-
1
-
-
0001450002
-
-
ed., 3rd ed. Lippincott-Raven, Philadelphia, PA
-
Britt, W. J., and C. A. Alford (ed.). 1996. Cytomegalovirus, 3rd ed. Lippincott-Raven, Philadelphia, PA.
-
(1996)
Cytomegalovirus
-
-
Britt, W.J.1
Alford, C.A.2
-
2
-
-
77953797194
-
Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection
-
Buchkovich, N. J., T. G. Maguire, and J. C. Alwine. 2010. Role of the endoplasmic reticulum chaperone BiP, SUN domain proteins, and dynein in altering nuclear morphology during human cytomegalovirus infection. J. Virol. 84:7005-7017.
-
(2010)
J. Virol.
, vol.84
, pp. 7005-7017
-
-
Buchkovich, N.J.1
Maguire, T.G.2
Alwine, J.C.3
-
3
-
-
70350647319
-
The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartment
-
Buchkovich, N. J., T. G. Maguire, A. W. Paton, J. C. Paton, and J. C. Alwine. 2009. The endoplasmic reticulum chaperone BiP/GRP78 is important in the structure and function of the human cytomegalovirus assembly compartment. J. Virol. 83:11421-11428.
-
(2009)
J. Virol.
, vol.83
, pp. 11421-11428
-
-
Buchkovich, N.J.1
Maguire, T.G.2
Paton, A.W.3
Paton, J.C.4
Alwine, J.C.5
-
4
-
-
37349040367
-
Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assembly
-
Buchkovich, N. J., et al. 2008. Human cytomegalovirus specifically controls the levels of the endoplasmic reticulum chaperone BiP/GRP78, which is required for virion assembly. J. Virol. 82:31-39.
-
(2008)
J. Virol.
, vol.82
, pp. 31-39
-
-
Buchkovich, N.J.1
-
5
-
-
77957944422
-
Human cytomegalovirus induces the endoplasmic reticulum chaperone BiP through increased transcription and activation of translation by using the BiP internal ribosome entry site
-
Buchkovich, N. J., Y. Yu, F. J. Pierciey, Jr., and J. C. Alwine. 2010. Human cytomegalovirus induces the endoplasmic reticulum chaperone BiP through increased transcription and activation of translation by using the BiP internal ribosome entry site. J. Virol. 84:11479-11486.
-
(2010)
J. Virol.
, vol.84
, pp. 11479-11486
-
-
Buchkovich, N.J.1
Yu, Y.2
Pierciey Jr., F.J.3
Alwine, J.C.4
-
6
-
-
40949116686
-
The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3KAkt-mTOR signalling pathway
-
Buchkovich, N. J., Y. Yu, C. A. Zampieri, and J. C. Alwine. 2008. The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3KAkt-mTOR signalling pathway. Nat. Rev. Microbiol. 6:266-275.
-
(2008)
Nat. Rev. Microbiol.
, vol.6
, pp. 266-275
-
-
Buchkovich, N.J.1
Yu, Y.2
Zampieri, C.A.3
Alwine, J.C.4
-
7
-
-
77951166692
-
Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage
-
Chakrabarti, P., T. English, J. Shi, C. M. Smas, and K. V. Kandror. 2010.Mammalian target of rapamycin complex 1 suppresses lipolysis, stimulates lipogenesis, and promotes fat storage. Diabetes 59:775-781.
-
(2010)
Diabetes
, vol.59
, pp. 775-781
-
-
Chakrabarti, P.1
English, T.2
Shi, J.3
Smas, C.M.4
Kandror, K.V.5
-
8
-
-
56249147509
-
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-typespecific repression of mRNA translation
-
Choo, A. Y., S. O. Yoon, S. G. Kim, P. P. Roux, and J. Blenis. 2008. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-typespecific repression of mRNA translation. Proc. Natl. Acad. Sci. U. S. A. 105:17414-17419.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 17414-17419
-
-
Choo, A.Y.1
Yoon, S.O.2
Kim, S.G.3
Roux, P.P.4
Blenis, J.5
-
9
-
-
75149112670
-
AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity
-
Chresta, C. M., et al. 2010. AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res. 70:288-298.
