The interferon-inducible p202 protein as a modulator of transcription: Inhibition of NF-κB, c-Fos, and c-Jun activities

Molecular and Cellular Biology

Volumn 16, Issue 1, 1996, Pages 359-368

  Min, Wang ^a,b,c   Ghosh, Sankar ^a   Lengyel, Peter ^a  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; NUCLEAR PROTEIN; PROTEIN C FOS; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STRAIN L 929; CONTROLLED STUDY; EMBRYO; GENE ACTIVITY; GENE CLUSTER; GENE EXPRESSION; MOUSE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

ANIMAL; BINDING SITES; CARRIER PROTEINS; CELL LINE; ENHANCER ELEMENTS (GENETICS); GENES, FOS; GENES, JUN; GENES, REPORTER; INTERFERONS; MICE; NF-KAPPA B; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; SUPPORT, U.S. GOV'T, P.H.S.; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0029656068     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.1.359     Document Type: Article

References (76)

1. Abate, C., D. Luk, and T. Curran. 1991. Transcriptional regulation by Fos and Jun in vitro: interaction among multiple activator and regulatory domains Mol Cell. Biol. 11:3624-3632.
2. Abate, C., D. Luk, R. Gentz, F. J. Rauscher III, and T. Curran. 1990. Expression and purification of the leucine zipper and DNA-binding domains of Fos and Jun: both Fos and Jun contact DNA directly Proc. Natl. Acad. Sci USA 87:1032-1036.
3. Angel, P., M. Imagawa, R. Chiu, B. Stein, R. J. Imbra, H. J. Rahmsdorf, C. Jonat, P. Herrlich, and M. Karin. 1987. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell 49:729-739.
4. Angel, P., and M. Karin. 1991 The role of Jun. Fos and the AP-1 complex in cell proliferation and transformation. Biochim. Biophys. Acta 1072:129-157.
5. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-kappa-B in the immune system. Annu. Rev. Immunol. 12:141-179.
6. Beg, A. A., and A. S. Baldwin, Jr. 1993. The IκB proteins: multifunctional regulators of Rel/NF-κB transcription factors. Genes Dev. 7:2064-2070.
7. Briggs, J. A., G. R. Burrus, B. D. Stickney, and R. C. Briggs. 1992. Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. J. Cell. Biochem. 49:82-92
8. Brown, K., S. Gerstberger, L. Carlson, G. Franzoso, and U. Siebenlist. 1995 Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation. Science 267:1485-1488.
9. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease Biochemistry 18:5294-5299.
10. Choubey, D., and P. Lengyel. 1995. Binding of an interferon-inducible protein (p202) to the retinoblastoma protein. J. Biol. Chem. 270:6134-6140.
11. Choubey, D., and P. Lengyel. 1992. Interferon action: nucleolar and nucleoplasmic localization of the interferon-inducible 70 kilodalton protein that is encoded by the Ifi 204 gene from the gene 200 cluster. J. Cell Biol. 116: 1333-1341.
12. Choubey, D., and P. Lengyel. 1993. Interferon action, cytoplasmic and nuclear localization of the interferon-inducible 52-kilodalton protein that is encoded by the Ifi 202 gene from the gene 200 cluster J. Interferon Res. 13: 43-52.
13. Choubey, D., J. Snoddy, V. Chaturvedi, E. Toniato, G. Opdenakker, A. Thakur, H. Samanta, D. Engel, and P. Lengyel. 1989. Interferons as gene activators: indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1. J Biol. Chem. 264:17182-17189.
14. Curran, T., and B. R. Franza, Jr. 1988 Fos and Jun: the AP-1 connection. Cell 55:395-397.
15. Dawson, M. J., and J. A. Trapani. 1995. IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines J Cell. Biochem. 57:39-51.
16. DeMaeyer, E., and J. DeMaeyer-Guignard. 1988. Interferons and other regulatory cytokines, p. 488. John Wiley * Sons, Inc., New York.
17. Derijard, B., M. Hibi, I.-H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R. J. Davis. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037
18. Du, W., D. Thanos, and T. Maniatis. 1993. Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell 74:887-898.
19. Fletcher, C., N. Heintz, and R. G. Roeder. 1987 Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2B gene. Cell 51:773-781.
20. Fort, P., L. Marty, M. Piechaczyk, S. El Sabrouty, C. H. Pani, P. Jeanteur, and J. M. Blanchard. 1985 Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multi-genic family. Nucleic Acids Res. 13:1431-1442.
21. Gariglio, M., S. Panico, G. Cavallo, D. Choubey, P. Lengyel, and S. Landolfo. 1992. Impaired transcription of the poly rI-rC and interferon-activatable 202 gene in mice and cell lines from the C57BL/6 strain. Virology 187: 115-123.
