-
1
-
-
33748359678
-
Questions linger about unexplained gene-therapy trial death
-
Abbott A. (2006) Questions linger about unexplained gene-therapy trial death. Nat Med 12: 597.
-
(2006)
Nat Med
, vol.12
, pp. 597
-
-
Abbott, A.1
-
2
-
-
0030750528
-
Profile of the DNArecognition site of the archaeal homing endonuclease I-DmoI
-
Agaard C, Awayez MJ, Garrett RA. (1997) Profile of the DNArecognition site of the archaeal homing endonuclease I-DmoI. Nucl Acids Res 25:1523-30.
-
(1997)
Nucl Acids Res
, vol.25
, pp. 1523-1530
-
-
Agaard, C.1
Awayez, M.J.2
Garrett, R.A.3
-
3
-
-
28944449341
-
Engineering of large numbers of highly specific homing endonucleases that induce recombination on novelDNAtargets
-
Arnould S, Chames P, Perez C, et al. (2006) Engineering of large numbers of highly specific homing endonucleases that induce recombination on novelDNAtargets. J Mol Biol 355: 443-58.
-
(2006)
J Mol Biol
, vol.355
, pp. 443-458
-
-
Arnould, S.1
Chames, P.2
Perez, C.3
-
4
-
-
34447109864
-
Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells
-
Arnould S, Perez C, Cabaniols J-P, et al. (2007) Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells. J Mol Biol 371: 49-65.
-
(2007)
J Mol Biol
, vol.371
, pp. 49-65
-
-
Arnould, S.1
Perez, C.2
Cabaniols, J.-P.3
-
5
-
-
33745278855
-
Computational redesign of endonuclease DNAbinding and cleavage specificity
-
Ashworth J, Havranek JJ, Duarte CM, et al. (2006) Computational redesign of endonuclease DNAbinding and cleavage specificity. Nature 441: 656-59.
-
(2006)
Nature
, vol.441
, pp. 656-659
-
-
Ashworth, J.1
Havranek, J.J.2
Duarte, C.M.3
-
8
-
-
0036168937
-
Engineering polydactyl zinc-finger transcription factors
-
Beerli RR, Barbas CF. (2002) Engineering polydactyl zinc-finger transcription factors. Nat Biotechnol 20: 130-41.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 130-141
-
-
Beerli, R.R.1
Barbas, C.F.2
-
9
-
-
0029059329
-
Prokaryotic introns and inteins: A panoply of form and function
-
Belfort M, Reaban ME, Coetzee T, Dalgaard JZ. (1995) Prokaryotic introns and inteins: a panoply of form and function. J Bacter 177: 3897-903.
-
(1995)
J Bacter
, vol.177
, pp. 3897-3903
-
-
Belfort, M.1
Reaban, M.E.2
Coetzee, T.3
Dalgaard, J.Z.4
-
10
-
-
0030812487
-
Homing endonucleases-keeping the house in order
-
Belfort M, Roberts RJ. (1997) Homing endonucleases-keeping the house in order. Nucl Acids Res 25: 3379-88.
-
(1997)
Nucl Acids Res
, vol.25
, pp. 3379-3388
-
-
Belfort, M.1
Roberts, R.J.2
-
11
-
-
0029772623
-
Recombinase-mediated gene therapy: Strategies based on Lesch-Nyhan mutants for gene repair/inactivation using human RAD51 nucleoprotein filaments
-
Bertolotti R. (1996) Recombinase-mediated gene therapy: strategies based on Lesch-Nyhan mutants for gene repair/inactivation using human RAD51 nucleoprotein filaments. Biogenic Amines 12: 487-98.
-
(1996)
Biogenic Amines
, vol.12
, pp. 487-498
-
-
Bertolotti, R.1
-
12
-
-
0037510038
-
Enhancing gene targeting with designed zinc finger nucleases
-
Bibikova M, Beumer K, Trautman JK, Carroll D. (2003) Enhancing gene targeting with designed zinc finger nucleases. Science 300: 764.
-
(2003)
Science
, vol.300
, pp. 764
-
-
Bibikova, M.1
Beumer, K.2
Trautman, J.K.3
Carroll, D.4
-
13
-
-
0034749283
-
Stimulation of homologous recombination through targeted cleavage by chimeric nucleases
-
Bibikova M, Carroll D, Segal DJ, et al. (2001) Stimulation of homologous recombination through targeted cleavage by chimeric nucleases. Mol Cell Biol 21: 289-97.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 289-297
-
-
Bibikova, M.1
Carroll, D.2
Segal, D.J.3
-
14
-
-
0346030573
-
Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing cofator
-
Bolduc JM, Spiegel PC, Chatterjee P, et al. (2003) Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing cofator. Genes Dev 17: 2875-88.
