Two functionally distinctive phosphopantetheinyl transferases from amoeba dictyostelium discoideum

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Nair, Divya R ^a   Ghosh, Ratna ^a   Manocha, Alzu ^a   Mohanty, Debasisa ^a   Saran, Shweta ^b   Gokhale, Rajesh S ^a,c,d  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

^c CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^d JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CARRIER PROTEIN; FATTY ACID SYNTHASE; MEMBRANE PROTEIN; PHOSPHOPANTETHEINYL TRANSFERASE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; ISOENZYME; PHOSPHOTRANSFERASE; PROTOZOAL PROTEIN;

ARTICLE; CONTROLLED STUDY; DICTYOSTELIUM DISCOIDEUM; ENZYME SPECIFICITY; EUKARYOTE; GENE DISRUPTION; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; BIOCATALYSIS; CHEMISTRY; DICTYOSTELIUM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; LIFE CYCLE STAGE; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMOEBA (GENUS); DICTYOSTELIUM; DICTYOSTELIUM DISCOIDEUM; EUKARYOTA; FUNGI; PROTOZOA;

ACYL CARRIER PROTEIN; AMINO ACID SEQUENCE; ANIMALS; BACTERIAL PROTEINS; BIOCATALYSIS; DICTYOSTELIUM; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FATTY ACID SYNTHETASE COMPLEX; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKOUT TECHNIQUES; ISOENZYMES; LIFE CYCLE STAGES; MOLECULAR SEQUENCE DATA; POLYKETIDE SYNTHASES; PROTOZOAN PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 80052618991     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024262     Document Type: Article

References (39)

