MK-801 increases the baseline level of anxiety in mice introduced to a spatial memory task without prior habituation

Neuropharmacology

Volumn 61, Issue 5-6, 2011, Pages 981-991

  Ennaceur, A ^a   Michalikova, S ^a,b   Van Rensburg, R ^a,b   Chazot, P L ^b  

^a UNIVERSITY OF SUNDERLAND   (United Kingdom)

^b DURHAM UNIVERSITY   (United Kingdom)

Author keywords

Anxiety; Consolidation; Dizocilpine; Habituation; Maze; NMDA; Open space; Spatial navigation

Indexed keywords

DIZOCILPINE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; C57BL 6 MOUSE; CLIMBING; CONTROLLED STUDY; ERROR; HABITUATION; LEARNING; MALE; MAZE TEST; MEMORY; MENTAL TASK; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPATIAL MEMORY; TASK PERFORMANCE; TRAINING; WORKING MEMORY;

ANIMALS; ANXIETY; DIZOCILPINE MALEATE; DRUG EVALUATION, PRECLINICAL; EXCITATORY AMINO ACID ANTAGONISTS; HABITUATION, PSYCHOPHYSIOLOGIC; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR TARGETED THERAPY; TIME FACTORS;

EID: 80051788356     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.06.027     Document Type: Article

References (113)

