Dysfunction of lacrimal and salivary glands in Sjögren's syndrome: Nonimmunologic injury in preinflammatory phase and mouse model

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Hayashi, Toshiharu ^a  

^a YAMAGUCHI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; AQUAPORIN 5; CLAUDIN 3; CLAUDIN 4; COMPLEMENT COMPONENT C3; CORTICOTROPIN; ESTROGEN; FC RECEPTOR; GAMMA INTERFERON; IMMUNOGLOBULIN G2A; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 5; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 7; LAMININ ALPHA2; LAMININ ALPHA4; LIPOCALIN; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN; PRASTERONE; PRASTERONE SULFATE; RIBONUCLEOPROTEIN; SEX HORMONE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADAPTIVE IMMUNITY; APOPTOSIS; AUTONOMIC NERVE; BASEMENT MEMBRANE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; ENVIRONMENTAL FACTOR; EPSTEIN BARR VIRUS; GENETIC SUSCEPTIBILITY; HEPATITIS C VIRUS; HUMAN; HUMORAL IMMUNITY; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; IMMUNOPATHOGENESIS; INFLAMMATION; INNATE IMMUNITY; LACRIMAL GLAND DISEASE; NONHUMAN; REVIEW; SALIVARY GLAND DISEASE; SJOEGREN SYNDROME; TIGHT JUNCTION; ANIMAL; AUTOIMMUNITY; DACRYOCYSTITIS; DISEASE MODEL; IMMUNOLOGY; LACRIMAL APPARATUS; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; SALIVARY GLAND; SIALOADENITIS;

ADAPTIVE IMMUNITY; ANIMALS; AUTOIMMUNITY; DACRYOCYSTITIS; DISEASE MODELS, ANIMAL; HUMANS; LACRIMAL APPARATUS; MICE; SALIVARY GLANDS; SIALADENITIS; SJOGREN'S SYNDROME;

EID: 80052681759     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/407031     Document Type: Review

References (136)

1. Porola P., Laine M., Virkki L., Poduval P., Konttinen Y. T., The influence of sex steroids on Sjgren's syndrome Annals of the New York Academy of Sciences 2007 1108 426 432 (Pubitemid 47528756)
2. Bolch K. J., Bluchanan W. W., Wohl M. J., Bunim J. J., Sjgren's syndrome: clinical, pathological, and serological studies of sixty-two cases Medicine 1965 44 187 231
3. Feltkamp T. E. W., Sjogren's syndrome in relation to other autoimmune diseases Netherlands Journal of Medicine 1992 40 3 105 107
4. Anderson L. G., Talal N., The spectrum of benign to malignant lymphoproliferation in Sjgren's syndrome Clinical and Experimental Immunology 1972 10 2 199 221
5. Mavragani C. P., Moutsopoulos H. M., The geoepidemiology of Sjgren's syndrome Autoimmunity Reviews 2010 9 5 A305 A310
6. Mitsias D. I., Kapsogeorgou E. K., Moutsopoulos H. M., Sjgren's syndrome: why autoimmune epithelitis? Oral Diseases 2006 12 6 523 532 (Pubitemid 44624354)
7. Nishimori I., Yamamoto Y., Okazaki K., Morita M., Onodera M., Kino J., Tamura S., Yamamoto Y., Identification of autoantibodies to a pancreatic antigen in patients with idiopathic chronic pancreatitis and Sjgren's syndrome Pancreas 1994 9 3 374 381 (Pubitemid 24116725)
8. Scofield R. H., Genetics of systemic lupus erythematosus and Sjgren's syndrome Current Opinion in Rheumatology 2009 21 5 448 453
9. Mavragani C. P., Moutsopoulos H. M., The geoepidemiology of Sjgren's syndrome Autoimmunity Reviews 2010 9 5 A305 A310
10. Miceli-Richard C., Gestermann N., Ittah M., Comets E., Loiseau P., Puechal X., Hachulla E., Gottenberg J. E., Lebon P., Becquemont L., Mariette X., The CGGGG insertion/deletion polymorphism of the IRF5 promoter is a strong risk factor for primary Sjgren's syndrome Arthritis and Rheumatism 2009 60 7 1991 1997
11. Miceli-Richard C., Comets E., Loiseau P., Puechal X., Hachulla E., Mariette X., Association of an IRF5 gene functional polymorphism with Sjgren's syndrome Arthritis and Rheumatism 2007 56 12 3989 3994 (Pubitemid 350262326)
12. Mamtani M., Anaya J. M., He W., Ahuja S. K., Association of copy number variation in the FCGR3B gene with risk of autoimmune diseases Genes and Immunity 2010 11 2 155 160
13. Laine M., Porola P., Udby L., Kjeldsen L., Cowland J. B., Borregaard N., Hietanen J., Sthle M., Pihakari A., Konttinen Y. T., Low salivary dehydroepiandrosterone and androgen-regulated cysteine-rich secretory protein 3 levels in Sjgren's syndrome Arthritis and Rheumatism 2007 56 8 2575 2584 (Pubitemid 47237276)