1. Anjard C, Chang WT, Gross J, Nellen W, (1998) Production and activity of spore differentiation factors (SDFs) in Dictyostelium. Development 125: 4067-4075.
2. Sternfeld J, David CN, (1979) Ammonia plus another factor are necessary for differentiation in submerged clumps of Dictyostelium. J Cell Sci 38: 181-191.
3. Saran S, (1999) Calcium levels during cell cycle correlate with cell fate of Dictyostelium discoideum. Cell Biol Int 23: 399-405.
4. Serafimidis I, Kay RR, (2005) New prestalk and prespore inducing signals in Dictyostelium. Dev Biol 282: 432-441.
5. Saito T, Taylor GW, Yang JC, Neuhaus D, Stetsenko D, et al. (2006) Identification of new differentiation inducing factors from Dictyostelium discoideum. Biochim Biophys Acta 1760: 754-761.
6. Saito T, Kato A, Kay RR, (2008) DIF-1 induces the basal disc of the Dictyostelium fruiting body. Dev Biol 317: 444-453.
7. Austin MB, Saito T, Bowman ME, Haydock S, Kato A, et al. (2006) Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Nat Chem Biol 2: 494-502.
8. Ghosh R, Chhabra A, Phatale PA, Samrat SK, Sharma J, et al. (2008) Dissecting the functional role of polyketide synthases in Dictyostelium discoideum: biosynthesis of the differentiation regulating factor 4-methyl-5-pentylbenzene-1,3-diol. J Biol Chem 283: 11348-11354.
9. Eichinger L, et al. (2005) The genome of the social amoeba Dictyostelium discoideum. Nature 435: 43-57.
10. Walsh CT, Gehring AM, Weinreb PH, Quadri LE, Flugel RS, (1997) Post-translational modification of polyketide and nonribosomal peptide synthases. Curr Opin Chem Biol 1: 309-315.
11. Copp JN, Neilan BA, (2006) The phosphopantetheinyl transferase superfamily: phylogenetic analysis and functional implications in cyanobacteria. Appl Environ Microbiol 72: 2298-2305.
12. Mootz HD, Finking R, Marahiel MA, (2001) 4′-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis. J Biol Chem 276: 37289-37298.
13. Meiser P, Muller R, (2008) Two functionally redundant Sfp-type 4′-phosphopantetheinyl transferases differentially activate biosynthetic pathways in Myxococcus xanthus. Chembiochem 9: 1549-1553.
14. Marquez-Fernandez O, Trigos A, Ramos-Balderas JL, Viniegra-Gonzalez G, Deising HB, et al. (2007) Phosphopantetheinyl transferase CfwA/NpgA is required for Aspergillus nidulans secondary metabolism and asexual development. Eukaryot Cell 6: 710-720.
15. Copp JN, Roberts AA, Marahiel MA, Neilan BA, (2007) Characterization of PPTNs, a cyanobacterial phosphopantetheinyl transferase from Nodularia spumigena NSOR10. J Bacteriol 189: 3133-3139.
16. Chalut C, Botella L, de Sousa-D'Auria C, Houssin C, Guilhot C, (2006) The nonredundant roles of two 4′-phosphopantetheinyl transferases in vital processes of Mycobacteria. Proc Natl Acad Sci 103: 8511-8516.
17. Cai X, Herschap D, Zhu G, (2005) Functional characterization of an evolutionarily distinct phosphopantetheinyl transferase in the apicomplexan Cryptosporidium parvum. Eukaryot Cell 4: 1211-1220.
18. Huang Y, Wendt-Pienkowski E, Shen B, (2006) A dedicated phosphopantetheinyl transferase for the fredericamycin polyketide synthase from Streptomyces griseus. J Biol Chem 281: 29660-29668.
19. Finking R, Solsbacher J, Konz D, Schobert M, Schafer A, et al. (2002) Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa. J Biol Chem 277: 50293-50302.
20. McAllister KA, Peery RB, Zhao G, (2006) Acyl carrier protein synthases from gram-negative, gram-positive, and atypical bacterial species: Biochemical and structural properties and physiological implications. J Bacteriol 188: 4737-4748.
21. Barekzi N, Joshi S, Irwin S, Ontl T, Schweizer HP, (2004) Genetic characterization of pcpS, encoding the multifunctional phosphopantetheinyl transferase of Pseudomonas aeruginosa. Microbiology 150: 795-803.
22. Sanchez C, Du L, Edwards DJ, Toney MD, Shen B, (2001) Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin. Chem Biol 8: 725-738.
23. Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, et al. (1996) A new enzyme superfamily- the phosphopantetheinyl transferases. Chem Biol 3: 923-936.
24. Donato H, Krupenko NI, Tsybovsky Y, Krupenko SA, (2007) 10-formyltetrahydrofolate dehydrogenase requires a 4′-phosphopantetheine prosthetic group for catalysis. J Biol Chem 282: 34159-34166.
25. Quadri LE, Weinreb PH, Lei M, Nakano MM, Zuber P, et al. (1998) Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases. Biochemistry 37: 1585-1595.
26. Gehring AM, Lambalot RH, Vogel KW, Drueckhammer DG, Walsh CT, (1997) Ability of Streptomyces spp. acyl carrier proteins and coenzyme A analogs to serve as substrates in vitro for E. coli holo-ACP synthase. Chem Biol 4: 17-24.
27. Carreras CW, Gehring AM, Walsh CT, Khosla C, (1997) Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase. Biochemistry 36: 11757-11761.
28. Parris KD, Lin L, Tam A, Mathew R, Hixon J, et al. (2000) Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites. Structure 8: 883-895.
29. Reuter K, Mofid MR, Marahiel MA, Ficner R, (1999) Crystal structure of the surfactin synthetase-activating enzyme sfp: a prototype of the 4′-phosphopantetheinyl transferase superfamily. Embo J 18: 6823-6831.
30. McAllister KA, Peery RB, Meier TI, Fischl AS, Zhao G, (2000) Biochemical and molecular analyses of the Streptococcus pneumoniae acyl carrier protein synthase, an enzyme essential for fatty acid biosynthesis. J Biol Chem 275: 30864-30872.
31. Ansari MZ, Yadav G, Gokhale RS, Mohanty D, (2004) NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases. Nucleic Acids Res 32: 405-413.
32. Reed MA, Schweizer M, Szafranska AE, Arthur C, Nicholson TP, et al. (2003) The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs. Org Biomol Chem 1: 463-471.
33. Zucko J, Skunca N, Curk T, Zupan B, Long PF, et al. (2007) Polyketide synthase genes and the natural products potential of Dictyostelium discoideum. Bioinformatics 23: 2543-2549.
34. Byers DM, Gong H, (2007) Acyl carrier protein: structure-function relationships in a conserved multifunctional protein family. Biochem Cell Biol 85: 649-662.
35. Stuible HP, Meier S, Wagner C, Hannappel E, Schweizer E, (1998) A novel phosphopantetheine:protein transferase activating yeast mitochondrial acyl carrier protein. J Biol Chem 273: 22334-22339.
36. Brody S, Oh C, Hoja U, Schweizer E, (1997) Mitochondrial acyl carrier protein is involved in lipoic acid synthesis in Saccharomyces cerevisiae. FEBS Lett 408: 217-220.
37. Sackmann U, Zensen R, Rohlen D, Jahnke U, Weiss H, (1991) The acyl-carrier protein in Neurospora crassa mitochondria is a subunit of NADH:ubiquinone reductase (complex I). Eur J Biochem 200: 463-469.
38. Kuwayama H, Obara S, Morio T, Katoh M, Urushihara H, et al. (2002) PCR-mediated generation of a gene disruption construct without the use of DNA ligase and plasmid vectors. Nucleic Acids Res 30: E2.
39. Chopra T, Banerjee S, Gupta S, Yadav G, Anand S, et al. (2008) Novel intermolecular iterative mechanism for biosynthesis of mycoketide catalyzed by a bimodular polyketide synthase. PLoS Biol 6: 163.