Activated T Helper 1 and T Helper 2 Cells Differentially Express the β-2-Adrenergic Receptor: A Mechanism for Selective Modulation of T Helper 1 Cell Cytokine Production

Journal of Immunology

Volumn 159, Issue 10, 1997, Pages 4857-4867

  Ramer Quinn, D Susanne ^a   Baker, Raymond A ^a   Sanders, Virginia M ^a  

^a LOYOLA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CYTOKINE; INTERLEUKIN 2; NORADRENALIN; TERBUTALINE;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CLONE; DRUG EFFECT; DRUG POTENTIATION; FEMALE; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; PHYSIOLOGY; TH1 CELL; TH2 CELL;

ANIMALS; CLONE CELLS; CYTOKINES; FEMALE; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; NOREPINEPHRINE; RECEPTORS, ADRENERGIC, BETA-2; TERBUTALINE; TH1 CELLS; TH2 CELLS;

EID: 0031573079     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (76)

1. + T cells. Immunol. Rev. 123:209.
2. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
3. Liblau, R. S., S. M. Singer, and H. O. McDevitt. 1995. Th1 and Th2 CD4 T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16: 34.
4. Mosmann, T. R., and S. Sad. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17:138.
5. Debray-Sachs, M., C. Carnaud, C. Boitard, H. Cohen, I. Gresser, P. Bedossa, and J. Bach. 1991. Prevention of diabetes in NOD mice treated with antibody to murine IFN-γ. J. Autoimmun. 4:237.
6. Sarvetnick, N., J. Shizuru, D. Liggitt, L. Martin, B. McIntyre, A. Gregory, T. Parslow, and T. Stewart. 1990. Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma. Nature 346:844.
7. Kuchroo, V. K., C. A. Martin, J. M. Greer, S. Ju, R. A. Sobel, and M. E. Dorf. 1993. Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis. J. Immunol. 151:4371.
8. Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
9. Merrill, J. E., D. H. Kono, J. Clayton, D. G. Ando, D. R. Hinton, and F. M. Hofman. 1992. Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10. PI. mice. Proc. Natl. Acad. Sci. USA 89:574.
10. Miller, S. D., and W. J. Karpus. 1994. The immunopathogenesis and regulation of T-cell mediated demyelinating diseases. Immunol. Today 15:356.
11. Rapoport, M. J., A. Jaramillo, D. Zipris, A. H. Lazarus, D. V. Serreze, E. H. Leiter, P. Cyopick, J. S. Danska, and T. L. Delovitch. 1993. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 178:87.
12. O'Garra, A., and K. Murphy. 1993. T-cell subsets in autoimmunity. Curr. Opin. Immunol. 5:880.
13. Chen, Y., V. K. Kuchroo, J. Inobe, D. A. Hafler, and H. L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237.
14. Racke, M. K., A. Bonomo, D. E. Scott, B. Cannella, A. Levine, C. S. Raine, E. M. Shevach, and M. Rocken. 1994. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180:1961.
15. + T cells from allergic individuals. J. Exp. Med. 178:2123.
16. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383:787.
17. Sher, A., and R. L. Coffman. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385.
18. + T cells. Annu. Rev. Immunol. 12:635.
19. Madden, K. S., V. M. Sanders, and D. L. Felten. 1995. Catecholamine influences and sympathetic neural modulation of immune responsiveness. Annu. Rev. Pharmacol. Toxicol. 35:417.
20. Felten, D. L., S. Y. Felten, D. L. Bellinger, S. L. Carlson, K. D. Ackerman, K. S. Madden, J. A. Olschowki, and S. Livnat. 1987. Noradrenergic sympathetic neural interactions with the immune system: structure and function. Immunol. Rev. 100:225.
21. Ader, R., D. Felten, and N. Cohen. 1990. Interactions between the brain and the immune system. Annu. Rev. Pharmacol. Toxicol. 30:561.
22. Felten, D. L., K. D. Ackerman, S. J. Wiegand, and S. Y. Felten. 1987. Noradrenergic sympathetic innervation of the spleen. I. Nerve fibers associate with lymphocytes and macrophages in specific compartments of the splenic white pulp. J. Neurosci. Res. 18:28.
23. Bulloch, K., and W. Pomerantz. 1984. Autonomie nervous system innervation of thymic related lymphoid tissue in wild-type and nude mice. J. Comp. Neurol. 228:57.
24. Felten, S. Y., and J. Olschowka. 1987. Noradrenergic sympathetic innervation of the spleen. II. Tyrosine hydroxylase (TH)-positive nerve terminals form synaptic-like contacts on lymphocytes in the splenic white pulp. J. Neurosci. Res. 18:37.
25. Van Tits, L. J. H., M. C. Michel, H. Grosse-Wilde, M. Happel, F.-W. Eigler, A. Soliman, and O.-E. Brodde. 1990. Catecholamines increase lymphocyte beta-2-adrenergic receptors via a beta-2-adrenergic, spleen-dependent process. Am. J. Physiol. 258:E191.
