Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 8, 2009, Pages 2333-2337

  Lin, Ronghui ^a   Johnson, Sigmond G ^a   Connolly, Peter J ^a   Wetter, Steven K ^a   Binnun, Eva ^a   Hughes, Terry V ^a   Murray, William V ^a   Pandey, Niranjan B ^a   Moreno Mazza, Sandra J ^a   Adams, Mary ^a   Fuentes Pesquera, Angel R ^a   Middleton, Steven A ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

2,7 Diamino thiazolo 4,5 d pyrimidine analogues; EGFR inhibitors; Epidermal growth factor receptor tyrosine kinase inhibitors

Indexed keywords

2,7 DIAMINOTHIAZOLO[4,5 D]PYRIMIDINE DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; LAPATINIB; PROTEIN TYROSINE KINASE INHIBITOR; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; GENE OVEREXPRESSION; IN VITRO STUDY; NONHUMAN; RAT;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 63149166648     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.067     Document Type: Article

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