14. Porola P., Laine M., Virkki L., Poduval P., Konttinen Y. T., The influence of sex steroids on Sjgren's syndrome Annals of the New York Academy of Sciences 2007 1108 426 432 (Pubitemid 47528756)
15. Porola P., Virkki L., Przybyla B. D., Laine M., Patterson T. A., Pihakari A., Konttinen Y. T., Androgen deficiency and defective intracrine processing of dehydroepiandrosterone in salivary glands in Sjgren's syndrome Journal of Rheumatology 2008 35 11 2229 2235
16. Sullivan D. A., Block L., Pena J. D. O., Influence of androgens and pituitary hormones on the structural profile and secretory activity of the lacrimal gland Acta Ophthalmologica Scandinavica 1996 74 5 421 435 (Pubitemid 26390484)
17. Tzioufas A. G., Tsonis J., Moutsopoulos H. M., Neuroendocrine dysfunction in Sjgren's syndrome NeuroImmunoModulation 2008 15 1 37 45
18. Konttinen Y. T., Porola P., Konttinen L., Laine M., Poduval P., Immunohistopathology of Sjgren's syndrome Autoimmunity Reviews 2006 6 1 16 20
19. Nikolov N. P., Illei G. G., Pathogenesis of Sjgren's syndrome Current Opinion in Rheumatology 2009 21 5 465 470
20. Balada E., Ordi-Ros J., Vilardell-Tarrés M., Molecular mechanisms mediated by Human Endogenous Retroviruses (HERVs) in autoimmunity Reviews in Medical Virology 2009 19 5 273 286
21. Willoughby C. E., Baker K., Kaye S. B., Carey P., O'Donnell N., Field A., Longman L., Bucknall R., Hart C. A., Epstein-Barr virus (types 1 and 2) in the tear film in Sjgren's syndrome and HIV infection Journal of Medical Virology 2002 68 3 378 383
22. Toussirot., Roudier J., Epstein-Barr virus in autoimmune diseases Best Practice and Research 2008 22 5 883 896
23. Venables P. J. W., Rigby S. P., Viruses in the etiopathogenesis of Sjgren's syndrome Journal of Rheumatology 1997 24 50 3 5
24. Moyes D., Martin A., Sawcer S., Temperton N., Griffiths D., Venables P., The distribution of the endogenous retroviruses HERV-K113 and-K115 in health and disease: HERV-K113 as a novel risk factor for Sjgren's syndrome Genomics 2005 86 337 341 (Pubitemid 41096703)
25. Couderc L.-J., D'Agay M.-F., Danon F., Harzic M., Brocheriou C., Clauvel J. P., Sicca complex and infection with human immunodeficiency virus Archives of Internal Medicine 1987 147 898 901 (Pubitemid 17082481)
26. Navone R., Lunardi C., Gerli R., Tinazzi E., Peterlana D., Bason C., Corrocher R., Puccetti A., Identification of tear lipocalin as a novel autoantigen target in Sjgren's syndrome Journal of Autoimmunity 2005 25 3 229 234 (Pubitemid 41654468)
27. Francis L., Perl A., Infection in systemic lupus erythematosus: friend or foe? International Journal of Clinical Rheumatology 2010 5 1 59 74
28. Amital H., Govoni M., Maya R., Meroni P. L., Ori B., Shoenfeld Y., Tincani A., Trotta F., Sarzi-Puttini P., Atzeni F., Role of infectious agents in systemic rheumatic diseases Clinical and Experimental Rheumatology 2008 26 1 S27 S32
29. Kamradt T., Gggel R., Erb K. J., Induction, exacerbation and inhibition of allergic and autoimmune diseases by infection Trends in Immunology 2005 26 5 260 267 (Pubitemid 41556849)
30. Vitali C., Bombardieri S., Jonsson R., Moutsopoulos H. M., Alexander E. L., Carsons S. E., Daniels T. E., Fox P. C., Fox R. I., Kassan S. S., Pillemer S. R., Talal N., Weisman M. H., Classification criteria for Sjgren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group Annals of the Rheumatic Diseases 2002 61 6 554 558 (Pubitemid 34539104)
31. Soyfoo M. S., Steinfeld S., Delporte C., Usefulness of mouse models to study the pathogenesis of Sjgren's syndrome Oral Diseases 2007 13 4 366 375 (Pubitemid 46934581)
32. Cha S., Peck A. B., Humphreys-Beher M. G., Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update Critical Reviews in Oral Biology and Medicine 2002 13 1 5 16 (Pubitemid 34792757)
