Michael C ^c   Saletti, Roberto ^b   Coluccia, Antonio ^a,g   Piscitelli, Francesco ^a   Minelli, Lara ^a   Gatti, Valerio ^a   Mazzoccoli, Carmela ^a,h   Palermo, Vanessa ^a   Mazzoni, Cristina ^a   Falcone, Claudio ^a   Scovassi, Anna Ivana ^e   Giansanti, Vincenzo ^e   Campiglia, Pietro ^f   Porta, Amalia ^f   Maresca, Bruno ^f   Hamel, Ernest ^c   Brancale, Andrea ^b   Novellino, Ettore ^d   Silvestri, Romano ^a   more..

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e CNR   (Italy)

^f UNIVERSITY OF SALERNO   (Italy)

^g UNIVERSITY OF PENNSYLVANIA   (United States)

^h REFERRAL CANCER CENTER OF BASILICATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLTHIOINDOLE; INDOLE DERIVATIVE; KETONE; METHYL 5 BROMO 3 (3,4,5 TRIMETHOXYBENZYL) 1H INDOLE 2 CARBOXYLATE; METHYL 5 BROMO 3 (3,4,5 TRIMETHOXYPHENYLTHIO) 1H INDOLE 2 CARBOXYLATE; METHYL 5 METHOXY 3 (3,4,5 TRIMETHOXYBENZOYL) 1H INDOLE 2 CARBOXYLATE; SULFUR DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL STRAIN HCT116; CELL STRAIN MCF 7; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TOXICITY; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; MOLECULAR MODEL; NONHUMAN; SACCHAROMYCES CEREVISIAE; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; CELL PROLIFERATION; COLCHICINE; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR; TUBULIN;

EID: 72249084715     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900016t     Document Type: Article

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