-
(2010)
Cancer Res.
, vol.70
, pp. 288-298
-
-
Chresta, C.M.1
-
10
-
-
79952844950
-
The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection
-
Clippinger, A. J., T. G. Maguire, and J. C. Alwine. 2011. The changing role of mTOR kinase in the maintenance of protein synthesis during human cytomegalovirus infection. J. Virol. 85:3930-3939.
-
(2011)
J. Virol.
, vol.85
, pp. 3930-3939
-
-
Clippinger, A.J.1
Maguire, T.G.2
Alwine, J.C.3
-
11
-
-
18544375193
-
Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
-
Dan, H. C., et al. 2002. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J. Biol. Chem. 277:35364-35370.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35364-35370
-
-
Dan, H.C.1
-
12
-
-
61349141302
-
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
-
Feldman, M. E., et al. 2009. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 7:e38.
-
(2009)
PLoS Biol.
, vol.7
-
-
Feldman, M.E.1
-
13
-
-
42649112409
-
Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34
-
Gulati, P., et al. 2008. Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell Metab. 7:456-465.
-
(2008)
Cell Metab.
, vol.7
, pp. 456-465
-
-
Gulati, P.1
-
14
-
-
33746370728
-
The role of BiP in endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain induced by cytomegalovirus proteins
-
Hegde, N. R., et al. 2006. The role of BiP in endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain induced by cytomegalovirus proteins. J. Biol. Chem. 281:20910-20919.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 20910-20919
-
-
Hegde, N.R.1
-
15
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki, K., Y. Li, T. Zhu, J. Wu, and K. L. Guan. 2002. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4:648-657.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
16
-
-
18844419215
-
Human cytomegalovirus infection activates and regulates the unfolded protein response
-
Isler, J. A., A. H. Skalet, and J. C. Alwine. 2005. Human cytomegalovirus infection activates and regulates the unfolded protein response. J. Virol. 79:6890-6899.
-
(2005)
J. Virol.
, vol.79
, pp. 6890-6899
-
-
Isler, J.A.1
Skalet, A.H.2
Alwine, J.C.3
-
17
-
-
63049095364
-
Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress
-
Jin, H. O., et al. 2009. Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress. Free Radic. Biol. Med. 46:1158-1167.
-
(2009)
Free Radic. Biol. Med.
, vol.46
, pp. 1158-1167
-
-
Jin, H.O.1
-
18
-
-
0034973856
-
Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling
-
Johnson, R. A., X. Wang, X. L. Ma, S. M. Huong, and E. S. Huang. 2001. Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling. J. Virol. 75:6022-6032.
-
(2001)
J. Virol.
, vol.75
, pp. 6022-6032
-
-
Johnson, R.A.1
Wang, X.2
Ma, X.L.3
Huong, S.M.4
Huang, E.S.5
-
19
-
-
0029833422
-
Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
-
Kinsella, T. M., and G. P. Nolan. 1996. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum. Gene Ther. 7:1405-1413.
-
(1996)
Hum. Gene Ther.
, vol.7
, pp. 1405-1413
-
-
Kinsella, T.M.1
Nolan, G.P.2
-
20
-
-
33947403537
-
AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection
-
Kudchodkar, S. B., G. Q. Del Prete, T. G. Maguire, and J. C. Alwine. 2007. AMPK-mediated inhibition of mTOR kinase is circumvented during immediate-early times of human cytomegalovirus infection. J. Virol. 81:3649-3651.
-
(2007)
J. Virol.
, vol.81
, pp. 3649-3651
-
-
Kudchodkar, S.B.1
Prete, G.Q.D.2
Maguire, T.G.3
Alwine, J.C.4
-
21
-
-
33749040235
-
Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes
-
Kudchodkar, S. B., Y. Yu, T. G. Maguire, and J. C. Alwine. 2006. Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes. Proc. Natl. Acad. Sci. U. S. A. 103:14182-14187.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 14182-14187
-
-
Kudchodkar, S.B.1
Yu, Y.2
Maguire, T.G.3
Alwine, J.C.4
-
22
-
-
4644252994
-
Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase
-
Kudchodkar, S. B., Y. Yu, T. G. Maguire, and J. C. Alwine. 2004. Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase. J. Virol. 78:11030-11039.
