Regulation of secondary metabolism in bacteria

The Metabolic Pathway Engineering Handbook: Fundamentals

Volumn , Issue , 2009, Pages 13-1-13-26

  Zhang, Wenjun ^a   Ferreira, Joshua P ^a   Tang, Yi ^a  

^a Engineering IV   (United States)

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[No Author keywords available]

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EID: 80052844919     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (157)

1. Demain, A. L. Microbial secondary metabolism: a new theoretical frontier for academia, a new opportunity for industry. Ciba Found. Symp., 171, 3-16; discussion 16-23, 1992.
2. Williams, D. H., Stone, M. J., Hauck, P. R., and Rahman, S. K. Why are secondary metabolites (natural products) biosynthesized? J. Nat. Prod., 52 (6), 1189-208, 1989.
3. Challis, G. L. and Hopwood, D. A. Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species. Proc. Natl. Acad. Sci. USA, 100 Suppl 2, 14555-61, 2003.
4. Strohl, W. R. e. Biotechnology of Antibiotics, 2nd ed. Marcel Dekker, Inc., New York, 1997.
5. Park, H. S., Kang, S. H., Park, H. J., and Kim, E. S. Doxorubicin productivity improvement by the recombinant Streptomyces peucetius with high-copy regulatory genes cultured in the optimized media composition. J.Microbiol. Biotechnol., 15 (1), 66-71, 2005.
6. Bruheim, P., Sletta, H., Bibb, M. J., White, J., and Levine, D. W. High-yield actinorhodin production in fed-batch culture by a Streptomyces lividans strain overexpressing the pathway-specific activator gene actll-ORF4. J. Ind. Microbiol. Biotechnol., 28 (2), 103-11, 2002.
7. Yu, J. H. and Keller, N. Regulation of secondary metabolism in filamentous fungi. Annu. Rev. Phytopathol., 43, 437-58, 2005.
8. Champness, W. C. and Chater, K. F. Regulation and integration of antibiotic production and morphological differentiation in Streptomyces spp. In P. Piggot, C. Moran, and P. Youngman, eds. Regulation of Bacterial Differentiation. American Society for Microbiology, Washington, DC, 61-94, 1994.
9. Chater, K. F. and Bibb, M. J. Regulation of bacterial antibiotic production. In H. Kleinkauf and H. von Dohren, eds. Biotechnology. Vol. 6. Products of Secondary Metabolism. VCH, Weinheim, Germany, 57-105, 1997.
10. Bibb, M. J. Regulation of secondary metabolism in streptomycetes. Curr. Opin. Microbiol., 8 (2), 208-15, 2005.
11. Ikeda, H., Ishikawa, J., Hanamoto, A., Shinose, M., Kikuchi, H., Shiba, T., Sakaki, Y., Hattori, M., and Omura, S. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat. Biotechnol., 21 (5), 526-31, 2003.
12. Bentley, S. D., Chater, K. F., Cerdeno-Tarraga, A. M., Challis, G. L., Thomson, N. R., James, K. D., Harris, D. E., Quail, M. A., Kieser, H., Harper, D., Bateman, A., Brown, S., Chandra, G., Chen, C. W., Collins, M., Cronin, A., Fraser, A., Goble, A., Hidalgo, J., Hornsby, T., Howarth, S., Huang, C. H., Kieser, T., Larke, L., Murphy, L., Oliver, K., O’Neil, S., Rabbinowitsch, E., Rajandream, M. A., Rutherford, K., Rutter, S., Seeger, K., Saunders, D., Sharp, S., Squares, R., Squares, S., Taylor, K., Warren, T., Wietzorrek, A., Woodward, J., Barrell, B. G., Parkhill, J., and Hopwood, D. A. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature, 417 (6885), 141-7, 2002.
13. Novotna, J., Vohradsky, J., Berndt, P., Gramajo, H., Langen, H., Li, X. M., Minas, W., Orsaria, L., Roeder, D., and Thompson, C. J. Proteomic studies of diauxic lag in the differentiating prokaryote Streptomyces coelicolor reveal a regulatory network of stress-induced proteins and central metabolic enzymes. Mol. Microbiol., 48 (5), 1289-303, 2003.
14. Borodina, I., Krabben, P., and Nielsen, J. Genome-scale analysis of Streptomyces coelicolor A3(2) metabolism. Genome Res., 15 (6), 820-29, 2005.
15. Bishop, A., Fielding, S., Dyson, P., and Herron, P. Systematic insertional mutagenesis of a streptomycete genome: a link between osmoadaptation and antibiotic production. Genome Res., 14 (5), 893-900, 2004.
16. Gehring, A. M., Nodwell, J. R., Beverley, S. M., and Losick, R. Genomewide insertional mutagenesis in Streptomyces coelicolor reveals additional genes involved in morphological differentiation. Proc. Natl. Acad. Sci. USA, 97 (17), 9642-47, 2000.
17. Huang, J., Lih, C. J., Pan, K. H., and Cohen, S. N. Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays. Genes Dev., 15 (23), 3183-92, 2001.