1. M. hlander, I. Misane, P.A. Schött, and S.O. Ögren A behavioral analysis of the spatial learning deficit induced by the NMDA receptor antagonist MK-801 (Dizocilpine) in the rat Neuropsychopharmacol. 21 1999 414 426 (Pubitemid 29333080)
2. A. Anand, D.S. Charney, D.A. Oren, R.M. Berman, X.S. Hu, A. Cappiello, and J.H. Krystal Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-d-aspartate receptor antagonists Arch. Gen. Psychiatry 57 2000 270 276 (Pubitemid 30140436)
3. S. Barak, M. Arad, A. De Levie, M.D. Black, G. Griebel, and I. Weiner Pro-cognitive and antipsychotic efficacy of the α7 nicotinic partial agonist ssr180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia Neuropsychopharmacol. 34 2009 1753 1763
4. M.E. Bardgett, R. Boeckman, D. Krochmal, H. Fernando, R. Ahrens, and J.G. Csernansky NMDA receptor blockade and hippocampal neuronal loss impair fear conditioning and position habit reversal in C57Bl/6 mice Brain Res. Bull. 60 2003 131 142 (Pubitemid 36506460)
5. R. Bernabeu, L. Bevilaqua, P. Ardenghi, E. Bromberg, P. Schmitz, M. Bianchin, I. Izquierdo, and J. Medina Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats PNAS 94 1997 7041 7046 (Pubitemid 27281987)
6. R. Bourtchouladze, T. Abel, N. Berman, R. Gordon, K. Lapidus, and E.R. Kandel Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA Learn. Mem. 5 1998 365 374 (Pubitemid 29115266)
7. A.M. Bradford, K.M. Savage, D.N. Jones, and M. Kalinichev Validation and pharmacological characterisation of MK-801-induced locomotor hyperactivity in BALB/C mice as an assay for detection of novel antipsychotics Psychopharmacol. 212 2010 155 170
8. M.A. Burman, and J.C. Gewirtz Hippocampal activity, but not plasticity, is required for early consolidation of fear conditioning with a short trace interval Eur. J. Neurosci. 25 2007 2483 2490 (Pubitemid 46625923)
9. D.P. Cain, D. Saucier, and F. Boon Testing hypotheses of spatial learning: the role of NMDA receptors and NMDA-mediated long-term potentiation Behav. Brain Res. 84 1997 179 193 (Pubitemid 27112696)
10. Z. Caramanos, and M.L. Shapiro Spatial memory and N-methyl-d-aspartate receptor antagonists APV and MK-801: memory impairments depend on familiarity with the environment, drug dose, and training duration Behav. Neurosci. 108 1994 30 43 (Pubitemid 24097742)
11. C. Castellano, A. Mele, and A. Oliverio Glutamatergic-cholinergic interaction on memory consolidation in mice Psychobiol. 24 1996 57 61 (Pubitemid 26088150)
12. W.Y. Chan, and G.P. McNally Conditioned stimulus familiarity determines effects of MK-801 on fear extinction Behav. Neurosci. 123 2009 303 314
13. E.H. Chartoff, C.L. Heusner, and R.D. Palmiter Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists Neuropsychopharmacol. 30 2005 1324 1333 (Pubitemid 40848086)
14. S. Chew, D. Vicario, and F. Nottebohm Quantal duration of auditory memories Science 274 1996 1909 1914 (Pubitemid 26424771)
15. B.V. Clineschmidt, M. Williams, J.J. Witoslawski, P.R. Bunting, E.A. Risley, and J.A. Totaro Restoration of shock suppressed behavior by treatment with (+)-5-methyl-10, 11-dihydro-5H-dibenzo[a, d]cyclohepten-5. 10-imine (MK-801), a substance with potent anticonvulsant, central sympathomimetic and apparent anxiolytic properties Drug Devl. Res. 2 1982 147 163 (Pubitemid 12107826)
16. E.J. Coan, W. Saywooda, and G.L. Collingridge MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices Neurosci. Lett. 80 1987 111 114 (Pubitemid 17129781)
17. G.L. Collingridge, and T.V.P. Bliss NMDA receptor-their role in long-term potentiation Trends Neurosci. 10 1987 288 293 (Pubitemid 17090075)
18. P.R. Corlett, G.D. Honey, and P.C. Fletcher From prediction error to psychosis: ketamine as a pharmacological model of delusions J. Psychopharmacol. 21 2007 238 252 (Pubitemid 46934047)
