Genetic polymorphism of CYP4A11 and CYP4A22 genes and in silico insights from comparative 3D modelling in a French population

Gene

Volumn 487, Issue 1, 2011, Pages 10-20

  Lino Cardenas, Christian L ^a   Renault, Nicolas ^b   Farce, Amaury ^b   Cauffiez, Christelle ^a   Allorge, Delphine ^a   Lo Guidice, Jean Marc ^a   Lhermitte, Michel ^a   Chavatte, Philippe ^b   Broly, Franck ^a   Chevalier, Dany ^a  

^a France Institut Pasteur de Lille   (France)

^b UNIV LILLE   (France)

Author keywords

Hydroxylation; Comparative 3D modelling; CYP4A genes; Fatty acids; Genetic polymorphism; PCR SSCP

Indexed keywords

ARGININE; ASPARAGINE; CYSTEINE; CYTOCHROME P450; CYTOCHROME P450 4A11; CYTOCHROME P450 4A22; FATTY ACID; GLYCINE; LEUCINE; PHENYLALANINE; SERINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; BIOINFORMATICS; COMPARATIVE STUDY; COMPUTER MODEL; ENZYME ACTIVITY; ENZYME STRUCTURE; FRENCH GUIANA; GENE IDENTIFICATION; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MISSENSE MUTATION; MOLECULAR DOCKING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SINGLE STRAND CONFORMATION POLYMORPHISM;

AMINO ACID SEQUENCE; BINDING SITES; BIOCATALYSIS; COMPUTATIONAL BIOLOGY; CYTOCHROME P-450 ENZYME SYSTEM; DATABASES, GENETIC; FATTY ACIDS; FRANCE; GENE FREQUENCY; GENOTYPE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 80052341598     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2011.07.015     Document Type: Article

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