18. Volokhan, O., Sletta, H., Sekurova, O. N., Ellingsen, T. E., and Zotchev, S. B. An unexpected role for the putative 4'-phosphopantetheinyl transferase-encoding gene nysF in the regulation of nystatin biosynthesis in Streptomyces noursei ATCC 11455. FEMS Microbiol. Lett., 249 (1), 57-64, 2005.
19. Wietzorrek, A. and Bibb, M. A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold. Mol. Microbiol., 25 (6), 1181-84, 1997.
20. Wilson, D. J., Xue, Y., Reynolds, K. A., and Sherman, D. H. Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. J. Bacteriol., 183 (11), 3468-75, 2001.
21. Hopwood, D. A., Chater, K. F., and Bibb, M. J. Genetics of antibiotic production in Streptomyces coelicolor A3(2), a model streptomycete. Biotechnology, 28, 65-102, 1995.
22. Sheldon, P. J., Busarow, S. B., and Hutchinson, C. R. Mapping the DNA-binding domain and target sequences of the Streptomyces peucetius daunorubicin biosynthesis regulatory protein, DnrI. Mol. Microbiol., 44 (2), 449-60, 2002.
23. Floriano, B. and Bibb, M. afsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2). Mol. Microbiol., 21 (2), 385-96, 1996.
24. Horinouchi, S. AfsR as an integrator of signals that are sensed by multiple serine/threonine kinases in Streptomyces coelicolor A3(2). J. Ind. Microbiol. Biotechnol., 30 (8), 462-67, 2003.
25. Bibb, M. 1995. Colworth Prize Lecture. The regulation of antibiotic production in Streptomyces coelicolor A3(2). Microbiology, 142 (Pt 6), 1335-44, 1996.
26. Arias, P., Fernandez-Moreno, M. A., and Malpartida, F. Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein. J. Bacteriol., 181 (22), 6958-68, 1999.
27. Retzlaff, L. and Distler, J. The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites. Mol. Microbiol., 18 (1), 151-62, 1995.
28. Tang, L., Grimm, A., Zhang, Y. X., and Hutchinson, C. R. Purification and characterization of the DNA-binding protein DnrI, a transcriptional factor of daunorubicin biosynthesis in Streptomyces peucetius. Mol. Microbiol., 22 (5), 801-13, 1996.
29. Takano, E., Gramajo, H. C., Strauch, E., Andres, N., White, J., and Bibb, M. J. Transcriptional regulation of the redD transcriptional activator gene accounts for growth-phase-dependent production of the antibiotic undecylprodigiosin in Streptomyces coelicolor A3(2). Mol. Microbiol., 6 (19), 2797-804, 1992.
30. Narva, K. E. and Feitelson, J. S. Nucleotide sequence and transcriptional analysis of the redD locus of Streptomyces coelicolor A3(2). J. Bacteriol., 172 (1), 326-33, 1990.
31. Ylihonko, K., Tuikkanen, J., Jussila, S., Cong, L., and Mantsala, P. A gene cluster involved in nogalamycin biosynthesis from Streptomyces nogalater: sequence analysis and complementation of early-block mutations in the anthracycline pathway. Mol. Gen. Genet., 251 (2), 113-20, 1996.
32. Perez-Llarena, F. J., Liras, P., Rodriguez-Garcia, A., and Martin, J. F. A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds. J. Bacteriol., 179 (6), 2053-59, 1997.
33. Santamarta, I., Rodriguez-Garcia, A., Perez-Redondo, R., Martin, J. F., and Liras, P. CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus. J. Bacteriol., 184 (11), 3106-13, 2002.
34. Lombo, F., Brana, A. F., Mendez, C., and Salas, J. A. The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster. J. Bacteriol., 181 (2), 642-7, 1999.
35. Aigle, B., Pang, X., Decaris, B., and Leblond, P. Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the duplicated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens. J. Bacteriol., 187 (7), 2491-500, 2005.
36. Eustaquio, A. S., Li, S. M., and Heide, L. NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis. Microbiology, 151 (Pt 6), 1949-61, 2005.
37. Rebets, Y., Ostash, B., Luzhetskyy, A., Hoffmeister, D., Brana, A., Mendez, C., Salas, J. A., Bechthold, A., and Fedorenko, V. Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators. FEMS Microbiol. Lett., 222 (1), 149-53, 2003.
38. Rebets, Y., Ostash, B., Luzhetskyy, A., Kushnir, S., Fukuhara, M., Bechthold, A., Nashimoto, M., Nakamura, T., and Fedorenko, V. DNA-binding activity of LndI protein and temporal expression of the gene that upregulates landomycin E production in Streptomyces globisporus 1912. Microbiology, 151 (Pt 1), 281-90, 2005.
39. Sekurova, O. N., Brautaset, T., Sletta, H., Borgos, S. E., Jakobsen, M. O., Ellingsen, T. E., Strom, A. R., Valla, S., and Zotchev, S. B. In vivo analysis of the regulatory genes in the nystatin biosynthetic gene cluster of Streptomyces noursei ATCC 11455 reveals their differential control over antibiotic biosynthesis. J. Bacteriol., 186 (5), 1345-54, 2004.
