Conditioned Stimulus Familiarity Determines Effects of MK-801 on Fear Extinction

Behavioral Neuroscience

Volumn 123, Issue 2, 2009, Pages 303-314

  Chan, Wan Yee Macy ^a   McNally, Gavan P ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

extinction; fear; memory; NMDA

Indexed keywords

DIZOCILPINE; IFENPRODIL;

ANIMAL EXPERIMENT; ARTICLE; CONDITIONED REFLEX; CONTROLLED STUDY; DRUG EFFECT; FEAR; FREEZING; LEARNING; MALE; NONHUMAN; RAT; REINFORCEMENT; SENSITIVITY ANALYSIS; STIMULUS RESPONSE; TRAINING;

ANIMALS; BEHAVIOR, ANIMAL; CONDITIONING, CLASSICAL; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; EXTINCTION, PSYCHOLOGICAL; FEAR; MALE; RATS; RATS, WISTAR; RECOGNITION (PSYCHOLOGY);

EID: 65249089647     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/a0014988     Document Type: Article

References (28)

1. Baker J.D., and Azorlosa J.L. The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning. Behavioral Neuroscience 110 (1996) 618-620
2. Bannerman D.M., Good M.A., Butcher S.P., Ramsay M., and Morris R.G. Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature 378 (1995) 182-186
3. Cox J., and Westbrook R.F. The NMDA receptor antagonist MK-801 blocks acquisition and extinction of conditioned hypoalgesic responses in the rat. Quarterly Journal of Experimental Psychology 47B (1994) 187-210
4. Falls W.A., Miserendino M.J., and Davis M. Extinction of fear-potentiated startle: Blockade by infusion of an NMDA antagonist into the amygdala. Journal of Neuroscience 12 (1992) 854-863
5. Guastella A.J., Dadds M.R., Lovibond P.F., Mitchell P., and Richardson R. A randomized controlled trial of the effect of D-cycloserine on exposure therapy for spider fear. Journal of Psychiatry Research 41 (2007) 466-471
6. Hall G. Perceptual and associative learning (1991), Oxford University Press, Oxford, England
7. Hofmann S.G., Meuret A.E., Smits J.A., Simon N.M., Pollack M.H., Eisenmenger K., et al. Augmentation of exposure therapy with D-cycloserine for social anxiety disorder. Archives of General Psychiatry 63 (2006) 298-304
8. Kim J.J., DeCola J.P., Landeira-Fernandez J., and Fanselow M.S. N-methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning. Behavioral Neuroscience 105 (1991) 126-133
9. Kushner M.G., Kim S.W., Donahue C., Thuras P., Adson D., Kotlyar M., et al. D-cycloserine augmented exposure therapy for obsessive-compulsive disorder. Biological Psychiatry 62 (2007) 835-838
10. Langton J.M., Kim J.H., Nicholas J., and Richardson R. The effect of the NMDA receptor antagonist MK-801 on the acquisition and extinction of learned fear in the developing rat. Learning & Memory 14 (2007) 665-668
11. Langton, J. M., & Richardson, R. (in press). D-cycloserine facilitates extinction the first time but not the second time: An examination of the role of NMDA across the course of repeated extinction sessions. Neuropsychopharmacology
12. Laurent V., Marchand A.R., and Westbrook R.F. The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear. Learning & Memory 15 (2008) 304-314
13. Ledgerwood L., Richardson R., and Cranney J. Effects of D-cycloserine on extinction of conditioned freezing. Behavioral Neuroscience 117 (2003) 341-349
14. Lee H., and Kim J.J. Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats. Journal of Neuroscience 18 (1998) 8444-8454
15. Miserendino M.J., Sananes C.B., Melia K.R., and Davis M. Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 345 (1990) 716-718
16. Myers K.M., and Davis M. Mechanisms of fear extinction. Molecular Psychiatry 12 (2007) 120-150
17. Quirk G.J., and Mueller D. Neural mechanisms of extinction learning and retrieval. Neuropsychopharmacology 33 (2008) 56-72
18. Rescorla R.A. Summation and retardation tests of latent inhibition. Journal of Comparative and Physiological Psychology 75 (1971) 77-81
19. Rescorla R.A. Retraining of extinguished Pavlovian stimuli. Journal of Experimental Psychology: Animal Behavior Processes 27 (2001) 115-124
20. Ressler K.J., Rothbaum B.O., Tannenbaum L., Anderson P., