Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a μ-opioid receptor-dependent manner

European Journal of Pharmacology

Volumn 667, Issue 1-3, 2011, Pages 144-152

  Daijo, Hiroki ^a   Kai, Shinichi ^a   Tanaka, Tomoharu ^a   Wakamatsu, Takuhiko ^a   Kishimoto, Shun ^a   Suzuki, Kengo ^a,b   Harada, Hiroshi ^c,d   Takabuchi, Satoshi ^a   Adachi, Takehiko ^e   Fukuda, Kazuhiko ^a   Hirota, Kiichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e Kitano Hospital   (Japan)

Author keywords

Fentanyl; Hypoxia inducible factor 1 (HIF 1); Opioid; SH SY5Y cells

Indexed keywords

FENTANYL; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1 ALPHA ANTIBODY; HYPOXIA INDUCIBLE FACTOR 1 BETA ANTIBODY; LUCIFERASE; MESSENGER RNA; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; PROTEIN ANTIBODY; REMIFENTANIL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL HYPOXIA; CONTROLLED STUDY; DRUG TARGETING; ENZYME ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPOXIA INDUCIBLE FACTOR 1 GENE; LIVER CELL CARCINOMA; LUNG ADENOCARCINOMA; MALE; MOUSE; NEUROBLASTOMA; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BRAIN; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; FENTANYL; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY; MALE; MICE; MORPHINE; NEURONS; PIPERIDINES; PROTEIN STABILITY; RECEPTORS, OPIOID, MU; TIME;

EID: 80052028647     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.06.014     Document Type: Article

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