40. Aparicio, J. F., Molnar, I., Schwecke, T., Konig, A., Haydock, S. F., Khaw, L. E., Staunton, J., and Leadlay, P. F. Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase. Gene, 169 (1), 9-16, 1996.
41. Anton, N., Mendes, M. V., Martin, J. F., and Aparicio, J. F. Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis. J. Bacteriol., 186 (9), 2567-75, 2004.
42. Stock, A. M., Robinson, V. L., and Goudreau, P. N. Two-component signal transduction, Annu., Rev. Biochem., 69, 183-215, 2000.
43. Brian, P., Riggle, P. J., Santos, R. A., and Champness, W. C. Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system. J. Bacteriol., 178 (11), 3221-31, 1996.
44. Chang, H. M., Chen, M. Y., Shieh, Y. T., Bibb, M. J., and Chen, C. W. The cutRS signal transduction system of Streptomyces lividans represses the biosynthesis of the polyketide antibiotic actinorhodin. Mol. Microbiol., 21 (5), 1075-85, 1996.
45. Novakova, R., Homerova, D., Feckova, L., and Kormanec, J. Characterization of a regulatory gene essential for the production of the angucycline-like polyketide antibiotic auricin in Streptomyces aureofaciens CCM 3239. Microbiology, 151 (Pt 8), 2693-706, 2005.
46. Guthrie, E. P., Flaxman, C. S., White, J., Hodgson, D. A., Bibb, M. J., and Chater, K. F., A responseregulator-like activator of antibiotic synthesis from Streptomyces coelicolor A3(2) with an aminoterminal domain that lacks a phosphorylation pocket. Microbiology, 144 (Pt 3), 727-38, 1998.
47. Furuya, K. and Hutchinson, C. R. The DnrN protein of Streptomyces peucetius, a pseudo-response regulator, is a DNA-binding protein involved in the regulation of daunorubicin biosynthesis. J. Bacteriol., 178 (21), 6310-8, 1996.
48. Uguru, G. C., Stephens, K. E., Stead, J. A., Towle, J. E., Baumberg, S., and McDowall, K. J., Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor. Mol. Microbiol., 58 (1), 131-50, 2005.
49. Elliot, M. A. and Talbot, N. J. Building filaments in the air: aerial morphogenesis in bacteria and fungi. Curr. Opin. Microbiol., 7 (6), 594-601, 2004.
50. Cozzone, A. J. Protein phosphorylation in prokaryotes. Annu. Rev. Microbiol., 42, 97-125, 1988.
51. Anderson, T. B., Brian, P., and Champness, W. C. Genetic and transcriptional analysis of absA, an antibiotic gene cluster-linked two-component system that regulates multiple antibiotics in Streptomyces coelicolor. Mol. Microbiol., 39 (3), 553-66, 2001.
52. Aceti, D. J. and Champness, W. C. Transcriptional regulation of Streptomyces coelicolor pathwayspecific antibiotic regulators by the absA and absB loci. J. Bacteriol., 180 (12), 3100-6, 1998.
53. Martin, J. F. Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story. J. Bacteriol., 186 (16), 5197-201, 2004.
54. Ishizuka, H., Horinouchi, S., Kieser, H. M., Hopwood, D. A., and Beppu, T. A putative two-component regulatory system involved in secondary metabolism in Streptomyces spp. J. Bacteriol., 174 (23), 7585-94, 1992.
55. Sola-Landa, A., Moura, R. S., and Martin, J. F. The two-component PhoR-PhoP system controls both primary metabolism and secondary metabolite biosynthesis in Streptomyces lividans. Proc. Natl. Acad. Sci. USA, 100 (10), 6133-38, 2003.
56. Kim, D. and Forst, S. Genomic analysis of the histidine kinase family in bacteria and archaea. Microbiology, 147 (Pt 5), 1197-212, 2001.
57. Hutchings, M. I., Hoskisson, P. A., Chandra, G., and Buttner, M. J. Sensing and responding to diverse extracellular signals? Analysis of the sensor kinases and response regulators of Streptomyces coelicolor A3(2). Microbiology, 150 (Pt 9), 2795-806, 2004.
58. Kennelly, P. J. Protein kinases and protein phosphatases in prokaryotes: a genomic perspective. FEMS Microbiol. Lett., 206 (1), 1-8, 2002.
59. Petrickova, K. and Petricek, M. Eukaryotic-type protein kinases in Streptomyces coelicolor: variations on a common theme. Microbiology, 149 (Pt 7), 1609-21, 2003.
60. Umeyama, T. and Horinouchi, S. Autophosphorylation of a bacterial serine/threonine kinase, AfsK, is inhibited by KbpA, an AfsK-binding protein. J. Bacteriol., 183 (19), 5506-12, 2001.
61. Lee, P. C., Umeyama, T., and Horinouchi, S. afsS is a target of AfsR, a transcriptional factor with ATPase activity that globally controls secondary metabolism in Streptomyces coelicolor A3(2). Mol. Microbiol., 43 (6), 1413-30, 2002.
