In silico improvement of heterologous biosynthesis of erythromycin precursor 6-deoxyerythronolide b in escherichia coli

Biotechnology and Bioprocess Engineering

Volumn 16, Issue 3, 2011, Pages 445-456

  Meng, Hailin ^a,b,c   Lu, Zhiguo ^b   Wang, Yong ^c   Wang, Xiaoning ^a   Zhang, Siliang ^b  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

6 deoxyerythronolide B (6dEB); Gene targets; Heterologous biosynthesis; In silico strain improvement

Indexed keywords

6-DEOXYERYTHRONOLIDE B (6DEB); BACILLUS SUBTILIS; CARBON SOURCE; E. COLI; EXPERIMENTAL RESEARCH; EXPERIMENTAL VALIDATIONS; FLUX DISTRIBUTIONS; HETEROLOGOUS BIOSYNTHESIS; IN SILICO STRAIN IMPROVEMENT; IN-SILICO; INDUSTRIAL PRODUCTION; KEY FACTORS; PRODUCT YIELDS; SPECIFIC GROWTH RATE; SPECIFIC OXYGEN UPTAKE RATE; STRAIN IMPROVEMENT; UPTAKE RATE;

BACTERIOLOGY; BIOCHEMISTRY; ESCHERICHIA COLI; GENES; GENETIC ENGINEERING; GLUCOSE; GLYCEROL; INDUSTRIAL RESEARCH; VOLATILE FATTY ACIDS; YEAST;

BIOSYNTHESIS;

DEOXYERYTHRONOLIDE B; ERYTHRONOLIDE B; GLUCOSE; GLYCEROL; PROPIONIC ACID; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; BACILLUS SUBTILIS; CARBON SOURCE; COMPUTER MODEL; CONTROLLED STUDY; DRUG SYNTHESIS; ESCHERICHIA COLI; FLUX DISTRIBUTION COMPARISON ANALYIS; INFORMATION PROCESSING; LINEAR MINIMIZATION OF METABOLIC ADJUSTMENT METHOD; NONHUMAN; OXYGEN CONSUMPTION; SACCHAROMYCES CEREVISIAE;

BACILLUS SUBTILIS; ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

EID: 80052463176     PISSN: 12268372     EISSN: 19763816     Source Type: Journal    
DOI: 10.1007/s12257-010-0321-7     Document Type: Article

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