Myelination in the absence of UDP-galactose: Ceramide galactosyl-transferase and fatty acid 2 -hydroxylase

BMC Neuroscience

Volumn 12, Issue , 2011, Pages

  Meixner, Marion ^a   Jungnickel, Julia ^b   Grothe, Claudia ^b   Gieselmann, Volkmar ^a   Eckhardt, Matthias ^a  

^a UNIVERSITY OF BONN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE GLUCOSYLTRANSFERASE; FATTY ACID; GALACTOSE; MYELIN; OXYGENASE; SPHINGOLIPID; SPHINGOMYELIN; URIDINE DIPHOSPHATE; AMIDASE; CERAMIDE; FATTY ACID AMIDASE; FATTY-ACID AMIDE HYDROLASE; GALACTOSYLCERAMIDE; GANGLIOSIDE; MEMBRANE LIPID; N ACYLSPHINGOSINE GALACTOSYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE DELETION; MOUSE; MYELINATION; NERVE FIBER; NONHUMAN; PHENOTYPE; SPINAL CORD; ANIMAL; GENETICS; HISTOLOGY; LIPID METABOLISM; MALE; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOUSE MUTANT; MYELIN SHEATH; NERVOUS SYSTEM; THIN LAYER CHROMATOGRAPHY; ULTRASTRUCTURE; UPREGULATION;

AMIDOHYDROLASES; ANIMALS; CERAMIDES; CHROMATOGRAPHY, THIN LAYER; GALACTOSYLCERAMIDES; GANGLIOSIDES; LIPID METABOLISM; MALE; MEMBRANE LIPIDS; MICE; MICE, KNOCKOUT; MYELIN SHEATH; N-ACYLSPHINGOSINE GALACTOSYLTRANSFERASE; NERVOUS SYSTEM; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; UP-REGULATION;

EID: 79952097851     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-12-22     Document Type: Article

References (30)