-
(2004)
J. Virol.
, vol.78
, pp. 11030-11039
-
-
Kudchodkar, S.B.1
Yu, Y.2
Maguire, T.G.3
Alwine, J.C.4
-
23
-
-
77649251207
-
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis
-
Laplante, M., and D. M. Sabatini. 2010. mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis. Proc. Natl. Acad. Sci. U. S. A 107:3281-3282.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A
, vol.107
, pp. 3281-3282
-
-
Laplante, M.1
Sabatini, D.M.2
-
24
-
-
33749492425
-
Endoplasmic reticulum stress signaling in disease
-
Marciniak, S. J., and D. Ron. 2006. Endoplasmic reticulum stress signaling in disease. Physiol. Rev. 86:1133-1149.
-
(2006)
Physiol. Rev.
, vol.86
, pp. 1133-1149
-
-
Marciniak, S.J.1
Ron, D.2
-
25
-
-
58049201001
-
-
ed., 5th ed., Lippincott Williams & Wilkins, Philadelphia, PA
-
Mocarski, E. S., T. Shenk, and R. F. Pass (ed.). 2007. Cytomegaloviruses, 5th ed., vol. 2. Lippincott Williams & Wilkins, Philadelphia, PA.
-
(2007)
Cytomegaloviruses
, vol.2
-
-
Mocarski, E.S.1
Shenk, T.2
Pass, R.F.3
-
26
-
-
41849101685
-
Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex
-
Moorman, N. J., et al. 2008. Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. Cell Host Microbe 3:253-262.
-
(2008)
Cell Host Microbe
, vol.3
, pp. 253-262
-
-
Moorman, N.J.1
-
27
-
-
77951480815
-
Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication
-
Moorman, N. J., and T. Shenk. 2010. Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication. J. Virol. 84:5260-5269.
-
(2010)
J. Virol.
, vol.84
, pp. 5260-5269
-
-
Moorman, N.J.1
Shenk, T.2
-
28
-
-
44649190782
-
Endoplasmic reticulum chaperones participate in human cytomegalovirus US2-mediated degradation of class I major histocompatibility complex molecules
-
Oresic, K., and D. Tortorella. 2008. Endoplasmic reticulum chaperones participate in human cytomegalovirus US2-mediated degradation of class I major histocompatibility complex molecules. J. Gen. Virol. 89:1122-1130.
-
(2008)
J. Gen. Virol.
, vol.89
, pp. 1122-1130
-
-
Oresic, K.1
Tortorella, D.2
-
29
-
-
78650074979
-
Translational control of the abundance of cytoplasmic poly(A) binding protein in human cytomegalovirus-infected cells
-
Perez, C., C. McKinney, U. Chulunbaatar, and I. Mohr. 2011. Translational control of the abundance of cytoplasmic poly(A) binding protein in human cytomegalovirus-infected cells. J. Virol. 85:156-164.
-
(2011)
J. Virol.
, vol.85
, pp. 156-164
-
-
Perez, C.1
McKinney, C.2
Chulunbaatar, U.3
Mohr, I.4
-
30
-
-
79955384525
-
Human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts
-
Perng, Y., Z. Qian, A. R. Fehr, B. Xuan, and D. Yu. 2011. Human cytomegalovirus gene UL79 is required for the accumulation of late viral transcripts. J. Virol. 85:4841-4852.
-
(2011)
J. Virol.
, vol.85
, pp. 4841-4852
-
-
Perng, Y.1
Qian, Z.2
Fehr, A.R.3
Xuan, B.4
Yu, D.5
-
31
-
-
50049116472
-
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
-
Porstmann, T., et al. 2008. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab. 8:224-236.
-
(2008)
Cell Metab.