-
(2003)
Genes Dev
, vol.17
, pp. 2875-2888
-
-
Bolduc, J.M.1
Spiegel, P.C.2
Chatterjee, P.3
-
15
-
-
0036890441
-
Cutting-edge technology: IV. Genomic engineering for studies of the gastrointestinal tract in mice
-
Bullard DC, Weaver CT. (2002) Cutting-edge technology: IV. Genomic engineering for studies of the gastrointestinal tract in mice. Am J Physiol Gastrointest Liver Physiol 283: G1232-37.
-
(2002)
Am J Physiol Gastrointest Liver Physiol
, vol.283
, pp. G1232-G1237
-
-
Bullard, D.C.1
Weaver, C.T.2
-
16
-
-
0035912721
-
Exploring the DNA-binding specificities of zinc fingers with DNA microarrays
-
Bulyk ML, Huang XH, Choo Y, Church GM. (2001) Exploring the DNA-binding specificities of zinc fingers with DNA microarrays. Proc Natl Acad Sci USA 98: 7158-63.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 7158-7163
-
-
Bulyk, M.L.1
Huang, X.H.2
Choo, Y.3
Church, G.M.4
-
17
-
-
0038027293
-
Site-specific selfish genes as tools for the control and genetic engineering of natural populations
-
Burt A. (2003) Site-specific selfish genes as tools for the control and genetic engineering of natural populations. Proc R Soc Lond B Biol Sci 270: 921-28.
-
(2003)
Proc R Soc Lond B Biol Sci
, vol.270
, pp. 921-928
-
-
Burt, A.1
-
19
-
-
29144460892
-
In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination
-
Chames P, Epinat JC, Guillier S, et al. (2005) In vivo selection of engineered homing endonucleases using double-strand break induced homologous recombination. Nucl Acids Res 33: e178.
-
(2005)
Nucl Acids Res
, vol.33
, pp. e178
-
-
Chames, P.1
Epinat, J.C.2
Guillier, S.3
-
20
-
-
30144436350
-
Genetically engineered cytoplasmic male sterility
-
Chase CD. (2006) Genetically engineered cytoplasmic male sterility. Trends Plant Sci 11: 7-9.
-
(2006)
Trends Plant Sci
, vol.11
, pp. 7-9
-
-
Chase, C.D.1
-
21
-
-
33646469805
-
Analysis of the symmetric metaldependent I-CreI homing endonuclease mechanism
-
Chevalier B, Sussman D, Otis C, et al. (2004) Analysis of the symmetric metaldependent I-CreI homing endonuclease mechanism. Biochemistry 43: 4015-26.
-
(2004)
Biochemistry
, vol.43
, pp. 4015-4026
-
-
Chevalier, B.1
Sussman, D.2
Otis, C.3
-
22
-
-
0038061526
-
FlexibleDNAtarget site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI
-
Chevalier B, Turmel M, Lemieux C, et al. (2003) FlexibleDNAtarget site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI. J Mol Biol 329: 253-69.
-
(2003)
J Mol Biol
, vol.329
, pp. 253-269
-
-
Chevalier, B.1
Turmel, M.2
Lemieux, C.3
-
23
-
-
0036810246
-
Design, activity and structure of a highly specific artificial endonuclease
-
Chevalier BS, Kortemme T, Chadsey MS, et al. (2002) Design, activity and structure of a highly specific artificial endonuclease. Mol Cell 10: 895-905.
-
(2002)
Mol Cell
, vol.10
, pp. 895-905
-
-
Chevalier, B.S.1
Kortemme, T.2
Chadsey, M.S.3
-
24
-
-
0035066732
-
The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites
-
Chevalier BS, Monnat RJ Jr, Stoddard BL. (2001) The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites. Nat Struct Biol 8: 312-16.
-
(2001)
Nat Struct Biol
, vol.8
, pp. 312-316
-
-
Chevalier, B.S.1
Monnat, R.J.2
Stoddard, B.L.3
-
25
-
-
0035883706
-
Homingendonucleases: Structural and functional insight into the catalysts of intron/intein mobility
-
Chevalier BS, Stoddard BL. (2001) Homingendonucleases: structural and functional insight into the catalysts of intron/intein mobility. Nucl Acids Res 29: 3757-74.
-
(2001)
Nucl Acids Res
, vol.29
, pp. 3757-3774
-
-
Chevalier, B.S.1
Stoddard, B.L.2
-
27
-
-
22744443611
-
Site-directed genome modification: Derivatives of DNA-modifying enzymes as targeting tools
-
Coates CJ, Kaminski JM, Summers JB, et al. (2005) Site-directed genome modification: derivatives of DNA-modifying enzymes as targeting tools. Trends Biotechnol 23: 407-19.
