Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (Hed KR): Molecular basis of stereo- and regiospecificities

Biochemistry

Volumn 50, Issue 34, 2011, Pages 7426-7439

  Javidpour, Pouya ^a   Das, Abhirup ^b   Khosla, Chaitan ^b   Tsai, Shiou Chuan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMORS; ANTITUMOR ANTIBIOTICS; BIOCHEMICAL STUDIES; CARBONYL GROUPS; DOCKING SIMULATIONS; HEDAMYCIN; IN-VITRO; MOLECULAR BASIS; MOLECULAR FEATURE; POLYKETIDE SYNTHASES; POLYKETIDES; PROTEIN ENGINEERING; SEQUENCE ALIGNMENTS; STEREOSPECIFICITY; STRUCTURAL STUDIES; TYPE II;

ANTIBIOTICS; ASSAYS; COMPUTER SIMULATION; GENETIC ENGINEERING; KETONES; SUBSTRATES;

CRYSTAL STRUCTURE;

ACTINORHODINE; ALIZARIN; DAUNORUBICIN; DOCKING PROTEIN; EMODIN; EPIGALLOCATECHIN GALLATE; FRENOLICIN; GRISEUCIN; HEDAMYCIN; HEDAMYCIN TYPE II POLYKETIDE KETOREDUCTASE; NOGALAMYCIN; OXIDOREDUCTASE; POLYKETIDE; QUERCETIN; TETRACENOMYCIN C; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; INHIBITION KINETICS; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN STRUCTURE; REDUCTION; SEQUENCE ALIGNMENT; STEREOSPECIFICITY;

ACYL CARRIER PROTEIN; ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; ANTHRAQUINONES; BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; QUERCETIN; SEQUENCE ALIGNMENT; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 80051978457     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2006866     Document Type: Article

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