62. Umeyama, T., Lee, P. C., and Horinouchi, S. Protein serine/threonine kinases in signal transduction for secondary metabolism and morphogenesis in Streptomyces. Appl. Microbiol. Biotechnol., 59 (4-5), 419-25, 2002.
63. Shi, L. and Zhang, W. Comparative analysis of eukaryotic-type protein phosphatases in two streptomycete genomes. Microbiology, 150 (Pt 7), 2247-56, 2004.
64. Li, Y. and Strohl, W. R. Cloning, purification, and properties of a phosphotyrosine protein phosphatase from Streptomyces coelicolor A3(2). J. Bacteriol., 178 (1), 136-42, 1996.
65. Umeyama, T., Tanabe, Y., Aigle, B. D., and Horinouchi, S. Expression of the Streptomyces coelicolor A3(2) ptpA gene encoding a phosphotyrosine protein phosphatase leads to overproduction of secondary metabolites in S. lividans. FEMS Microbiol. Lett., 144 (2-3), 177-84, 1996.
66. Sheeler, N. L., MacMillan, S. V., and Nodwell, J. R. Biochemical activities of the absA two-component system of Streptomyces coelicolor. J. Bacteriol., 187 (2), 687-96, 2005.
67. Yamada, Y. Autoregulatory factors and regulation of antibiotic production in Streptomyces. In England, R. R., Hobbs, G., Bainton, N. J., and Roberts, D. McL., eds. Microbial Signalling and Communication. Cambridge University Press, Cambridge, U.K., 177-196, 1999.
68. Choi, S. U., Lee, C. K., Hwang, Y. I., Kinosita, H., and Nihira, T. Gamma-butyrolactone autoregulators and receptor proteins in non-Streptomyces actinomycetes producing commercially important secondary metabolites. Arch. Microbiol., 180 (4), 303-7, 2003.
69. Fuqua, C. and Greenberg, E. P., Listening in on bacteria: acyl-homoserine lactone signaling. Nat. Rev. Mol. Cell. Biol., 3 (9), 685-95, 2002.
70. Horinouchi, S. and Beppu, T. A-factor as a microbial hormone that controls cellular differentiation and secondary metabolism in Streptomyces griseus. Mol. Microbiol., 12 (6), 859-64, 1994.
71. Ohnishi, Y., Yamazaki, H., Kato, J. Y., Tomono, A., and Horinouchi, S. AdpA, a central transcriptional regulator in the A-factor regulatory cascade that leads to morphological development and secondary metabolism in Streptomyces griseus. Biosci. Biotechnol. Biochem., 69 (3), 431-39, 2005.
72. Tomono, A., Tsai, Y., Yamazaki, H., Ohnishi, Y., and Horinouchi, S. Transcriptional control by A-factor of strR, the pathway-specific transcriptional activator for streptomycin biosynthesis in Streptomyces griseus. J. Bacteriol., 187 (16), 5595-604, 2005.
73. Kato, J. Y., Miyahisa, I., Mashiko, M., Ohnishi, Y., and Horinouchi, S. A single target is sufficient to account for the biological effects of the A-factor receptor protein of Streptomyces griseus. J. Bacteriol., 186 (7), 2206-11, 2004.
74. Yamazaki, H., Tomono, A., Ohnishi, Y., and Horinouchi, S. DNA-binding specificity of AdpA, a transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus. Mol. Microbiol., 53 (2), 555-72, 2004.
75. Kato, J. Y., Ohnishi, Y., and Horinouchi, S. Autorepression of AdpA of the AraC/XylS family, a key transcriptional activator in the A-factor regulatory cascade in Streptomyces griseus. J. Mol. Biol., 350 (1), 12-26, 2005.
76. Onaka, H. and Horinouchi, S. DNA-binding activity of the A-factor receptor protein and its recognition DNA sequences. Mol. Microbiol., 24 (5), 991-1000, 1997.
77. Santamarta, I., Perez-Redondo, R., Lorenzana, L. M., Martin, J. F., and Liras, P. Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus. Mol. Microbiol., 56 (3), 824-35, 2005.
78. Yamada, Y., Sugamura, K., Kondo, K., Yanagimoto, M., and Okada, H. The structure of inducing factors for virginiamycin production in Streptomyces virginiae. J. Antibiot. (Tokyo), 40 (4), 496-504, 1987.
79. Kitani, S., Yamada, Y., and Nihira, T. Gene replacement analysis of the butyrolactone autoregulator receptor (FarA) reveals that FarA acts as a Novel regulator in secondary metabolism of Streptomyces lavendulae FRI-5. J. Bacteriol., 183 (14), 4357-63, 2001.
80. Takano, E., Chakraburtty, R., Nihira, T., Yamada, Y., and Bibb, M. J. A complex role for the gamma-butyrolactone SCB1 in regulating antibiotic production in Streptomyces coelicolor A3(2). Mol. Microbiol., 41 (5), 1015-28, 2001.
