Acyl carrier protein synthases from gram-negative, gram-positive, and atypical bacterial species: Biochemical and structural properties and physiological implications

Journal of Bacteriology

Volumn 188, Issue 13, 2006, Pages 4737-4748

  McAllister, Kelly A ^a   Peery, Robert B ^a   Zhao, Genshi ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CARRIER PROTEIN; ACYL CARRIER PROTEIN SYNTHETASE; COENZYME A; FATTY ACID; PANTETHEINE PHOSPHATE; SERINE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL FUNCTION; CROSS LINKING; ENZYME ANALYSIS; ENZYME PURIFICATION; ENZYME STRUCTURE; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; GEL FILTRATION CHROMATOGRAPHY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MYCOPLASMA PNEUMONIAE; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ACYL COENZYME A; BACTERIAL PROTEINS; ESCHERICHIA COLI; MYCOPLASMA PNEUMONIAE; SPECIES SPECIFICITY; STREPTOCOCCUS PNEUMONIAE; SUBSTRATE SPECIFICITY; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MYCOPLASMA PNEUMONIAE; NEGIBACTERIA; POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 33745439554     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01917-05     Document Type: Article

References (48)

1. Altschul, S. F., W. Gish, W. Miller, E. W. Myers, and D. J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
2. Baltz, R. H., P. Matsushima, R. B. Peery, J. Hoskins, M. Young, F. H. Norris, B. S. DeHoff, P. Rockey, G. Porter, S. G. Burgett, P. R. Rosteck, P. L. Skatrud, and S. R. Jaskunas. 1997. Abstr. 37th Intersci. Conf. Antimicrob. Agents Chemother., abstr. S-46, p. 391.
3. Blattner, F. R., G. Plunkett III, C. A. Bloch, et al. 1997. The complete genome sequence of Escherichia coli K-12. Science 277:1453-1462.
4. Carreras, C. W., A. M. Gehring, C. T. Walsh, and C. Khosla. 1997. Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase. Biochemistry 36:11757-11761.
5. Chirgadze, N. Y., S. L. Briggs, K. A. McAllister, A. S. Fischl, and G. Zhao. 2000. Crystal structure of Streptococcus pneumoniae acyl carrier protein synthase: an essential enzyme in bacterial fatty acid biosynthesis. EMBO J. 19:5281-5287.
6. Cole, S. T., R. Brosch, et al. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-544.
7. Cronan, J. E., Jr., and D. Laporte. 1996. Tricarboxylic acid cycle and glyoxylate bypass, p. 206-216. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: cellular and molecular biology. ASM Press, Washington, D.C.
8. Cronan, J. E., Jr., and C. O. Rock. 1996. Biosynthesis of membrane lipids, p. 612-636 In F. C. Neidhaidt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: cellular and molecular biology. ASM Press, Washington, D.C.
9. Crosby, J., D. H. Sherman, M. J. Bibb, W. P. Revill, D. A. Hopwood, and T. J. Simpson. 1995. Polyketide synthase acyl carrier proteins from Streptomyces: expression in Escherichia coli, purification and partial characterization. Biochim. Biophys. Acta 1251:32-42.
10. Daubaras, D. L., E. M. Wilson, T. Black, C. Strickland, B. M. Beyer, and P. Orth. 2004. Crystallization and preliminary X-ray analysis of the acyl carrier protein synthase (AcpS) from Staphylococcus aureus. Acta Cryst. D60:773-774.
11. Elovson, J., and P. R. Vagelos. 1968. Acyl carrier protein. X. Acyl carrier protein synthetase. J. Biol. Chem. 243:3603-3611.
12. Finking, R., J. Solsbacher, D. Konz, M. Schobert, A. Schafer, D. Jahn, and M. A. Marahiel. 2002. Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa. J. Biol. Chem. 277:50293-50302.
13. Flugel, R. S., Y. Hwangbo, R. H. Lambalot, J. E. Cronan, Jr., and C. T. Walsh. 2000. Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli. J. Biol. Chem. 275:959-968.
14. Gehring, A. M., R. H. Lambalot, K. W. Vogel, D. G. Drueckhammer, and C. T. Walsh. 1997. Ability of Streptomyces spp. acyl carrier proteins and coenzyme A analogs to serve as substrates in vitro for E. coli holo-ACP synthase. Chem. Biol. 4:17-24.
15. Heath, R. J., and C. O. Rock. 1996. Regulation of fatty acid elongation and initiation by acyl-acyl carrier protein in Escherichia coli. J. Biol. Chem. 271:1833-1836.
16. Heath, R. J., and C. O. Rock. 2004. Fatty acid biosynthesis as a target for novel Antibacterials. Curr. Opin. Investig. Drugs 5:146-153.
17. Heath, R. J., S. W. White, and C. O. Rock. 2001. Lipid biosynthesis as a target for antibacterial agents. Progress Lipid Res. 40:467-497.
18. Himmelreich, R., H. Hubert, H. Plagens, E. Pirkl, B.-C. Li, and R. Herrmann. 1996. Complete sequence analysis of the genome of the bacterium Mycoplasma pneumoniae. Nucleic Acids Res. 24:4420-4449.
19. Hoskins, J., W. E. Alborn, Jr., J. Arnold, et al. 2001. Genome of the bacterium Streptococcus pneumoniae strain R6. J. Bacteriol. 183:5709-5717.
20. Jackowski, S., and C. O. Rock. 1984. Metabolism of 4́- phosphopantetheine in Escherichia coli. J. Bacteriol. 158:115-120.