1. Norton W, Cammer W. Isolation and characterization of myelin. Myelin 1984, 147-180. New York: Plenum Press, Morell P.
2. Eckhardt M. The role and metabolism of sulfatide in the nervous system. Mol. Neurobiol 2008, 37:93-103. 10.1007/s12035-008-8022-3, 18465098.
3. Coetzee T, Fujita N, Dupree J, Shi R, Blight A, Suzuki K, Suzuki K, Popko B. Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell 1996, 86:209-219. 10.1016/S0092-8674(00)80093-8, 8706126.
4. Bosio A, Binczek E, Stoffel W. Functional breakdown of the lipid bilayer of the myelin membrane in central and peripheral nervous system by disrupted galactocerebroside synthesis. Proc. Natl. Acad. Sci. U. S. A 1996, 93:13280-13285. 10.1073/pnas.93.23.13280, 24084, 8917582.
5. Dupree JL, Coetzee T, Blight A, Suzuki K, Popko B. Myelin galactolipids are essential for proper node of Ranvier formation in the CNS. J. Neurosci 1998, 18:1642-1649.
6. Marcus J, Popko B. Galactolipids are molecular determinants of myelin development and axo-glial organization. Biochim. Biophys. Acta 2002, 1573:406-413.
7. Honke K, Hirahara Y, Dupree J, Suzuki K, Popko B, Fukushima K, Fukushima J, Nagasawa T, Yoshida N, Wada Y. Paranodal junction formation and spermatogenesis require sulfoglycolipids. Proc. Natl. Acad. Sci. U. S. A 2002, 99:4227-4232. 10.1073/pnas.032068299, 123630, 11917099.
8. Marcus J, Honigbaum S, Shroff S, Honke K, Rosenbluth J, Dupree JL. Sulfatide is essential for the maintenance of CNS myelin and axon structure. Glia 2006, 53:372-381. 10.1002/glia.20292, 16288467.
9. Suzuki K, Vanier MT, Coetzee T, Popko B. Drastically abnormal gluco- and galactosylceramide composition does not affect ganglioside metabolism in the brain of mice deficient in galactosylceramide synthase. Neurochem. Res 1999, 24:471-474. 10.1023/A:1022571410445, 10227678.
10. Coetzee T, Suzuki K, Popko B. New perspectives on the function of myelin galactolipids. Trends Neurosci 1998, 21:126-130. 10.1016/S0166-2236(97)01178-8, 9530920.
11. Alderson NL, Rembiesa BM, Walla MD, Bielawska A, Bielawski J, Hama H. The human FA2H gene encodes a fatty acid 2-hydroxylase. J. Biol. Chem 2004, 279:48562-48568. 10.1074/jbc.M406649200, 15337768.
12. Alderson NL, Maldonado EN, Kern MJ, Bhat NR, Hama H. FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain. J. Lipid Res 2006, 47:2772-2780. 10.1194/jlr.M600362-JLR200, 16998236.
13. Eckhardt M, Yaghootfam A, Fewou SN, Zoller I, Gieselmann V. A mammalian fatty acid hydroxylase responsible for the formation of alpha-hydroxylated galactosylceramide in myelin. Biochem. J 2005, 388:245-254. 10.1042/BJ20041451, 1186713, 15658937.
14. Maldonado EN, Alderson NL, Monje PV, Wood PM, Hama H. FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin. J. Lipid Res 2008, 49:153-161. 10.1194/jlr.M700400-JLR200, 2662131, 17901466.
15. Zöller I, Meixner M, Hartmann D, Büssow H, Meyer R, Gieselmann V, Eckhardt M. Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration. J. Neurosci 2008, 28:9741-9754.
16. Edvardson S, Hama H, Shaag A, Gomori JM, Berger I, Soffer D, Korman SH, Taustein I, Saada A, Elpeleg O. Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia. Am. J. Hum. Genet 2008, 83:643-648. 10.1016/j.ajhg.2008.10.010, 2668027, 19068277.
17. Dick KJ, Eckhardt M, Paisan-Ruiz C, Alshehhi AA, Proukakis C, Sibtain NA, Maier H, Sharifi R, Patton MA, Bashir W, Koul R, Raeburn S, Gieselmann V, Houlden H, Crosby AH. Mutation of FA2H underlies a complicated form of hereditary spastic paraplegia (SPG35). Hum. Mutat 2010, 31:E1251-E1260. 10.1002/humu.21205, 20104589.
18. Bosio A, Binczek E, Haupt WF, Stoffel W. Composition and biophysical properties of myelin lipid define the neurological defects in galactocerebroside- and sulfatide-deficient mice. J. Neurochem 1998, 70:308-315. 10.1046/j.1471-4159.1998.70010308.x, 9422376.
19. Saadat L, Dupree JL, Kilkus J, Han X, Traka M, Proia RL, Dawson G, Popko B. Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice. Glia 2010, 58:391-398. 10.1002/glia.20930, 2807477, 19705459.
20. Zöller I, Büssow H, Gieselmann V, Eckhardt M. Oligodendrocyte-specific ceramide galactosyltransferase (CGT) expression phenotypically rescues CGT-deficient mice and demonstrates that CGT activity does not limit brain galactosylceramide level. Glia 2005, 52:190-198.
21. Simons M, Kramer EM, Thiele C, Stoffel W, Trotter J. Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains. J. Cell Biol 2000, 151:143-154. 10.1083/jcb.151.1.143, 2189802, 11018060.
22. Hama H. Fatty acid 2-hydroxylation in mammalian sphingolipid biology. Biochim. Biophys. Acta 2010, 1801:405-414.
23. Ladisch S, Sweeley CC, Becker H, Gage D. Aberrant fatty acyl alpha-hydroxylation in human neuroblastoma tumor gangliosides. J. Biol. Chem 1989, 264:12097-12105.
24. van der Bijl P, Lopes-Cardozo M, van Meer G. Sorting of newly synthesized galactosphingolipids to the two surface domains of epithelial cells. J. Cell Biol 1996, 132:813-821. 10.1083/jcb.132.5.813, 2120744, 8603914.
25. Ishibashi T, Dupree JL, Ikenaka K, Hirahara Y, Honke K, Peles E, Popko B, Suzuki K, Nishino H, Baba H. A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation. J. Neurosci 2002, 22:6507-6514.
26. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol 1959, 37:911-917.
27. van Echten-Deckert G. Sphingolipid extraction and analysis by thin-layer chromatography. Methods Enzymol 2000, 312:64-79. full_text, 11070863.
28. Folch J, Lees M, Sloane GH. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem 1957, 226:497-509.
29. Norton WT, Poduslo SE. Myelination in rat brain: method of myelin isolation. J. Neurochem 1973, 21:749-757. 10.1111/j.1471-4159.1973.tb07519.x, 4271082.
30. Eckhardt M, Barth H, Blöcker D, Aktories K. Binding of Clostridium botulinum C2 toxin to asparagine-linked complex and hybrid carbohydrates. J. Biol. Chem 2000, 275:2328-2334. 10.1074/jbc.275.4.2328, 10644682.