Eugenol reverses mechanical allodynia after peripheral nerve injury by inhibiting hyperpolarization-activated cyclic nucleotide-gated (HCN) channels

Pain

Volumn 152, Issue 9, 2011, Pages 2108-2116

  Yeon, Kyu Yong ^a   Chung, Gehoon ^a   Kim, Yong Ho ^a   Hwang, Jae Hong ^a   Davies, Alexander J ^a   Park, Min Kyoung ^b   Ahn, Dong Kuk ^b   Kim, Joong Soo ^a   Jung, Sung Jun ^a,c   Oh, Seog Bae ^a  

^a Seoul National University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Hanyang University   (South Korea)

Author keywords

Eugenol; HCN channels; I h; Mechanical allodynia; Neuropathic pain; Thermal hyperalgesia

Indexed keywords

CYCLIC AMP; CYCLIC NUCLEOTIDE GATED CHANNEL; CYCLIC NUCLEOTIDE GATED CHANNEL 1; CYCLIC NUCLEOTIDE GATED CHANNEL 2; EUGENOL; UNCLASSIFIED DRUG;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DOSE RESPONSE; HYPERALGESIA; HYPERPOLARIZATION; IC 50; INFRAORBITAL NERVE; MALE; NERVE POTENTIAL; NEWBORN; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; THERMAL HYPERALGESIA; TRIGEMINUS GANGLION; TRIGEMINUS NEURALGIA;

ACTION POTENTIALS; ANIMALS; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; EUGENOL; HYPERALGESIA; MALE; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; TRIGEMINAL GANGLION;

EID: 80051788881     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2011.05.018     Document Type: Article

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