33. Robinson C. P., Cornelius J., Bounous D. E., Yamamoto H., Humphreys-Beher M. G., Peck A. B., Characterization of the changing lymphocyte populations and cytokine expression in the exocrine tissues of autoimmune NOD mice Autoimmunity 1998 27 1 29 44 (Pubitemid 28070069)
34. Humphreys-Beher M. G., Brayer J., Yamachika S., Peck A. B., Jonsson R., An alternative perspective to the immune response in autoimmune exocrinopathy: induction of functional quiescence rather than destructive autoaggression Scandinavian Journal of Immunology 1999 49 1 7 10 (Pubitemid 29052430)
35. Talal N., Sylvester R. A., Daniels T. E., Greenspan J. S., Williams R. C. Jr., T and B lymphocytes in peripheral blood and tissue lesions in Sjgren's syndrome Journal of Clinical Investigation 1974 53 1 180 189
36. Ohyama Y., Nakamura S., Matsuzaki G., Shinohara M., Hiroki A., Fujimura T., Yamada A., Itoh K., Nomoto K., Cytokine messenger RNA expression in the labial salivary glands of patients with Sjgren's syndrome Arthritis and Rheumatism 1996 39 8 1376 1384 (Pubitemid 26270098)
37. Fox R. I., Kang H. I., Ando D., Abrams J., Pisa E., Cytokine mRNA expression in salivary gland biopsies of Sjgren's syndrome Journal of Immunology 1994 152 11 5532 5539 (Pubitemid 24153003)
38. Mitsias D. I., Tzioufas A. G., Veiopoulou C., Zintzaras E., Tassios I. K., Kogopoulou O., Moutsopoulos H. M., Thyphronitis G., The Th1/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjgren's syndrome Clinical and Experimental Immunology 2002 128 3 562 568 (Pubitemid 34639321)
39. Katsifis G. E., Rekka S., Moutsopoulos N. M., Pillemer S., Wahl S. M., Systemic and local interleukin-17 and linked cytokines associated with Sjgren's syndrome immunopathogenesis American Journal of Pathology 2009 175 3 1167 1177
40. Espinosa A., Dardalhon V., Brauner S., Ambrosi A., Higgs R., Quintana F. J., Sjstrand M., Eloranta M. L., Gabhann J. N., Winqvist O., Sundelin B., Jefferies C. A., Rozell B., Kuchroo V. K., Wahren-Herlenius M., Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway Journal of Experimental Medicine 2009 206 8 1661 1671
41. Sakai A., Sugawara Y., Kuroishi T., Sasano T., Sugawara S., Identification of IL-18 and Th17 cells in salivary glands of patients with Sjgren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18 Journal of Immunology 2008 181 4 2898 2906
42. Nguyen C. Q., Hu M. H., Li Y., Stewart C., Peck A. B., Salivary gland tissue expression of interleukin-23 and interleukin-17 in Sjgren's syndrome: findings in humans and mice Arthritis and Rheumatism 2008 58 3 734 743 (Pubitemid 351364871)
43. Espinosa A., Dardalhon V., Brauner S., Ambrosi A., Higgs R., Quintana F. J., Sjstrand M., Eloranta M. L., Gabhann J. N., Winqvist O., Sundelin B., Jefferies C. A., Rozell B., Kuchroo V. K., Wahren-Herlenius M., Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway Journal of Experimental Medicine 2009 206 8 1661 1671
44. Fox R. I., Kang H. I., Pathogenesis of Sjgren's syndrome Rheumatic Disease Clinics of North America 1992 18 3 517 538
45. Haneji N., Hamano H., Yanagi K., Hayashi Y., A new animal model for primary Sjgren's syndrome in NFS/sld mutant mice Journal of Immunology 1994 153 6 2769 2777
46. Kino-Ohsaki J., Nishimori I., Morita M., Okazaki K., Yamamoto Y., Onishi S., Serum antibodies to carbonic anhydrase I and II in patients with idiopathic chronic pancreatitis and Sjgren's syndrome Gastroenterology 1996 110 5 1579 1586 (Pubitemid 26134092)
47. Bacman S. R., Berra A., Sterin-Borda L., Borda E. S., Human primary Sjgren's syndrome autoantibodies as mediators of nitric oxide release coupled to lacrimal gland muscarinic acetylcholine receptors Current Eye Research 1998 17 12 1135 1142 (Pubitemid 28562895)
48. Bacman S., Sterin-Borda L., Camusso J. J., Arana R., Hubscher O., Borda E., Circulating antibodies against rat parotid gland M muscarinic receptors in primary Sjgren's syndrome Clinical and Experimental Immunology 1996 104 3 454 459