19. IBM Corporation PASW Statistics 18.0 2009 IBM Corporation, PASW Statistics Somers, NY
20. H.E. Criswell, D.J. Knapp, D.H. Overstreet, and G.R. Breese Effects of ethanol, chlordiazepoxide, and MK-801 on performance in the elevated-plus maze and on locomotor activity Alcohol Clin. Exp. Res. 18 1994 596 601 (Pubitemid 24189284)
21. V. Crunelli, S. Forda, and J.S. Kelly Excitatory aminoacids in the hippocampus: synaptic physiology and pharmacology Trends Neurosci. 8 1985 26 30
22. J.F. Cryan, and K.K. Dev The glutamatergic system as a potential therapeutic target for the treatment of anxiety disorders Handbook Behav. Neurosci. 17 2008 269 301
23. F.C. da Silva, M. do Carmo de Oliveira Cito, M.I. da Silva, B.A. Moura, M.R. de Aquino Neto, M.L. Feitosa, R. de Castro Chaves, D.S. Macedo, S.M. de Vasconcelos, M.M. de Frana Fonteles, and F.C. de Sousa Behavioral alterations and pro-oxidant effect of a single ketamine administration to mice Brain Res. Bull. 83 2010 9 15
24. H. Dai, and R.J. Carey The NMDA antagonist MK-801 can impair attention to exteroceptive stimuli Behav. Brain Res. 62 1994 149 156 (Pubitemid 24222822)
25. W. Danysz, J.T. Wroblewski, and E. Costa Learning impairment in rats by N-methyl-d-aspartate receptor antagonists Neuropharmacol. 27 1988 653 656
26. W. Danysz, W. Zajaczkowski, and C.G. Parsons Modulation of learning processes by ionotropic glutamate receptor ligands Behav. Pharmacol. 6 1995 455 474
27. S. Davis, S.P. Butcher, and R.G.M. Morris The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP-5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro J. Neurosci. 12 1992 21 34
28. G.R. Dawson, and M.D. Tricklebank Use of the elevated plus maze in the search for novel anxiolytic agents TIPS 16 1995 33 36
29. G.R. Dawson, S.P. Crawford, N. Collinson, S.D. Iversen, and M.D. Tricklebank Evidence that the anxiolytic-like effects of chlordiazepoxide on the elevated plus-maze are confounded by increases in locomotor activity Psychopharmacol. 118 1995 316 323
30. M. Day, and R.F. Langston Post-training N-methyl-d-aspartate receptor blockade offers protection from retrograde interference but does not affect consolidation of weak or strong memory traces in the water maze Neurosci. 137 2006 19 28 (Pubitemid 43031471)
31. M.N. de Lima, D.C. Laranja, E. Bromberg, R. Roesler, and N. Scroder Pre- or post-training administration of the NMDA receptor blocker MK-801 impairs object recognition memory in rats Behav. Brain Res. 156 2005 139 143 (Pubitemid 39330444)
32. R.W. Dunn, R. Corbett, and S. Fielding Effects of 5-HT1A receptor agonists and NMDA receptor antagonists in the social interaction test and the elevated plus maze Eur. J. Pharmacol. 169 1989 1 10 (Pubitemid 19244943)
33. G. Ellison The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias Brain Res. Rev. 20 1995 250 267
34. E. Engin, D. Treit, and C.T. Dickson Anxiolytic- and antidepressant-like properties of ketamine in behavioral and neurophysiological animal models Neurosci. 161 2009 359 369
35. A. Ennaceur, S. Michalikova, R. van Rensburg, and P.L. Chazot Models of anxiety: responses of mice to novelty and open spaces in a 3D maze Behav. Brain Res. 174 2006 9 38 (Pubitemid 44397174)
36. A. Ennaceur, S. Michalikova, R. van Rensburg, and P.L. Chazot Are benzodiazepines really anxiolytic? Evidence from a 3D maze spatial navigation task Behav. Brain Res. 188 2008 136 153 (Pubitemid 351178787)
37. A. Ennaceur, S. Michalikova, R. van Rensburg, and P.L. Chazot Detailed analysis of the behavior and memory performance of middle-aged male and female CD-1 mice in a 3D maze Behav. Brain Res. 187 2008 312 326
38. A. Ennaceur Omission of the habituation procedure in the acquisition of a working memory task - evidence from Balb/c, c57/BL6J, and CD-1 mice Behav. Brain Res. 223 2011 203 210
