A remarkably simple α-oximation of ketones to 1,2-dione monooximes using the chlorotrimethylsilane-isoamyl nitrite combination

Tetrahedron Letters

Volumn 44, Issue 13, 2003, Pages 2753-2755

  Mohammed, Abdulkarim H A ^a   Nagendrappa, Gopalpur ^a  

^a BANGALORE UNIVERSITY   (India)

Author keywords

1,2 diketone monooxime; Amyl nitrite; NOCl; Oximation; TMSCl

Indexed keywords

CHLOROTRIMETHYLSILANE; KETONE DERIVATIVE; NITRITE; OXIME DERIVATIVE;

ALPHA OXIMATION; ARTICLE; CHEMICAL REACTION; HYDROLYSIS; MOLECULAR STABILITY; OXIDATION; STEREOSPECIFICITY;

EID: 0037463746     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(03)00248-X     Document Type: Article

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32. 2 (20 mL) was added and the reaction worked up in the usual way. The product was eluted on a silica gel column using pet. ether (bp 50-55°C) containing 5% ethyl acetate to get pure product.