Structural basis of binding by cyclic nonphosphorylated peptide antagonists of Grb7 implicated in breast cancer progression

Journal of Molecular Biology

Volumn 412, Issue 3, 2011, Pages 397-411

  Ambaye, Nigus D ^a   Pero, Stephanie C ^b   Gunzburg, Menachem J ^a   Yap, Minyin ^a   Clayton, Daniel J ^a   Del Borgo, Mark P ^a   Perlmutter, Patrick ^a   Aguilar, Marie Isabel ^a   Shukla, Girja S ^b   Peletskaya, Elena ^b   Cookson, Michelle M ^b   Krag, David N ^b   Wilce, Matthew C J ^a   Wilce, Jacqueline A ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

cyclic peptide; Grb7 inhibitor; ITC; phage display; SH2 domain

Indexed keywords

CYCLIC NONPHOSPHORYLATED PEPTIDE ANTAGONIST; G7 18NATE PEPTIDE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7 SH2 G7 18NATE COMPLEX; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7 SH2 PROTEIN; HYBRID PROTEIN; MULTIPROTEIN COMPLEX; PROTEIN INHIBITOR; PROTEIN SH2; SULFIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER GROWTH; CELL MEMBRANE PERMEABILITY; CELL MIGRATION; CELL PROLIFERATION; CELL STIMULATION; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; ISOTHERMAL TITRATION CALORIMETRY; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

EID: 80052353024     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.07.030     Document Type: Article

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