Salivary gland changes in the NOD mouse model for Sjögren's syndrome: Is there a non-immune genetic trigger?

European Journal of Morphology

Volumn 36, Issue 2 SUPPL., 1998, Pages 247-251

  Humphreys Beher, Michael G ^a   Yamachika, Shigeo ^a   Yamamoto, Hideo ^b   Maeda, Nobuko ^b   Nakagawa, Yoici ^b   Peck, Ammon B ^a   Robinson, Christopher P ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b TSURUMI UNIVERSITY   (Japan)

Author keywords

Autoimmunity; Rheumatoid arthritis; Salivary glands; Sj gren's syndrome; Xerostomia

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; AUTOIMMUNITY; CONFERENCE PAPER; DISEASE COURSE; EXOCRINE SECRETION; HISTOPATHOLOGY; LYMPHOCYTE ACTIVATION; MOUSE; MUTATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SALIVARY GLAND FUNCTION; SJOEGREN SYNDROME;

ANIMALS; DISEASE MODELS, ANIMAL; IMMUNE TOLERANCE; LYMPHATIC SYSTEM; MICE; MICE, INBRED NOD; SALIVA; SALIVARY GLANDS; SJOGREN'S SYNDROME;

ANIMALIA;

EID: 0031731678     PISSN: 09243860     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Dang H, Geiser A, Letterio J, Nakabayashi T, Kong L, Fernandes G, Talal N (1995): SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-β knockout mice. J Immunol 155: 3205-3212.
2. Fox P, Speight P (1996): Current concepts of autoimmune exocrinopathy: immunologic mechanisms in the salivary pathology of Sjögren's syndrome. Crit Rev Oral Biol Med 7: 144-158.
3. Fox RI, Kang H-I (1992): Pathogenesis of Sjögren's syndrome. Rheum Clin N Am 18: 517-538.
4. Fox RI (1996): Sjögren's syndrome: clinical features, pathogenesis and treatment. Second International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Revelance. Southampton, Bermuda.
5. Garchon HJ, Luan JJ, Eloy L, Bedossa P, Bach JF (1994): Genetic analysis of immune dysfunction in non-obese diabetic (NOD) mice: Mapping of a susceptibility locus close to bcl-2 gene correlates with increased resistance of NOD T cells to apoptosis induction. Eur J Immunol 24: 380-384.
6. Gerling IC, Serreze DV, Christianson SW, Leiter EH (1992): Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice. Diabetes 41: 1672-1676.
7. Haneji N, Hamano H, Yanagi K, Hayashi Y (1994): A new animal model for primary Sjögren's syndrome in NFS/sld mutant mice. J Immunol 153: 2769-2777.
8. Hayashi Y, Haneji N, Hamano H, Yanagi K (1994) Transfer of Sjögren's-like syndrome autoimmune lesions into scid mice and prevention of lesions by anti-CD4 and anti-T cell receptor antibody treatment. Eur J Immunol 24: 2826-2831.
9. Hu Y, Humphreys-Beher MG (1995): Decreased levels of adenylate cyclase contribute to the down-regulation of beta-adrenergic signal transduction in the salivary glands of the non-diabetic (NOD) mouse. Autoimmunity 21: 137-142.
10. Hu Y, Nakagawa Y, Purushotham KR, Humphreys-Beher MG (1992): Functional changes in salivary glands of autoimmune disease prone NOD mice. Am J Physiol 263: E607-E614.
11. Hu Y, Purushotham KR, Wang P, Dawson R, Humphreys-Beher MG (1994): Down-regulation of β-adrenergic receptors and signal transduction response in the salivary glands of NOD mice. Am J Physiol 266: G433-G443.
12. Humphreys-Beher MG, Hu Y, Nakagawa Y, Wang P-L, Purushotham KR (1994): Utilization of the NOD mouse as an animal model for the study of secondary Sjögren's syndrome. Adv Exp Med Biol 350: 631-636.
13. Kessler H (1968): A laboratory model for Sjögren's syndrome. Am J Pathol 52: 671-685.
14. Leiter E (1993): The non-obese diabetic mouse: a model for analyzing the interplay between heredity and environment in development of autoimmune disease. ILAR News 35: 1-4.
15. Robinson CP, Yamamoto H, Peck AB, Humphreys-Beher MG (1996): Genetically programmed development of salivary gland abnormalities in the NOD (non-obese diabetic)-scid mouse in the absence of detectable lymphocytic infiltration: a potential trigger for sialoadenitis of NOD mice. Clin Immunol Immunopathol 79: 50-59.
16. Robinson CP, Bounous DI, Alford CE, Nguyen K-HT, Nanni JM, Peck AB, Humphreys-Beher MG (1997a): Expression of parotid secretory protein (PSP) in murine lacrimal glands and its possible function as a bacterial binding protein in exocrine secretions. Am J Physiol 272: G863-G871.
17. Robinson CP, Yamachicka S, Alford CE, Cooper C, Pichardo EL, Shah N, Peck AB, Humphreys-Beher MG (1997b): Elevated levels of cysteine protease activity in the saliva and salivary glands of the NOD mouse model for Sjögren's syndrome. Proc Natl Acad Sci USA 94: 5767-5771.
18. Robinson CP, Cornelius J, Bounous DI, Yamamoto H, Humphreys-Beher MG, Peck AB (1998a): Characterization of the changing lymophocyte populations and cytokine expression in the exocrine tissues of autoimmune NOD mice. Autoimmunity 27: 29-44
19. Robinson CP, Yamachicka S, Bounous DI, Brayer J, Peck AB, Humphreys-Beher MG (1998b): A novel NOD-derived murine model for primary Sjögren's syndrome. Arthritis Rheumat 41: 150-156.
20. null mice. J Exp Med 184: 2049-2053.
21. Skarstein K, Holmdahl R, Johanssessen AC & Jonsson R (1995): Characterization of the T cell receptor repertoire and anti-Ro/SSa autoantibodies in relation to sialoadenitis in NOD mice. Autoimmunity 22: 9-16.
22. Ussing AP, Prause JU & Spärck JV (1988) SLE and Sjögren's syndrome in transplant chimeras. The GVH mouse model as a model for autoimmune disease. Scan J Immunol 28: 267 (abstract).
23. Wicker LS, Appel MC, Dotta F, Pressey A, Miller BJ, De-Larato NH, Fischer PA, Boltz RC, Peterson LB (1992): Autoimmune syndromes in the major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice. The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes. J Exp Med 176: 67-77.
24. Wicker LS, Leiter EH, Todd JA, Renjilian RJ, Peterson E, Fischer PA, Podolin PL, Zijlstra M, Jaenisch R, Peterson LB (1994): β2-Microglobulin-deficient NOD mice do not develop insulitis or diabetes. Diabetes 43: 500-504.
25. Wicker LS, Todd JA, Peterson LB (1995): Genetic control of autoimmune diabetes in the NOD mouse. Annu Rev Immunol 13: 179-200.
26. Yamamoto H, Ishibashi K, Nakagawa Y, Maeda N, Zeng T, Robinson CP, Oxford GE, Chegini N, Humphreys-Beher MG (1997): Detection of alterations in the levels of neuropeptides and salivary gland responses in the non-obese diabetic (NOD) mouse model for autoimmune sialoadenitis. Scand J Immunol 45: 55-61.
27. Yamamoto H, Simms NE, Macauley SP, Nguyen K-HT, Nakagawa Y, Humphreys-Beher MG (1996): Alterations in the secretory response of non-obese diabetic (NOD) mice to muscarinic receptor stimulation. Clin Immunol Immunopathol 78: 245-255.