22. Getz, M. J., P. K. Elder, E. W. Benz, Jr., R. E. Stephens, and H. L. Moses. 1976 Effect of cell proliferation on levels and diversity of poly(A)-containing mRNA. Cell 7:255-265
23. Ghosh, S., A, M. Gifford, L. R. Riviere, P. Tempst, G. P. Nolan, and D. Baltimore. 1990. Cloning of the p50 DNA binding subunit of NF-κB. homology to rel and dorsal. Cell 62:1019-1029.
24. Gilmore, T. D., and P. J. Morin. 1993 The IκB proteins: members of a multifunctional family Trends Genet. 9:427-433.
25. Glover, J. N. M., and S. C. Harrison. 1995. Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA. Nature (London) 373:257-261.
26. Higashi, Y., Y. Sokawa, Y. Watanabe, Y. Kawade, S. Ohno, C. Takaoka, and T. Taniguchi. 1983. Structure and expression of a cloned cDNA for mouse interferon-beta. J Biol. Chem 258:9522-9529.
27. Hill, C. S., and R. Treisman. 1995. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80:199-211.
28. Jain, J., P. G. McCaffrey, Z. Miner, T. K. Kerppola, J. N. Lambert, G. L. Verdine, T. Curran, and A. Rao. 1993 The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and Jun. Nature (London) 365:352-355.
29. Jonat, C., H. J. Rahmsdorf, K.-K. Park, A. C. B. Cato, S. Gebel, H. Ponta, and P. Herrlich. 1990. Antitumor promotion and antiinflammation down-modulation of AP-1 Fos-Jun activity by glucocorticoid hormone Cell 62: 1189-1204.
30. Kadonaga, J. T., K. R. Carner, F. R. Masiarz, and R. Tjian. 1987 Isolation of complementary DNA encoding transcription factor SP1 and functional analysis of the DNA binding domain Cell 51:1079-1090.
31. Kallunki, T., B. Su, I. Tsigelny, H. K. Sluss, B. Derijard, G. Moore, R. Davis, and M. Karin. 1994. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 8:2996-3007.
32. Karin, M. 1994. Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Curr Opin. Cell Biol. 6:415-424.
33. Keller, A. D., and T. Maniatis. 1991. Identification and characterization of a novel repressor of beta interferon gene expression. Genes Dev. 5:868-879.
34. Kerppola, T. K., and T. Curran. 1991 Transcription factor interactions: basics on zippers. Curr Opin. Struct. Biol. 1:71-79.
35. Kerr, L. D., L. J. Ransone, P. Wamsley, M. J. Schmitt, T. G. Boyer, Q. Zhou, A. J. Berk, and I. M. Verma. 1993. Association between proto-oncoprotein Rcl and TATA-binding protein mediates transcriptional activation by NF-κB. Nature (London) 365:412-419.
36. Kingsmore, S. F., J. Snoddy, D. Choubey, P. Lengyel, and M. F. Seldin. 1990. Physical mapping of a family of interferon-activated genes, serum amyloid P-component, and α-spectrin on mouse chromosome 1. Immunogenetics 30: 169-174.
37. Kopp, E., and S. Ghosh. 1994. Inhibition of NF-κB by sodium salicylate and aspirin. Science 265:956-959.
38. Landschulz, W. H., P. F. Johnson, and S. L. McKnight. 1988. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240:1759-1764.
39. Lee, W., A. Haslinger, M. Karin, and R. Tjian. 1987. Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40 Nature (London) 325:368-372.
40. Lehming, N., D. Thanos, J. M. Brickman, J. Ma, T. Maniatis, and M. Ptashne. 1994. An HMG-like protein that can switch a transcriptional activator to a repressor. Nature (London) 371:175-179.
41. Lengyel, P. 1982 Biochemistry of interferons and their actions Annu. Rev. Biochem. 51:251-282
42. Lengyel, P., D. Choubey, S. J. Li, and B. Datta. 1995. The interferon-activatable gene 200 cluster: from structure toward function. Semin. Virol. 6: 203-230.
43. Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:387-393.
44. Maran, A., R. K. Maitra, A. Kumar, B. Dong, W. Xiao, G. Li, B. R. G. Williams, P. F. Torrence, and R. H. Silverman. 1994. Blockage of NF-κB signaling by selective ablation of an mRNA target by 2-5A antisense chimeras. Science 265:789-792
45. Minden, A., A. Lin, M. McMahon, C. Lange-Carter, B. Derijard, R. J. Davis, L. G. Johnson, and M. Karin. 1994. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK Science 266:1719-1723.
46. Miyamoto, S., M. Maki, J. J. Schmit, M. Hatanaka, and I. M. Verma. 1994. Tumor necrosis factor alpha-induced phosphorylation of IκB-α is a signal for its degradation but not dissociation from NF-κB. Proc Natl. Acad. Sci. USA 91:12740-12744.
47. Nolan, G. P., S. Ghosh, H.-C. Liou, P. Tempst, and D. Baltimore. 1991. DNA binding and IκB-β inhibition of the cloned p65 subunit of NF-κB, a Rel-related polypeptide. Cell 64:961-969.
