Role of Bim in apoptosis induced in H460 lung tumor cells by the spindle poison Combretastatin-A4

Apoptosis

Volumn 16, Issue 9, 2011, Pages 940-949

  Mendez, G ^a   Policarpi, C ^a   Cenciarelli, C ^a,b   Tanzarella, C ^a   Antoccia, A ^a  

^a ROMA TRE UNIVERSITY   (Italy)

^b Innovus   (Italy)

Author keywords

Apoptosis; Bim; CA 4; H460; Lung tumor; Mitotic catastrophe

Indexed keywords

BIM PROTEIN; CASPASE 3; COMBRETASTATIN A4; DYNEIN ADENOSINE TRIPHOSPHATASE; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL DEATH; DEPOLYMERIZATION; DRUG MECHANISM; GENE SILENCING; HUMAN; HUMAN CELL; LIGHT CHAIN; LUNG NON SMALL CELL CANCER; MICROTUBULE; MITOSIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SYNTHESIS; SURVIVAL; TREATMENT RESPONSE; TUMOR CELL; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 3; CELL LINE, TUMOR; CYTOSOL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOPRECIPITATION; M PHASE CELL CYCLE CHECKPOINTS; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MICROTUBULES; MITOCHONDRIA; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STILBENES; TRANSFECTION;

EID: 80052508953     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-011-0619-8     Document Type: Article

References (36)

