Knowns and unknowns of the alveolus

Proceedings of the American Thoracic Society

Volumn 5, Issue 7, 2008, Pages 778-782

  Herzog, Erica L ^a   Brody, Arnold R ^b   Colby, Thomas V ^c   Mason, Robert ^d   Williams, Mary C ^e  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c MAYO CLINIC   (United States)

^d NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^e BOSTON UNIVERSITY   (United States)

Author keywords

Alveolus; Fibroblast; Pneumocyte

Indexed keywords

LUNG SURFACTANT; SCLEROPROTEIN;

BREATHING; CELL FUNCTION; CELL PROLIFERATION; CONFERENCE PAPER; FLUID TRANSPORT; HUMAN; HUMAN CELL; INNATE IMMUNITY; ION TRANSPORT; LUNG ALVEOLUS; LUNG ALVEOLUS CELL; LUNG ALVEOLUS CELL TYPE 2; LUNG FIBROBLAST; LUNG FUNCTION; LUNG GAS EXCHANGE; MOLECULAR INTERACTION; PHENOTYPE; STEM CELL;

CELL DIFFERENTIATION; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; HUMANS; PULMONARY ALVEOLI; PULMONARY SURFACTANTS;

EID: 50849098529     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200803-028HR     Document Type: Conference Paper

References (47)

