Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension

Circulation

Volumn 111, Issue 1, 2005, Pages 63-69

  Gainer, James V ^a   Bellamine, Aouatef ^a   Dawson, Elliott P ^b   Womble, Kristie E ^b   Grant, Sarah W ^b   Wang, Yarong ^a   Cupples, L Adrienne ^c   Guo, Chao Yu ^c   Demissie, Serkalem ^c   O'Donnell, Christopher J ^d   Brown, Nancy J ^a   Waterman, Michael R ^a,e   Capdevila, Jorge H ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BioVentures Inc   (United States)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^d NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^e VANDERBILT UNIVERSITY   (United States)

Author keywords

Genetics; Hypertension, renal; Lipids; Metabolism

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; 20 HYDROXYICOSATETRAENOIC ACID SYNTHASE; AMINO ACID; ARACHIDONATE LIPOXYGENASE; ARACHIDONIC ACID; COMPLEMENTARY DNA; CYTOCHROME P450 4A11; CYTOSINE; ENZYME VARIANT; LAURIC ACID; NUCLEOTIDE; PHENYLALANINE; SERINE; THYMIDINE; UNCLASSIFIED DRUG;

ADULT; AGE; AMINO ACID SUBSTITUTION; ARACHIDONIC ACID METABOLISM; ARTICLE; BLOOD PRESSURE REGULATION; BODY MASS; CAUCASIAN; COMORBIDITY; CONTROLLED STUDY; ENZYME ACTIVITY; ESSENTIAL HYPERTENSION; FATTY ACID METABOLISM; FEMALE; GENDER; GENE EXPRESSION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; MULTIFACTORIAL INHERITANCE; NEGRO; NUCLEOTIDE SEQUENCE; POPULATION RESEARCH; PRIORITY JOURNAL; RENOVASCULAR HYPERTENSION;

ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; ALLELES; AMINO ACID SUBSTITUTION; ARACHIDONIC ACID; BLOOD PRESSURE; CODON; COHORT STUDIES; COMORBIDITY; CYTOCHROME P-450 ENZYME SYSTEM; DNA MUTATIONAL ANALYSIS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; HYPERTENSION; INTRONS; KIDNEY; LAURIC ACIDS; MALE; MIDDLE AGED; MULTIFACTORIAL INHERITANCE; MUTAGENESIS, INSERTIONAL; MUTATION, MISSENSE; POINT MUTATION; SEQUENCE DELETION; TENNESSEE; UNITED STATES; VARIATION (GENETICS);

EID: 19944428214     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000151309.82473.59     Document Type: Article

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