81. Takano, E., Kinoshita, H., Mersinias, V., Bucca, G., Hotchkiss, G., Nihira, T., Smith, C. P., Bibb, M., Wohlleben, W., and Chater, K. A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor. Mol. Microbiol., 56 (2), 465-79, 2005.
82. Stratigopoulos, G., Gandecha, A. R., and Cundliffe, E. Regulation of tylosin production and morphological differentiation in Streptomyces fradiae by TylP, a deduced gamma-butyrolactone receptor. Mol. Microbiol., 45 (3), 735-44, 2002.
83. Kim, H. S., Lee, Y. J., Lee, C. K., Choi, S. U., Yeo, S. H., Hwang, Y. I., Yu, T. S., Kinoshita, H., and Nihira, T. Cloning and characterization of a gene encoding the gamma-butyrolactone autoregulator receptor from Streptomyces clavuligerus. Arch. Microbiol., 182 (1), 44-50, 2004.
84. Lee, K. M., Lee, C. K., Choi, S. U., Park, H. R., Kitani, S., Nihira, T., and Hwang, Y. I. Cloning and in vivo functional analysis by disruption of a gene encoding the gamma-butyrolactone autoregulator receptor from Streptomyces natalensis. Arch. Microbiol., 184 (4), 249-57, 2005.
85. Choi, S. U., Lee, C. K., Hwang, Y. I., Kinoshita, H., and Nihira, T. Cloning and functional analysis by gene disruption of a gene encoding a gamma-butyrolactone autoregulator receptor from Kitasatospora setae. J. Bacteriol., 186 (11), 3423-30, 2004.
86. Folcher, M., Gaillard, H., Nguyen, L. T., Nguyen, K. T., Lacroix, P., Bamas-Jacques, N., Rinkel, M., and Thompson, C. J. Pleiotropic functions of a Streptomyces pristinaespiralis autoregulator receptor in development, antibiotic biosynthesis, and expression of a superoxide dismutase. J. Biol. Chem., 276 (47), 44297-306, 2001.
87. Matsuno, K., Yamada, Y., Lee, C. K., and Nihira, T. Identification by gene deletion analysis of barB as a negative regulator controlling an early process of virginiamycin biosynthesis in Streptomyces virginiae. Arch. Microbiol., 181 (1), 52-9, 2004.
88. Bate, N., Butler, A. R., Gandecha, A. R., and Cundliffe, E. Multiple regulatory genes in the tylosin biosynthetic cluster of Streptomyces fradiae. Chem. Biol., 6 (9), 617-24, 1999.
89. Stratigopoulos, G., Bate, N., and Cundliffe, E. Positive control of tylosin biosynthesis: pivotal role of TylR. Mol. Microbiol., 54 (5), 1326-34, 2004.
90. Stratigopoulos, G. and Cundliffe, E. Expression analysis of the tylosin-biosynthetic gene cluster: pivotal regulatory role of the tylQ product. Chem. Biol., 9 (1), 71-8, 2002.
91. Bate, N., Stratigopoulos, G., and Cundliffe, E. Differential roles of two SARP-encoding regulatory genes during tylosin biosynthesis. Mol. Microbiol., 43 (2), 449-58, 2002.
92. Kawachi, R., Akashi, T., Kamitani, Y., Sy, A., Wangchaisoonthorn, U., Nihira, T., and Yamada, Y. Identification of an AfsA homologue (BarX) from Streptomyces virginiae as a pleiotropic regulator controlling autoregulator biosynthesis, virginiamycin biosynthesis and virginiamycin M1 resistance. Mol. Microbiol., 36 (2), 302-13, 2000.
93. Shikura, N., Yamamura, J., and Nihira, T. barS1, a gene for biosynthesis of a gamma-butyrolactone autoregulator, a microbial signaling molecule eliciting antibiotic production in Streptomyces species. J. Bacteriol., 184 (18), 5151-57, 2002.
94. Recio, E., Colinas, A., Rumbero, A., Aparicio, J. F., and Martin, J. F. PI factor, a novel type quorumsensing inducer elicits pimaricin production in Streptomyces natalensis. J. Biol. Chem., 279 (40), 41586-93, 2004.
95. Price, B., Adamidis, T., Kong, R., and Champness, W. A Streptomyces coelicolor antibiotic regulatory gene, absB, encodes an RNase III homolog. J. Bacteriol., 181 (19), 6142-51, 1999.
96. Aigle, B., Wietzorrek, A., Takano, E., and Bibb, M. J. A single amino acid substitution in region 1.2 of the principal sigma factor of Streptomyces coelicolor A3(2) results in pleiotropic loss of antibiotic production. Mol. Microbiol., 37 (5), 995-1004, 2000.
97. Bignell, D. R., Lau, L. H., Colvin, K. R., and Leskiw, B. K. The putative anti-anti-sigma factor BldG is post-translationally modified by phosphorylation in Streptomyces coelicolor. FEMS Microbiol. Lett., 225 (1), 93-9, 2003.