-
(2005)
Trends Biotechnol
, vol.23
, pp. 407-419
-
-
Coates, C.J.1
Kaminski, J.M.2
Summers, J.B.3
-
28
-
-
0023058299
-
Universal code equivalent of a yeast mitochondrial intron reading frame is expressed into E. coli as a specific double strand endonuclease
-
Colleaux L, D’Auriol L, Betermier M, et al. (1986) Universal code equivalent of a yeast mitochondrial intron reading frame is expressed into E. coli as a specific double strand endonuclease. Cell 44: 521-33.
-
(1986)
Cell
, vol.44
, pp. 521-533
-
-
Colleaux, L.1
D’Auriol, L.2
Betermier, M.3
-
30
-
-
0027999532
-
Purification and characterization of two forms of I-DmoI, a thermophilic site-specific endonuclease encoded by an archaeal intron
-
Dalgaard JZ, Garrett RA, Belfort M. (1994) Purification and characterization of two forms of I-DmoI, a thermophilic site-specific endonuclease encoded by an archaeal intron. J Biol Chem 269: 28885-92.
-
(1994)
J Biol Chem
, vol.269
, pp. 28885-28892
-
-
Dalgaard, J.Z.1
Garrett, R.A.2
Belfort, M.3
-
31
-
-
0030729344
-
Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family
-
Dalgaard JZ, Klar AJ, Moser MJ, et al. (1997) Statistical modeling and analysis of the LAGLIDADG family of site-specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family. Nucl Acids Res 25: 4626-38.
-
(1997)
Nucl Acids Res
, vol.25
, pp. 4626-4638
-
-
Dalgaard, J.Z.1
Klar, A.J.2
Moser, M.J.3
-
32
-
-
0024966052
-
Site-specific DNA endonuclease and RNA maturase activities of two homologous intron-encoded proteins from yeast mitochondria
-
Delahodde A, Goguel V, Becam AM, et al. (1989) Site-specific DNA endonuclease and RNA maturase activities of two homologous intron-encoded proteins from yeast mitochondria. Cell 56: 431-41.
-
(1989)
Cell
, vol.56
, pp. 431-441
-
-
Delahodde, A.1
Goguel, V.2
Becam, A.M.3
-
33
-
-
0023630807
-
Targetted correction of a mutant HPRT gene in mouse embryonic stem cells
-
Doetschman T, Gregg RG, Maeda N, et al. (1987) Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature 330: 576-78.
-
(1987)
Nature
, vol.330
, pp. 576-578
-
-
Doetschman, T.1
Gregg, R.G.2
Maeda, N.3
-
34
-
-
33644507991
-
Directed evolution and substrate specificity profile of homing endonuclease I-SceI
-
Doyon JB, Pattanayak V, Meyer CB, Liu DR. (2006) Directed evolution and substrate specificity profile of homing endonuclease I-SceI. J Am Chem Soc 128: 2477-84.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 2477-2484
-
-
Doyon, J.B.1
Pattanayak, V.2
Meyer, C.B.3
Liu, D.R.4
-
35
-
-
0030611387
-
Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity
-
Duan X, Gimble FS, Quiocho FA. (1997) Crystal structure of PI-SceI, a homing endonuclease with protein splicing activity. Cell 89: 555-64.
-
(1997)
Cell
, vol.89
, pp. 555-564
-
-
Duan, X.1
Gimble, F.S.2
Quiocho, F.A.3
-
36
-
-
0018903049
-
Sequence of the intron and flanking exons of the mitochondrial 21S rRNA gene of yeast strains having different alleles at the omega and rib-1 loci
-
Dujon B. (1980) Sequence of the intron and flanking exons of the mitochondrial 21S rRNA gene of yeast strains having different alleles at the omega and rib-1 loci. Cell 20: 185-97.
-
(1980)
Cell
, vol.20
, pp. 185-197
-
-
Dujon, B.1
-
37
-
-
0024446859
-
Group I introns as mobile genetic elements: Facts and mechanistic speculations - a review
-
Dujon B. (1989) Group I introns as mobile genetic elements: facts and mechanistic speculations - a review. Gene 82: 91-114.
-
(1989)
Gene
, vol.82
, pp. 91-114
-
-
Dujon, B.1
-
38
-
-
0024418461
-
Mobile introns: Definition of terms and recommended nomenclature
-
Dujon B, Belfort M, Butow RA, et al. (1989) Mobile introns: definition of terms and recommended nomenclature. Gene 82: 115-18.
-
(1989)
Gene
, vol.82
, pp. 115-118
-
-
Dujon, B.1
Belfort, M.2
Butow, R.A.3
-
39
-
-
0027396921
-
Characterization of the cleavage site and the recognition sequence of the I-CreI DNAendonuclease encoded by the chloroplast ribosomal intron of Chlamydomonas reinhardtii
-
Durrenberger F, Rochaix J-D. (1993) Characterization of the cleavage site and the recognition sequence of the I-CreI DNAendonuclease encoded by the chloroplast ribosomal intron of Chlamydomonas reinhardtii. Mol Gen Genet 236: 409-14.
