Development of a source-to-outcome model for dietary exposures to insecticide residues: An example using chlorpyrifos

Regulatory Toxicology and Pharmacology

Volumn 61, Issue 1, 2011, Pages 82-92

  Hinderliter, Paul M ^a   Price, Paul S ^b   Bartels, Michael J ^b   Timchalk, Charles ^a   Poet, Torka S ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b DOW CHEMICAL COMPANY   (United States)

Author keywords

Anthropometry; Chlorpyrifos; Diet; Longitudinal exposure; PBPD; PBPK; Source to outcome; Variation

Indexed keywords

ACETYLCHOLINESTERASE; CHLORPYRIFOS; INSECTICIDE;

ADULT; ARTICLE; BIOLOGICAL MONITORING; BODY HEIGHT; BODY MASS; BODY WEIGHT; BRAIN CELL; CHILD; CONTROLLED STUDY; DETOXIFICATION; DIETARY INTAKE; ENVIRONMENTAL EXPOSURE; ENZYME INHIBITION; ERYTHROCYTE; FEMALE; FOOD POISONING; HEART OUTPUT; HUMAN; HUMAN CELL; MALE; MATHEMATICAL MODEL; METABOLIC CLEARANCE RATE; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK ASSESSMENT; SENSITIVITY ANALYSIS;

ACETYLCHOLINESTERASE; ADIPOSE TISSUE; ADULT; BRAIN; CHILD, PRESCHOOL; CHLORPYRIFOS; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FOOD CONTAMINATION; FORECASTING; HUMANS; INSECTICIDES; LIVER; MALE; MODELS, BIOLOGICAL; MODELS, STATISTICAL; PESTICIDE RESIDUES; SOFTWARE;

EID: 80052407078     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.06.004     Document Type: Article

References (52)

