Molecular insights into DNA polymerase deterrents for ribonucleotide insertion

Journal of Biological Chemistry

Volumn 286, Issue 36, 2011, Pages 31650-31660

  Cavanaugh, Nisha A ^a   Beard, William A ^a   Batra, Vinod K ^a   Perera, Lalith ^a   Pedersen, Lee G ^a,b   Wilson, Samuel H ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b The University of North Carolina at Chapel Hill   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALANINE SUBSTITUTION; BACKBONE CARBONYL; CARBONYL OXYGEN; CRYSTALLOGRAPHIC STRUCTURE; DNA POLYMERASE; DNA SUBSTRATES; ENERGETIC COSTS; GENOMIC INSTABILITY; MOLECULAR INSIGHTS; MUTANT ENZYMES; PRIMER TERMINUS; PROTEIN RESIDUES; RIBONUCLEOSIDES; RIBONUCLEOTIDES; SIDE-CHAINS; STRUCTURE-BASED; TERNARY SUBSTRATES; WILD TYPES; WILD-TYPE ENZYMES;

AMINO ACIDS; CARBONYLATION; CATALYSTS; COMPLEXATION; ENZYMES; HYDROGEN BONDS; MANGANESE; MANGANESE COMPOUNDS; OXYGEN; POLYMERS; SUBSTRATES; SUGARS;

DNA;

ALANINE; AMINO ACID; CARBONYL DERIVATIVE; DNA DIRECTED DNA POLYMERASE BETA; HYDROGEN; MAGNESIUM ION; MANGANESE; MUTANT PROTEIN; OXYGEN; PHENYLALANINE; RIBONUCLEOTIDE; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTALLOGRAPHY; GENOMIC INSTABILITY; GEOMETRY; HUMAN; HYDROGEN BOND; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN STRUCTURE; WILD TYPE;

AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DNA POLYMERASE BETA; HUMANS; HYDROGEN BONDING; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEOTIDES; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 80052401675     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.253401     Document Type: Article

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