-
(1993)
Mol Gen Genet
, vol.236
, pp. 409-414
-
-
Durrenberger, F.1
Rochaix, J.-D.2
-
40
-
-
0038268049
-
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells
-
Epinat JC, Arnould S, Chames P, et al. (2003) A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells. Nucl Acids Res 31: 2952-62.
-
(2003)
Nucl Acids Res
, vol.31
, pp. 2952-2962
-
-
Epinat, J.C.1
Arnould, S.2
Chames, P.3
-
41
-
-
0036404911
-
Creation of an artificial bifunctional intein by grafting a homing endonuclease into a mini-intein
-
Fitzsimons-Hall M, Noren CJ, Perler FB, Schildkraut I. (2002) Creation of an artificial bifunctional intein by grafting a homing endonuclease into a mini-intein. J Mol Biol 323: 173-79.
-
(2002)
J Mol Biol
, vol.323
, pp. 173-179
-
-
Fitzsimons-Hall, M.1
Noren, C.J.2
Perler, F.B.3
Schildkraut, I.4
-
42
-
-
0034972429
-
A comprehensive characterization of a group IB intron and its encoded maturase reveals that protein-assisted splicing requires an almost intact intron RNA
-
Geese WJ, Waring RB. (2001) A comprehensive characterization of a group IB intron and its encoded maturase reveals that protein-assisted splicing requires an almost intact intron RNA. J Mol Biol 308: 609-22.
-
(2001)
J Mol Biol
, vol.308
, pp. 609-622
-
-
Geese, W.J.1
Waring, R.B.2
-
43
-
-
33745034707
-
Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors
-
Ghatge M, Palaniappan N, Das Choudhuri S, Reynolds K. (2006) Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors. J Ind Microbiol Biotechnol 33: 589-99.
-
(2006)
J Ind Microbiol Biotechnol
, vol.33
, pp. 589-599
-
-
Ghatge, M.1
Palaniappan, N.2
Das Choudhuri, S.3
Reynolds, K.4
-
44
-
-
0344441707
-
Assessing the plasticity of DNAtarget site recognition of the PI-SceI homing endonuclease using a bacterial two-hybrid selection system
-
Gimble FS, Moure CM, Posey KL. (2003) Assessing the plasticity of DNAtarget site recognition of the PI-SceI homing endonuclease using a bacterial two-hybrid selection system. J Mol Biol 334: 993-1008.
-
(2003)
J Mol Biol
, vol.334
, pp. 993-1008
-
-
Gimble, F.S.1
Moure, C.M.2
Posey, K.L.3
-
46
-
-
33744781256
-
Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break
-
Gouble A, Smith J, Bruneau S, et al. (2006) Efficient in toto targeted recombination in mouse liver by meganuclease-induced double-strand break. J Gene Med 8: 616-22.
-
(2006)
J Gene Med
, vol.8
, pp. 616-622
-
-
Gouble, A.1
Smith, J.2
Bruneau, S.3
-
47
-
-
33745755929
-
Gene therapy progress and prospects: Cystic fibrosis
-
Griesenbach U, Geddes DM, Alton EW. (2006) Gene therapy progress and prospects: cystic fibrosis. Gene Ther 13: 1061-67.
-
(2006)
Gene Ther
, vol.13
, pp. 1061-1067
-
-
Griesenbach, U.1
Geddes, D.M.2
Alton, E.W.3
-
48
-
-
0036551212
-
An in vivo selection system for homing endonuclease activity
-
Gruen M, Chang K, Serbanescu I, Liu DR. (2002) An in vivo selection system for homing endonuclease activity. Nucl Acids Res 30: 29-34.
-
(2002)
Nucl Acids Res
, vol.30
, pp. 29-34
-
-
Gruen, M.1
Chang, K.2
Serbanescu, I.3
Liu, D.R.4
-
49
-
-
0142084745
-
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
-
Hacein-Bey-Abina S, Von Kalle C, Schmidt M, et al. (2003) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 302: 415-19.
-
(2003)
Science
, vol.302
, pp. 415-419
-
-
Hacein-Bey-Abina, S.1
Von Kalle, C.2
Schmidt, M.3
-
52
-
-
0022399493
-
An intron-encoded protein is active in a gene conversion process that spreads an intron into a mitochondrial gene
-
Jacquier A, Dujon B. (1985) An intron-encoded protein is active in a gene conversion process that spreads an intron into a mitochondrial gene. Cell 41: 383-94.