39. A. Field Discovering Statistics Using SPSS for Windows third ed. 2009 Sage Publications, Inc London
40. T. Frankiewicz, B. Potier, Z.I. Bashir, G.L. Collingridge, and C.G. Parsons Effects of memantine and MK-801 on NMDA-induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices Br. J. Pharmacol. 117 1996 689 697 (Pubitemid 26070246)
41. C.M. Fraser, M.J. Cooke, A. Fisher, I.D. Thompson, and T.W. Stone Interactions between ifenprodil and dizocilpine on mouse behaviour in models of anxiety and working memory Eur. Neuropsychopharmacol. 6 1996 311 316 (Pubitemid 26422792)
42. F. Freeman, S.P. Rose, and A. Scholey Two time windows of anisomycin-induced amnesia for passive avoidance training in the day-old chick Neurobiol. Learn. Mem. 63 1995 291 295
43. I. Gaisler-Salomon, and I. Weiner Systemic administration of MK-801 produces an abnormally persistent latent inhibition which is reversed by clozapine but not haloperidol Psychopharmacol. 166 2003 333 342 (Pubitemid 36469935)
44. G. Grecksch, and H. Matthies Two sensitive periods for the amnesic effect of anisomycin Pharmacol. Biochem. Behav. 12 1980 663 665 (Pubitemid 10045707)
45. F.S. Guimarães, A.P. Carobrez, J.C. Aguiar, and F.G. Graeff Anxiolytic effect in the elevated plus-maze of the NMDA receptor antagonist AP7 microinjected into the dorsal periaqueductal grey Psychopharmacol. 103 1991 91 94
46. E.L. Hargreaves, and D.P. Cain Hyperactivity, hyper-reactivity, and sensorimotor deficits induced by low doses of the N-methyl-d-aspartate non-competitive channel blocker MK801 Behav. Brain Res. 47 1992 23 33
47. R.H. Hatfield, R. Gill, and C. Brazell The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model Eur. J. Pharmacol. 216 1992 1 7
48. S.M. Hölter, T.M. Tzschentke, and W.J. Schmidt Effects of amphetamine, morphine and dizocilpine (MK-801) on spontaneous alternation in the 8-arm radial maze Behav. Brain Res. 81 1996 53 59 (Pubitemid 26384963)
49. W.M. Howe, and J.A. Burk Dizocilpine-induced accuracy deficits in a visual signal detection task are not present following d-cycloserine administration in rats Eur. J. Pharmacol. 577 2007 87 90 (Pubitemid 47632530)
50. K.M. Huber, M.D. Mauk, and P.T. Kelly Distinct LTP induction mechanisms: contribution of NMDA receptors and voltage-dependent calcium currents J. Neurophysiol. 73 1995 270 279
51. H.B. Hucker, J.E. Hutt, and S.D. White Disposition and metabolism of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a, d]cyclohepten-5,10-imine in rats, dogs, and monkeys Drug Metab. Dispos. 11 1983 54 58 (Pubitemid 13180901)
52. L.M. Igaz, M.R.M. Vianna, J.H. Medina, and I. Izquierdo Two time periods of hippocampal mRNA synthesis are required for memory consolidation of fear-motivated learning J. Neurosci. 22 2002 6781 6789 (Pubitemid 35386435)
53. M. Kalinichev, S.T. Bate, S.A. Coggon, and D.N.C. Jones Locomotor reactivity to a novel environment and sensitivity to MK-801 in five strains of mice Behav. Pharmacol. 19 2008 71 75
54. M. Karcz-Kubicha, M. Jessa, M. Nazar, A. Plaznik, S. Hartmann, C.G. Parsons, and W. Danysz Anxiolytic activity of glycine-B antagonists and partial agonists - no relation to intrinsic activity in the patch clamp Neuropharmacol. 36 1997 1355 1367 (Pubitemid 27502193)
55. A. Kleinschmidt, M.F. Bear, and W. Winger Blockage of NMDA receptors disrupts experience-dependent plasticity of kitten striate cortex Science 238 1987 355 358 (Pubitemid 17151726)
56. W. Koek, and F.C. Colpaert Use of a conflict procedure in pigeons to characterize anxiolytic drug activity: evaluation of N-methylo-aspartate antagonists Life Sci. 49 1991 PL37 42
