Effect of plant sterols on the lipid profile of patients with hypercholesterolaemia. Randomised, experimental study

BMC Complementary and Alternative Medicine

Volumn 11, Issue , 2011, Pages

  Párraga, Ignacio ^a   López Torres, Jesús ^a   Andrés, Fernando ^a   Navarro, Beatriz ^a   del Campo, José M ^b   García Reyes, Mercedes ^c   Galdón, María P ^d   Lloret, Ángeles ^e   Precioso, Juan C ^d   Rabanales, Joseba ^a  

^a Research Unit   (Spain)

^b Health Care Service of Castilla La Mancha   (Spain)

^c Albacete Area III Health Centre   (Spain)

^d Health Care Service of Castilla La Mancha   (Spain)

^e Health Care Service of Castilla La Mancha   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL; PLACEBO; YOGHURT;

ADULT; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DAIRY PRODUCT; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXPERIMENTAL STUDY; FOOD INTAKE; GENERAL PRACTITIONER; HEALTH CENTER; HUMAN; HYPERCHOLESTEROLEMIA; PHYSICAL ACTIVITY; PHYSICAL EXAMINATION; RANDOMIZED CONTROLLED TRIAL; SMOKING HABIT; SPAIN; UNSPECIFIED SIDE EFFECT;

EID: 80052605212     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-11-73     Document Type: Article

References (55)