1. Brown R.P., Delp M.D., Lindstedt S.L., Rhomberg L.R., Beliles R.P. Physiologicaly Parameter Values for Physiologically Based Pharmacokinetic Models. Toxicol. Ind. Health 1997, 13:407-484.
2. Busby-Hjerpe A.L., Campbell J.A., Smith J.N., Lee S., Poet T.S., Barr D.B., et al. Comparative pharmacokinetics of chlorpyrifos versus its major metabolites following oral administration in the rat. Toxicology 2010, 268(1-2):55-63.
3. Butler A.M., Murray M. Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation. J. Pharmacol. Exp. Ther. 1997, 280(2):966-973.
4. Clarys J.P., Martin A.D., Drinkwater D.T. Gross tissue weights in the human body by cadaver dissection. Human Biol. 1984, 56(3):459-473.
5. Cole T.B., Jampsa R.L., Walter B.J., Arndt T.L., Richter R.J., Shih D.M., et al. Expression of human paraoxonase (PON1) during development. Pharmacogenetics 2003, 13(6):357-364.
6. Cole T.B., Walter B.J., Shih D.M., Tward A.D., Lusis A.J., Timchalk C., et al. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenet. Genomics 2005, 15(8):589-598.
7. Costa L.G., Cole T.B., Vitalone A., Furlong C.E. Measurement of paraoxonase (PON1) status as a potential biomarker of susceptibility to organophosphate toxicity. Clin. Chim. Acta 2005, 352(1-2):37-47.
8. Davies H.G., Richter R.J., Keifer M., Broomfield C.A., Sowalla J., Furlong C.E. The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin. Nat. Genet. 1996, 14(3):334-336.
9. Deurenberg P., Weststrate J.A., Seidell J.C. Body mass index as a measure of body fatness: age- and sex-specific prediction formulas. Br. J. Nutr. 1991, 65(2):105-114.
10. Dinkel E., Ertel M., Dittrich M., Peters H., Berres M., Schulte-Wissermann H. Kidney size in childhood. Sonographical growth charts for kidney length and volume. Pediatr. Radiol. 1985, 15(1):38-43.
11. Ellis K.J. Body composition of a young multiethnic male population. Am. J. Clin. Nutr. 1997, 66:1323-1331.
12. Ellis K.J., Abrams S.J., Wong W.W. Body composition of a young multiethnic female population. Am. J. Clin. Nutr. 1997, 65:724-731.
13. Furlong C.E., Cole T.B., Jarvik G.P., Pettan-Brewer C., Geiss G.K., Richter R.J., et al. Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. Neurotoxicology 2005, 26(4):651-659.
14. Furlong C.E., Cole T.B., Walter B.J., Shih D.M., Tward A., Lusis A.J., et al. Paraoxonase 1 (PON1) status and risk of insecticide exposure. J. Biochem. Mol. Toxicol. 2005, 19(3):182-183.
15. Garabrant D.H., Aylward L.L., Berent S., Chen Q.X., Timchalk C., Burns C.J., et al. Cholinesterase inhibition in chlorpyrifos workers: Characterization of biomarkers of exposure and response in relation to urinary TCPy. J. Exposure Sci. Environ. Epidemiol. 2009, 19(7):634-642.
16. Ginsberg G., Hattis D., Sonawane B. Incorporating pharmacokinetic differences between children and adults in assessing children's risks to environmental toxicants. Toxicol. Appl. Pharmacol. 2004, 198(2):164-183.
17. Griffin P., Mason H., Heywood K., Cocker J. Oral and dermal absorption of chlorpyrifos: a human volunteer study. Occup. Environ. Med. 1999, 56(1):10-13.
18. Haycock G.B., Schwartz G.J., Wisotsky D.H. Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. J. Pediatr. 1978, 93(1):62-66.
19. Ho K.C., Roessmann U., Straumfjord J.V., Monroe G. Analysis of brain weight. I. Adult brain weight in relation to sex, race, and age. Arch. Pathol. Lab. Med. 1980, 104(12):635-639.
20. Jonsson F., Bois F., Johanson G. Physiologically based pharmacokinetic modeling of inhalation exposure of humans to dichloromethane during moderate to heavy exercise. Toxicol Sci. 2001, 59(2):209-218.
21. Kasiske B.L., Umen A.J. The influence of age, sex, race, and body habitus on kidney weight in humans. Arch. Pathol. Lab. Med. 1986, 110(1):55-60.
22. Kisicki, J. C., Seip, C. W., Combs, M. L., 1999. A Rising Dose Toxicology Study to Determine the No-Observable-Effect-Levels (NOEL) for Erythrocyte Acetylcholinesterase (AChE) Inhibition and Cholinergic Signs and Symptoms of Chlorpyrifos at Three Dose Levels. The Toxicology Research Laboratory: Health and Environmental Research Laboratories, The Dow Chemical Company, Midland, MI, USA.
23. ILSI, Cumulative and Aggregate Risk Evaluation System (CARES)™. Available: [accessed December 12 2009]. http://www.ilsi.org.
24. Lee S., Busby A.L., Timchalk C., Poet T.S. Effects of Nicotine Exposure on In Vitro Metabolism of Chlorpyrifos in Male Sprague-Dawley Rats. J. Toxicol. Environ. Health Part A 2009, 72(2):74-82.
25. LifeLine, 2006. Technical Manual LifeLine™ Version 4.3 Software The LifeLine Group Inc.
26. Lowe E.R., Poet T.S., Rick D.L., Marty M.S., Mattsson J.L., Timchalk C., et al. The effect of plasma lipids on the pharmacokinetics of chlorpyrifos and the impact on interpretation of blood biomonitoring data. Toxicol. Sci. 2009, 108(2):258-272.
27. Marty M.S., Domoradzki J.Y., Hansen S.C., Timchalk C., Bartels M.J., Mattsson J.L. The effect of route, vehicle, and divided doses on the pharmacokinetics of chlorpyrifos and its metabolite trichloropyridinol in neonatal Sprague-Dawley rats. Toxicol. Sci. 2007, 100(2):360-373.
