Epstein-Barr virus in autoimmune diseases

Best Practice and Research: Clinical Rheumatology

Volumn 22, Issue 5, 2008, Pages 883-896

  Toussirot, Éric ^a   Roudier, Jean ^b  

^a UNIVERSITY HOSPITAL JEAN MINJOZ   (France)

^b INSERM   (France)

Author keywords

autoimmune diseases; Epstein Barr virus; molecular mimicry

Indexed keywords

ACICLOVIR; AUTOANTIGEN; AZATHIOPRINE; CD20 ANTIBODY; CD4 ANTIGEN; CD40 LIGAND MONOCLONAL ANTIBODY; CD69 ANTIGEN; CD8 ANTIGEN; CORTICOSTEROID; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; EPSTEIN BARR VIRUS ANTIGEN; ETANERCEPT; GAMMA INTERFERON; GANCICLOVIR; HYDROXYCHLOROQUINE; INFLIXIMAB; LA ANTIBODY; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NUCLEAR PROTEIN; RO ANTIBODY; SM ANTIBODY; UNINDEXED DRUG; VIDARABINE; VIRUS ANTIBODY; VIRUS DNA; VIRUS PROTEIN; VIRUS RNA;

ANTIBODY TITER; AUTOIMMUNE DISEASE; BIOLOGICAL THERAPY; CANCER RISK; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ENVIRONMENTAL FACTOR; EPSTEIN BARR VIRUS; HEREDITY; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; LATENT VIRUS INFECTION; LYMPHOMA; MOLECULAR MIMICRY; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SALIVARY GLAND; SJOEGREN SYNDROME; SYNOVIUM; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; VIRUS LOAD;

ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; DNA, VIRAL; EPSTEIN-BARR VIRUS INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOMA; RNA, VIRAL; SJOGREN'S SYNDROME; VIRAL LOAD;

EID: 57049087977     PISSN: 15216942     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.berh.2008.09.007     Document Type: Review

References (59)

