Normal Heart Rhythm is Initiated and Regulated by an Intracellular Calcium Clock Within Pacemaker Cells

Heart Lung and Circulation

Volumn 16, Issue 5, 2007, Pages 335-348

  Maltsev, Victor A ^a   Lakatta, Edward G ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Calcium; Heart rate; Ion channels; Ryanodine receptor calcium release channel; Sarcoplasmic reticulum; Sinoatrial node

Indexed keywords

CALCIUM ION; ION CHANNEL; SODIUM CALCIUM EXCHANGE PROTEIN;

ACTION POTENTIAL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL SURFACE; DIASTOLE; HEART RATE; HEART RHYTHM; ION CURRENT; MEMBRANE CURRENT; MEMBRANE DEPOLARIZATION; NONHUMAN; OSCILLATION; PACEMAKER NERVE CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SARCOPLASMIC RETICULUM; SINUS NODE;

ANIMALS; BIOLOGICAL CLOCKS; CALCIUM; HUMANS; MYOCARDIAL CONTRACTION; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SINOATRIAL NODE;

EID: 34848845270     PISSN: 14439506     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hlc.2007.07.005     Document Type: Review

References (45)

1. Cranefield P.F. Action potentials, afterpotentials, and arrhythmias. Circ Res 41 (1977) 415-423
2. Maltsev V.A., Vinogradova T.M., and Lakatta E.G. The emergence of a general theory of the initiation and strength of the heartbeat. J Pharmacol Sci 100 (2006) 338-369
3. Hodgkin A.L., and Huxley A.F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117 (1952) 500-544
4. Noble D. Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations. Nature 188 (1960) 495-497
5. 2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res 98 (2006) 505-514
6. Lakatta E.G. Beyond Bowditch: the convergence of cardiac chronotropy and inotropy. Cell Calcium 35 (2004) 629-642
7. 2+ exchanger: molecular partners in pacemaker regulation. Circ Res 88 (2001) 1254-1258
8. 2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol 524 Pt 2 (2000) 415-422
9. 2+ release in the heart. Cardiovasc Res 26 (1992) 193-214
10. 2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization. Circ Res 94 (2004) 802-809
11. 2+ release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells. Circ Res 90 (2002) 73-79
12. Fabiato A. Time and calcium dependence of activation and inactivation of calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cell. J Gen Physiol 85 (1985) 247-289
13. 2+ spark frequency in ventricular myocytes. Am J Physiol 272 (1997) H657-H668
14. Maltsev V.A., Vinogradova T.M., Bogdanov K.Y., Lakatta E.G., and Stern M.D. Diastolic calcium release controls the beating rate of rabbit sinoatrial node cells: numerical modeling of the coupling process. Biophys J 86 (2004) 2596-2605
15. Capogrossi M.C., Suarez-Isla B.A., and Lakatta E.G. The interaction of electrically stimulated twitches and spontaneous contractile waves in single cardiac myocytes. J Gen Physiol 88 (1986) 615-633
16. Vinogradova T.M., Ruknudin A.M., Zhu W., Lyashkov A.E., Volkova M., Boheler K.R., Xiao R.P., Spurgeon H., and Lakatta E.G. High basal cAMP content markedly elevates PKA-dependent protein phosphorylation and sustains spontaneous beating in rabbit sinoatrial nodal pacemaker cells (SANC). Biophys J 90 (2006) 155a [Abstract]
17. Vinogradova T.M., Lyashkov A.E., Zhu W., Spurgeon H., Maltsev V.A., and Lakatta E.G. Constitutive phosphodiesterase activity confers negative feedback on intrinsic scAMP-PKA regulation of local rhythmic subsarcolemmal calcium releases and spontaneous beating in rabbit sinoatrial nodal. Biophys J 88 (2005) 303a [Abstract]
18. Petit-Jacques J., Bois P., Bescond J., and Lenfant J. Mechanism of muscarinic control of the high-threshold calcium current in rabbit sino-atrial node myocytes. Pflugers Arch 423 (1993) 21-27
19. Lakatta E.G., Maltsev V.A., Bogdanov K.Y., Stern M.D., and Vinogradova T.M. Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance. Circ Res 92 (2003) e45-e50