28. McDowell, M., Fryar, C.D., Hirsch, R., Ogden, C.L. 2005. Anthropometric Reference Data for Children and Adults: US Population, 1999-2002, 361.Centers of Disease Control.
29. Morgan M.K., Sheldon L.S., Croghan C.W., Jones P.A., Robertson G.L., Chuang J.C., Wilson N.K., Lyu C.W. Exposures of preschool children to chlorpyrifos and its degradation product 3,5,6-trichloro-2-pyridinol in their everyday environments. J. Exposure Anal. Environ. Epidemiol. 2005, 15:297-309.
30. Morgan M.K., Sheldon L.S., Jones P.A., Croghan C.W., Chuang J.C., Wilson N.K. The reliability of using urinary biomarkers to estimate children's exposures to chlorpyrifos and diazinon. J. Exposure Sci. Environ. Epidemiol. 2011, 21(3):280-290.
31. Morgenstern B.Z., Mahoney D.W., Warady B.A. Estimating total body water in children on the basis of height and weight: a reevaluation of the formulas of Mellits and Cheek. J. Am. Soc. Nephrol. 2002, 13(7):1884-1888.
32. Nigg H.N., Knaak J.B. Blood cholinesterases as human biomarkers of organophosphorus pesticide exposure. Rev. Environ. Contam. T 2000, 163:29-111.
33. Noda T., Todani T., Watanabe Y., Yamamoto S. Liver volume in children measured by computed tomography. Pediatr. Radiol. 1997, 27(3):250-252.
34. Nolan R.J., Rick D.L., Freshour N.L., Saunders J.H. Chlorpyrifos: pharmacokinetics in human volunteers. Toxicol. Appl. Pharmacol. 1984, 73(1):8-15.
35. Ogiu N., Nakamura Y., Ijiri I., Hiraiwa K., Ogiu T. A statistical analysis of the internal organ weights of normal Japanese people. Health Phys. 1997, 72(3):368-383.
36. Poet, T., Hinderliter, P., Lee, S., Smith, J.N., Timchalk, C. 2011. Evolution of a PBPK model for the pesticide chlorpyrifos.
37. Pond A.L., Chambers H.W., Chambers J.E. Organophosphate detoxication potential of various rat tissues via A- esterase and aliesterase activities. Toxicol. Lett. 1995, 78(3):245-252.
38. Preston R.J. Children as a sensitive subpopulation for the risk assessment process. Toxicol. Appl. Pharmacol. 2004, 199(2):132-141.
39. Price, P., Schnelle, K., Cleveland, C., Bartels, M., Hinderliter, P., Timchalk, C., et al. 2011. Application of a Source-to-Outcome Model for the Assessment of Dietary Exposures to Insecticide Residues. Environ. Regul. Toxicol. Pharmacol.
40. Price P.S., Conolly R.B., Chaisson C.F., Gross E.A., Young J.S., Mathis E.T., et al. Modeling interindividual variation in physiological factors used in PBPK models of humans. Crit. Rev. Toxicol. 2003, 33(5):469-503.
41. Savolainen K. Understanding the toxic actions of organophosphates. Handbook of Pesticide Toxiology, (2nd Ed.) 2001, 1013-1041. Academic Press, San Diego, CA. R. Krieger (Ed.).
42. Siegel J.A., Urbain J.L., Adler L.P., Charkes N.D., Maurer A.H., Krevsky B., et al. Biphasic nature of gastric emptying. Gut 1988, 29(1):85-89.
43. Smith J.N., Campbell J.A., Busby-Hjerpe A.L., Lee S., Poet T.S., Barr D.B., et al. Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat. Toxicology 2009, 261(1-2):47-58.
44. Timchalk C., Busby A., Campbell J.A., Needham L.L., Barr D.B. Comparative pharmacokinetics of the organophosphorus insecticide chlorpyrifos and its major metabolites diethylphosphate, diethylthiophosphate and 3,5,6-trichloro-2-pyridinol in the rat. Toxicology 2007, 237(1-3):145-157.
45. Timchalk C., Kousba A., Poet T. Monte Carlo analysis of the human chlorpyrifos-oxonase (PON1) polymorphism using a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model. Toxicol. Lett. 2002, 135(1-2):51.
46. Timchalk C., Kousba A., Poet T.S. Development of a neonatal rat physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model for chlorpyrifos. Toxicol. Sci. 2003, 72(1):305.
47. Timchalk C., Kousba A.A., Poet T.S. An age-dependent physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus insecticide chlorpyrifos in the preweanling rat. Toxicol. Sci. 2007, 98(2):348-365.
48. Timchalk C., Nolan R.J., Mendrala A.L., Dittenber D.A., Brzak K.A., Mattsson J.L. A Physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model for the organophosphate insecticide chlorpyrifos in rats and humans. Toxicol. Sci. 2002, 66(1):34-53.
49. Timchalk C., Poet T.S. Development of a physiologically based pharmacokinetic and pharmacodynamic model to determine dosimetry and cholinesterase inhibition for a binary mixture of chlorpyrifos and diazinon in the rat. Neurotoxicology 2008, 29(3):428-443.
50. US EPA, 2007. Analysis of Total Food Intake and Composition of Individual's Diet Based on USDA's 1994-1996, 1998 Continuing Survey of Food Intakes by Individuals (CSFII). Washington, DC, United States Environmental Protection Agency, Office of Prevention, Pesticides and Toxic Substances.
51. Washington State Department of Labor and Industries. 2005. Final Report Cholinesterase Monitoring of Pesticide Handlers in Agriculture: 2004 Report to the Washington Department of Labor and Industries The Scientific Advisory Committee for Cholinesterase Monitoring formed under RCW 49.17.288 MARCH 30, 2005.Washington State Department of Labor and Industries.
52. Watanabe Y., Todani T., Noda T., Yamamoto S. Standard splenic volume in children and young adults measured from CT images. Surg. Today 1997, 27(8):726-728.