1. DC Huang A Strasser 2000 BH3-only proteins-essential initiators of apoptotic cell death Cell 103 839 842 11136969 10.1016/S0092-8674(00)00187-2 1:CAS:528:DC%2BD3cXovFCjt7o%3D
2. EH Cheng MC Wei S Weiler RA Flavell TW Mak T Lindsten SJ Korsmeyer 2001 BCL-2, BCL-X-L sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis Mol Cell 8 705 711 11583631 10.1016/S1097-2765(01)00320-3 1:CAS:528:DC%2BD3MXnslGmt7s%3D (Pubitemid 32946946)
3. S Lucken-Ardjomande JC Martinou 2005 Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane C R Biol 328 616 631 15992745 10.1016/j.crvi.2005.05.002 1:CAS:528:DC%2BD2MXlvVWkur8%3D (Pubitemid 40903696)
4. L Chen SN Willis A Wei BJ Smith JI Fletcher MG Hinds PM Colman CL Day JM Adams DC Huang 2005 Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function Mol Cell 17 393 403 15694340 10.1016/j.molcel.2004.12.030 1:CAS:528:DC%2BD2MXhs1Oit78%3D (Pubitemid 40193310)
5. L O'Connor A Strasser LA O'Reilly G Hausmann JM Adams S Cory DC Huang 1998 Bim: a novel member of the Bcl-2 family that promotes apoptosis EMBO J 17 384 395 9430630 10.1093/emboj/17.2.384 (Pubitemid 28045479)
6. LA O'Reilly L Cullen J Visvader GJ Lindeman C Print ML Bath DC Huang A Strasser 2000 The proapoptotic BH3-only protein Bim is expressed in hematopoietic, epithelial, neuronal, and germ cells Am J Pathol 157 449 461 10934149 10.1016/S0002-9440(10)64557-9 (Pubitemid 30626908)
7. H Puthalakath DC Huang LA O'Reilly SM King A Strasser 1999 The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex Mol Cell 3 287 296 10198631 10.1016/S1097- 2765(00)80456-6 1:CAS:528:DyaK1MXit1Oms7k%3D (Pubitemid 29290669)
8. T Tong J Ji S Jin X Li W Fan Y Song M Wang Z Liu M Wu Q Zhan 2005 Gadd45a expression induces Bim dissociation from the cytoskeleton and translocation to mitochondria Mol Cell Biol 25 4488 4500 15899854 10.1128/MCB.25.11.4488-4500. 2005 1:CAS:528:DC%2BD2MXkslemt78%3D (Pubitemid 40705755)
9. A Strasser H Puthalakath P Bouillet DC Huang L O'Connor LA O'Reilly L Cullen S Cory JM Adams 2000 The role of Bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control Ann N Y Acad Sci 917 541 548 11268382 10.1111/j.1749-6632.2000.tb05419.x 1:CAS:528:DC%2BD3cXovFymtr8%3D
10. K Lei RJ Davis 2003 JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis Proc Natl Acad Sci USA 100 2432 2437 12591950 10.1073/pnas.0438011100 1:CAS:528:DC%2BD3sXitVaisr8%3D (Pubitemid 36297516)
11. RJ Davis 2000 Signal transduction by the JNK group of MAP kinases Cell 103 239 252 11057897 10.1016/S0092-8674(00)00116-1 1:CAS:528: DC%2BD3cXns1Cltrk%3D
12. H Puthalakath A Strasser 2002 Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins Cell Death Differ 9 505 512 11973609 10.1038/sj.cdd.4400998 1:CAS:528:DC%2BD38XktF2qs7c%3D (Pubitemid 34521178)
13. PF Dijkers RH Medema JW Lammers L Koenderman PJ Coffer 2000 Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1 Curr Biol 10 1201 1204 11050388 10.1016/S0960-9822(00)00728-4 1:CAS:528:DC%2BD3cXotVSrtLs%3D
14. A Sunters S Fernandez de Mattos M Stahl J Brosens G Zoumpoulidou CA Saunders PJ Coffer RH Medema RC Coombes EW Lam 2003 FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines J Biol Chem 278 49795 49805 14527951 10.1074/jbc.M309523200 1:CAS:528:DC%2BD3sXpslSrurs%3D (Pubitemid 37548813)
15. J Gilley PJ Coffer J Ham 2003 FOXO transcription factors directly activate Bim gene expression and promote apoptosis in sympathetic neurons J Cell Biol 162 613 622 12913110 10.1083/jcb.200303026 1:CAS:528:DC%2BD3sXms1SqtrY%3D (Pubitemid 37022939)
16. MA Estève M Carré D Braguer 2007 Microtubules in apoptosis induction: are they necessary? Curr Cancer Drug Targets 7 713 729 18220532 10.2174/156800907783220480
17. MA Jordan L Wilson 2004 Microtubules as a target for anticancer drugs Nat Rev Cancer 4 253 265 15057285 10.1038/nrc1317 1:CAS:528:DC%2BD2cXis1Gmt74%3D (Pubitemid 38525281)
18. F Mollinedo C Gajate 2003 Microtubules, microtubule-interfering agents and apoptosis Apoptosis 8 413 450 12975575 10.1023/A:1025513106330 1:CAS:528:DC%2BD3sXmvVOmur4%3D (Pubitemid 37247987)
19. A Jordan JA Hadfield NJ Lawrence AT McGown 1998 Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle Med Res Rev 8 259 296 10.1002/(SICI)1098-1128(199807)18:4<259::AID-MED3>3.0.CO;2-U (Pubitemid 28346389)