20. 2+ releases in rabbit sinoatrial nodal cells impart an exponential phase to the late diastolic depolarization that controls their chronotropic state. Circ Res 99 (2006) 979-987
21. Bers D.M. The beat goes on: diastolic noise that just won't quit. Circ Res 99 (2006) 921-923
22. 2+ cycling and surface membrane ion channel activation entrains normal automaticity in cells of the heart's pacemaker. Ann N Y Acad Sci 1080 (2006) 178-206
23. Anumonwo J.M., Delmar M., Vinet A., Michaels D.C., and Jalife J. Phase resetting and entrainment of pacemaker activity in single sinus nodal cells. Circ Res 68 (1991) 1138-1153
24. Abramovich-Sivan S., and Akselrod S. A single pacemaker cell model based on the phase response curve. Biol Cybern 79 (1998) 67-76
25. 2+/calmodulin-dependent protein kinase II activation. Circ Res 87 (2000) 760-767
26. 2+ releases within rabbit sinoatrial nodal cells not only regulate beating rate but also ensure normal rhythm during protein kinase A inhibition. Biophys J 88 (2005) 89a-90a [Abstract]
27. Du Y.M., and Nathan R.D. Ionic basis of ischemia-induced bradycardia in the rabbit sinoatrial node. J Mol Cell Cardiol 42 (2007) 315-325
28. Bleeker W.K., Mackaay A.J., Masson-Pevet M., Bouman L.N., and Becker A.E. Functional and morphological organization of the rabbit sinus node. Circ Res 46 (1980) 11-22
29. Vassalle M. The pacemaker current (I(f)) does not play an important role in regulating SA node pacemaker activity. Cardiovasc Res 30 (1995) 309-310
30. DiFrancesco D. The contribution of the 'pacemaker' current (if) to generation of spontaneous activity in rabbit sino-atrial node myocytes. J Physiol 434 (1991) 23-40
31. DiFrancesco D., Ferroni A., Mazzanti M., and Tromba C. Properties of the hyperpolarizing-activated current (if) in cells isolated from the rabbit sino-atrial node. J Physiol 377 (1986) 61-88
32. DiFrancesco D., and Mangoni M. Modulation of single hyperpolarization-activated channels (i(f)) by cAMP in the rabbit sino-atrial node. J Physiol 474 (1994) 473-482
33. Bucchi A., Baruscotti M., Robinson R.B., and DiFrancesco D. I(f)-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells. J Mol Cell Cardiol 35 (2003) 905-913
34. Stieber J., Herrmann S., Feil S., Loster J., Feil R., Biel M., Hofmann F., and Ludwig A. The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. Proc Natl Acad Sci USA 100 (2003) 15235-15240
35. 2+ exchange for the pacemaking mechanism in guinea-pig sino-atrial node. J Physiol 571 (2006) 639-649
36. 2+ releases (LCR) and the spontaneous beating rate of sinoatrial node cells (SANC). Biophys J (2007) 31a
37. Maltsev V.A., and Lakatta E.G. Cardiac pacemaker cell failure with preserved I(f), I(CaL), and I(Kr): A lesson about pacemaker function learned from ischemia-induced bradycardia. J Mol Cell Cardiol 42 (2007) 289-294
38. 2+ channels in the heart. Cell Calcium 40 (2006) 205-220
39. 2+ oscillations in isolated hearts. Am J Physiol 257 (1989) H665-H673
40. Weiss R.G., Gerstenblith G., and Lakatta E.G. Calcium oscillations index the extent of calcium loading and predict functional recovery during reperfusion in rat myocardium. J Clin Invest 85 (1990) 757-765
41. Zhang H., Holden A.V., Kodama I., Honjo H., Lei M., Varghese T., and Boyett M.R. Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node. Am J Physiol Heart Circ Physiol 279 (2000) H397-H421
42. Kurata Y., Hisatome I., Imanishi S., and Shibamoto T. Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell. Am J Physiol Heart Circ Physiol 283 (2002) H2074-H2101
43. 2+ cycling provides a novel mechanism of normal cardiac pacemaker function. Biophys J (2007) 77a
44. 2+ clock within cardiac cells. Biophys J (2007) 344a
45. Shannon T.R., Wang F., Puglisi J., Weber C., and Bers D.M. A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J 87 (2004) 3351-3371