The prolyl isomerase Pin1 is overexpressed in human esophageal cancer

Oncology Letters

Volumn 2, Issue 6, 2011, Pages 1191-1196

  Jin, Huawei ^a   Jiang, Jie ^b   Sun, Lifang ^a   Zheng, Fangfang ^a   Wu, Chengyan ^a   Peng, Lin ^a   Zhao, Yufen ^a   Wu, Xueji ^a  

^a XIAMEN UNIVERSITY   (China)

^b Xiamen Hospital of Traditional Chinese Medicine   (China)

Author keywords

Esophageal cancer; Immunohistochemistry; Peptidyl prolyl isomerase; Reverse transcription polymerase chain reaction

Indexed keywords

PEPTIDYLPROLYL ISOMERASE PIN1; PROTEIN P53;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; ESOPHAGUS CANCER; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; ISOMERIZATION; LUNG CANCER; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; STATISTICAL SIGNIFICANCE;

EID: 80052760494     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.392     Document Type: Article

References (25)

1. Lu KP, Hanes SD and Hunter T: A human peptidyl-prolyl isomerase essential for regulation of mitosis. Nature 380: 544-547, 1996.
2. Ranganathan R, Lu KP, Hunter T and Noel JP: Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell 89: 875-886, 1997.
3. Lu KP: Pinning down cell signaling, cancer and Alzheimer's disease. Trends Biochem Sci 29: 200-209, 2004.
4. Zhou XZ, Lu PJ, Wulf G and Lu KP: Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism. Cell Mol Life Sci 56: 788-806, 1999.
5. Kim MR, Choi HS, Heo TH, Hwang SW and Kang KW: Induction of vascular endothelial growth factor by peptidyl-prolyl isomerase Pin1 in breast cancer cells. Biochem Biophys Res Commun 369: 547-553, 2008.
6. Ryo A, Liou YC, Wulf G, Nakamura M, Lee SW and Lu KP: PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells. Mol Cell Biol 22: 5281-5295, 2002.
7. Lu KP, Liou YC and Zhou XZ: Pinning down proline-directed phosphorylation signaling. Trends Cell Biol 12: 164-172, 2002.
8. Wulf GM, Ryo A, Wulf GG, et al: Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1. EMBO J 20: 3459-3472, 2001.
9. Bao L, Kimzey A, Sauter G, Sowadski JM, Lu KP and Wang DG: Prevalent overexpression of prolyl isomerase Pin1 in human cancers. Am J Pathol 164: 1727-1737, 2004.
10. Ayala G, Wang D, Wulf G, et al: The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer. Cancer Res 63: 6244-6251, 2003.
11. He J, Zhou F, Shao K, et al: Overexpression of Pin1 in non-small cell lung cancer (NSCLC) and its correlation with lymph node metastases. Lung Cancer 56: 51-58, 2007.
12. Lu KP: Prolyl isomerase Pin1 as a molecular target for cancer diagnostics and therapeutics. Cancer Cell 4: 175-180, 2003.
13. Wulf G, Garg P, Liou YC, Iglehart D and Lu KP: Modeling breast cancer invivo and exvivo reveals an essential role of Pin1 in tumorigenesis. EMBO J 23: 3397-3407, 2004.
14. Lim J and Lu KP: Pinning down phosphorylated tau and tauopathies. Biochim Biophys Acta 1739: 311-322, 2005.
15. Brondani V, Schefer Q, Hamy F and Klimkait T: The peptidyl-prolyl isomerase Pin1 regulates phospho-Ser77 retinoic acid receptor alpha stability. Biochem Biophys Res Commun 328: 6-13, 2005.
16. Liou YC, Ryo A, Huang HK, et al: Loss of Pin1 function in the mouse causes phenotypes resembling cyclin D1-null phenotypes. Proc Natl Acad Sci USA 99: 1335-1340, 2002.
17. Liou YC, Sun A, Ryo A, et al: Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature 424: 556-561, 2003.
18. Balastik M, Lim J, Pastorino L and Lu KP: Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism? Biochim Biophys Acta 1772: 422-429, 2007.
19. Bulavin DV, Saito S, Hollander MC, et al: Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 18: 6845-6854, 1999.
20. Buschmann T, Potapova O, Bar-Shira A, et al: Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress. Mol Cell Biol 21: 2743-2754, 2001.
21. Radhakrishnan SK and Gartel AL: CDK9 phosphorylates p53 on serine residues 33, 315 and 392. Cell Cycle 5: 519-521, 2006.
22. D'Orazi G, Cecchinelli B, Bruno T, et al: Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis. Nat Cell Biol 4: 11-19, 2002.
23. Kurihara A, Nagoshi H, Yabuki M, Okuyama R, Obinata M and Ikawa S: Ser46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53-dependent apoptosis. Genes Cells 12: 853-861, 2007.
24. Wulf GM, Liou YC, Ryo A, Lee SW and Lu KP: Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J Biol Chem 277: 47976-47979, 2002.
25. Ryo A, Liou YC, Lu KP and Wulf G: Prolyl isomerase Pin 1: a catalyst for oncogenesis and a potential therapeutic target in cancer. J Cell Sci 116: 773-783, 2003.