20. GR Pettit GM Cragg SB Singh 1987 Antineoplastic agents, 122. Constituents of Combretum caffrum J Nat Prod 50 386 391 3668557 10.1021/np50051a008 1:CAS:528:DyaL1cXnt1SgtQ%3D%3D (Pubitemid 17134088)
21. GR Pettit SB Singh MR Boyd E Hamel RK Pettit JM Schmidt F Hogan 1995 Isolation and synthesis of combretastatins A-4, A-5, and A-6 J Med Chem 38 1666 1672 7752190 10.1021/jm00010a011 1:CAS:528:DyaK2MXltlyru74%3D
22. MN Islam MN Iskander 2004 Microtubulin binding sites as target for developing anticancer agents Mini Rev Med Chem 4 1077 1104 15579115 1:CAS:528:DC%2BD2cXhtVWitbfN (Pubitemid 39545451)
23. H Wehbe CM Kearney KG Pinney 2005 Combretastatin A-4 resistance in H460 human lung carcinoma demonstrates distinctive alterations in beta-tubulin isotype expression Anticancer Res 25 3865 3870 16309172 1:CAS:528: DC%2BD2MXht12itrbI (Pubitemid 41665156)
24. SM Nabha RM Mohammad MH Dandashi B Coupaye-Gerard A Aboukameel GR Pettit AM Al-Katib 2002 Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukaemia cell line independent of caspase activation and poly (ADP-ribose) polymerase cleavage Clin Cancer Res 8 2735 2741 12171907 1:CAS:528:DC%2BD38XmvVahtL4%3D (Pubitemid 34856363)
25. I Vitale A Antoccia C Cenciarelli P Crateri S Meschini G Arancia C Pisano C Tanzarella 2007 Combretastatin CA-4 and combretastatin derivative induce mitotic catastrophe dependent on spindle checkpoint and caspase-3 activation in non-small cell lung Apoptosis 12 155 166 17143747 10.1007/s10495-006-0491-0 1:CAS:528:DC%2BD28XhtlalurrL (Pubitemid 46009511)
26. R Li T Moudgil HJ Ross HM Hu 2005 Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim Cell Death Differ 12 292 303 15711598 10.1038/sj.cdd.4401554 1:CAS:528:DC%2BD2MXhtlSrtrY%3D (Pubitemid 40360952)
27. M Czernick A Rieger IS Goping 2009 Bim is reversibly phosphorylated but plays a limited role in paclitaxel cytotoxicity of breast cancer cell lines Biochem Biophys Res Commun 379 145 150 19101511 10.1016/j.bbrc.2008.12.025 1:CAS:528:DC%2BD1MXosVSitA%3D%3D
28. C Cenciarelli C Tanzarella I Vitale C Pisano P Crateri S Meschini G Arancia A Antoccia 2008 The tubulin-depolymerising agent combretastatin-4 induces ectopic aster assembly and mitotic catastrophe in lung cancer cells H460 Apoptosis 13 659 669 18386182 10.1007/s10495-008-0200-2 1:CAS:528: DC%2BD1cXkslGqt7w%3D
29. YN Zhu BJ Swanson M Wang DA Hildeman BC Schaefer XQ Liu H Suzuki K Mihara J Kappler P Marrack 2004 Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells Proc Natl Acad Sci USA 101 7681 7686 15136728 10.1073/pnas.0402293101 1:CAS:528: DC%2BD2cXktlOlur8%3D (Pubitemid 38658089)
30. AJ Butt CG Roberts AA Seawright PB Oelrichs JK Macleod TY Liaw M Kavallaris TJ Somers-Edgar GM Lehrbach CK Watts RL Sutherland 2006 A novel plant toxin, persin, with in vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells Mol Cancer Ther 5 2300 2309 16985064 10.1158/1535-7163.MCT-06-0170 1:CAS:528:DC%2BD28Xps1ynsLg%3D (Pubitemid 44530467)
31. EN Maginn PV Browne P Hayden E Vandenberghe B MacDonagh P Evans M Goodyer P Tewari G Campiani S Butini DC Williams DM Zisterer MP Lawler AM McElligott 2011 PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells Br J Cancer 104 281 289 21179037 10.1038/sj.bjc.6606035 1:CAS:528:DC%2BC3MXnsFalug%3D%3D
32. M Erlacher EM Michalak PN Kelly V Labi H Niederegger L Coultas JM Adams A Strasser A Villunger 2005 BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo Blood 106 4131 4138 16118324 10.1182/blood-2005-04-1595 1:CAS:528: DC%2BD2MXhtlaltr3O (Pubitemid 41775918)
33. TT Tan K Degenhardt DA Nelson B Beaudoin W Nieves-Neira P Bouillet A Villunger JM Adams E White 2005 Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy Cancer Cell 7 227 238 15766661 10.1016/j.ccr.2005.02.008 1:CAS:528:DC%2BD2MXivFCqurc%3D (Pubitemid 40568682)
34. GM Tozer C Kanthou CS Parkins SA Hill 2002 The biology of the combretastatins as tumour vascular targeting agents Int J Exp Pathol 83 21 38 12059907 10.1046/j.1365-2613.2002.00211.x 1:CAS:528:DC%2BD38Xmt1WksLc%3D (Pubitemid 34638944)
35. 2-Terminal kinase and Akt Cancer Res 66 212 220 16397234 10.1158/0008-5472.CAN-05-1997 1:CAS:528:DC%2BD28XhsFWhuw%3D%3D (Pubitemid 43166027)
36. T Kuwana MR Mackey G Perkins MH Ellisman M Latterich R Schneiter DR Green DD Newmeyer 2002 Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane Cell 111 331 342 12419244 10.1016/S0092-8674(02)01036-X 1:CAS:528:DC%2BD38XovVakurc%3D (Pubitemid 35341388)