1. James J.A., Harley J.B., and Scofield R.H. Role of viruses in systemic lupus erythematosus and Sjögren syndrome. Current Opinion in Rheumatology 13 (2001) 370-376
2. James J.A., Harley J.B., and Scofield R.H. Epstein-Barr virus and systemic lupus erythematosus. Current Opinion in Rheumatology 18 (2006) 462-467
3. Vaughan J.H. The Epstein-Barr virus in autoimmunity. Springer Seminars in Immunopathology 17 (1995) 203-230
4. Lotz M., and Roudier J. Epstein-Barr virus and rheumatoid arthritis. Cellular and molecular aspects. Rheumatology International 9 (1989) 147-152
5. Kanegane H., Wakiguchi H., Kanegane C., et al. Viral interleukin-10 in chronic active Epstein-Barr virus infection. The Journal of Infectious Diseases 176 (1997) 254-257
6. Harley J.B., Harley I.T.W., Guthridge J.M., et al. The curiously suspicious: a role for Epstein-Barr virus in lupus. Lupus 15 (2006) 768-777
7. McClain M.T., Harley B., and James J.A. The role of Epstein-Barr virus in systemic lupus erythematosus. Frontiers in Bioscience 6 (2001) 137-147
8. Poole B.D., Scofield R.H., Harley J.B., et al. Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus. Autoimmunity 39 (2006) 63-70
9. James J.A., Kaufman K.M., Farris A.D., et al. An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus. The Journal of Clinical Investigation 100 (1997) 3019-3026
10. James J.A., Neas B.N., Moser K.L., et al. Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure. Arthritis and Rheumatism 44 (2001) 1122-1146
11. Lu J.J.Y., Chen D.Y., Hsich C.W., et al. Association of Epstein-Barr virus infection with systemic lupus eythematosus in Taiwan. Lupus 16 (2007) 168-175
12. Parks C.G., Cooper G.S., Hudson L.L., et al. Association of Epstein-Barr virus with systemic lupus erythematosus. Effect modification by race, age and cytotoxic lymphocyte - associated antigen 4 genotype. Arthritis and Rheumatism 52 (2005) 1148-1159
13. Petersen J., Rhodes G., Roudier J., et al. Altered immune response to glycine-rich sequences of Epstein-Barr nuclear antigen-1 in patients with rheumatoid arthritis and systemic lupus erythematosus. Arthritis and Rheumatism 33 (1990) 993-1000
14. Yu S.F., Wu H.C., Tsai W.C., et al. Detecting Epstein-Barr virus DNA from peripheral blood mononuclear cells in adult patients with systemic lupus erythematosus in Taiwan. Medical Microbiology and Immunology 194 (2005) 15-120
15. Gross A.J., Hochberg D., Rand W., et al. EBV and systemic lupus erythematosus: a new perspective. Journal of Immunology 174 (2005) 6599-6607
16. Moon U.Y., Park S.J., Oh S.T., et al. Patients with systemic lupus erythematosus have abnormally elevated Epstein-Barr virus load in blood. Arthritis Research & Therapy 6 (2004) R295-R302
17. Kang I., Quan T., Nolasco H., et al. Defective control of latent Epstein-Barr virus infection in systemic lupus erythematosus. Journal of Immunology 172 (2004) 1287-1294
18. Tsokos G., Magrath I.T., and Balow J.E. Epstein-Barr virus infection induces normal B cell responses but defective suppressor T cell responses in patients with systemic lupus erythematosus. Journal of Immunology 131 (1983) 1797-1804
19. Berner B.R., Tary-Lehman M., Yonkers N.L., et al. Phenotypic and functional analysis of EBV specific memory CD8 cells in SLE. Cellular Immunology 235 (2005) 29-38
20. Vaughan J.H., Nguyen M.D., Valbrecht J.R., et al. Epstein-Barr virus induced autoimmune responses. The Journal of Clinical Investigation 95 (1995) 1316-1327
21. James J.A., and Harley J.B. Lupus humoral autoimmunity after short peptide immunization. Annals of the New York Academy of Sciences 815 (1997) 124-127
22. Riemekasten G., Marell J., Trebelijahr G., et al. A novel epitope on the C terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus. The Journal of Clinical Investigation 102 (1998) 754-763
23. Mc Clain M.T., Heinlen L.D., Dennis G.J., et al. Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nature Medicine 11 (2005) 85-89
24. Verdolini R., Bugatti R., Giangacomi M., et al. Systemic lupus eythematosus induced by Epstein-Barr virus infection. The British Journal of Dermatology 146 (2002) 877-881
25. Kasapcopur O., Ergul Y., Kutlug S., et al. Systemic lupus erythematosus due to Epstein-Barr virus or Epstein-Barr virus infection provocating acute exacerbation of systemic lupus erythematosus?. Clinical Rheumatology 26 (2006) 765-767
26. Toussirot E., and Roudier J. Pathophysiological links between rheumatoid arthritis and the Epstein-Barr virus: an update. Joint Bone Spine 74 5 (2007 Oct) 418-426
27. Klatt T., Ouyang Q., Flad T., et al. Expansion of peripheral CD8 + CD28 - T cells in response to Epstein-Barr virus in patients with rheumatoid arthritis. The Journal of Rheumatology 32 (2005) 239-251
28. Fox R.I., Luppi M., Pisa P., et al. Potential role of Epstein-Barr virus in Sjögren's syndrome and rheumatoid arthritis. The Journal of Rheumatology 19 Suppl. 32 (1992) 18-24
29. Van Eden W., Hogervorst J., Hensen E., et al. A cartilage mimicking epitope on a 65 kD mycobacterial heat shock protein: adjuvant arthritis as amodel for human rheumatoid arthritis. Current Topics in Microbiology and Immunology 145 (1989) 27-43
30. Baboonian C., Venables P.J.W., Willaim D.G., et al. Cross reaction of antibodies to a glycine alanine repeat sequence of Epstein-Barr virus nuclear antigen 1 with collagen, cytokeratin and actin. Annals of the Rheumatic Diseases 50 (1991) 772-775
31. Roudier J., Petersen J., Rhodes G., et al. Susceptibility to rheumatoid arthritis maps to a T cell epitope shared by HLA-Dw4 DR beta 1 chain and the Epstein-Barr virus glycoprotein gp110. Proceedings of the National Academy of Sciences of the United States of America 86 (1989) 5104-5108