57. J.H. Krystal, L.P. Karper, J.P. Seibyl, G.K. Freeman, R. Delaney, J.D. Bremner, G.R. Heninger, M.B. Bowers Jr., and D.S. Charney Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: psychotomimetic, perceptual, cognitive, and neuroendocrine responses Arch. Gen. Psychiat. 51 1994 199 214 (Pubitemid 24081509)
58. A.E. Larkin, B. Fahey, O. Gobbo, C.K. Callaghan, E. Cahill, S.M. O'Marab, and Á.M. Kelly Blockade of NMDA receptors pre-training, but not post-training, impairs object displacement learning in the rat Brain Res. 1199 2008 126 132
59. L.S. Leung, and B. Shen Long-term potentiation in hippocampal CA1: effects of after discharges NMDA antagonists, and anticonvulsants Expl. Neurol. 119 1993 205 214 (Pubitemid 23132017)
60. D.A. MacQueen, L. Bullard, and M. Galizio Effects of dizocilpine (MK801) on olfactory span in rats Neurobiol. Learn. Mem. 95 2011 57 63
61. R.S. Mansbach, J. Willetts, S.A. Jortani, and R.L. Balster NMDA antagonists: lack of antipunishment effect in squirrel monkeys Pharmacol. Biochem. Behav. 39 1991 977 981
62. P. Martin, N.R. Waters, S.E. Waters, A. Carlsson, and M.L. Carlsson MK-801-induced hyperlocomotion: differential effects of M100907, SDZ PSD 958 and raclopride Eur. J. Pharmacol. 335 1997 107 116 (Pubitemid 27450474)
63. R.L. McLamb, L.R. Williams, K.P. Nanry, W.A. Wilson, and H.A. Tilson MK-801 impedes the acquisition of a spatial memory task in rats Pharmacol. Biochem. Behav. 37 1990 41 45 (Pubitemid 20341683)
64. B.L. McNaughton, and R.G.M. Morris Hippocampal synaptic enhancement and information storage within a distributed memory system TINS 10 1987 408 415 (Pubitemid 17149102)
65. A. Mele, C. Castellano, V. Cestari, and A. Oliverio Interaction between the NMDA competitive antagonist CPP and the dopaminergic system in one-trial inhibitory avoidance in C57BL/6 mice Neurobiol. Learn. Mem. 63 1995 143 148
66. S. Michalikova, R. van Rensburg, P.L. Chazot, and A. Ennaceur Anxiety responses in Balb/c, c57 and CD-1 mice exposed to a novel open space test Behav. Brain Res. 207 2010 402 417
67. S.J. Mizumori, M.R. Rosenzweig, and M.G. Kermisch Failure of mice to demonstrate spatial memory in the radial maze Behav. Neural Biol. 35 1982 33 45 (Pubitemid 12021183)
68. R.G. Morris, E. Anderson, G.S. Lynch, and M. Baudry Selective impairment of learning and blockade of long-term potentiation by an N-methyl-d-aspartate receptor antagonist, AP5 Nature 319 1986 774 776 (Pubitemid 16145031)
69. K.W. Muir, and K.R. Lees Clinical experience with excitatory amino acid antagonist drugs Stroke 26 1995 503 513
70. M. Nilsson, S. Hansson, A. Carlsson, and M.L. Carlsson Differential effects of the N-methyl-d-Aspartate receptor antagonist MK-801 on different stages of object recognition memory in mice Neurosci. 149 2007 123 130 (Pubitemid 47488657)
71. I. Ninan, and S.K. Kulkarni 5-HT2A receptor antagonists block MK-801-induced stereotypy and hyperlocomotion Eur. J. Pharmacol. 358 1998 111 116 (Pubitemid 28458882)
72. S.O. Ögren, and M. Goldstein Phencyclidine- and dizocilpine-induced hyperlocomotion are differentially mediated Neuropsychopharmacol. 11 1994 167 177 (Pubitemid 24351284)
73. D.S. Olton, and R.J. Samuelson Remembrance places passed: spatial memory rats J. Exp. Psychol: Anim. Behav. Process 2 1976 97 116
74. M.K. Otnaess, V.H. Brun, M.B. Moser, and E.I. Moser Pretraining prevents spatial learning impairment after saturation of hippocampal long-term potentiation J. Neurosci. 19 1999 RC49
75. M.G. Packard, and L.A. Teather Posttraining injections of MK-801 produce a time-dependent impairment of memory in two water maze tasks Neurobiol. Learn. Mem. 68 1997 42 50 (Pubitemid 27423889)
76. T.A. Paine, and W.A. Carlezon Jr. Effects of antipsychotic drugs on MK-801-induced attentional and motivational deficits in rats Neuropharmacol. 56 2009 788 797