1. Instituto Nacional de Estadística of Spain Defunciones por causa de muerte 2006, 172. Boletín Mensual Estadística, INE; c2006. Available from: 2009. http://www.ine.es/jaxi/menu.do?type=pcaxis&path=/t15/p417/&file=inebase, Instituto Nacional de Estadística of Spain.
2. Medrano MJ, Cerrato E, Boix R, Delgado-Rodriguez M. Cardiovascular risk in Spanish population: metaanalysis of cross-sectional studies. Med Clin (Bar) 2005, 124:606-612.
3. Gutiérrez Fuentes JA, Gómez Gerique JA, Gómez de la Cámara A, Rubio MA, García Hernández A, Arístegui I. Diet and Cardiovascular Risk in Spain Study (DRECE II). Description of the evolution of cardiovascular profile. Med Clin (Barc) 2000, 115:726-729.
4. Villar Álvarez F, Banegas JR, Donado Campos JM, Rodríguez Artalejo F. Las enfermedades cardiovasculares y sus factores de riesgo en España: hechos y cifras. Informe SEA 2003 2003, Madrid: Ergon.
5. Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?. BMJ 1994, 308:367-72. 2539460, 8043072.
6. Law MR, Wald NJ. Risk factor thresholds: their existence under scrutiny. BMJ 2002, 324:1570-6. 10.1136/bmj.324.7353.1570, 1123506, 12089098.
7. Keys A. Coronary heart disease, serum cholesterol, and the diet. Acta Med Scand 1980, 207:153-60.
8. Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, Kirby A, Sourjina T, Peto R, Collins R, simes R, . Cholesterol Treatment Trialist' (CTT) Collaborators Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005, 366:1267-78. Cholesterol Treatment Trialist' (CTT) Collaborators.
9. McCullough ML, Feskanich D, Stampfer MJ, Giovannucci EL, Rimm EB, Hu FB, Spiegelman D, Hunter DJ, Colditz GA, Willett WC. Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr 2002, 76:1261-1271.
10. Sudhop T, Von Bergman K. Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia. 2002, 62:2333-47.
11. Jenkins DJA, Kendall CWC, Marchie A, Faulkner DA, Wong JMW, De Souza R, Emam A, Parker TL, Vidgen E, Trautwein EA, Lapsley KG, Josse RG, Leiter LA, Singer W, Conelly PW. Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterlemic participants. Am J Clin Nutr 2005, 81:380-387.
12. Bellisle F, Diplock AT, Hornstra G, Koletzko B, Roberfroid M, Salminen S, Saris WHM. Functional food science in Europe. Br J Nutr 1998, 80:173-193.
13. Milner JA, Craig L. Physiologically active food components: their role in optimizing health and aging. Am J Clin Nutr 2000, 71:1653-1743.
14. Ross E. Introduction to functional food. Med Clin (Bar) 2001, 116:617-9.
15. Silveira MB, Monereo S, Molina B. Funtional nutrition and optimal nutricion. Near or far?. Rev Esp Salud Pública 2003, 77(3):317-331.
16. Plaza I. Los fitosteroles, el colesterol y la prevención de las enfermedades cardiovasculares. Clin Invest Arterioesclerosis 2001, 5:209-18.
17. Piironen V, Lindsay DG, Miettinen TA, Toivo J, Lampi AM. Plant sterols: biosynthesis: biological function and their importance to human nutrition. J Sci Food Agric 2000, 80:939-966.
18. Heinemann T, Kullabak-Ublick A, Pietruck B, von Bergmann K. Mechanism of action of plant sterols on inhbition of cholesterol absorption. Eur J Clin Pharmacol 1991, 20:59-63.
19. Cater NB. Plant Stanol Ester: Review of cholesterol-lowering efficacy and implications for coronary heart disease risk reduction. Prev Cardiol 2000, 3:121-30. 10.1111/j.1520-037X.2000.80370.x, 11834929.
20. Hallikainen MA, Sarkkinen ES, Uusitupa MIJ. Plant stanol esters affect serum cholesterol concentrations of hypercholesteroemic men and women in a dose-dependent manner. J Nutr 2000, 130:767-776.
21. Miettinen TA, Puska P, Gylling H, Vanhanen H, Vartiainen E. Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolemic population. N Engl J Med 1995, 333:1308-1312. 10.1056/NEJM199511163332002, 7566021.
22. Miettinen TA, Vuoristo M, Nissinen M, Jarvinen HJ, Gylling H. Serum, biliary and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. Am J Clin Nutr 2000, 71:1095-1102.
23. Noakes M, Clifton PM, Doornbos AM, Trautwein EA. Plant sterol ester-enriched milk and yoghurt effectively reduce serum cholesterol in modestly hypercholesterolemic subjects. Eur J Nutr 2005, 44:214-222. 10.1007/s00394-004-0513-z, 15316827.
24. Blari SN, Capuzzi DM, Gottlieb SO, Nguyen T, Morgan JM, cater NB. Incremental reduction in total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol ester-containing spread to statin therapy. Am J Cardiol 2000, 86:46-52.
25. Nigon F, Serfaty L, Beucler I, Chauvois D, Neveu C, Giral P, Chapman MJ, Bruckert E. Plant sterol-enriched margarine lowers plasma LDL in hyperlipidaemia subjects with low cholesterol intake: effect of fibrate treatment. Clin Chem Lab Med 2001, 39:634-640. 10.1515/CCLM.2001.103, 11522112.
26. Gylling H, Miettinen TA. Combination therapy with statins. Curr Opin Investig Drugs 2002, 3:1318-23.
27. Katan MB, Grundy SM, Jones P, Law M, Miettinen TA, Paoletti R, . Stresa Workshop Participants Efficacy and safety of plant stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 2003, 78:965-978. 10.4065/78.8.965, 12911045, Stresa Workshop Participants.
28. Law M. Plant sterol and stanol margarines and health. Br Med J 2000, 320:861-864.
29. Mensink RP, Ebbing S, Lindhout M, Plat J, van Heugten MM. Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations. Atherosclerosis 2002, 160:205-213. 10.1016/S0021-9150(01)00562-7, 11755939.
30. O'Neill FH, Brynes A, Mandeno R, Rendell N, Taylor G, Seed M, Thompson GR. Comparison of the effects of dietary plant sterol and stanol esters on lipid metabolism. Nutr Metab Cardiovasc Dis 2004, 14:133-142. 10.1016/S0939-4753(04)80033-4, 15330272.
31. Mattson FH, Grundy SM, Crouse JR. Optimizing the effect of plant sterols on cholesterol absorption in man. Am J Clin Nutr 1982, 35:697-700.
32. Plat J, van OE, van Heugten MM, Mensink RP. Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters. Eur J Clin Nutr 2000, 54:671-677. 10.1038/sj.ejcn.1601071, 11002377.
33. . Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adults Treatment Panel III) National Cholesterol Education Program. Executive Summary of the Third Report of the National Cholesterol Education Program (NECEP). JAMA 2001, 285:2486-2497. 10.1001/jama.285.19.2486, 11368702, Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adults Treatment Panel III).
34. Van Horn L, Ernst N. A summary of the science supporting the new National cholesterol Education Program dietary recommendations: What dietitians should know. J Am Diet Ass 2001, 101:1148-54.
35. Lichtenstein AH, Deckelbaum RJ, . AHA Science Advisory Stanol/sterol ester-containing foods and blood cholesterol levels. A statement for healthcare professionals from the Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism of the American Heart Association. Circulation 2001, 103:1177-9. AHA Science Advisory.
36. Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, Franklin B, Kris-Etherton P, Harris WS, Howard B, Karanja N, Lefevre M, Rudel L, Sacks F, Van Horn L, Winston M, Wylie-Rosett J. American Heart Association Nutrition Committee Diet and Lifestyle Recommendations Revision 2006: A Scientific Statement From the American Heart Association Nutrition Committee. Circulation 2006, 114:82-96. 10.1161/CIRCULATIONAHA.106.176158, 16785338, American Heart Association Nutrition Committee.
37. Algorta J, Chinchetru MJ, Aguirre J, Francisco S. Hypocholesteremic effectiveness of a yogurt containing plant stanol esters. Rev Clin Esp 2005, 205:63-66. 10.1157/13072497, 15766477.
38. Slesinski RS, Turnbull DV, Frankos VH, Wolterbeek AP, Waalkens-Berendsen DH. Developmental toxicity study of vegetable oil-derived stanol fatty acid esters. Regul Toxicol Pharmacol 1999, 29:227-233. 10.1006/rtph.1999.1292, 10341155.
39. De Jong N, Pijpers L, Bleeker JK, Ocke MC. Potential intake of phytosterols/-stanols: results of a simulation study. Eur J Clin Nutr 2004, 58:907-919. 10.1038/sj.ejcn.1601912, 15164112.
40. Brufau G, Canela MA, Rafecas M. Phytosterols: physiologic and metabolic aspects related to cholesterol-lowering properties. Nutrition Research 2008, 28:217-225. 10.1016/j.nutres.2008.02.003, 19083411.
41. Moruisi KG, Oosthuizen W, Opperman AM. Phytosterols/Stanols Lower Cholesterol Concentrations in Familial Hypercholesterolemic Subjects: A Systematic Review with Meta-Analysis. J Am Coll Nutr 2006, 25:41-48.
42. Jordan S, Griffiths J, Pilon K. Sterol and sterolin-containing products: hematologic adverse reactions. CMAJ 2004, 170:1347-8. 1351-2.
43. Hallikainen MA, Sarkkinen ES, Uusitupa MIJ. Effect of low-fat stanol enriched margarine on concentrations of serum carotenoids in subjects with elevated serum cholesterol concentrations. Eur J Clin Nutr 1999, 53:966-969. 10.1038/sj.ejcn.1600882, 10602355.
44. Noakes M, Clifton P, Ntanios F, Shrapnel W, Record I, McInerney J. An increase in dietary carotenoids when consuming plant sterols or stanols is effective in maintaining plasma carotenoid concentrations. The American journal of clinical nutrition 2002, 75:79-86.
45. Commision Decission on authorising the placing on the market of yellow fat spreads with added phytosterols esters as a novel food or novel food ingredient under regulation (EC) No 258/97 of the European Parliament and of the Council. Official Journal of the European Communities 2000, 2121. 200/59-60.
46. Rajaratnam RA, Gylling H, Miettinen TA. Independent association of serum squalene and noncholesterol sterols with coronary artery disease in postmenopausal women. J Am Coll Cardiol 2000, 35:1185-1191. 10.1016/S0735-1097(00)00527-1, 10758959.
47. Assmann G, Cullen P, Erbey J, Ramey DR, Kannenberg F, Schulte H. Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: results of a Nested Case-Control Analysis of the prospective Cardiovascular Munster (PROCAM) Study. Nutr Metab Cardiovasc Dis 2006, 16:13-21. 10.1016/j.numecd.2005.04.001, 16399487.
48. Moghadasian MH, McManus BM, Godin DV, Rodrigues B, Frohlich JJ. Proatherogenic and antiatherogenic effects of probucol and phytosterols in apolipoprotein E-deficient mice. Possible mechanisms of action. Circulation 1999, 99:1733-1739.
49. Volger OL, Mensink RP, Plat J, Honstra G, Havekes LM, Princen HM. Dietary vegetable oil and wood derived plant stanol esters reduce atherosclerotic lesion size and severity in ApoE 3-Leiden transgenic mice. Atherosclerosis 2001, 157:375-381. 10.1016/S0021-9150(00)00750-4, 11472737.
50. Ratnayake WM, l'Abbe MR, Mueller R, Hayward S, Plouffe L, Hollywood R, trick K. Vegetable oils high in phytosterols make erythrocytes less deformable and shorten the life span of stroke-prone spontaneously hypertensive rats. J Nutr 2000, 130:1166-1178.
51. Child P, Kuksis A. Differential uptake of cholesterol and plant sterols by rat erythrocytes in vitro. Lipids 1982, 17:748-754. 10.1007/BF02534662, 7176832.
52. De Jong A, Plat J, Mensink RP. Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment. Eur J Clin Nutr 2006, 60:985-990. 10.1038/sj.ejcn.1602409, 16482072.
53. Hendriks HFJ, Brink EJ, Meijer GW, Princen HMG, Ntanios FY. Safety of long-term consumption of plant sterol ester-enriched spread. Eur J Clin Nutr 2003, 57:681-692. 10.1038/sj.ejcn.1601598, 12771969.
54. Grundy SM. Stanol esters as a component of maximal dietary therapy in the National Cholesterol Education Program Adult Treatment Panel III report. Am J Cardiol 2001, 96:47-50.
55. National Institute of Health and Clinical Excellence Clinical guidelines and evidence review for familial hypercholesterolaemia: the identification and management of adults and children with familial hypercholesterolaemia. NICE; 2008. (Clinical guideline 71.) Availble from: 2009 www.nice.org.uk/CG71., National Institute of Health and Clinical Excellence.