-
(1985)
Cell
, vol.41
, pp. 383-394
-
-
Jacquier, A.1
Dujon, B.2
-
53
-
-
0030896554
-
Ho endonuclease cleaves MAT DNA in vitro by an inefficient stoichiometric reaction mechanism
-
Jin Y, Binkowski G, Simon LD, Norris D. (1997) Ho endonuclease cleaves MAT DNA in vitro by an inefficient stoichiometric reaction mechanism. J Biol Chem 272: 7352-59.
-
(1997)
J Biol Chem
, vol.272
, pp. 7352-7359
-
-
Jin, Y.1
Binkowski, G.2
Simon, L.D.3
Norris, D.4
-
54
-
-
0032185110
-
DNArecognition and cleavage by the LAGLIDADG homing endonuclease I- CreI
-
Jurica MS, Monnat RJ Jr, Stoddard BL. (1998) DNArecognition and cleavage by the LAGLIDADG homing endonuclease I- CreI. Mol Cell 2: 469-76.
-
(1998)
Mol Cell
, vol.2
, pp. 469-476
-
-
Jurica, M.S.1
Monnat, R.J.2
Stoddard, B.L.3
-
55
-
-
22744459066
-
Site-directed genome modification: Nucleic acid and protein modules for targeted integration and gene correction
-
Kolb AF, Coates CJ, Kaminski JM, et al. (2005) Site-directed genome modification: nucleic acid and protein modules for targeted integration and gene correction. Trends Biotechnol 23: 399-406.
-
(2005)
Trends Biotechnol
, vol.23
, pp. 399-406
-
-
Kolb, A.F.1
Coates, C.J.2
Kaminski, J.M.3
-
56
-
-
0024409025
-
Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination
-
Koller BH, Smithies O. (1989) Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proc Natl Acad Sci USA 86: 8932-35.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 8932-8935
-
-
Koller, B.H.1
Smithies, O.2
-
57
-
-
0021053220
-
Asite-specific endonuclease essential for mating-type switching in Saccharomyces cerevisiae
-
Kostriken R, Strathern JN, Klar AJ, et al. (1983) Asite-specific endonuclease essential for mating-type switching in Saccharomyces cerevisiae. Cell 35: 167-74.
-
(1983)
Cell
, vol.35
, pp. 167-174
-
-
Kostriken, R.1
Strathern, J.N.2
Klar, A.J.3
-
58
-
-
33748523075
-
Recognizing DNA
-
Lavery R. (2005) Recognizing DNA. Q Rev Biophys 38: 339-44.
-
(2005)
Q Rev Biophys
, vol.38
, pp. 339-344
-
-
Lavery, R.1
-
59
-
-
0024600410
-
Protein encoded by the third intron of cytochrome b gene in Saccharomyces cerevisiae is an mRNAmaturase. Analysis of mitochondrial mutants, RNA transcripts proteins and evolutionary relationships
-
Lazowska J, Claisse M, Gargouri A, et al. (1989) Protein encoded by the third intron of cytochrome b gene in Saccharomyces cerevisiae is an mRNAmaturase. Analysis of mitochondrial mutants, RNA transcripts proteins and evolutionary relationships. J Mol Biol 205: 275-89.
-
(1989)
J Mol Biol
, vol.205
, pp. 275-289
-
-
Lazowska, J.1
Claisse, M.2
Gargouri, A.3
-
60
-
-
0019127414
-
Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron
-
Lazowska J, Jacq C, Slonimski PP. (1980) Sequence of introns and flanking exons in wild-type and box3 mutants of cytochrome b reveals an interlaced splicing protein coded by an intron. Cell 22: 333-48.
-
(1980)
Cell
, vol.22
, pp. 333-348
-
-
Lazowska, J.1
Jacq, C.2
Slonimski, P.P.3
-
62
-
-
29744454288
-
Successful correction of the human Cooley’s anemia beta-thalassemia major phenotype using a lentiviral vector flanked by the chicken hypersensitive site 4 chromatin insulator
-
Malik P, Arumugam PI, Yee JK, Puthenveetil G. (2005) Successful correction of the human Cooley’s anemia beta-thalassemia major phenotype using a lentiviral vector flanked by the chicken hypersensitive site 4 chromatin insulator. Ann N Y Acad Sci 1054: 238-49.
-
(2005)
Ann N Y Acad Sci
, vol.1054
, pp. 238-249
-
-
Malik, P.1
Arumugam, P.I.2
Yee, J.K.3
Puthenveetil, G.4
-
63
-
-
0347003513
-
The burden of genetic disease on inpatient care in a children’s hospital
-
McCandless SE, Brunger JW, Cassidy SB. (2004) The burden of genetic disease on inpatient care in a children’s hospital. Am J Hum Genet 74: 121-27.