77. M. Papp, and E. Moryl Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression Eur. J. Pharmacol. 263 1994 1 7 (Pubitemid 24290246)
78. E. Pomarol-Clotet, G.D. Honey, G.K. Murray, P.R. Corlett, A.R. Absalom, M. Lee, P.J. McKenna, E.T. Bullmore, and P.C. Fletcher Psychological effects of ketamine in healthy volunteers. Phenomenological study Br. J. Psychiat. 189 2006 173 179 (Pubitemid 44231278)
79. M.J. Pontecorvo, D.B. Clissold, M.F. White, and J.W. Ferkany N-Methyl-d-Aspartate antagonists and working memory performance: comparison with the effects of scopolamine, propranolol, diazepam, and phenylisopropyladenosine Behav. Neurosci. 105 1991 521 535
80. E.J. Popke, R.R. Allen, E.C. Pearson, T.G. Hammond, and M.G. Paule Differential effects of two NMDA receptor antagonists on cognitive- behavioral development in nonhuman primates Neurotoxicol. Teratol. 23 2001 319 332 (Pubitemid 32727364)
81. C. Qi, H. Zou, R. Zhang, G. Zhao, M. Jin, and L. Yu Age-related differential sensitivity to MK-801-induced locomotion and stereotypy in C57BL/6 mice Eur. J. Pharmacol. 580 2008 161 168
82. F.W. Reimherr, D.R. Wood, and P.H. Wender The use of MK-801, a novel sympathomimetic, in adults with attention deficit disorder, residual type Psychopharmacol. Bull. 22 1986 237 242 (Pubitemid 16101363)
83. M. Roberts, and M. Shapiro NMDA receptor antagonists impair memory for nonspatial, socially transmitted food preference Behav. Neurosci. 116 2002 1059 1069 (Pubitemid 35429640)
84. G.B. Robinson, and G.D. Reed Effect of MK-801 on the induction and subsequent decay of long-term potentiation in the unanesthetized rabbit hippocampal dentate gyrus Brain Res. 569 1992 78 85
85. G.S. Robinson, G.B. Crooks, P.G. Shinkman, and M. Gallagher Behavioral effects of MK-801 mimic deficits associated with hippocampal damage Psychobiol. 17 1989 156 164 (Pubitemid 19145021)
86. R. Roesler, M. Vianna, M.K. Sant'Anna, C.R. Kuyven, A.V. Kruel, and J. Quevedo Intrahippocampal infusion of the NMDA receptor antagonist AP5 impairs retention of an inhibitory avoidance task: protection from impairment by pretraining or preexposure to the task apparatus Neurobiol. Learn. Mem. 69 1998 87 91 (Pubitemid 28364509)
87. M.J. Sanders, and M.S. Fanselow Pre-training prevents context fear conditioning deficits produced by hippocampal NMDA receptor blockade Neurobiol. Learn. Mem. 80 2003 123 129 (Pubitemid 36970233)
88. D.J. Sanger, and D. Joly The effects of NMDA antagonists on punished exploration in mice Behav. Pharmacol. 2 1991 57 63
89. E. Santini, R.U. Muller, and G.J. Quirk Consolidation of extinction learning involves transfer from NMDA-independent to NMDA-dependent memory J. Neurosci. 21 2001 9009 9017 (Pubitemid 33054862)
90. K. Sato, K. Morimoto, and M. Okamoto Anticonvulsant action of a non-competitive antagonist of NMDA receptors (MK-801) in the kindling model of epilepsy Brain Res. 463 1988 12 20
91. D. Saucier, and D.P. Cain Spatial learning without NMDA receptor-dependent long-term potentiation Nature 378 1995 186 189
92. D. Saucier, E.L. Hargreaves, F. Boon, C.H. Vanderwolf, and D.P. Cain Detailed behavioral analysis of water maze acquisition under systemic NMDA or muscarinic antagonism: nonspatial pretraining eliminates spatial learning deficits Behav. Neurosci. 110 1996 103 116 (Pubitemid 26068799)
93. E.E. Schenberg, and M.G. Oliveira Effects of pre or posttraining dorsal hippocampus D-AP5 injection on fear conditioning to tone, background, and foreground context Hippocampus 18 2008 1089 1093
94. M.L. Shapiro, and C. O'Connor N-methyl-d-aspartate receptor antagonist MK-801 and spatial memory representation: working memory is impaired in an unfamiliar environment but not in a familiar environment Behav. Neurosci. 106 1992 604 612
