Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase

Journal of Biological Chemistry

Volumn 284, Issue 11, 2009, Pages 6861-6868

  Baron, Rudi A ^a,g   Tavaré, Richard ^a,h   Figueiredo, Ana C ^a   Błazewska, Katarzyna M ^b   Kashemirov, Boris A ^b   McKenna, Charles E ^b   Ebetino, Frank H ^c   Taylor, Adam ^d   Rogers, MIchael J ^d   Coxon, Fraser P ^d   Seabra, Miguel C ^a,e,f  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

^e INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^f NOVA MEDICAL SCHOOL   (Portugal)

^g Cerenis Therapeutics   (France)

^h KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BISPHOSPHONATE; GERANYLGERANYLATION; IN-VITRO; IN-VIVO; N-TERMINAL; PHOSPHONATE GROUP; RAB GTPASES; RELATED COMPOUNDS; TERMINAL CYSTEINE;

BINDING ENERGY; CARBOXYLATION; ENZYMES; PROTEINS; SUBSTRATES;

BINDING SITES;

BISPHOSPHONIC ACID DERIVATIVE; PHOSPHONOCARBOXYLIC ACID; RAB GERANYLGERANYLTRANSFERASE; TRANSFERASE; UNCLASSIFIED DRUG; 2 (3 PYRIDINYL) 1 HYDROXYETHYLIDENE 1,1 PHOSPHONOCARBOXYLIC ACID; 2-(3-PYRIDINYL)-1-HYDROXYETHYLIDENE-1,1-PHOSPHONOCARBOXYLIC ACID; ENZYME INHIBITOR; GERANYLGERANYL PYROPHOSPHATE; ISOPRENOID PHOSPHATE; PYRIDINE DERIVATIVE; RAB PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN TARGETING; STRUCTURE ANALYSIS; ANIMAL; CELL LINE; DOG; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHYSIOLOGY; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE;

ALKYL AND ARYL TRANSFERASES; AMINO ACID MOTIFS; ANIMALS; BINDING SITES; CELL LINE; DIPHOSPHONATES; DOGS; ENZYME INHIBITORS; HUMANS; POLYISOPRENYL PHOSPHATES; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PYRIDINES; RAB GTP-BINDING PROTEINS;

EID: 65449173985     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806952200     Document Type: Article

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