Dominant-negative suppression of HCN1- and HCN2-encoded pacemaker currents by an engineered HCN1 construct: Insights into structure-function relationships and multimerization

Circulation Research

Volumn 90, Issue 12, 2002, Pages 1267-1273

  Xue, Tian ^a   Marbán, Eduardo ^a   Li, Ronald A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Coassembly; Dominant negative; HCN channels; Pacemaker; Signature motif

Indexed keywords

ALANINE; COMPLEMENTARY RNA; CYCLIC NUCLEOTIDE; GLYCYLTYROSYLGLYCINE; MEMBRANE PROTEIN; POTASSIUM CHANNEL; PROTEIN HCN1; PROTEIN HCN2; PROTEIN HCN3; PROTEIN HCN4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; HEART PACING; HYPERPOLARIZATION; ION PERMEABILITY; NONHUMAN; OOCYTE; POLYMERASE CHAIN REACTION; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN MOTIF; SINUS NODE; SITE DIRECTED MUTAGENESIS; SODIUM CURRENT; STOICHIOMETRY; VOLTAGE CLAMP; XENOPUS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL CLOCKS; CELLS, CULTURED; ELECTRIC CONDUCTIVITY; ION CHANNEL GATING; ION CHANNELS; ION TRANSPORT; MACROMOLECULAR SUBSTANCES; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; OOCYTES; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0037188937     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000024390.97889.C6     Document Type: Article

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