The intravenous anesthetic propofol inhibits lipopolysaccharide-induced hypoxia-inducible factor 1 activation and suppresses the glucose metabolism in macrophages

Journal of Anesthesia

Volumn 24, Issue 1, 2010, Pages 54-60

  Tanaka, Tomoharu ^a   Takabuchi, Satoshi ^a   Nishi, Kenichiro ^b   Oda, Seiko ^a   Wakamatsu, Takuhiko ^a   Daijo, Hiroki ^a   Fukuda, Kazuhiko ^a   Hirota, Kiichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Glucose metabolism; Hypoxia inducible factor 1; Macrophage; Propofol

Indexed keywords

ADENOSINE TRIPHOSPHATE; ENOLASE; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTATE DEHYDROGENASE; LACTIC ACID; LIPOPOLYSACCHARIDE; PROPOFOL; PYRUVATE DEHYDROGENASE; VASCULOTROPIN;

ARTICLE; CELL HYPOXIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; GENE REPRESSION; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; MACROPHAGE; MOLECULAR MECHANICS; TRANSCRIPTION INITIATION;

ADENOSINE TRIPHOSPHATE; ANESTHETICS, INTRAVENOUS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; CELL DIFFERENTIATION; CELL HYPOXIA; CELL LINE, TUMOR; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LACTIC ACID; LIPOPOLYSACCHARIDES; MACROPHAGES; PROPOFOL; PROTEIN BIOSYNTHESIS; RNA, MESSENGER;

EID: 76649111039     PISSN: 09138668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00540-009-0829-1     Document Type: Article

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