26. Khan, M. M., P. Sansoni, E. D. Silverman, E. G. Engleman, and K. L. Melmon. 1986. Beta-adrenergic receptors on human suppressor, helper, and cytolytic lymphocytes. Biol. Psychiatry 35:1137.
27. Fuchs, B. A., J. W. Albright, and J. F. Albright. 1988. Beta-adrenergic receptor on murine lymphocytes: density varies with cell maturity and lymphocyte subtype and is decreased after antigen administration. Cell. Immunol. 114:231.
28. Radojcic, T., S. Baird, D. Darko, D. Smith, and K. Bulloch. 1991. Changes in beta-adrenergic receptor distribution on immunocytes during differentiation: an analysis of T cells and macrophages. J. Neurosci. Res. 30:328.
29. Sanders, V. M., R. A. Baker, D. S. Ramer-Quinn, D. J. Kasprowicz, B. A. Fuchs, and N. E. Street. 1997. Differential expression of the β-2-adrenergic receptor by Th1 and Th2 clones: implications for cytokine production and B cell help. J. Immunol. 158:4200.
30. Fuchs, B. A., K. S. Campbell, and A. E. Munson. 1988. Norepinephrine and serotonin content of the murine spleen: its relationship to lymphocyte beta-adrenergic receptor density and the humoral immune response in vivo and in vitro. Cell. Immunol. 117:339.
31. Makman, M. H. 1971. Properties of adenylate cyclase of lymphoid cells. Proc. Natl. Acad. Sci. USA 68:885.
32. 3H-alprenolol binding. J. Clin. Invest. 57:149.
33. Conolly, M. H., and J. K. Greenacre. 1977. The beta-adrenoceptor of the human lymphocyte and human lung parenchyma. Br. J. Pharmacol. 59:17.
34. Bishopric, N. H., H. J. Cohen, and R. J. Lefkowitz. 1980. Beta-adrenergic receptors in lymphocyte subpopulations. J. Allergy Clin. Immunol. 65:29.
35. Bourne, H. R., and K. L. Melmon. 1971. Adenyl cyclase in human leukocytes: evidence for activation by separate beta adrenergic and prostaglandin receptors. J. Pharmacol. Exp. Ther. 178:1.
36. Pochet, R., and G. Delespesse. 1983. Beta-adrenoceptors display different efficiency on lymphocyte subpopulations. Biochem. Pharmacol. 32:1651.
37. Gajewski, T. F., S. R. Schell, and F. W. Fitch. 1990. Evidence implicating utilization of different T cell receptor-associated signaling pathways by Th-1 and Th-2 clones. J. Immunol. 144:4110.
38. Novak, T. J., and E. V. Rothenberg. 1990. cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells. Proc. Natl. Acad. Sci. USA 87:9353.
39. 2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146:108.
40. 2 differentially modulates cytokine secretion profiles of human T helper lymphocytes. J. Immunol. 150:5321.
41. 2 may reside down-stream of the PKC-dependent pathway. Cytokine 8:346.
42. + T cells while decreasing IL-2 release and NF-AT induction. Int. Immunol. 6:1333.
43. Parker, C. W., M. G. Huber, and S. M. Godt. 1995. Modulation of IL-4 production in murine spleen cells by prostaglandins. Cell. Immunol. 160:278.
44. Borger, P., H. F. Kauffman, D. S. Postma, and E. Vellenga. 1996. Interleukin-4 gene expression in activated human T lymphocytes is regulated by the cyclic adenosine monophosphate-dependent signaling pathway. Blood 87:691.
45. Hemler, M. E., M. B. Brenner, J. M. McLean, and J. L. Strominger. 1984. Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells. Proc. Natl. Acad. Sci. USA 81:2172.
46. Haynes, B. F., M. Hemler, T. Cotner, D. L. Mann, G. S. Eisenbarth, J. L. Strominger, and A. S. Fauci. 1981. Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. J. Immunol. 127:347.
47. Helderman, J. H., T. C. Reynolds, and T. B. Strom. 1978. The insulin receptor as a universal marker of activated lymphocytes. Eur. J. Immunol. 8:589.
48. Braciale, V. L., J. R. Gavin III, and T. J. Braciale. 1982. Inducible expression of insulin receptors on T lymphocyte clones. J. Exp. Med. 156:664.
49. Aune, T. M., K. M. McGrath, T. Sarr, M. P. Bombara, and K. A. Kelley. 1993. Expression of 5HT1a receptors on activated human T cells: regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine. J. Immunol. 151: 1175.
50. 2 receptors during human T cell activation. Cell. Immunol. 134:287.
51. Kurt-Jones, E. A., S. Hamberg, J. Ohara, W. E. Paul, and A. K. Abbas. 1987. Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J. Exp. Med. 166:1774.
52. H1 clones. J. Immunol. 138: 3688.
53. Stack, R. M., D. J. Lenschow, G. S. Gray, J. A. Bluestone, and F. W. Fitch. 1994. IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2. J. Immunol. 152:5723.
54. Tony, H.-P., N. E. Phillips, and D. C. Parker. 1985. Role of membrane immunoglobulin (Ig) cross-linking in membrane Ig-mediated, major histocompatibility-restricted T cell-B cell cooperation. J. Exp. Med. 162:1695.
