Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 18, 2011, Pages 5734-5741

  Robertson, Mark J ^a   Gordon, Christopher P ^a   Gilbert, Jayne ^b   McCluskey, Adam ^a   Sakoff, Jennette A ^b  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b CALVARY MATER NEWCASTLE HOSPITAL   (Australia)

Author keywords

Anti cancer; Cantharidin; Cytotoxicity; Norcantharidin; Norcantharimide

Indexed keywords

4 (1,3 DIOXOISOINDOLIN 2 YL)BUTYL DIPHENYLPHOSPHATE; 4 AZA 4 (2 [BIS (2,2,2 TRICHLOROETHYL)PHOSPHATE]CYCLOHEXYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (2 [BIS (2,2,2 TRICHLOROETHYL)PHOSPHATE]ETHYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (2 [DIETHYLPHOSPHATE]CYCLOHEXYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (2 [DIETHYLPHOSPHATE]ETHYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (2 [DIPHENYLPHOSPHATE]CYCLOHEXYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (2 [DIPHENYLPHOSPHATE]ETHYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (2 HYDROXYCYCLOHEXYLL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (2 HYDROXYETHYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (3 [BIS (2,2,2 TRICHLOROETHYL)PHOSPHATE]PROPYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (3 [DIPHENYLPHOSPHATE]PROPYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (3 HYDROXYPROPYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (4 [BIS (2,2,2 TRICHLOROETHYL)PHOSPHATE]BUTYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (4 [DIETHYLPHOSPHATE]BUTYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (4 [DIPHENYLPHOSPHATE]BUTYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (4 HYDROXYBUTYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (5 [BIS (2,2,2 TRICHLOROETHYL)PHOSPHATE]PENTYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (5 [DIETHYLPHOSPHATE]PENTYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (5 [DIPHENYLPHOSPHATE]PENTYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (5 HYDROXYPENTYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (6 [BIS (2,2,2 TRICHLOROETHYL)PHOSPHATE]HEXYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (6 [DIETHYLPHOSPHATE]HEXYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (6 [DIPHENYLPHOSPHATE]HEXYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; 4 AZA 4 (6 HYDROXYHEXYL) 10 OXATRICYCLO [5.2.1.0] DECANE 3,5 DIONE; CANTHARIDIN; N (4 HYDROXYBUTYL)PHTHALIMIDE; NORCANTHARIDIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN CANCER; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DEATH; COLON CARCINOMA; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; LUNG CARCINOMA; OVARY CARCINOMA; PROSTATE CARCINOMA; PROTON NUCLEAR MAGNETIC RESONANCE; SKIN CARCINOMA;

ANTINEOPLASTIC AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MOLECULAR STRUCTURE; PHOSPHORIC ACID ESTERS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 80052600913     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.031     Document Type: Article

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