49. Warnock M. G., Goodacre J. A., Cryptic T-cell epitopes and their role in the pathogenesis of autoimmune diseases British Journal of Rheumatology 1997 36 11 1144 1150
50. Paranyuk Y., Claros N., Birzgalis A., Moore L. C., Brink P. R., Walcott B., Lacrimal gland fluid secretion and lymphocytic infiltration in the NZB/W mouse model of Sjgren's syndrome Current Eye Research 2001 23 3 199 205 (Pubitemid 34497360)
51. Jonsson M. V., Delaleu N., Brokstad K. A., Berggreen E., Skarstein K., Impaired salivary gland function in NOD mice: association with changes in cytokine profile but not with histopathologic changes in the salivary gland Arthritis and Rheumatism 2006 54 7 2300 2305 (Pubitemid 44051088)
52. Deshmukh U. S., Ohyama Y., Bagavant H., Guo X., Gaskin F., Fu S. M., Inflammatory stimuli accelerate Sjgren's syndrome-like disease in (NZB x NZW)F 1 mice Arthritis and Rheumatism 2008 58 5 1318 1323 (Pubitemid 351705921)
53. Robinson C. P., Yamamoto H., Peck A. B., Humphreys-Beher M. G., Genetically programmed development of salivary gland abnormalities in the NOD (nonobese diabetic)-scid mouse in the absence of detectable lymphocytic infiltration: a potential trigger for sialoadenitis of NOD mice Clinical Immunology and Immunopathology 1996 79 1 50 59 (Pubitemid 26150330)
54. Rosignoli F., Roca V., Meiss R., Leceta J., Gomariz R. P., Leirs C. P., Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis Clinical and Experimental Immunology 2005 142 3 411 418 (Pubitemid 41719835)
55. Wildenberg M. E., van Helden-Meeuwsen C. G., van de Merwe J. P., Drexhage H. A., Versnel M. A., Systemic increase in type I interferon activity in Sjgren's syndrome: a putative role for plasmacytoid dendritic cells European Journal of Immunology 2008 38 7 2024 2033
56. Voulgarelis M., Tzioufas A. G., Pathogenetic mechanisms in the initiation and perpetuation of Sjgren's syndrome Nature Reviews Rheumatology 2010 6 9 529 537
57. Humphreys-Beher M. G., Yamachika S., Yamamoto H., Maeda N., Nakagawa Y., Peck A. B., Robinson C. P., Salivary gland changes in the NOD mouse model for Sjgren's syndrome: is there a non-immune genetic trigger? European Journal of Morphology 1998 36 2 247 251
58. Kong L., Robinson C. P., Peck A. B., Vela-Roch N., Sakata K. M., Dang H., Talal N., Humphreys-Beher M. G., Inappropriate apoptosis of salivary and lacrimal gland epithelium of immunodeficient NOD-scid mice Clinical and Experimental Rheumatology 1998 16 6 675 681 (Pubitemid 28506087)
59. Qi GE., Hua H., Gao Y., Lin Q., Yu G. Y., Sialoadenitis progression in nonobese diabetic mice and its correlation with expression of apoptosis-associated proteins in salivary glands and serum IgG levels Chinese Medical Journal 2007 120 16 1426 1431 (Pubitemid 47364974)
60. Ohlsson M., Skarstein K., Bolstad A. I., Johannessen A. C., Jonsson R., Fas-induced apoptosis is a rare event in Sjgren's syndrome Laboratory Investigation 2001 81 1 95 105 (Pubitemid 32108643)
61. Fox R. I., Maruyama T., Pathogenesis and treatment of Sjgren's syndrome Current Opinion in Rheumatology 1997 9 5 393 399
62. Dawson L. J., Field E. A., Harmer A. R., Smith P. M., Acetylcholine-evoked calcium mobilization and ion channel activation in human labial gland acinar cells from patients with primary Sjgren's syndrome Clinical and Experimental Immunology 2001 124 3 480 485 (Pubitemid 32701712)
63. Pedersen A. M., Dissing S., Fahrenkrug J., Hannibal J., Reibel J., Nauntofte B., Innervation pattern and Ca 2+ signalling in labial salivary glands of healthy individuals and patients with primary Sjogren's syndrome (pSS) Journal of Oral Pathology and Medicine 2000 29 3 97 109 (Pubitemid 30156929)
64. Van Blokland S. C., Van Helden-Meeuwsen C. G., Wierenga-Wolf A. F., Apoptosis and apoptosis-related molecules in the submandibular gland of the nonobese diabetic mouse model for Sjgren's syndrome: limited role for apoptosis in the development of sialoadenitis Lavoratory Investigation 2000 80 4 575 585
65. Manganelli P., Fietta P., Apoptosis and Sjgren syndrome Seminars in Arthritis and Rheumatism 2003 33 1 49 65