-
(2004)
Am J Hum Genet
, vol.74
, pp. 121-127
-
-
McCandless, S.E.1
Brunger, J.W.2
Cassidy, S.B.3
-
64
-
-
0036786717
-
Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence
-
Moure C, Gimble F, Quiocho F. (2002) Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence. Nat Struct Biol 9: 764-70.
-
(2002)
Nat Struct Biol
, vol.9
, pp. 764-770
-
-
Moure, C.1
Gimble, F.2
Quiocho, F.3
-
65
-
-
0242636378
-
The crystal structure of the gene targeting homing endonuclease I-SceI reveals the origins of its target site specificity
-
Moure CM, Gimble FS, Quiocho FA. (2003) The crystal structure of the gene targeting homing endonuclease I-SceI reveals the origins of its target site specificity. J Mol Biol 334: 685-96.
-
(2003)
J Mol Biol
, vol.334
, pp. 685-696
-
-
Moure, C.M.1
Gimble, F.S.2
Quiocho, F.A.3
-
67
-
-
0034682882
-
Geometric analysis and comparison of protein-DNA interfaces: Why is there no simple code for recognition?
-
Pabo CO, Nekludova L. (2000) Geometric analysis and comparison of protein-DNA interfaces: Why is there no simple code for recognition? J Mol Biol 301: 597-624.
-
(2000)
J Mol Biol
, vol.301
, pp. 597-624
-
-
Pabo, C.O.1
Nekludova, L.2
-
68
-
-
33847246298
-
Meganucleases and DNA double-strand breakinduced recombination: Perspectives for gene therapy
-
Pâques F, Duchateau P. (2007) Meganucleases and DNA double-strand breakinduced recombination: perspectives for gene therapy. Curr Gene Ther 7: 49-66.
-
(2007)
Curr Gene Ther
, vol.7
, pp. 49-66
-
-
Pâques, F.1
Duchateau, P.2
-
69
-
-
0027227703
-
Asymmetrical recognition and activity of the I-SceI endonuclease on its site and on intron-exon junctions
-
Perrin A, Buckle M, Dujon B. (1993) Asymmetrical recognition and activity of the I-SceI endonuclease on its site and on intron-exon junctions. EMBOJ 12: 2939-47.
-
(1993)
EMBOJ
, vol.12
, pp. 2939-2947
-
-
Perrin, A.1
Buckle, M.2
Dujon, B.3
-
70
-
-
30344473645
-
Mammalian gene targeting with designed zinc finger nucleases
-
Porteus MH. (2006) Mammalian gene targeting with designed zinc finger nucleases. Mol Ther 13: 438-46.
-
(2006)
Mol Ther
, vol.13
, pp. 438-446
-
-
Porteus, M.H.1
-
71
-
-
0038523969
-
Chimeric nucleases stimulate gene targeting in human cells
-
Porteus MH, Baltimore D. (2003) Chimeric nucleases stimulate gene targeting in human cells. Science 300: 763.
-
(2003)
Science
, vol.300
, pp. 763
-
-
Porteus, M.H.1
Baltimore, D.2
-
72
-
-
0345504146
-
Markerless gene replacement in Escherichia coli stimulated by a double-strand break in the chromosome
-
Posfai G, Kolisnychenko V, Bereczki Z, Blattner FR. (1999) Markerless gene replacement in Escherichia coli stimulated by a double-strand break in the chromosome. Nucl Acids Res 27: 4409-15.
-
(1999)
Nucl Acids Res
, vol.27
, pp. 4409-4415
-
-
Posfai, G.1
Kolisnychenko, V.2
Bereczki, Z.3
Blattner, F.R.4
-
73
-
-
9444281434
-
Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector
-
Puthenveetil G, Scholes J, Carbonell D, et al. (2004) Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector. Blood 104: 3445-53.
-
(2004)
Blood
, vol.104
, pp. 3445-3453
-
-
Puthenveetil, G.1
Scholes, J.2
Carbonell, D.3
-
74
-
-
33750209424
-
Homing endonuclease I-CreI derivatives with novel DNAtarget specificities
-
Rosen LE, Morrison HA, Masri S, et al. (2006) Homing endonuclease I-CreI derivatives with novel DNAtarget specificities. Nucl Acids Res 34: 4791-800.
-
(2006)
Nucl Acids Res
, vol.34
, pp. 4791-4800
-
-
Rosen, L.E.1
Morrison, H.A.2
Masri, S.3
-
75
-
-
33646779583
-
Recent advances in globin gene transfer for the treatment of beta-thalassemia and sickle cell anemia
-
Sadelain M. (2006) Recent advances in globin gene transfer for the treatment of beta-thalassemia and sickle cell anemia. Curr Opin Hematol 13: 142-48.
-
(2006)
Curr Opin Hematol
, vol.13
, pp. 142-148
-
-
Sadelain, M.1
-
76
-
-
30544436003
-
A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference
-
Samakoglu S, Lisowski L, Budak-Alpdogan T, et al. (2006) A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference. Nat Biotechnol 24: 89-94.