98. Bignell, D. R., Tahlan, K., Colvin, K. R., Jensen, S. E., and Leskiw, B. K. Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG. Antimicrob., Agents Chemother., 49 (4), 1529-41, 2005.
99. Leskiw, B. K., Lawlor, E. J., Fernandez-Abalos, J. M., and Chater, K. F. TTA codons in some genes prevent their expression in a class of developmental, antibiotic-negative, Streptomyces mutants. Proc. Natl. Acad. Sci. USA, 88 (6), 2461-5, 1991.
100. Fernandez-Moreno, M. A., Caballero, J. L., Hopwood, D. A., and Malpartida, F. The act cluster contains regulatory and antibiotic export genes, direct targets for translational control by the bldA tRNA gene of Streptomyces. Cell, 66 (4), 769-80, 1991.
101. Leskiw, B. K., Mah, R., Lawlor, E. J., and Chater, K. F. Accumulation of bldA-specified tRNA is temporally regulated in Streptomyces coelicolor A3(2). J. Bacteriol., 175 (7), 1995-2005, 1993.
102. Wright, F. and Bibb, M. J. Codon usage in the G+C-rich Streptomyces genome. Gene, 113 (1), 55-65, 1992.
103. Rebets, Y. V., Ostash, B. O., Fukuhara, M., Nakamura, T., and Fedorenko, V. O. Expression of the regulatory protein LndI for landomycin E production in Streptomyces globisporus 1912 is controlled by the availability of tRNA for the rare UUA codon. FEMS Microbiol. Lett. 256 (1), 30-7, 2006.
104. Ryding, N. J., Anderson, T. B., and Champness, W. C. Regulation of the Streptomyces coelicolor calcium-dependent antibiotic by absA, encoding a cluster-linked two-component system. J. Bacteriol. 184 (3), 794-805, 2002.
105. Huang, J., Shi, J., Molle, V., Sohlberg, B., Weaver, D., Bibb, M. J., Karoonuthaisiri, N., Lih, C. J., Kao, C. M., Buttner, M. J., and Cohen, S. N. Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor. Mol. Microbiol., 58 (5), 1276-87, 2005.
106. Stulke, J. and Hillen, W. Carbon catabolite repression in bacteria. Curr. Opin. Microbiol., 2 (2), 195-201, 1999.
107. Escalante, L., Ramos, I., Imriskova, I., Langley, E., and Sanchez, S. Glucose repression of anthracycline formation in Streptomyces peucetius var. caesius. Appl. Microbiol. Biotechnol., 52, 572-78, 1999.
108. Titgemeyer, F., Walkenhorst, J., Reizer, J., Stuiver, M. H., Cui, X., and Saier, M. H., Jr. Identification and characterization of phosphoenolpyruvate: fructose phosphotransferase systems in three Streptomyces species. Microbiology, 141 (Pt 1), 51-8, 1995.
109. Butler, M. J., Deutscher, J., Postma, P. W., Wilson, T. J., Galinier, A., and Bibb, M. J. Analysis of a ptsH homologue from Streptomyces coelicolor A3(2). FEMS Microbiol. Lett., 177 (2), 279-88, 1999.
110. Guzman, S., Ramos, I., Moreno, E., Ruiz, B., Rodriguez-Sanoja, R., Escalante, L., Langley, E., and Sanchez, S. Sugar uptake and sensitivity to carbon catabolite regulation in Streptomyces peucetius var. caesius. Appl. Microbiol. Biotechnol., 69 (2), 200-6, 2005.
111. Ramos, I., Guzman, S., Escalante, L., Imriskova, I., Rodriguez-Sanoja, R., Sanchez, S., and Langley, E. Glucose kinase alone cannot be responsible for carbon source regulation in Streptomyces peucetius var. caesius. Res. Microbiol., 155 (4), 267-74, 2004.
112. Camilli, A. and Bassler, B. L. Bacterial small-molecule signaling pathways. Science, 311 (5764), 1113-36, 2006.
113. Postma, P. W., Lengeler, J. W., and Jacobson, G. R. Phosphoenolpyruvate: carbohydrate phosphotransferase systems of bacteria. Microbiol. Rev., 57 (3), 543-94, 1993.
114. Susstrunk, U., Pidoux, J., Taubert, S., Ullmann, A., and Thompson, C. J. Pleiotropic effects of cAMP on germination, antibiotic biosynthesis and morphological development in Streptomyces coelicolor. Mol. Microbiol., 30 (1), 33-46, 1998.
115. Chatterjee, S. and Vining, L. C. Catabolite repression in Streptomyces venezuelae. Induction of betagalactosidase, chloramphenicol production, and intracellular cyclic adenosine 3',5'-monophosphate concentrations. Can. J. Microbiol., 28 (3), 311-7, 1982.
116. Chakraburtty, R. and Bibb, M. The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation. J. Bacteriol., 179 (18), 5854-61, 1997.
117. Sun, J., Hesketh, A., and Bibb, M. Functional analysis of relA and rshA, two relA/spoT homologues of Streptomyces coelicolor A3(2). J. Bacteriol., 183 (11), 3488-98, 2001.