66. Dawson L. J., Fox P. C., Smith P. M., Sjgrens syndromethe non-apoptotic model of glandular hypofunction Rheumatology 2006 45 7 792 798 (Pubitemid 43985364)
67. King L. S., Yasui M., Agre P., Aquaporins in health and disease Molecular Medicine 2000 6 2 60 65 (Pubitemid 30070667)
68. Delporte C., Steinfeld S., Distribution and roles of aquaporins in salivary glands Biochimica et Biophysica Acta 2006 1758 8 1061 1070 (Pubitemid 44373853)
69. Xiao L., Ng T. B., Feng Y. B., Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjgren's syndrome Phytomedicine 2011 18 2-3 194 198
70. Steinfeld S., Cogan E., King L. S., Agre P., Kiss R., Delporte C., Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjgren's syndrome patients Laboratory Investigation 2001 81 2 143 148 (Pubitemid 32176377)
71. Beroukas D., Hiscock J., Gannon B. J., Jonsson R., Gordon T. P., Waterman S. A., Selective down-regulation of aquaporin-1 in salivary glands in primary Sjgren's syndrome Laboratory Investigation 2002 82 11 1547 1552 (Pubitemid 35332913)
72. Tsubota K., Hirai S., King L. S., Agre P., Ishida N., Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjgren's syndrome Lancet 2001 357 9257 688 689 (Pubitemid 32206430)
73. Beroukas D., Hiscock J., Jonsson R., Waterman S. A., Gordon T. P., Subcellular distribution of aquaporin 5 in salivary glands in primary Sjgren's syndrome Lancet 2001 358 9296 1875 1876 (Pubitemid 34008658)
74. Groneberg D. A., Peiser C., Fischer A., Distribution of salivary aquaporin-5 in Sjgren's syndrome Lancet 2002 359 9319 1778 1779
75. Sasaki Y., Tsubota K., Kawedia J. D., Menon A. G., Yasui M., The difference of aquaporin 5 distribution in acinar and ductal cells in lacrimal and parotid glands Current Eye Research 2007 32 11 923 929 (Pubitemid 350135722)
76. Krane C. M., Melvin J. E., Nguyen HA. V., Richardson L., Towne J. E., Doetschman T., Menon A. G., Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation Journal of Biological Chemistry 2001 276 26 23413 23420
77. Moore M., Ma T., Yang B., Verkman A. S., Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5 Experimental Eye Research 2000 70 5 557 562
78. Soyfoo M. S., De Vriese C., Debaix H., Martin-Martinez M. D., Mathieu C., Devuyst O., Steinfeld S. D., Delporte C., Modified aquaporin 5 expression and distribution in submandibular glands from NOD mice displaying autoimmune exocrinopathy Arthritis and Rheumatism 2007 56 8 2566 2574 (Pubitemid 47237275)
79. Nishimura H., Yakeishi A., Saga T., Yamaki K., Effects of cevimeline on the immunolocalization of aquaporin-5 and the ultrastructure of salivary glands in Sjgren's syndrome model mice Kurume Medical Journal 2009 56 3-4 39 47
80. Konttinen Y. T., Tensing E. K., Laine M., Porola P., Trnwall J., Hukkanen M., Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjgren's syndrome Journal of Rheumatology 2005 32 6 1071 1075 (Pubitemid 40828081)
81. Taniguchi T., Takaoka A., A weak signal for strong responses: interferon- / revisited Nature Reviews Molecular Cell Biology 2001 2 5 378 386 (Pubitemid 33674050)
82. Rnnblom L., Alm G. V., An etiopathogenic role for the type I IFN system in SLE Trends in Immunology 2001 22 8 427 431 (Pubitemid 32709976)
83. Anaya J. M., Mantilla R. D., Correa P. A., Immunogenetics of primary Sjgren's syndrome in Colombians Seminars in Arthritis and Rheumatism 2005 34 5 735 743
84. Bve U., Nordmark G., Lvgren T., Rnnelid J., Cajander S., Eloranta M. L., Alm G. V., Rnnblom L., Activation of the type I interferon system in primary Sjgren's syndrome: a possible etiopathogenic mechanism Arthritis and Rheumatism 2005 52 4 1185 1195 (Pubitemid 40530126)
85. Oxholm P., Daniels T. E., Bendtzen K., Cytokine expression in labial salivary glands from patients with primary Sjgren's syndrome Autoimmunity 1992 12 3 185 191