-
(2006)
Nat Biotechnol
, vol.24
, pp. 89-94
-
-
Samakoglu, S.1
Lisowski, L.2
Budak-Alpdogan, T.3
-
78
-
-
0028280890
-
A mitochondrial group-I intron in fission yeast encodes a maturase and is mobile in crosses
-
Schafer B, Wilde B, Massardo DR, et al. (1994) A mitochondrial group-I intron in fission yeast encodes a maturase and is mobile in crosses. Curr Genet 25: 336-41.
-
(1994)
Curr Genet
, vol.25
, pp. 336-341
-
-
Schafer, B.1
Wilde, B.2
Massardo, D.R.3
-
79
-
-
0344839044
-
Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins
-
Segal DJ, Beerli RR, Blancafort P, et al. (2003) Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins. Biochemistry 42: 2137-48.
-
(2003)
Biochemistry
, vol.42
, pp. 2137-2148
-
-
Segal, D.J.1
Beerli, R.R.2
Blancafort, P.3
-
80
-
-
0032981699
-
Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNAtarget sequences
-
Segal DJ, Dreier B, Beerli RR, Barbas CF. (1999) Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNAtarget sequences. Proc Natl Acad Sci USA 96: 2758-63.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 2758-2763
-
-
Segal, D.J.1
Dreier, B.2
Beerli, R.R.3
Barbas, C.F.4
-
81
-
-
0036714153
-
Mutations altering the cleavage specificity of a homing endonuclease
-
Seligman L, Chisholm KM, Chevalier BS, et al. (2002) Mutations altering the cleavage specificity of a homing endonuclease. Nucl Acids Res 30: 3870-79.
-
(2002)
Nucl Acids Res
, vol.30
, pp. 3870-3879
-
-
Seligman, L.1
Chisholm, K.M.2
Chevalier, B.S.3
-
82
-
-
3042574822
-
Analysis of theLAGLIDADGinterface of the monomeric homing endonuclease I-DmoI
-
Silva GH, Belfort M. (2004) Analysis of theLAGLIDADGinterface of the monomeric homing endonuclease I-DmoI. Nucl Acids Res 32: 3156-68.
-
(2004)
Nucl Acids Res
, vol.32
, pp. 3156-3168
-
-
Silva, G.H.1
Belfort, M.2
-
83
-
-
33746820661
-
From monomeric to homodimeric endonucleases and back: Engineering novel specificity of LAGLIDADG enzymes
-
Silva GH, Belfort M, Wende W, Pingoud A. (2006) From monomeric to homodimeric endonucleases and back: engineering novel specificity of LAGLIDADG enzymes. J Mol Biol 361: 744-54.
-
(2006)
J Mol Biol
, vol.361
, pp. 744-754
-
-
Silva, G.H.1
Belfort, M.2
Wende, W.3
Pingoud, A.4
-
84
-
-
0642367806
-
Newtypes of conserved sequence domains in DNAbinding regions of homing endonucleases
-
Sitbon E, Pietrokovski S. (2003) Newtypes of conserved sequence domains in DNAbinding regions of homing endonucleases. Trends Biochem Sci 28: 473-77.
-
(2003)
Trends Biochem Sci
, vol.28
, pp. 473-477
-
-
Sitbon, E.1
Pietrokovski, S.2
-
85
-
-
0034283804
-
Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains
-
Smith J, Bibikova M, Whitby FG, et al. (2000) Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains. Nucl Acids Res 28: 3361-69.
-
(2000)
Nucl Acids Res
, vol.28
, pp. 3361-3369
-
-
Smith, J.1
Bibikova, M.2
Whitby, F.G.3
-
86
-
-
33845914020
-
Acombinatorial approach to create artificial homing endonucleases cleaving chosen sequences
-
Smith J, Grizot S, Arnould S, et al. (2006) Acombinatorial approach to create artificial homing endonucleases cleaving chosen sequences. Nucl Acids Res 34: e149.
-
(2006)
Nucl Acids Res
, vol.34
, pp. e149
-
-
Smith, J.1
Grizot, S.2
Arnould, S.3
-
87
-
-
33646363729
-
The structure of I-CeuI homing endonuclease: Evolving asymmetric DNArecognition from a symmetric protein scaffold
-
Spiegel PC, Chevalier B, Sussman D, et al. (2006) The structure of I-CeuI homing endonuclease: evolving asymmetric DNArecognition from a symmetric protein scaffold. Structure 14: 869-80.
