Effects of β-arrestin 2 on cytokine production of CD4 + T lymphocytes of mice with allergic asthma

Indian Journal of Experimental Biology

Volumn 49, Issue 8, 2011, Pages 585-593

  Wang, Guyi ^a   Liu, Yi ^b   Yang, Muyi ^a   Liu, Shaokun ^a   Ma, Libing ^a   Gong, Subo ^a   Li, Keng ^a   Zhang, Li ^a   Xiang, Xudong ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CHANGSHA CENTRAL HOSPITAL   (China)

Author keywords

arrestin 2; 2 adrenergic receptors; Asthma; CD4 +; Interleukin 4; Tlymphocytes

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ARRESTIN; GAMMA INTERFERON; GATA3 PROTEIN, MOUSE; INTERLEUKIN 4; RETINA S ANTIGEN; SMALL INTERFERING RNA; TERBUTALINE; TRANSCRIPTION FACTOR GATA 3;

ANIMAL; ARTICLE; ASTHMA; BAGG ALBINO MOUSE; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CYTOLOGY; DISEASE MODEL; DRUG POTENTIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; LUNG LAVAGE; MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; ARRESTINS; ASTHMA; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE FLUID; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GATA3 TRANSCRIPTION FACTOR; INTERFERON-GAMMA; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; RECEPTORS, ADRENERGIC, BETA-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TERBUTALINE;

MUS;