86. Ittah M., Miceli-Richard C., Gottenberg J. E., Sellam J., Eid P., Lebon P., Pallier C., Lepajolec C., Mariette X., Viruses induce high expression of BAFF by salivary gland epithelial cells through TLR- and type-I IFN-dependent and -independent pathways European Journal of Immunology 2008 38 4 1058 1064
87. Horwitz D. A., Zheng S. G., Wang J., Gray J. D., Critical role of IL-2 and TGF- in generation, function and stabilization of Foxp3 + CD4 + Treg European Journal of Immunology 2008 38 4 912 915
88. Banchereau J., Pascual V., Type I interferon in systemic lupus erythematosus and other autoimmune diseases Immunity 2006 25 3 383 392 (Pubitemid 44354221)
89. Deshmukh U. S., Nandula S. R., Thimmalapura P. R., Scindia Y. M., Bagavant H., Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function Journal of Oral Pathology and Medicine 2009 38 1 42 47
90. Gottenberg J. E., Cagnard N., Lucchesi C., Letourneur F., Mistou S., Lazure T., Jacques S., Ba N., Ittah M., Lepajolec C., Labetoulle M., Ardizzone M., Sibilia J., Fournier C., Chiocchia G., Mariette X., Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjgren's syndrome Proceedings of the National Academy of Sciences of the United States of America 2006 103 8 2770 2775
91. Moutsopoulos N. M., Katsifis G. E., Angelov N., Leakan R. A., Sankar V., Pillemer S., Wahl S. M., Lack of efficacy of etanercept in Sjgren syndrome correlates with failed suppression of tumour necrosis factor and systemic immune activation Annals of the Rheumatic Diseases 2008 67 10 1437 1443
92. Shiozawa S., Shiozawa K., Shimizu S., Tanaka Y., Morimoto I., Yoshihara R., Kuroki Y., Hashimoto M., Fujita T., Immunoreactive circulating alpha-interferon is low in Sjgren's syndrome British Journal of Rheumatology 1990 29 1 50 52 (Pubitemid 20040240)
93. Niewold T. B., Rivera T. L., Buyon J. P., Crow M. K., Serum type I interferon activity is dependent on maternal diagnosis in anti-SSA/Ro-positive mothers of children with neonatal lupus Arthritis and Rheumatism 2008 58 2 541 546 (Pubitemid 351294888)
94. Mariette X., Gottenberg J. E., Pathogenesis of Sjgren's syndrome and therapeutic consequences Current Opinion of Rheumatology 2010 22 5 471 477
95. Voulgarelis M., Tzioufas A. G., Pathogenetic mechanisms in the initiation and perpetuation of Sjgren's syndrome Nature Reviews Rheumatology 2010 6 9 529 537
96. Hayashi T., Hayashi H., Fujii T., Adachi C., Hasegawa K., Ultrastructure of myoepithelial cells as a target cell in sialoadenitis of submandibular glands of lupus-prone female NZBxNZWF 1 mice Virchows Archiv 2008 453 2 177 188
97. Nguyen C. Q., Kim H., Cornelius J. G., Peck A. B., Development of Sjgren's syndrome in nonobese diabetic-derived autoimmune-prone C57BL/6.NOD-Aec1Aec2 mice is dependent on complement component-3 Journal of Immunology 2007 179 4 2318 2329
98. Szodoray P., Alex P., Brun J. G., Centola M., Jonsson R., Circulating cytokines in primary Sjgren's syndrome determined by a multiplex cytokine array system Scandinavian Journal of Immunology 2004 59 6 592 599 (Pubitemid 38789229)
99. Roescher N., Tak P. P., Illei G. G., Cytokines in Sjgren's syndrome Oral Diseases 2009 15 8 519 526
100. Baturone R., Soto M. J., Mrquez M., Macas I., Montes De Oca M., Medina F., Chozas N., Garca-Pérez S., Girn-Gonzlez J. A., Health-related quality of life in patients with primary Sjgren's syndrome: relationship with serum levels of proinflammatory cytokines Scandinavian Journal of Rheumatology 2009 38 5 386 389
101. Willeke P., Schotte H., Schlter B., IL-1beta and TNF alpha secreting cells are increased in the peripheral blood of patients with primary Sjgren's syndrome Annals of Rheumatic Diseases 2003 62 4 359 362 (Pubitemid 36363446)
102. Solomon A., Dursun D., Liu Z., Xie Y., Macri A., Pflugfelder S. C., Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease Investigative Ophthalmology and Visual Science 2001 42 10 2283 2292 (Pubitemid 32848857)
103. Jabs D. A., Gérard H. C., Wei Y., Campbell A. L., Hudson A. P., Akpek E. K., Lee B., Prendergast R. A., Whittum-Hudson J. A., Inflammatory mediators in autoimmune lacrimal gland disease in MRL/Mpj mice Investigative Ophthalmology and Visual Science 2004 45 7 2293 2298 (Pubitemid 38902601)
