Abnormal distribution of aquaporin-5 water channel protein in salivary glands from Sjögren's syndrome patients

Laboratory Investigation

Volumn 81, Issue 2, 2001, Pages 143-148

  Steinfeld, Serge ^a   Cogan, Elie ^a   King, Landon S ^b   Agre, Peter ^b   Kiss, Robert ^c   Delporte, Christine ^c  

^a ERASME HOSPITAL   (Belgium)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AQUAPORIN; AQP5 PROTEIN, HUMAN; AQUAPORIN 5; EPITOPE; MEMBRANE PROTEIN;

ADULT; AGED; APICAL MEMBRANE; ARTICLE; AUTOIMMUNE DISEASE; BASEMENT MEMBRANE; BIOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SALIVARY GLAND; SARCOIDOSIS; SECRETION; SIALOADENITIS; SJOEGREN SYNDROME; WESTERN BLOTTING; XEROSTOMIA; AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; MIDDLE AGED; MITOSIS INDEX; MOLECULAR GENETICS; MUCOLIPIDOSIS; PATHOLOGY; REFERENCE VALUE;

ADULT; AGED; AMINO ACID SEQUENCE; ANTIBODY SPECIFICITY; AQUAPORIN 5; AQUAPORINS; EPITOPES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; MIDDLE AGED; MITOTIC INDEX; MOLECULAR SEQUENCE DATA; MUCOLIPIDOSES; REFERENCE VALUES; SALIVARY GLANDS; SARCOIDOSIS; SJOGREN'S SYNDROME;

EID: 0034745705     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3780221     Document Type: Article

References (40)

1. Aquaporin water channels: Unanswered questions and unresolved controversies
2. Morphometric analysis of secretory glands in Sjögren's syndrome
3. Role of cytokines in the destruction of acinar structure in Sjögren's syndrome salivary glands
4. Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren's syndrome
5. Cellular and molecular biology of the aquaporin water channels
6. Supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and ganglioblastomas are characterized by a differential expression of S100 proteins
7. Secretion by the major salivary glands
8. Adenovirus-mediated expression of aquaporin-5 in epithelial cells
9. Increased fluid secretion following transfer of the aquaporin-1 cDNA to irradiated rat salivary glands
10. Sjögren's syndrome. Proposed criteria for classification
11. Sjögren's syndrome: Controversies and progress
12. The histopathology of Sjögren's syndrome in labial salivary gland biopsies
13. Polarized distribution of key membrane transport proteins in the rat submandibular gland
14. New concepts for the development of autoimmune exocrinopathy derived from studies with the NOD mouse model
15. Pathophysiology of the aquaporin water channels
16. Aquaporins in complex tissues: I. Developmental patterns in respiratory tract and glandular tissue of rat
17. Interrelationships of ion transport in rat submaxillary duct epithelium
18. The aquaporin family of molecular water channels
19. The human aquaporin-5 gene: Molecular characterization and chromosomal localization
20. Examination of rat salivary glands for the presence of the aquaporin CHIP
21. Defective secretion of saliva in transgenic mice lacking aquaporin-5 channels
22. Aquaporin-5 (AQP5), a water channel protein, in the rat salivary and lacrimal glands: Immunolocalization and effect of secretory stimulation
23. Na+ channels in membrane vesicles from intralobular salivary ducts
24. Distribution of the aquaporin CHIP in secretory and resorptire epithelia and capillary endothelia
25. Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat
26. Safety of adenovirus-mediated transfer of the human aquaporin-1 cDNA to irradiated parotid glands of non-human primates
27. The mercury-sensitive residue at cysteine-189 in the CHIP28 water channel
28. Molecular cloning and characterization of an aquaporin cDNA from salivary, lacrimal, and respiratory tissues
29. Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism
30. Precancerous lesions and oral cancer in the elderly
31. Tumor necrosis factor alpha regulates responses of cultures of sympathetic neurons and nonneuronal cells
32. Localization of aquaporin CHIP in the human eye: Implications in the pathogenesis of glaucoma and other disorders of ocular fluid balance
33. D-Mannose and N-acetylglucosamine moieties and their respective binding sites in salivary glands of Sjögren's syndrome
34. Distribution of aquaporin-4 water channel expression within rat kidney
35. Sjögren's syndrome: A community-based study of prevalence and impact
36. Salivary gland acinar epithelial cells are deficient in their protein kinase C expression in Sjögren's syndrome
37. Anion exchanger immunoreactivity in human salivary glands in health and Sjögren's syndrome
38. Water transport across mammalian cell membranes
39. Acute irradiation effects on morphology and function of rat submandibular glands
40. Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European Community