EID: 80052599332     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Ray A & Cohn L, Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation, J Clin Invest, 104 (1999) 985.
2. Steinke J W & Borish L, Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists, Respir Res, 2 (2001) 66.
3. Bohn L M, Gainetdinov R R, Lin F T, Lefkowitz R J & Caron M G, Mu-opioid receptor desensitization by betaarrestin-2 determines morphine tolerance but not dependence, Nature, 408 (2000) 720.
4. Goodman O B, Jr., Krupnick J G, Santini F, Gurevich V V, Penn R B, Gagnon A W, Keen J H & Benovic J L, Betaarrestin acts as a clathrin adaptor in endocytosis of the beta2- adrenergic receptor, Nature, 383 (1996) 447.
5. Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L & Pei G, Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2, J Biol Chem, 278 (2003) 6363.
6. Basher F, Fan H, Zingarelli B, Borg K T, Luttrell L M, Tempel G E, Halushka P V & Cook J A, beta-Arrestin 2: A negative regulator of inflammatory responses in polymorphonuclear leukocytes, Int J Clin Exp Med, 1 (2008) 32.
7. Walker J K, Fong A M, Lawson B L, Savov J D, Patel D D, Schwartz D A & Lefkowitz R J, Beta-arrestin-2 regulates the development of allergic asthma, J Clin Invest, 112 (2003) 566.
8. Heijink I H, Kauffman H F, Vellenga E, Veltman-Starkenburg C A, Postma D S & de Monchy J G, Effect of ciclesonide treatment on allergen-induced changes in T cell regulation in asthma, Int Arch Allergy Immunol, 145 (2008) 111.
9. Heijink I H, van den Berge M, Vellenga E, de Monchy J G, Postma D S & Kauffman H F, Altered beta2-adrenergic regulation of T cell activity after allergen challenge in asthma, Clin Exp Allergy, 34 (2004) 1356.
10. Sanders V M, Baker R A, Ramer-Quinn D S, Kasprowicz D J, Fuchs B A & Street N E, Differential expression of the beta2-adrenergic receptor by Th1 and Th2 clones: implications for cytokine production and B cell help, J Immunol, 158 (1997) 4200.
11. Ahn S, Nelson C D, Garrison T R, Miller W E & Lefkowitz R J, Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference, Proc Natl Acad Sci U S A, 100 (2003) 1740.
12. North M L, Khanna N, Marsden P A, Grasemann H & Scott J A, Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma, Am J Physiol Lung Cell Mol Physiol, 296 (2009) L911.
13. Vanoirbeek J A, De Vooght V, Vanhooren H M, Nawrot T S, Nemery B & Hoet P H, How long do the systemic and ventilatory responses to toluene diisocyanate persist in dermally sensitized mice?, J Allergy Clin Immunol, 121 (2008) 456.
14. Ferrada M A, Gordon E L, Jen K Y, He H Z, Lu X, Barone L M, Amirifeli S, Perkins D L & Finn P W, (R)-albuterol decreases immune responses: role of activated T cells, Respir Res, 9 (2008) 3.
15. Ramer-Quinn D S, Baker R A & Sanders V M, Activated T helper 1 and T helper 2 cells differentially express the beta-2-adrenergic receptor: a mechanism for selective modulation of T helper 1 cell cytokine production, J Immunol, 159 (1997) 4857.
16. Lee Y C, Lee K H, Lee H B & Rhee Y K, Serum levels of interleukins (IL)-4, IL-5, IL-13, and interferon-gamma in acute asthma, J Asthma, 38 (2001) 665.
17. Perry S J, Baillie G S, Kohout T A, McPhee I, Magiera M M, Ang K L, Miller W E, McLean A J, Conti M, Houslay M D & Lefkowitz R J, Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins, Science, 298 (2002) 834.
18. Zheng W & Flavell R A, The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells, Cell, 89 (1997) 587.
19. Zhu J, Yamane H, Cote-Sierra J, Guo L & Paul W E, GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors, Cell Res, 16 (2006) 3.
20. Hollingsworth J W, Theriot B S, Li Z, Lawson B L, Sunday M, Schwartz D A & Walker J K, Both Hematopoietic- and Non-hematopoietic-derived {beta}-arrestin-2 Regulates Murine Allergic Airway Disease, Am J Respir Cell Mol Biol,43 (2010) 269.
21. Deshpande D A, Theriot B S, Penn R B & Walker J K, Betaarrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle, FASEB J, 22 (2008) 2134.
22. Nelson C D, Kovacs J J, Nobles K N, Whalen E J & Lefkowitz R J, Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor, J Biol Chem, 283 (2008) 21093.
23. Krasel C, Bunemann M, Lorenz K & Lohse M J, Betaarrestin binding to the beta2-adrenergic receptor requires both receptor phosphorylation and receptor activation, J Biol Chem, 280 (2005) 9528.
24. Moore R H, Millman E E, Godines V, Hanania N A, Tran T M, Peng H, Dickey B F, Knoll B J & Clark R B, Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization, Am J Respir Cell Mol Biol, 36 (2007) 254.
25. Penn R B, Panettieri R A, Jr. & Benovic J L, Mechanisms of acute desensitization of the beta2AR-adenylyl cyclase pathway in human airway smooth muscle, Am J Respir Cell Mol Biol, 19 (1998) 338.
26. Peek E J, Richards D F, Faith A, Lavender P, Lee T H, Corrigan C J & Hawrylowicz C M, Interleukin-10-secreting regulatory T cells induced by glucocorticoids and beta2- agonists, Am J Respir Cell Mol Biol, 33 (2005) 105.
27. Hashimoto T, Kitamura N, Kobayashi N, Suko M, Kaminuma O & Mori A, Effect of formoterol on allergeninduced cytokine synthesis by atopic asthmatics, Int Arch Allergy Immunol, 143 Suppl 1 (2007) 106.
28. Borger P, Jonker G J, Vellenga E, Postma D S, De Monchy J G & Kauffman H F, Allergen challenge primes for IL-5 mRNA production and abrogates beta-adrenergic function in peripheral blood T lymphocytes from asthmatics, Clin Exp Allergy, 29 (1999) 933.
29. Shenoy S K, Drake M T, Nelson C D, Houtz D A, Xiao K, Madabushi S, Reiter E, Premont R T, Lichtarge O & Lefkowitz R J, beta-arrestin-dependent, G proteinindependent ERK1/2 activation by the beta2 adrenergic receptor, J Biol Chem, 281 (2006) 1261.
30. Yamashita M, Shinnakasu R, Asou H, Kimura M, Hasegawa A, Hashimoto K, Hatano N, Ogata M & Nakayama T, Ras-ERK MAPK cascade regulates GATA3 stability and Th2 differentiation through ubiquitin-proteasome pathway, J Biol Chem, 280 (2005) 29409.
31. Meurs H, Koeter G H, de Vries K & Kauffman H F, The beta-adrenergic system and allergic bronchial asthma: changes in lymphocyte beta-adrenergic receptor number and adenylate cyclase activity after an allergen-induced asthmatic attack, J Allergy Clin Immunol, 70 (1982) 272.
32. Meurs H, Kauffman H F, Timmermans A, de Monchy J G, Koeter G H & de Vries K, Specific immunological modulation of lymphocyte adenylate cyclase in asthmatic patients after allergenic bronchial provocation, Int Arch Allergy Appl Immunol, 81 (1986) 224.