Impaired regulation of 3-hydroxy-3-methylglutaryl-coenzyme a reductase degradation in lovastatin-resistant cells

Journal of Biological Chemistry

Volumn 274, Issue 41, 1999, Pages 29341-29351

  Ravid, Tommer ^a   Avner, Rachel ^b   Polak Charcon, Sylvie ^b   Faust, Jerry R ^c   Roitelman, Joseph ^a,b  

^a TEL AVIV UNIVERSITY   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYCHOLESTEROL; DNA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIPOPROTEIN; LUCIFERASE; MESSENGER RNA; MEVALONIC ACID; MEVINOLIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG RESISTANCE; ENZYME DEGRADATION; GENE AMPLIFICATION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSCRIPTION REGULATION;

ANIMALS; CELL DIVISION; CELL LINE; CHO CELLS; CRICETINAE; DRUG RESISTANCE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; HYDROXYCHOLESTEROLS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIPIDS; LIPOPROTEINS; LIPOPROTEINS, LDL; LOVASTATIN; MEVALONIC ACID; MICROSCOPY, ELECTRON; PROMOTER REGIONS (GENETICS); RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TRANSFECTION;

ANIMALIA;

EID: 0032832568     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.41.29341     Document Type: Article

References (66)

1. Siperstein, M. D., and Fagan, V. M. (1966) J. Biol. Chem. 241, 602-609
2. Schroepfer, J. G., Jr. (1981) Annu. Rev. Biochem. 50, 585-621
3. Goldstein, J. L., and Brown, M. S. (1990) Nature 343, 425-430
4. Clarke, S. (1992) Annu. Rev. Biochem. 61, 355-386
5. Brown, M. S., and Goldstein, J. L. (1986) Science 232, 34-47
6. Brown, M. S., Faust, J. R., Goldstein, J. L., Kaneko, I., and Endo, A. (1978) J. Biol. Chem. 253, 1121-1128
7. Brown, M. S., and Goldstein, J. L. (1980) J. Lipid Res. 21, 505-517
8. Endo, A. (1992) J. Lipid Res. 33, 1569-1582
9. Alberts, A. W., Chen, J., Curon, G., Hunt, V., Huff, J., Hoffman, C., Rothrock, J., Lopez, M., Joshau, H., Harris, E., Patchett, A., Monaghan, R., Currie, S., Stapely, E., Albers-Schonberg, G., Hensens, O., Hirshfield, J., Hoogsteen, K., Liesch, J., and Springer, J. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 3957-3961
10. Ryan, J., Hardeman, E. C., Endo, A., and Simoni, R. D. (1981) J. Biol. Chem. 256, 6762-6768
11. Liscum, L., Luskey, K. L., Chin, D. J., Ho, Y. K., Goldstein, J. L., and Brown, M. S. (1983) J. Biol. Chem. 258, 8450-8455
12. Osborne, T. F., Goldstein, J. L., and Brown, M. S. (1985) Cell 42, 203-212
13. Clarke, C. F., Fogelman, A. M., and Edwards, P. A. (1985) J. Biol. Chem. 260, 14363-14367
14. Peffley, D., and Sinensky, M. (1985) J. Biol. Chem. 260, 9949-9952
15. Nakanishi, M., Goldstein, J. L., and Brown, M. S. (1988) J. Biol. Chem. 263, 8929-8937
16. Peffley, D. M., and Gayen, A. K. (1995) Somat. Cell Mol. Genet. 21, 189-204
17. Gayen, A. K., and Peffley, D. M. (1995) Arch. Biochem. Biophys. 322, 475-485
18. Choi, J. W., and Peffley, D. M. (1995) Biochem. J. 307, 233-238
19. Faust, J. R., Luskey, K. L., Chin, D. J., Goldstein, J. L., and Brown, M. S. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 5205-5209
20. Sinensky, M., and Logel, J. (1983) J. Biol. Chem. 258, 8547-8549
21. Edwards, P. A., Lan, S. F., and Fogelman, A. M. (1983) J. Biol. Chem. 258, 10219-10222
22. Chin, D. J., Gil, G., Faust, J. R., Goldstein, J. L., Brown, M. S., and Luskey, K. L. (1985) Mol. Cell. Biol. 5, 634-641
23. Liscum, L., Cummings, R. D., Anderson, R. G. W., DeMartino, G. N., Goldstein, J. L., and Brown, M. S. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 7165-7169
24. Roitelman, J., Olender, E. H., Bar-Nun, S., Dunn, W. A., Jr., and Simoni, R. D. (1992) J. Cell Biol. 117, 959-973
25. Gil, G., Faust, J. R., Chin, D. J., Goldstein, J. L., and Brown, M. S. (1985) Cell 41, 249-258
26. Skalnik, D. G., Narita, H., Kent, C., and Simoni, R. D. (1988) J. Biol. Chem. 263, 6836-6841
27. Chun, K. T., and Simoni, R. D. (1992) J. Biol. Chem. 267, 4236-4246