95. J.S. Silvestre, R. Nadal, M. Pallarés, and N. Ferré Acute effects of ketamine in the holeboard, the elevated-plus maze, and the social interaction test in Wistar rats Depress Anxiety 5 1997 29 33 (Pubitemid 28106010)
96. A.K. Soderpalm, O. Blomqvist, J.A. Engel, and B. Soderpalm Characterization of the anticonflict effect of MK-801, a non-competitive NMDA antagonist Pharmacol. Toxicol. 76 1995 122 127
97. J.L. Stringer, and P.G. Guyenet Elimination of long-term potentiation in the hippocampus by phencyclidine and ketamine Brain Res. 258 1983 159 164 (Pubitemid 13217150)
98. H.S. Swartzwelder, C. Ferrari, W.W. Anderson, and W.A. Wilson The drug MK-801 attenuates the development, but not expression, of long-term potentiation and stimulus train-induced bursting in hippocampal slices Neuropharmacol. 28 1989 441 445 (Pubitemid 19131675)
99. K. Takehara-Nishiuchi, S. Kawahara, and Y. Kirino NMDA receptor-dependent processes in the medial prefrontal cortex are important for acquisition and the early stage of consolidation during trace but not delay eyeblink conditioning Learn. Mem. 12 2005 606 614 (Pubitemid 41770085)
100. A.H. Tang, and P.M. Ho Both competitive and noncompetitive antagonists of N-methyl-d-aspartic acid disrupt brightness discrimination in rats Eur. J. Pharmacol. 151 1988 143 146
101. A.S. Troupin, J.R. Mendius, F. Cheng, and M.W. Risinger MK-801 B. Meldrum, R. Porter, New Anticonvulsant Drugs 1986 John Libbey London 191 201
102. R. Trullas, and P. Skolnick Functional antagonists at the NMDA receptor complex exhibit antidepressant actions Eur. J. Pharmacol. 185 1990 1 10 (Pubitemid 20254891)
103. T. Uekita, and H. Okaichi NMDA antagonist MK-801 does not interfere with the use of spatial representation in a familiar environment Behav. Neurosci. 119 2005 548 556 (Pubitemid 40547960)
104. I.Q. Whishaw, and R.N. Auer Immediate and long-lasting effects of MK-801 on motor activity, spatial navigation in a swimming pool and EEG in the rat Psychopharmacol. 98 1989 500 507 (Pubitemid 19193898)
105. J.M. Wieronska, B. Szewczyk, A. Palucha, P. Branski, and M. Smialowska Involvement of CRF but not NPY in the anxiety regulation via NMDA receptors Pol J. Pharmacol. 55 2003 1119 1124 (Pubitemid 38128950)
106. J.L. Wiley, A.F. Cristello, and R.L. Balster Effects of site-selective NMDA receptor antagonists in an elevated plus-maze model of anxiety in mice Eur. J. Pharmacol. 294 1995 101 107 (Pubitemid 26016818)
107. B.J. Winer, D.R. Brown, and K.M. Michels Statistical Principles in Experiment Design third ed. 1991 McGraw-Hill New York
108. E.H. Wong, J.A. Kemp, T. Priestley, A.R. Knight, G.N. Woodruff, and L.L. Iversen The anticonvulsant MK-801 is a potent N-methyl-d-aspartate antagonist PNAS 83 1986 7104 7108 (Pubitemid 16002378)
109. D.F. Wozniak, J.W. Olney, L. Kettinger, M. Price, and J.P. Miller Behavioral effects of MK-801 in the rat Psychopharmacol. 101 1990 47 56 (Pubitemid 20124741)
110. J. Wu, H. Zou, J.A. Strong, J. Yu, X. Zhou, Q. Xie, G. Zhao, M. Jin, and L. Yu Bimodal effects of MK-801 on locomotion and stereotypy in C57BL/6 mice Psychopharmacol. 177 2005 256 263 (Pubitemid 40137285)
111. W. Yen, J. Williamson, E.H. Bertram, and J. Kapur A comparison of three NMDA receptor antagonists in the treatment of prolonged status epilepticus Epilepsy Res. 59 2004 43 50 (Pubitemid 38595420)
112. T. Yoshihara, and Y. Ichitani Hippocampal N-methyl-d-aspartate receptor-mediated encoding and retrieval processes in spatial working memory: delay-interposed radial maze performance in rats Neurosci. 129 2004 1 10 (Pubitemid 39360936)
113. T.J.J. Zethof, J.A.M. Van Der Heyden, J.T.B.M. Tolboom, and B. Olivier Stress-induced hyperthermia as a putative anxiety model Eur. J. Pharmacol. 294 1995 125 135 (Pubitemid 26016820)