104. Li X., Wu K., Edman M., Increased expression of cathepsins and obesity-induced pro-inflammatory cytokines in lacrimal glands of male NOD mouse Investigative Ophthalmology Visual Science 2010 51 10 5019 5029
105. Hamano H., Haneji N., Yanagi K., Ishimaru N., Hayashi Y., Expression of HLA-DR and cytokine genes on interferon- -stimulated human salivary gland cell line Pathobiology 1996 64 5 255 261 (Pubitemid 27090904)
106. Manoussakis M. N., Dimitriou I. D., Kapsogeorgou E. K., Xanthou G., Paikos S., Polihronis M., Moutsopoulos H. M., Expression of B7 costimulatory molecules by salivary gland epithelial cells in patients with Sjgren's syndrome Arthritis and Rheumatism 1999 42 2 229 239 (Pubitemid 29072839)
107. Hayashi T., Hasegawa K., Adachi C., Elimination of CD4 + CD25 + T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZBxNZWF1 mice Intenational Journal of Experimental Pathology 2005 86 5 289 296 (Pubitemid 41413624)
108. Hayashi T., Adachi C., Hasegawa K., Systemic treatment of anti-CD4 + CD25 + T cell monoclonal antibody exacerbates sialoadenitis in submandibular glands during the early life in lupus-prone female NZB NZWF 1 mice Journal of Oral Pathology and Medicine 2009 38 2 234 240
109. Hayashi T., Hasegawa K., Ichinohe N., ICAM-1 expression on endothelium and systemic cytokine production in cutaneous neutrophilic leucocytoclastic vasculitis in NZBxNZWF 1 mice Histology and Histopathology 2005 20 1 45 52 (Pubitemid 40028982)
110. Hasegawa K., Hayashi T., Synthetic CpG oligodeoxynucleotides accelerate the development of lupus nephritis during preactive phase in NZB NZWF 1 mice Lupus 2003 12 11 838 845 (Pubitemid 37463101)
111. Yamakawa M., Weinstein R., Tsuji T., McBride J., Wong D. T. W., Login G. R., Age-related alterations in IL-1, TNF-, and IL-6 concentrations in parotid acinar cells from BALB/c and non-obese diabetic mice Journal of Histochemistry and Cytochemistry 2000 48 8 1033 1041 (Pubitemid 30640190)
112. Yao C., Li X., Murdiastuti K., Kosugi-Tanaka C., Akamatsu T., Kanamori N., Hosoi K., Lipopolysaccharide-induced elevation and secretion of interleukin-1 in the submandibular gland of male mice Immunology 2005 116 2 213 222 (Pubitemid 41368663)
113. Zoukhri D., Hodges R. R., Byon D., Kublin C. L., Role, of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia Investigative Ophthalmology and Visual Science 2002 43 5 1429 1436 (Pubitemid 34462641)
114. Andonopoulos A. P., Christodoulou J., Ballas C., Bounas A., Alexopoulos D., Autonomic cardiovascular neuropathy in Sjgren's syndrome. A controlled study Journal of Rheumatology 1998 25 12 2385 2388 (Pubitemid 28551856)
115. Cai F. Z. J., Lester S., Lu T., Keen H., Boundy K., Proudman S. M., Tonkin A., Rischmueller M., Mild autonomic dysfunction in primary Sjgren's syndrome: a controlled study Arthritis Research and Therapy 2008 10 2, article R31
116. Kovacs L., Papos M., Takacs R., Autonomic nervous system dysfunction involving the gastrointestinal and the urinary tracts in primary Sjgren's syndrome Clinicla Experimental Rheumatology 2003 21 697 703 (Pubitemid 38008751)
117. Mandl T., Granberg V., Apelqvist J., Wollmer P., Manthorpe R., Jacobsson L. T. H., Autonomic nervous symptoms in primary Sjgren's syndrome Rheumatology 2008 47 6 914 919 (Pubitemid 351796384)
118. Barendregt P. J., Visser M. R. M., Smets E. M. A., Tulen J. H. M., Van Den Meiracker A. H., Boomsma F., Markusse H. M., Fatigue in primary Sjgren's syndrome Annals of the Rheumatic Diseases 1998 57 5 291 295
119. Zoukhri D., Kublin C. L., Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjgren's syndrome Investigative Ophthalmology and Visual Science 2001 42 5 925 932 (Pubitemid 32289786)
120. Gordon T. P., Bolstad A. I., Rischmueller M., Jonsson R., Waterman S. A., Autoantibodies in primary Sjgren's syndrome: new insights into mechanisms of autoantibody diversification and disease pathogenesis Autoimmunity 2001 34 2 123 132 (Pubitemid 34149800)