21. Jackowski, S., and C. O. Rock. 1983. Ratio of active to inactive forms of acyl carrier protein in Escherichia coli. J. Biol. Chem. 258:15186-15191.
22. Jackowski, S., and C. O. Rock. 1981. Regulation of coenzyme A biosynthesis. J. Bacteriol. 148:926-932.
23. Jackowski, S., and C. O. Rock. 1986. Consequences of reduced intracellular coenzyme A content in Escherichia coli. J. Bacteriol. 166:866-871.
24. Kalman, S., W. Mitchell, R. Marathe, C. Lammel, J. Fan, R. W. Hyman, L. Olinger, J. Grimwood, R. W. Davis, and R. S. Stephens. 1999. Comparative genomes of Chlamydia pneumoniae and C. trachomatis. Nat. Genet. 21:385-389.
25. Kunst, F., N. Ogasawara, I. Moszer, et al. 1997. The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature 390:249-256.
26. Kutchma, A. J., T. T. Hoang, and H. P. Schweizer. 1999. Characterization of a Pseudomonas aeruginosa fatty acid biosynthetic gene cluster: purification of acyl carrier protein (ACP) and malonyl-coenzyme A:ACP transacylase (FabD). J. Bacteriol. 181:5498-5504.
27. Lam, H.-M., E. Tancula, W. B. Dempsey, and M. E. Winkler. 1992. Suppression of insertions in the complex pdxJ operon of Escherichia coli K-12 by Ion and other mutations. J. Bacteriol. 174:1554-1567.
28. Lambalot, R. H., A. M. Gehring, R. S. Flugel, P. Zuber, M. LaCelle, M. A. Marahiel, R. Reid, C. Khosla, and C. T. Walsh. 1996. A new enzyme superfamily: the phosphopantetheinyl transferases. Chem. Biol. 3:923-936.
29. Lambalot, R. H., and C. T. Walsh. 1995. Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase. J. Biol. Chem. 270:24658-24661.
30. Leon, O., and C. Panos. 1981. Long-chain fatty acid perturbations in Mycoplasma pneumoniae. J. Bacteriol. 146:1124-1134.
31. Majerus, P. W., A. W. Alberts, and P. R. Vagelos. 1965. Acyl carrier protein. IV. The identification of 4′-phosphopantetheine as the prosthetic group of the acyl carrier protein. Proc. Natl. Acad. Sci. USA 53:410-417.
32. McAllister, K. A., R. B. Peery, T. I. Meier, A. S. Fischl, and G. Zbao. 2000. Biochemical and molecular analyses of the Streptococcus pneumoniae acyl carrier protein synthase, an enzyme essential for fatty acid biosynthesis. J. Biol. Chem. 275:30864-30872.
33. Mootz, H. D., R. Finking, and M. A. Marahiel. 2001. 4′- Phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis. J. Biol. Chem. 276:37289-37298.
34. Morbidoni, H. R., D. De Mendoza, and J. E. Cronan, Jr. 1996. Bacillus subtilis acyl carrier protein is encoded in a cluster of lipid biosynthesis genes. J. Bacteriol. 178:4794-4800.
35. Parris, K. D., L. Lin, A. Tam, R. Mathew, J. Hixon, M. Stahl, C. C. Fritz, J. Seehra, W. S. Somers. 2000. Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites. Struct. Fold Des. 8:883-895.
36. Quadri, L. E. N., P. H. Weinreb, M. Lie, M. M. Nakano, P. Zuber, and C. T. Walsh. 1998. Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases. Biochemistry 37:1585-1595.
37. Rawlings, M., and, J. E. Cronan, Jr. 1992. The gene encoding Escherichia coli acyl carrier protein lies within a cluster of fatty acid biosynthetic genes. J. Biol. Chem. 267:5751-5754.
38. Rock, C. O., and, J. E. Cronan, Jr. 1996. Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis. Biochem. Biophys. Acta 1302:1-16.
39. Shen, Z., and D. M. Byers. 1996. Isolation of Vibrio harveyi acyl carrier protein and the fabG, acpP, and fabF genes involved in fatty acid biosynthesis. J. Bacteriol. 178:571-573.
40. Smith, S. 1994. The animal fatty acid synthase: one gene, one polypeptide, seven enzymes. FASEB 8:1248-1259.
41. Takiff, J. E., T. Baker, T. Copeland, S.-M. Chen, and D. L. Court. 1992. Locating essential Escherichia coli genes by using mini-Tn10 transposons: the pdxJ operon. J. Bacteriol. 174:1544-1553.
42. Tettelin H., K. E. Nelson, et. al. 2001. Complete genome sequence of a virulent isolate of Streptococcus pneumoniae. Science 293:498-506.
43. Tomb, J.-F., O. White, A. R. Kerlavageet, et al. 1997. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388:539-547.
44. Tropf, S., W. P. Revill, M. J. Bibb, D. A. Howood, and M. Schweizer. 1998. Heterologously expressed acyl carrier protein domain of rat fatty acid synthase functions in Escherichia coli fatty acid synthase and Streptomyces coelicolor polyketide synthase systems. Chem. Biol. 5:135-146.
45. Vallari, D. S., and S. Jackowski. 1988. Biosynthesis and degradation both contribute to the regulation of coenzyme A content in Escherichia coli. J. Bacteriol. 170:3961-3966.
46. Vallari, D. S., S. Jackowski, and C. O. Rock. 1987. Regulation of pantothenate kinase by coenzyme A and its thioesters. J. Biol. Chem. 262:2468-2471.
47. Zhao, G., T. I. Meier, R. B. Peery, P. Matsushima, and P. L. Skatrud. 1999. Biochemical and molecular analyses of the C-terminal domain of Era GTPase from Streptococcus pneumoniae. Microbiology 145:791-800.
48. Zhou, P., G. Florova, and K. A. Reynolds. 1999. Polyketide synthase acyl carrier protein (ACP) as a substrate and a catalyst for malonyl ACP biosynthesis. Chem. Biol. 6:577-584.