Physiologically based pharmacokinetic modeling of inhalation exposure of humans to dichloromethane during moderate to heavy exercise

Toxicological Sciences

Volumn 59, Issue 2, 2001, Pages 209-218

  Jonsson, Fredrik ^a   Bois, Frédéric ^b   Johanson, Gunnar ^a,c  

^a NATIONAL INSTITUTE FOR WORKING LIFE   (Sweden)

^b INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES INERIS   (France)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Dichloromethane; Inhalation; Markov chain Monte Carlo simulations; Pharmacokinetics; Physiologically based modelling; Population kinetics

Indexed keywords

DICHLOROMETHANE; MIXED FUNCTION OXIDASE;

ADIPOSE TISSUE; ADULT; ANALYTIC METHOD; ARTICLE; BAYES THEOREM; CALCULATION; CONJUGATION; CONTROLLED STUDY; ENZYME MECHANISM; EXERCISE; EXPOSURE; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; INHALATION; LIVER METABOLISM; MALE; METABOLIC CAPACITY; MODEL; MUSCLE CONTRACTION; OXIDATION; PARTITION COEFFICIENT; PHYSIOLOGY; PROBABILITY; REST; TISSUE PERFUSION; TOXICOKINETICS;

CARCINOGENS; EXERCISE; HUMANS; INHALATION EXPOSURE; MALE; METHYLENE CHLORIDE; MIXED FUNCTION OXYGENASES; MODELS, BIOLOGICAL;

EID: 0035121426     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/59.2.209     Document Type: Article

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