28. Hampton, R. Y., Koning, A., Wright, R., and Rine, J. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 828-833
29. Kumagai, H., Chun, K. T., and Simoni, R. D. (1995) J. Biol. Chem. 270, 19107-19113
30. Brown, M. S., and Goldstein, J. L. (1997) Cell 89, 331-340
31. Chun, K. T., Bar-Nun, S., and Simoni, R. D. (1990) J. Biol. Chem. 265, 22004-22010
32. Roitelman, J., and Simoni, R. D. (1992) J. Biol. Chem. 267, 25264-25273
33. Inoue, S., Bar-Nun, S., Roitelman, J., and Simoni, R. D. (1991) J. Biol. Chem. 266, 13311-13317
34. Inoue, S., and Simoni, R. D. (1992) J. Biol. Chem. 267, 9080-9086
35. McGee, T. P., Cheng, H. H., Kumagai, H., Omura, S., and Simoni, R. D. (1996) J. Biol. Chem. 271, 25630-25638
36. Hampton, R. Y., Gardner, R. G., and Rine, J. (1996) Mol. Biol. Cell 7, 2029-2044
37. Hampton, R. Y., and Bhakta, H. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 12944-12948
38. Goldstein, J. L., Basu, S. K., and Brown, M. S. (1983) Methods Enzymol. 98, 241-260
39. Smith, J. R., Osborne, T. F., Brown, M. S., Goldstein, J. L., and Gil, G. (1988) J. Biol. Chem. 263, 18480-18487
40. Spear, D. H., Kutsunai, S. Y., Correll, C. C., and Edwards, P. A. (1992) J. Biol. Chem. 267, 14462-14469
41. Guan, G., Jiang, G., Koch, R. L., and Shechter, I. (1995) J. Biol Chem 270, 21958-21965
42. Bennett, M. K., Lopez, J. M., Sanchez, H. B., and Osborne, T. F. (1995) J. Biol. Chem. 270, 25578-25583
43. Yu, H., Kaung, G., Kobayashi, S., and Kopito, R. R. (1997) J. Biol. Chem. 272, 20800-20804
44. Yamamoto, T., Davis, C. G., Brown, M. S., Schneider, W. J., Casey, M. L., Goldstein, J. L., and Russell, D. W. (1984) Cell 39, 27-38
45. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., p. 9.58, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
46. Skalnik, D. G., and Simoni, R. D. (1985) DNA (N. Y.) 4, 439-444
47. Liscum, L., and Faust, J. R. (1987) J. Biol. Chem. 262, 17002-17008
48. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275
49. Chin, D. J., Luskey, K. L., Anderson, R. G. W., Faust, J. R., Goldstein, J. L., and Brown, M. S. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 1185-1189
50. Yokoyama, C., Wang, X., Briggs, M. R., Admon, A., Wu, J., Hua, X., Goldstein, J. L., and Brown, M. S. (1993) Cell 75, 187-197
51. Hua, X., Yokoyama, C., Wu, J., Briggs, M. R., Brown, M. S., Goldstein, J. L., and Wang, X. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 11603-11607
52. Rosser, D. S., Ashby, M. N., Ellis, J. L., and Edwards, P. A. (1989) J. Biol. Chem. 264, 12653-12656
53. Lippincott-Schwartz, J., Bonifacino, J. S., Yuan, L. C., and Klausner, R. D. (1988) Cell 54, 209-220
54. Klausner, R. D., and Sitia, R. (1990) Cell 62, 611-614
55. Bonifacino, J. S., and Lippincott-Schwartz, J. (1991) Curr. Opin. Cell Biol. 3, 592-600
56. Huppa, J. B., and Ploegh, H. L. (1997) Immunity 7, 113-122
57. Skalnik, D. G., Brown, D. A., Brown, P. C., Friedman, R. L., Hardeman, E. C., Schimke, R. T., and Simoni, R. D. (1985) J. Biol. Chem. 260, 1991-1994
58. Hasumi, K., Yamada, A., Shimizu, Y., and Endo, A. (1987) Eur. J. Biochem. 164, 547-552
59. Luskey, K. L., Faust, J. R., Chin, D. J., Brown, M. S., and Goldstein, J. L. (1983) J. Biol. Chem. 258, 8462-8469
60. Bishop, R. W. (1992) J. Lipid Res. 33, 549-557
61. Schimke, R. T., Kaufman, R. J., Alt, F. W., and Kellems, R. F. (1978) Science 202, 1051-1056
62. Sinensky, M., Logel, J., Schnitzer-Polokoff, R., and Norcross, R. A. (1985) FEBS Lett. 186, 219-223
63. Lam, W. L., and Doolittle, W. F. (1992) J. Biol. Chem. 267, 5829-5834
64. Hampton, R., Dimster-Denk, D., and Rine, J. (1996) Trends Biochem. Sci. 21, 140-145
65. Bordallo, J., Plemper, R. K., Finger, A., and Wolf, D. H. (1998) Mol. Biol. Cell 9, 209-222
66. Rao, S., Porter, D. C., Chen, X., Herliczek, T., Lowe, M., and Keyomarsi, K. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 7797-7802