Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: Evidence for requirement of a geranylgeranylated protein

Journal of Biological Chemistry

Volumn 286, Issue 37, 2011, Pages 32150-32161

  Leichner, Gil S ^a,b   Avner, Rachel ^b   Harats, Dror ^b   Roitelman, Joseph ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

26 S PROTEASOME; CHIMERIC PROTEINS; FARNESYL PYROPHOSPHATES; GALACTOSIDASES; GERANYLGERANYLATION; LANOSTEROL; MAMMALIAN CELLS; MEVALONATE PATHWAY; PROTEASOMAL DEGRADATION; RATE-LIMITING STEPS; UBIQUITYLATION;

BIOMOLECULES; DEGRADATION; MAMMALS; METABOLISM; METABOLITES;

PROTEINS;

BETA GALACTOSIDASE; CHIMERIC PROTEIN; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; GERANYLGERANYLATED PROTEIN; HYBRID PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LANOSTEROL; LANOSTEROL SYNTHASE; MEVALONIC ACID; PROTEASOME; PROTEIN; SQUALENE; SQUALENE MONOOXYGENASE; SQUALENE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; DEGRADATION; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENZYME DEGRADATION; MAMMAL CELL; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UBIQUITINATION;

CELL LINE; DITERPENES; ENDOPLASMIC RETICULUM; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIPOYLATION; MEVALONIC ACID; POLYISOPRENYL PHOSPHATES; SESQUITERPENES; UBIQUITINATION;

MAMMALIA;

EID: 80052779813     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.278036     Document Type: Article

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