48. Opdenakker, G., J. Snoddy, D. Choubey, E. Toniato, D. D. Pravtcheva, M. F. Seldin, F. H. Ruddle, and P. Lengyel. 1989 Interferons, as gene activators: a cluster of six interferon-activatable genes is linked to the erythroid alpha spectrin locus on murine chromosome 1 Virology 171:568-578.
49. Palombella, V. J., O. J. Rando, A. L. Goldberg, and T. Maniatis. 1994. The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78:773-785.
50. Quinn, C. O., D. K. Scott, C. E. Brinkerhoff, L. Matrisian, J. J. Jeffery, and N. C. Partridge. 1990 Rat collagenase, cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells. J Biol. Chem. 265:22342-22347.
51. Ray, A., and K. E. Prefontaine. 1994. Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc Natl. Acad. Sci. USA 91:752-756.
52. Rincon, M., and R. A. Flavell. 1994. AP-1 transcriptional activity requires both T-cell receptor-mediated and costimulatory signals in primary T lymphocytes. EMBO J. 13:4370-4381
53. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989 Molecular cloning: a laboratory manual, 2nd ed Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
54. Schüle, R., P. Rangarajan, S. Kliewer, L. J. Ransone, J. Bolado, N. Yang, I. M. Verma, and R. M. Evans. 1990. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62:1217-1226.
55. Sen, G. C., and P. Lengyel. 1992 The interferon system - a bird's eye view of its biochemistry. J. Biol. Chem. 267:5017-5020.
56. Sen, R., and D. Baltimore. 1986. In vitro transcription of immunoglobulin genes in a B-cell extract: effects of enhancer and promoter sequences Cell 47:921-928.
57. Siebenlist, U., G. Franzoso, and K. Brown. 1994. Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10:405-455.
58. Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31-40.
59. Tannenbaum, C. S., J. Major, Y. Ohmuri, and T. A. Hamilton. 1993. A lipopolysaccharide-inducible macrophage gene D3 is a new member of an interferon-inducible gene cluster and is selectively expressed in mononuclear phagocytes. J. Leukocyte Biol. 53:563-568.
60. Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell 80: 529-532.
61. Thanos, D., and T. Maniatis. 1995. Identification of the rel family members required for virus induction of the human beta interferon gene. Mol Cell. Biol. 15:152-164.
62. Thompson, J. E., R. J. Philips, H. Erdjument-Bromage, P. Tempst, and S. Ghosh. 1995. IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell 80:573-582.
63. Traenckner, E. B.-M., S. Wilk, and P. A. Baeuerle. 1994. A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB EMBO J. 13:5433-5441.
64. Trapani, J. A., K. A. Browne, M. J. Dawson, R. G. Ramsay, R. L. Eddy, T. B. Shows, P. C. White, and B. Dupont. 1992. A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells. Immunogenetics 36:369-376.
65. Vilcek, J. 1990. Interferons, p. 3-38 In M B. Sporn and A. B. Roberts (ed.), Peptide growth factors and their receptors. Springer-Verlag, Berlin.
66. Wagner, S., and M. R. Green. 1994. DNA-binding domains: targets for viral and cellular regulators Curr. Opin. Cell Biol. 6:410-414.
67. Weber, H., D. Valenzuela, G. Lujber, M. Gubler, and C. Weissmann. 1987. Single amino acid changes that render human IFN-alpha 2 biologically inactive on mouse cells. EMBO J. 6:591-598.
68. Weinberg, R. A. 1995. The retinoblastoma protein and cell cycle control Cell 81:323-330.
69. Whittemore, L.-A., and T. Maniatis. 1990 Postinduction turnoff of beta interferon gene expression. Mol. Cell. Biol. 64:1329-1337.
70. Wigler, M., R. Sweet, G. K. Sim, B. Wold, R. Pellicer, E. Lacy, T. Maniatis, S. Silverstein, and R. Axel. 1979. Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell 16:777-785.
71. Williams, T., A. Admon, B. Lüscher, and R. Tjian. 1988. Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev. 2:1557-1569.
72. Williams, T., and R. Tjian. 1991. Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev. 5:670-682.
73. Yamamoto, K. R., D. Pearce, J. Thomas, and J. N. Miner. 1992. Combinatorial regulation at a mammalian composite response element, p. 1169-1192. In S. L. McKnight and K. R. Yamamoto (ed.), Transcriptional regulation Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
74. Yang-Yen, H.-F., J.-C. Chambard, Y.-L. Sun, T. Smeal, T. J. Schmidt, J. Drorin, and M. Karin. 1990. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205-1215.
75. Yew, P. R., X. Lin, and A. J. Berk. 1994. Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev. 8:190-202.
76. Zauberman, A., Y. Barak, N. Ragimov, N. Levy, and M. Oren. 1993. Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53-MDM2 complexes. EMBO J. 12:2799-2808.