1. Fishman AP, editor. Fishman's pulmonary diseases and disorders, 3rd ed. New York: McGraw-Hill Health Professions Division; 1998.
2. Crapo JD, Barry BE, Gehr P, Bachofen M, Weibel ER. Cell number and cell characteristics of the normal human lung. Am Rev Respir Dis 1982;126:332-337.
3. Williams MC. Alveolar type I cells: molecular phenotype and development. Annu Rev Physiol 2003;65:669-695.
4. Evans MJ, Hackney JD. Cell proliferation in lungs of mice exposed to elevated concentrations of oxygen. Aerosp Med 1972;43:620-622.
5. Danto SI, Shannon JM, Borok Z, Zabski SM, Crandall ED. Reversible transdifferentiation of alveolar epithelial cells. Am J Respir Cell Mol Biol 1995;12:497-502.
6. Williams MC, Cao Y, Hinds A, Rishi AK, Wetterwald A. T1 alpha protein is developmentally regulated and expressed by alveolar type I cells, choroid plexus, and ciliary epithelia of adult rats. Am J Respir Cell Mol Biol 1996;14:577-585.
7. Ma T, Fukuda N, Song Y, Matthay MA, Verkman AS. Lung fluid transport in aquaporin-5 knockout mice. J Clin Invest 2000;105:93-100.
8. Johnson MD, Bao HF, Helms MN, Chen XJ, Tigue Z, Jain L, Dobbs LG, Eaton DC. Functional ion channels in pulmonary alveolar type I cells support a role for type I cells in lung ion transport. Proc Natl Acad Sci USA 2006;103:4964-4969.
9. Factor P, Mutlu GM, Chen L, Mohameed J, Akhmedov AT, Meng FJ, Jilling T, Lewis ER, Johnson MD, Xu A, et al. Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci USA 2007;104:4083-4088.
10. Song Y, Fukuda N, Bai C, Ma T, Matthay MA, Verkman AS. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice. J Physiol 2000;525:771-779.
11. Krane CM, Fortner CN, Hand AR, McGraw DW, Lorenz JN, Wert SE, Towne JE, Paul RJ, Whitsett JA, Menon AG. Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation. Proc Natl Acad Sci USA 2001;98:14114-14119.
12. Millien G, Spira A, Hinds A, Wang J, Williams MC, Ramirez MI. Alterations in gene expression in T1 alpha null lung: a model of deficient alveolar sac development. BMC Dev Biol 2006;6:35.
13. Shin JS, Abraham SN. Cell biology: caveolae-not just craters in the cellular landscape. Science 2001;293:1447-1448.
14. Drab M, Verkade P, Elger M, Kasper M, Lohn M, Lauterbach B, Menne J, Lindschau C, Mende F, Luft FC, et al. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science 2001;293:2449-2452.
15. Kathuria H, Cao Y, Hinds A, Ramirez MI, Williams MC. ERM is expressed by alveolar epithelial cells in adult mouse lung and regulates caveolin-1 transcription in mouse lung epithelial cell lines. J Cell Biochem 2007;102:13-27.
16. Perl AK, Wert SE, Nagy A, Lobe CG, Whitsett JA. Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci USA 2002;99:10482-10487.
17. Lechner AJ, Banchero N. Advanced pulmonary development in newborn guinea pigs (Cavia porcellus). Am J Anat 1982;163:235-246.
18. Uhal BD. Cell cycle kinetics in the alveolar epithelium. Am J Physiol 1997;272:L1031-L1045.
19. Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, Crowley D, Bronson RT, Jacks T. Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 2005;121:823-835.
20. Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-377.
21. Harris RG, Herzog EL, Bruscia EM, Grove JE, Van Arnam JS, Krause DS. Lack of a fusion requirement for development of bone marrow-derived epithelia. Science 2004;305:90-93.
22. Herzog EL, Van Arnam J, Hu B, Zhang J, Chen Q, Haberman AM, Krause DS. Lung-specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation. FASEB J 2007;21:2592-2601.
23. Chen X, Hyatt BA, Mucenski ML, Mason RJ, Shannon JM. Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells. Proc Natl Acad Sci USA 2006;103:11724-11729.
24. Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T. Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1): expression in alveolar type II cells and possible involvement in surfactant production. J Biol Chem 2006;281:20140-20147.
25. Cheong N, Madesh M, Gonzales LW, Zhao M, Yu K, Ballard PL, Shuman H. Functional and trafficking defects in ATP binding cassette A3 mutants associated with respiratory distress syndrome. J Biol Chem 2006;281:9791-9800.
26. Williams GD, Christodoulou J, Stack J, Symons P, Wert SE, Murrell MJ, Nogee LM. Surfactant protein B deficiency: clinical, histological and molecular evaluation. J Paediatr Child Health 1999;35:214-220.
27. Nogee LM, Dunbar AE III, Wert SE, Askin F, Hamvas A, Whitsett JA. A mutation in the surfactant protein C gene associated with familial interstitial lung disease. N Engl J Med 2001;344:573-579.
28. Matthay MA, Fukuda N, Frank J, Kallet R, Daniel B, Sakuma T. Alveolar epithelial barrier: role in lung fluid balance in clinical lung injury. Clin Chest Med 2000;21:477-490.
29. Li T, Folkesson HG. RNA interference for alpha-ENaC inhibits rat lung fluid absorption in vivo. Am J Physiol Lung Cell Mol Physiol 2006;290:L649-L660.
30. Traebert M, Hattenhauer O, Murer H, Kaissling B, Biber J. Expression of type II Na-P(i) cotransporter in alveolar type II cells. Am J Physiol 1999;277:L868-L873.
31. Kapanci Y, Weibel ER, Kaplan HP, Robinson FR. Pathogenesis and reversibility of the pulmonary lesions of oxygen toxicity in monkeys. II. Ultrastructural and morphometric studies. Lab Invest 1969;20:101-118.
32. Kim KK, Kugler MC, Wolters PJ, Robillard L, Galvez MG, Brumwell AN, Sheppard D, Chapman HA. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA 2006;103:13180-13185.
33. Zissel G, Ernst M, Rabe K, Papadopoulos T, Magnussen H, Schlaak M, Muller-Quernheim J. Human alveolar epithelial cells type II are capable of regulating T-cell activity. J Investig Med 2000;48:66-75.
34. O'Brien AD, Standiford TJ, Christensen PJ, Wilcoxen SE, Paine R III. Chemotaxis of alveolar macrophages in response to signals derived from alveolar epithelial cells. J Lab Clin Med 1998;131:417-424.
35. Schneeberger EE, DeFerrari M, Skoskiewicz MJ, Russell PS, Colvin RB. Induction of MHC-determined antigens in the lung by interferon-gamma. Lab Invest 1986;55:138-144.
36. Isakson BE, Lubman RL, Seedorf GJ, Boitano S. Modulation of pulmonary alveolar type II cell phenotype and communication by extracellular matrix and KGF. Am J Physiol Cell Physiol 2001;281:C1291-C1299.
37. Hinz B, Phan SH, Thannickal VJ, Galli A, Bochaton-Piallat ML, Gabbiani G. The myofibroblast: one function, multiple origins. Am J Pathol 2007;170:1807-1816.
38. Brody JS, Kaplan NB. Proliferation of alveolar interstitial cells during postnatal lung growth: evidence for two distinct populations of pulmonary fibroblasts. Am Rev Respir Dis 1983;127:763-770.
39. Spees JL, Pociask DA, Sullivan DE, Whitney MJ, Lasky JA, Prockop DJ, Brody AR. Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis. Am J Respir Crit Care Med 2007;176:385-394.
40. Hashimoto N, Hong J, Liu T, Chensue SW, Phan SH. Bone marrow derived progenitor cells in pulmonary fibrosis. J Clin Invest 2004;113:243-252.
41. Phillips RJ, Burdick MD, Hong K, Lutz MA, Murray LA, Xue YY, Belperio JA, Keane MP, Strieter RM. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 2004;114:438-446.
42. Pereira RF, O'Hara MD, Laptev AV, Halford KW, Pollard MD, Class R, Simon D, Livezey K, Prockop DJ. Marrow stromal cells as a source of progenitor cells for nonhematopoietic tissues in transgenic mice with a phenotype of osteogenesis imperfecta. Proc Natl Acad Sci USA 1998;95:1142-1147.
43. Willis BC, Borok Z. TGF-b-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 2007;293:L525-L534.
44. Sanders YY, Kumbla P, Hagood JS. Enhanced myofibroblastic differentiation and survival in Thy-1(2) lung fibroblasts. Am J Respir Cell Mol Biol 2007;36:226-235.
45. Hagood JS, Prabhakaran P, Kumbla P, Salazar L, MacEwen MW, Barker TH, Ortiz LA, Schoeb T, Siegal GP, Alexander CB, et al. Loss of fibroblast Thy-1 expression correlates with lung fibrogenesis. Am J Pathol 2005;167:365-379.
46. Kaminski N, Allard JD, Pittet JF, Zuo F, Griffiths MJ, Morris D, Huang X, Sheppard D, Heller RA. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc Natl Acad Sci USA 2000;97:1778-1783.
47. Kelly MM, Leigh R, Gilpin SE, Cheng E, Martin GE, Radford K, Cox G, Gauldie J. Cell-specific gene expression in patients with usual interstitial pneumonia. Am J Respir Crit Care Med 2006;174:557-565.