118. Jin, W., Kim, H. K., Kim, J. Y., Kang, S. G., Lee, S. H., and Lee, K. J. Cephamycin C production is regulated by relA and rsh genes in Streptomyces clavuligerus ATCC27064. J. Biotechnol., 114 (1-2), 81-7, 2004.
119. Jin, W., Ryu, Y. G., Kang, S. G., Kim, S. K., Saito, N., Ochi, K., Lee, S. H., and Lee, K. J. Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus. Microbiology, 150 (Pt 5), 1485-93, 2004.
120. Hesketh, A., Sun, J., and Bibb, M. Induction of ppGpp synthesis in Streptomyces coelicolor A3(2) grown under conditions of nutritional sufficiency elicits actII-ORF4 transcription and actinorhodin biosynthesis. Mol. Microbiol., 39 (1), 136-44, 2001.
121. Xu, J., Tozawa, Y., Lai, C., Hayashi, H., and Ochi, K. A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2). Mol. Genet. Genomics, 268 (2), 179-89, 2002.
122. Hu, H., Zhang, Q., and Ochi, K. Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase beta subunit) of Streptomyces lividans. J. Bacteriol., 184 (14), 3984-91, 2002.
123. McDowall, K. J., Thamchaipenet, A., and Hunter, I. S. Phosphate control of oxytetracycline production by Streptomyces rimosus is at the level of transcription from promoters overlapped by tandem repeats similar to those of the DNA-binding sites of the OmpR family. J. Bacteriol., 181 (10), 3025-32, 1999.
124. Liras, P., Asturias, J. A., and Martin, J. F. Phosphate control sequences involved in transcriptional regulation of antibiotic biosynthesis. Trends Biotechnol., 8 (7), 184-89, 1990.
125. Sola-Landa, A., Rodriguez-Garcia, A., Franco-Dominguez, E., and Martin, J. F. Binding of PhoP to promoters of phosphate-regulated genes in Streptomyces coelicolor: identification of PHO boxes. Mol. Microbiol., 56 (5), 1373-85, 2005.
126. Chouayekh, H. and Virolle, M. J. The polyphosphate kinase plays a negative role in the control of antibiotic production in Streptomyces lividans. Mol. Microbiol., 43 (4), 919-30, 2002.
127. Chiang, P. K., Gordon, R. K., Tal, J., Zeng, G. C., Doctor, B. P., Pardhasaradhi, K., and McCann, P. P. S-Adenosylmethionine and methylation. Faseb J., 10 (4), 471-80, 1996.
128. Okamoto, S., Lezhava, A., Hosaka, T., Okamoto-Hosoya, Y., and Ochi, K. Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2). J. Bacteriol., 185 (2), 601-9, 2003.
129. Kim, D. J., Huh, J. H., Yang, Y. Y., Kang, C. M., Lee, I. H., Hyun, C. G., Hong, S. K., and Suh, J. W. Accumulation of S-adenosyl-L-methionine enhances production of actinorhodin but inhibits sporulation in Streptomyces lividans TK23. J. Bacteriol., 185 (2), 592-600, 2003.
130. Natsumi, S., Kazuhiko, K., Jun, X., Okamoto, X., and Ochi, K. Effect of S-adenosylmethionine on antibiotic production in Streptomyces griseus and Streptomyces griseuoflavus. Actinomyceteology, 17, 47-49, 2003.
131. Huh, J. H., Kim, D. J., Zhao, X. Q., Li, M., Jo, Y. Y., Yoon, T. M., Shin, S. K., Yong, J. H., Ryu, Y. W., Yang, Y. Y., and Suh, J. W. Widespread activation of antibiotic biosynthesis by S-adenosylmethionine in streptomycetes. FEMS Microbiol. Lett., 238 (2), 439-47, 2004.
132. Lee, H. S., Ohnishi, Y., and Horinouchi, S. A sigmaB-like factor responsible for carotenoid biosynthesis in Streptomyces griseus. J. Mol. Microbiol. Biotechnol., 3 (1), 95-101, 2001.
133. Takano, H., Obitsu, S., Beppu, T., and Ueda, K. Light-induced carotenogenesis in Streptomyces coelicolor A3(2): identification of an extracytoplasmic function sigma factor that directs photodependent transcription of the carotenoid biosynthesis gene cluster. J. Bacteriol., 187 (5), 1825-32, 2005.
134. Takano, H., Asker, D., Beppu, T., and Ueda, K. Genetic control for light-induced carotenoid production in non-phototrophic bacteria. J. Ind. Microbiol. Biotechnol., 33 (2), 88-93, 2006.
135. Price-Whelan, A., Dietrich, L. E., and Newman, D. K. Rethinking ‘secondary’ metabolism: physiological roles for phenazine antibiotics. Nat. Chem. Biol., 2 (2), 71-78, 2006.
136. Schuster, M., Lostroh, C. P., Ogi, T., and Greenberg, E. P. Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis. J. Bacteriol., 185 (7), 2066-79, 2003.
