Benzo[a]pyrene and tumor necrosis factor-α coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells

Toxicology Letters

Volumn 206, Issue 2, 2011, Pages 121-129

  Umannová, Lenka ^a,b   Machala, Miroslav ^b   Topinka, Jan ^c   Schmuczerová, Jana ^c   Krčmář, Pavel ^b   Neča, Jiří ^b   Šujanová, Klára ^a   Kozubík, Alois ^a   Vondráček, Jan ^a,b  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b VETERINARY RESEARCH INSTITUTE   (Czech Republic)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

Author keywords

COX 2; CYP1B1; DNA adducts; Lung epithelial cells; Polycyclic aromatic hydrocarbons; Proinflammatory cytokines

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACTIVATING TRANSCRIPTION FACTOR 2; BENZO[A]PYRENE; CYCLOOXYGENASE 2; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; PROTEIN P53; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGEN DNA INTERACTION; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REPRESSION; GENOTOXICITY; IN VITRO STUDY; INFLAMMATION; LUNG ALVEOLUS CELL TYPE 2; LUNG TOXICITY; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TIME; UPREGULATION;

ANIMALS; APOPTOSIS; ARYL HYDROCARBON HYDROXYLASES; BENZO(A)PYRENE; CARCINOGENS, ENVIRONMENTAL; CELL LINE; CELL PROLIFERATION; CYTOCHROME P-450 CYP1A1; DNA ADDUCTS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; MUTAGENS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PNEUMOCYTES; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53;

RATTUS;

EID: 80052084959     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.06.029     Document Type: Article

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