32. Toussirot E., Wendling D., Tiberghien P., et al. Decreased T cell precursor frequencies to Epstein-Barr virus glycoprotein gp110 in peripheral blood correlate with disease activity and severity in patients with rheumatoid arthritis. Annals of the Rheumatic Diseases 59 (2000) 533-538
33. Scotet E., David-Ameline J., Peyrat M.A., et al. T cell response to Epstein-Barr virus transactivators in chronic rheumatoid arthritis. The Journal of Experimental Medicine 184 (1996) 1791-1800
34. Toussirot E., Wendling D., Luka J., et al. Increased frequency of T cells specific for Epstein-Barr virus glycoprotein gp110 in the synovial fluid of patients with rheumatoid arthritis. Arthritis Research & Therapy 5 (2003) S25
35. Saal J.G., Krimmel M., Steidle M., et al. Synovial Epstein-Barr virus infection increases the risk of rheumatoid arthritis in individuals with the shared HLA-DR4 epitope. Arthritis and Rheumatism 42 (1999) 1485-1496
36. Balandraud N., Meynard J.B., Auger I., et al. Epstein-Barr virus load in the peripheral blood of patients with rheumatoid arthritis. Accurate quantification using real-time polymerase chain reaction. Arthritis and Rheumatism 48 (2003) 1223-1228
37. Anzilotti C., Merlini G., Pratesi F., et al. Antibodies to viral citrullinated peptide in rheumatoid arthritis. The Journal of Rheumatology 33 (2006) 647-651
38. Pratesi F., Tommasi C., Anzilotti C., et al. Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anti-citrullinated protein antibodies in rheumatoid arthritis. Arthritis and Rheumatism 54 (2006) 733-741
39. Wittingham S., McNeilage J., and Mackay I.R. Primary Sjögren's syndrome after infectious mononucleosis. Annals of Internal Medicine 102 (1985) 490-493
40. Fox R.I., Pearson G., and Vaughan J.H. Detection of Epstein-Barr virus associated antigens and DNA in salivary gland biopsies from patients with Sjögren's syndrome. Journal of Immunology 137 (1886) 3162-3168
41. Mariette X., Gozlan J., Clerc D., et al. Detection of Epstein-Barr virus DNA by in situ hybridization and polymerase chain reaction in salivary gland biopsy specimens from patients with Sjögren's syndrome. The American Journal of Medicine 90 (1991) 286-294
42. Wen S., Shimizu N., Yoshimaya H., et al. Association of Epstein-Barr virus with Sjögren's syndrome: differential EBV expression between epithelial cells and lymphocytes in salivay glands. The American Journal of Pathology 149 (1996) 1511-1517
43. Venables P.J.W., Teo C.G., Baboonian C., et al. Persistence of Epstein-Barr virus in salivary gland biopsies from healthy individuals and patients with Sjögren's syndrome. Clinical and Experimental Immunology 75 (1989) 359-364
44. Navone R., Lunardi C., Gerli R., et al. Identification of tear lipocalin as a novel autoantigen target in Sjögren's syndrome. Journal of Autoimmunity 25 (2005) 229-234
45. Nagata Y., Inoue H., Yamada K., et al. Activation of Epstein-Barr virus by saliva from Sjögren's syndrome patients. Immunology 111 (2004) 223-229
46. Okano M. The evolving therapeutic approaches for Epstein-Barr virus infection in immunocompetent and immunocompromized individuals. Current Drug Targets. Immune, Endocrine and Metabolic Diseases 3 (2003) 137-142
47. Okano M., and Gross T.G. Advanced therapeutic and prophylactic strategies for Epstein-Barr virus infection in immunocompromized patients. Expert Review of Anti-Infective Therapy 5 (2007) 403-413
48. Shoda H., Nakazaki K., Izutsu K., et al. Epstein-Barr virus associated mononucleosis caused by weekly low dose methotrexate therapy in a rheumatoid arthritis patient. Scandinavian Journal of Rheumatology 35 (2006) 152-163
49. Dawson T.M., Starkebaum G., Wood B.L., et al. Epstein-Barr virus, methotrexate and lymphoma in patients with rheumatoid arthritis and primary Sjögren's syndrome: case series. The Journal of Rheumatology 28 (2001) 47-53
50. Mariette X. Lymphomas in patients with Sjögren's syndrome: review of the literature and physiopathologic hypothesis. Leukemia & Lymphoma 33 (1999) 93-99
51. Royen B., Cazals-Hatem D., Sibilia J., et al. Lymphomas in patients with Sjögren's syndrome are marginal zone B - cell neoplasms, arise in diverse extranodal and nodal sites, and are not associated with viruses. Blood 90 (1997) 766-775
52. Hirose Y., Sugai S., Masaki Y., et al. Epstein-Barr virus study in malignant lymphoma in Sjögren's syndrome. International Journal of Hematology 69 (1999) 174-179
53. Xu Y., and Wiermick P.H. Systemic lupus erythematosus and B-cell hematologic neoplasm. Lupus 10 (2001) 841-850
54. Löfström B., Baklin C., Sundström C., et al. A closer look at non-Hodgkin's lymphoma cases in a national Swedish systemic lupus erythematosus cohort: a nested case-control study. Annals of the Rheumatic Diseases 66 (2007) 1627-1632
55. Bernatsky S., Ramsey-Goldman R., Rajan R., et al. Non -Hodgkin lymphoma in systemic lupus erythematosus. Annals of the Rheumatic Diseases 64 (2005) 1507-1509
56. Bernatsky S., Boivin J.F., Joseph L., et al. An international cohort study of cancer in systemic lupus erythematosus. Arthritis and Rheumatism 52 (2005) 1481-1490
57. Kojima M., Nakamura S., Futamura N., et al. Malignant lymphoma in patients with rheumatic diseases other than Sjögrens' syndrome: a review of the Japanese literature. Japanese Journal of Clinical Oncology 27 (1997) 84-90
58. Balandraud N., Guis S., Meynard J.B., et al. Long term treatment with methotrexate or TNF inhibitors does not increase Epstein Barr virus load in patients with rheumatoid arthritis. Arthritis and Rheumatism 57 (2007) 762-767
59. Balandraud N., Roudier J., and Roudier C. What are the links between Epstein-Barr virus, lymphoma, and tumor necrosis factor antagonism in rheumatoid arthritis?. Seminars in Arthritis and Rheumatism 34 Suppl. 1 (2005) 31-33