137. Wagner, V. E., Bushnell, D., Passador, L., Brooks, A. I., and Iglewski, B. H. Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment. J. Bacteriol., 185 (7), 2080-95, 2003.
138. Latifi, A., Foglino, M., Tanaka, K., Williams, P., and Lazdunski, A. A hierarchical quorum-sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary-phase sigma factor RpoS. Mol. Microbiol., 21 (6), 1137-46, 1996.
139. McGrath, S., Wade, D. S., and Pesci, E. C. Dueling quorum sensing systems in Pseudomonas aeruginosa control the production of the Pseudomonas quinolone signal (PQS). FEMS Microbiol., Lett 230 (1), 27-34, 2004.
140. Cao, H., Krishnan, G., Goumnerov, B., Tsongalis, J., Tompkins, R., and Rahme, L. G. A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism. Proc. Natl. Acad. Sci. USA, 98 (25), 14613-18, 2001.
141. Wade, D. S., Calfee, M. W., Rocha, E. R., Ling, E. A., Engstrom, E., Coleman, J. P., and Pesci, E. C. Regulation of Pseudomonas quinolone signal synthesis in Pseudomonas aeruginosa. J. Bacteriol., 187 (13), 4372-80, 2005.
142. Diggle, S. P., Winzer, K., Chhabra, S. R., Worrall, K. E., Camara, M., and Williams, P. The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR. Mol. Microbiol., 50 (1), 29-43, 2003.
143. Pesci, E. C., Milbank, J. B., Pearson, J. P., McKnight, S., Kende, A. S., Greenberg, E. P., and Iglewski, B. H. Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA, 96 (20), 11229-34, 1999.
144. Gallagher, L. A., McKnight, S. L., Kuznetsova, M. S., Pesci, E. C., and Manoil, C. Functions required for extracellular quinolone signaling by Pseudomonas aeruginosa. J. Bacteriol., 184 (23), 6472-80, 2002.
145. Deziel, E., Lepine, F., Milot, S., He, J., Mindrinos, M. N., Tompkins, R. G., and Rahme, L. G. Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication. Proc. Natl. Acad. Sci. USA, 101 (5), 1339-44, 2004.
146. Mashburn, L. M. and Whiteley, M. Membrane vesicles traffic signals and facilitate group activities in a prokaryote. Nature, 437 (7057), 422-5, 2005.
147. Mavrodi, D. V., Bonsall, R. F., Delaney, S. M., Soule, M. J., Phillips, G., and Thomashow, L. S. Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1. J. Bacteriol., 183 (21), 6454-65, 2001.
148. Diggle, S. P., Cornelis, P., Williams, P., and Camara, M. 4-quinolone signalling in Pseudomonas aeruginosa: old molecules, new perspectives. Int. J. Med. Microbiol., 296 (2-3), 83-91, 2006.
149. Ledgham, F., Ventre, I., Soscia, C., Foglino, M., Sturgis, J. N., and Lazdunski, A. Interactions of the quorum sensing regulator QscR: interaction with itself and the other regulators of Pseudomonas aeruginosa LasR and RhlR. Mol. Microbiol., 48 (1), 199-210, 2003.
150. Palma, M., Zurita, J., Ferreras, J. A., Worgall, S., Larone, D. H., Shi, L., Campagne, F., and Quadri, L. E. Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. Infect. Immun., 73 (5), 2958-66, 2005.
151. Whiteley, M., Lee, K. M., and Greenberg, E. P. Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA, 96 (24), 13904-9, 1999.
152. Aendekerk, S., Ghysels, B., Cornelis, P., and Baysse, C. Characterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium. Microbiology, 148 (Pt 8), 2371-81, 2002.
153. Aendekerk, S., Diggle, S. P., Song, Z., Hoiby, N., Cornelis, P., Williams, P., and Camara, M. The MexGHI-OpmD multidrug efflux pump controls growth, antibiotic susceptibility and virulence in Pseudomonas aeruginosa via 4-quinolone-dependent cell-to-cell communication. Microbiology, 151 (Pt 4), 1113-25, 2005.
154. Pearson, J. P., Van Delden, C., and Iglewski, B. H. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals. J. Bacteriol., 181 (4), 1203-10, 1999.
155. Kohler, T., van Delden, C., Curty, L. K., Hamzehpour, M. M., and Pechere, J. C. Overexpression of the MexEF-OprN multidrug efflux system affects cell-to-cell signaling in Pseudomonas aeruginosa. J. Bacteriol., 183 (18), 5213-22, 2001.
156. Hassan, H. M. and Fridovich, I. Mechanism of the antibiotic action pyocyanine. J. Bacteriol., 141 (1), 156-63, 1980.
157. Wilkinson, C. J., Hughes-Thomas, Z. A., Martin, C. J., Bohm, I., Mironenko, T., Deacon, M., Wheatcroft, M., Wirtz, G., Staunton, J., and Leadlay, P. F. Increasing the efficiency of heterologous promoters in actinomycetes. J. Mol. Microbiol. Biotechnol., 4 (4), 417-26, 2002.