121. Berggreen E., Nylkken K., Delaleu N., Hajdaragic-Ibricevic H., Jonsson M. V., Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice Arthritis Research and Therapy 2009 11 1, article R18
122. Pedersen A. M., Dissing S., Fahrenkrug J., Hannibal J., Reibel J., Nauntofte B., Innervation pattern and Ca 2+ signalling in labial salivary glands of healthy individuals and patients with primary Sjgren's syndrome (pSS) Journal of Oral Pathology and Medicine 2000 29 3 97 109 (Pubitemid 30156929)
123. Zoukhri D., Kublin C. L., Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjgren's syndrome Investigative Ophthalmolology Visual Science 2001 42 5 925 932 (Pubitemid 32289786)
124. Santavirta N., Konttinen Y. T., Trnwall J., Segerberg M., Santavirta S., Matucci-Cerinic M., Bjrvell H., Neuropeptides of the autonomic nervous system in Sjgren's syndrome Annals of the Rheumatic Diseases 1997 56 12 737 740 (Pubitemid 28064840)
125. Humphreys-Beher M. G., Brayer J., Yamachika S., Peck A. B., Jonsson R., An alternative perspective to the immune response in autoimmune exocrinopathy: induction of functional quiescence rather than destructive autoaggression Scandinavian Journal of Immunology 1999 49 1 7 10 (Pubitemid 29052430)
126. Mellgren S. I., Gransson L. G., Omdal R., Primary Sjgren's syndrome associated neuropathy Canadian Journal of Neurological Sciences 2007 34 3 280 287 (Pubitemid 47359830)
127. Ewert P., Aguilera S., Alliende C., Kwon Y. J., Albornoz A., Molina C., Urza U., Quest A. F. G., Olea N., Pérez P., Castro I., Barrera M. J., Romo R., Hermoso M., Leyton C., Gonzlez M. J., Disruption of tight junction structure in salivary glands from Sjgren's syndrome patients is linked to proinflammatory cytokine exposure Arthritis and Rheumatism 2010 62 5 1280 1289
128. Baker O. J., Camden J. M., Redman R. S., Jones J. E., Seye C. I., Erb L., Weisman G. A., Proinflammatory cytokines tumor necrosis factor- and interferon- alter tight junction structure and function in the rat parotid gland Par-C10 cell line American Journal of Physiology 2008 295 5 C1191 C1201
129. Molina C., Alliende C., Aguilera S., Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjgren's syndrome: association with mononuclear cell infiltration Annals of Rhematic Diseases 2006 65 2 178 183 (Pubitemid 43131990)
130. McArthur C. P., Fox N. W., Kragel P., Monoclonal antibody detection of laminin in minor salivary glands of patients with Sjgren's Syndrome Journal of Autoimmunity 1993 6 5 649 661 (Pubitemid 23334534)
131. Hayashi T., Shirachi T., Hasegawa K., Relationship between sialoadenitis and periductal laminin expression in the submandibular salivary gland of NZBxNZWF 1 mice Journal of Comparative Pathology 2001 125 2-3 110 116 (Pubitemid 33026324)
132. Defilippi P., Silengo L., Tarone G., Alpha 6.beta 1 integrin (laminin receptor) is down-regulated by tumor necrosis factor alpha and interleukin-1 beta in human endothelial cells Journal of Biological Chemistry 1992 267 26 18303 18307
133. Porola P., Laine M., Virtanen I., Pllnen R., Przybyla B. D., Konttinen Y. T., Androgens and integrins in salivary glands in Sjgren's syndrome Journal of Rheumatology 2010 37 6 1181 1187
134. Sullivan D. A., Sullivan B. D., Evans J. E., Schirra F., Yamagami H., Liu M., Richards S. M., Suzuki T., Schaumberg D. A., Sullivan R. M., Dana M. R., Androgen deficiency, meibomian gland dysfunction, and evaporative dry eye Annals of the New York Academy of Sciences 2002 966 211 222 (Pubitemid 34729176)
135. Kovcs L., Trk T., Bari F., Kéri Z., Kovcs A., Makula., Pokorny G., Impaired microvascular response to cholinergic stimuli in primary Sjgren's syndrome Annals of the Rheumatic Diseases 2000 59 1 48 53 (Pubitemid 30303897)
136. Hayashi T., Hayashi T., Environmental factors and concepts in the induction of type 1 diabetes Hand book of Type 1 Diabetes Mellitus 2010 Nova Science 1 54