55. Sanders, V. M., and F. E. Powell-Oliver. 1992. β-2-adrenoceptor stimulation increases the number of antigen-specific precursor B lymphocytes that differentiate into IgM-secreting cells without affecting burst size. J. Immunol. 148:1822.
56. Noelle, R. J., J. McCann, E. Marshall, and W. C. Bartlett. 1989. Cognate interactions between helper T cells and B cells. III. Contact-dependent, lymphokine-independent induction of B cell cycle entry by activated helper T cells. J. Immunol. 143:1807.
57. Munson, P. J. 1987. A User's Guide to LIGAND: Data Analysis and Curve-Fitting for Liqand Binding Experiments. Systex, Beltsville, MD.
58. Westly, H. J., and K. W. Kelley. 1987. Down-regulation of glucocorticoid and beta-adrenergic receptors on lectin-stimulated splenocytes. Proc. Soc. Exp. Biol. Med. 185:211.
59. Cazaux, C. A., L. Sterin-Borda, G. Gorelik, and G. A. Cremaschi. 1995. Down-regulation of beta-adrenergic receptors induced by mitogen activation of intracellular signaling events in lymphocytes. FEBS Lett. 364:120.
60. Madden, K. S., S. Y. Felten, D. L. Felten, P. R. Sundaresan, and S. Livnat. 1989. Sympathetic neural modulation of the immune system. I. Depression of T cell immunity in vivo and in vitro following chemical sympathectomy. Brain Behav. Immun. 3:72.
61. Collins, S., M. G. Caron, and R. J. Lefkowitz. 1991. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annu. Rev. Physiol. 53:497.
62. Kruszewska, B., S. Y. Felten, and J. A. Moynihan. 1995. Alterations in cytokine and antibody production following chemical sympathectomy in two strains of mice. J. Immunol. 155:4613.
63. Madden, K. S., J. A. Moynihan, G. J. Brenner, S. Y. Felten, D. L. Felten, and S. Livnat. 1994. Sympathetic nervous system modulation of the immune system. III. Alterations in T and B cell proliferation and differentiation in vitro following chemical sympathectomy. J. Neuroimmunol. 49:77.
64. Madden, K. S., and S. Livnat. 1991. Catecholamine action and immunologic reactivity. In Psychoneuroimmunology, 2nd Ed. R. Ader, N. Cohen, and D. L. Felten, eds. Academic Press, New York, p. 283.
65. Bucy, R. P., A. Panoskaltsis-Mortari, G.-Q. Huang, J. Li, L. Karr, M. Ross, J. H. Russell, K. M. Murphy, and C. T. Weaver. 1994. Heterogeneity of single cell cytokine gene expression in clonal T cell populations. J. Exp. Med. 180:1251.
66. Chen, D., and E. V. Rothenberg. 1994. Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles. J. Exp. Med. 179:931.
67. Tsuruta, L., H. J. Lee, E. S. Masuda, N. Koyano-Nakagawa, N. Arai, K. Arai, and T. Yokota. 1995. Cyclic AMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP. J. Immunol. 154: 5255.
68. Bartik, M. M., W. H. Brooks, and T. L. Roszman. 1995. Modulation of T cell proliferation by stimulation of the beta-adrenergic receptor: lack of correlation between inhibition of T cell proliferation and cAMP accumulation. Cell. Immunol. 148:408.
69. Carlson, S. L., W. H. Brooks, and T. L. Roszman. 1989. Neurotransmitter-lymphocyte interactions: dual receptor modulation of lymphocyte proliferation and cAMP production. J. Neuroimmunol. 24:155.
70. 2 acts at two distinct pathways of T lymphocyte activation: inhibition of interleukin 2 production and down-regulation of transferrin receptor expression. J. Immunol. 135:1172.
71. Wacholtz, M. C., R. Minakuchi, and P. E. Lipsky. 1991. Characterization of the 3′,5′-cyclic adenosine monophosphate-mediated regulation of IL2 production by T cells and Jurkat cells. Cell. Immunol. 135:285.
72. Bossie, A., and E. S. Vitetta. 1991. IFN-gamma enhances secretion of IgG2a from IgG2a-committed LPS-stimulated murine B cells: implications for the role of IFN-gamma in class switching. Cell. Immunol. 135:95.
73. 2 or the beta-adrenergic receptors: relationship between PKA activity and inhibition of anti-CD3 monoclonal antibody-induced T cell proliferation. Cell. Immunol. 158:182.
74. 2+ for production of IFN-γ by a cytolytic T cell clone is post-transcriptional. J. Immunol. 146:2382.
75. 2+-induced transcription followed by mRNA stabilization through activation of protein kinase C or increase in cAMP. Eur. J. Immunol. 25:889.
76. Aune, T. M., L. A. Penix, M. R. Rincon, and R. A. Flavell. 1997. Differential transcription directed by discrete gamma interferon promoter elements in naive and memory (effector) CD4 T cells and CDS T cells. Mol. Cell. Biol. 17:199.