, vol.8
, pp. 224-236
-
-
Porstmann, T.1
-
32
-
-
0036714127
-
Akt regulates growth by directly phosphorylating Tsc2
-
Potter, C. J., L. G. Pedraza, and T. Xu. 2002. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell Biol. 4:658-665.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 658-665
-
-
Potter, C.J.1
Pedraza, L.G.2
Xu, T.3
-
33
-
-
77953506788
-
ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy
-
Qin, L., Z. Wang, L. Tao, and Y. Wang. 2010. ER stress negatively regulates AKT/TSC/mTOR pathway to enhance autophagy. Autophagy 6:239-247.
-
(2010)
Autophagy
, vol.6
, pp. 239-247
-
-
Qin, L.1
Wang, Z.2
Tao, L.3
Wang, Y.4
-
34
-
-
22244446505
-
The mammalian unfolded protein response
-
Schroder, M., and R. J. Kaufman. 2005. The mammalian unfolded protein response. Annu. Rev. Biochem. 74:739-789.
-
(2005)
Annu. Rev. Biochem.
, vol.74
, pp. 739-789
-
-
Schroder, M.1
Kaufman, R.J.2
-
35
-
-
78649348967
-
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
-
Sengupta, S., T. R. Peterson, and D. M. Sabatini. 2010. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol. Cell 40:310-322.
-
(2010)
Mol. Cell
, vol.40
, pp. 310-322
-
-
Sengupta, S.1
Peterson, T.R.2
Sabatini, D.M.3
-
36
-
-
33947418741
-
Human cytomegalovirus pUL37x1 induces the release of endoplasmic reticulum calcium stores
-
Sharon-Friling, R., J. Goodhouse, A. M. Colberg-Poley, and T. Shenk. 2006. Human cytomegalovirus pUL37x1 induces the release of endoplasmic reticulum calcium stores. Proc. Natl. Acad. Sci. U. S. A. 103:19117-19122.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 19117-19122
-
-
Sharon-Friling, R.1
Goodhouse, J.2
Colberg-Poley, A.M.3
Shenk, T.4
-
37
-
-
33947399734
-
Human cytomegalovirus UL38 protein blocks apoptosis
-
Terhune, S., et al. 2007. Human cytomegalovirus UL38 protein blocks apoptosis. J. Virol. 81:3109-3123.
-
(2007)
J. Virol.
, vol.81
, pp. 3109-3123
-
-
Terhune, S.1
-
38
-
-
65549145048
-
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
-
Thoreen, C. C., et al. 2009. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J. Biol. Chem. 284:8023-8032.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 8023-8032
-
-
Thoreen, C.C.1
-
39
-
-
13944250933
-
Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products
-
Tirosh, B., et al. 2005. Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products. J. Virol. 79:2768-2779.
-
(2005)
J. Virol.
, vol.79
, pp. 2768-2779
-
-
Tirosh, B.1
-
40
-
-
64049088651
-
Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death
-
Xuan, B., Z. Qian, E. Torigoi, and D. Yu. 2009. Human cytomegalovirus protein pUL38 induces ATF4 expression, inhibits persistent JNK phosphorylation, and suppresses endoplasmic reticulum stress-induced cell death. J. Virol. 83:3463-3474.
-
(2009)
J. Virol.
, vol.83
, pp. 3463-3474
-
-
Xuan, B.1
Qian, Z.2
Torigoi, E.3
Yu, D.4
-
41
-
-
33745993633
-
Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase
-
Yan, L., et al. 2006. Hyperactivation of mammalian target of rapamycin (mTOR) signaling by a gain-of-function mutant of the Rheb GTPase. J. Biol. Chem. 281:19793-19797.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 19793-19797
-
-
Yan, L.1
-
42
-
-
0036171607
-
Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene
-
Yu, D., G. A. Smith, L. W. Enquist, and T. Shenk. 2002. Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene. J. Virol. 76:2316-2328.
-
(2002)
J. Virol.
, vol.76
, pp. 2316-2328
-
-
Yu, D.1
Smith, G.A.2
Enquist, L.W.3
Shenk, T.4
|