-
(2006)
Structure
, vol.14
, pp. 869-880
-
-
Spiegel, P.C.1
Chevalier, B.2
Sussman, D.3
-
88
-
-
4143093249
-
Chimeras of the homing endonuclease PI-SceI and the homologous Candida tropicalis intein: A study to explore the possibility of exchanging DNA-binding modules to obtain highly speciric endonucleases with altered specificity
-
Steuer S, Pingoud V, Pingoud A, Wende W. (2004) Chimeras of the homing endonuclease PI-SceI and the homologous Candida tropicalis intein: a study to explore the possibility of exchanging DNA-binding modules to obtain highly speciric endonucleases with altered specificity. Chembiochem 5: 206-13.
-
(2004)
Chembiochem
, vol.5
, pp. 206-213
-
-
Steuer, S.1
Pingoud, V.2
Pingoud, A.3
Wende, W.4
-
89
-
-
33644756595
-
Homing endonuclease structure and function
-
Stoddard BL. (2005) Homing endonuclease structure and function. Q Rev Biophys 38: 49-95.
-
(2005)
Q Rev Biophys
, vol.38
, pp. 49-95
-
-
Stoddard, B.L.1
-
90
-
-
4143097044
-
Isolation and characterization of new homing endonuclease specificities at individual target site positions
-
Sussman DJ, Chadsey M, Fauce S, et al. (2004) Isolation and characterization of new homing endonuclease specificities at individual target site positions. J Mol Biol 342: 31-41.
-
(2004)
J Mol Biol
, vol.342
, pp. 31-41
-
-
Sussman, D.J.1
Chadsey, M.2
Fauce, S.3
-
91
-
-
23844507993
-
Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice
-
Themis M, Waddington SN, Schmidt M, et al. (2005) Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice. Mol Ther 12: 763-71.
-
(2005)
Mol Ther
, vol.12
, pp. 763-771
-
-
Themis, M.1
Waddington, S.N.2
Schmidt, M.3
-
92
-
-
0026669635
-
Cleavage and recognition pattern of a double-strand-specific endonuclease (I-CreI) encoded by the chloroplast 23S rRNA intron of Chlamydomonas reinhardtii
-
Thompson AJ, Yuan X, Kudlicki W, Herrin DL. (1992) Cleavage and recognition pattern of a double-strand-specific endonuclease (I-CreI) encoded by the chloroplast 23S rRNA intron of Chlamydomonas reinhardtii. Gene 119: 247-51.
-
(1992)
Gene
, vol.119
, pp. 247-251
-
-
Thompson, A.J.1
Yuan, X.2
Kudlicki, W.3
Herrin, D.L.4
-
93
-
-
33748939587
-
Gene therapy: X-SCID transgene leukaemogenicity
-
Thrasher AJ, Gaspar HB, Baum C, et al. (2006) Gene therapy: X-SCID transgene leukaemogenicity. Nature 443: E5-E6; discussion E6-E7.
-
(2006)
Nature
, vol.443
-
-
Thrasher, A.J.1
Gaspar, H.B.2
Baum, C.3
-
94
-
-
27944487465
-
Towards targeted mutagenesis and gene replacement in plants
-
Tzfira T, White C. (2005) Towards targeted mutagenesis and gene replacement in plants. Trends Biotechnol 23: 567-69.
-
(2005)
Trends Biotechnol
, vol.23
, pp. 567-569
-
-
Tzfira, T.1
White, C.2
-
95
-
-
18944373328
-
Highly efficient endogenous human gene correction using designed zinc-finger nucleases
-
Urnov FD, Miller JC, Lee YL, et al. (2005) Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 435: 646-51.
-
(2005)
Nature
, vol.435
, pp. 646-651
-
-
Urnov, F.D.1
Miller, J.C.2
Lee, Y.L.3
-
97
-
-
34250316583
-
Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases
-
Volna P, Jarjour J, Baxter S, et al. (2007) Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases. Nucl Acids Res 35: 2748-58.
-
(2007)
Nucl Acids Res
, vol.35
, pp. 2748-2758
-
-
Volna, P.1
Jarjour, J.2
Baxter, S.3
-
99
-
-
0030595337
-
Structural classification of HTH DNA-binding domains and protein-DNA interaction modes
-
Wintjens R, Rooman M. (1996) Structural classification of HTH DNA-binding domains and protein-DNA interaction modes. J Mol Biol 262: 294-313.
-
(1996)
J Mol Biol
, vol.262
, pp. 294-313
-
-
Wintjens, R.1
Rooman, M.2
-
101
-
-
0034661843
-
Combining structure-based design with phage display to create new Cys2His2 zinc finger dimers
-
Wolfe SA, Ramm EI, Pabo CO. (2000b) Combining structure-based design with phage display to create new Cys2His2 zinc finger dimers. Structure 8: 739-50.
-
(2000)
Structure
, vol.8
, pp. 739-750
-
-
Wolfe, S.A.1
Ramm, E.I.2
Pabo, C.O.3
|