Abnormal distribution of aquaporin-5 in salivary glands in the NOD mouse model for Sjögren's syndrome

Journal of Rheumatology

Volumn 32, Issue 6, 2005, Pages 1071-1075

  Konttinen, Yrjö T ^a,b,d   Tensing, Eve Kai ^a   Laine, Mikael ^c   Porola, Pauliina ^c   Törnwall, Jyrki ^c   Hukkanen, Mika ^c  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b COXA Hospital for Joint Replacement ^*  (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d University of Helsinki ^*  (Finland)

Author keywords

Aquaporin 5; NOD mouse; Sj gren's syndrome

Indexed keywords

AQUAPORIN 5;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; COMPARATIVE STUDY; CONFOCAL LASER MICROSCOPY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PAROTID GLAND; PRIORITY JOURNAL; PROTEIN EXPRESSION; SALIVARY GLAND; SALIVARY GLAND ACINAR CELL; SJOEGREN SYNDROME; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND;

ANIMALS; AQUAPORIN 5; AQUAPORINS; DISEASE MODELS, ANIMAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOENZYME TECHNIQUES; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICROSCOPY, CONFOCAL; SALIVARY GLANDS; SPECIES SPECIFICITY;

EID: 20444455387     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Vitali C, Bombardieri S, Moutsopoulos HM, et al. Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European Community. Arthritis Rheum 1993;36:340-7.
2. Steinfeld S, Cogan E, King LS, Agre P, Kiss R, Delporte C. Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjögren's syndrome patients. Lab Invest 2001;81:143-8.
3. Tsubota K, Hirai S, King LS, Agre P, Ishida N. Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome. Lancet 2001;357:688-9.
4. Beroukas D, Hiscock J, Jonsson R, Waterman SA. Gordon TP. Subcellular distribution of aquaporin 5 in salivary glands in primary Sjögren's syndrome. Lancet 2001;358:1875-6.
5. Humphreys-Beher MG, Hu Y, Nakagawa Y, Wang PL, Purushotham KR. Utilization of the non-obese diabetic (NOD) mouse as an animal model for the study of secondary Sjögren's syndrome. Adv Exp Med Biol 1994;350:631-6.
6. Hu Y, Nakagawa Y, Purushotham KR, Humphreys-Beher MG. Functional changes in salivary glands of autoimmune disease-prone NOD mice. Am J Physiol 1992;263:E607-14.
7. Melvin JE, Kawaguchi M, Baum BJ, Turner RJ. A muscarinic agonist-stimulated chloride efflux pathway is associated with fluid secretion in rat parotid acinar cells. Biochem Biophys Res Commun 1987;145:754-9.
8. Pinkstaff CA. Cytology, histology, and histochemistry of salivary glands: an overview. In: Dobrosielski-Vergona K, editor. Biology of the salivary glands. Boca Raton, LA: CRC Press; 1993:30-1.
9. Zeidel ML, Ambudkar SV, Smith BL, Agre P. Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein. Biochemistry 1992;31:7436-40.
10. Nielsen S, King LS, Christensen BM, Agre P. Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat. Am J Physiol 1997;273:C1549-61.
11. Steinfeld SD, Appelboom T, Delporte C. Treatment with infliximab restores normal aquaporin 5 distribution in minor salivary glands of patients with Sjögren's syndrome. Arthritis Rheum 2002;46:2249-51.
12. Mariette X, Ravaud P, Steinfeld S, et al. Inefficacy of infliximab in primary Sjögren's syndrome: results of the randomized, controlled Trial of Remicade in Primary Sjögren's Syndrome (TRIPSS). Arthritis Rheum 2004;50:1270-6.
13. Gresz V, Kwon TH, Gong H, et al. Immunolocalization of AQP-5 in rat parotid and submandibular salivary glands after stimulation or inhibition of secretion in vivo. Am J Physiol Gastrointest Liver Physiol 2004;287:G151-61.
14. Koski H, Janin A, Humphreys-Beher MG, Sorsa T, Malmstrom M, Konttinen YT. Tumor necrosis factor-alpha and receptors for it in labial salivary glands in Sjögren's syndrome. Clin Exp Rheumatol 2001;19:131-7.
15. Fox RI, Stern M. Sjögren's syndrome: mechanisms of pathogenesis involve interaction of immune and neurosecretory systems. Scand J Rheumatol 2002;116 Suppl:3-13.
16. Zhu Z, Stevenson D, Schechter JE, et al. Tumor necrosis factor inhibitor gene expression suppresses lacrimal gland immunopathology in a rabbit model of autoimmune dacryoadenitis. Cornea 2003;22:343-51.
17. Takahashi M, Mimura Y, Hamano H, Haneji N, Yanagi K, Hayashi Y. Mechanism of the development of autoimmune dacryodenitis in the mouse model for primary Sjögren's syndrome. Cell Immunol 1996;170:54-62.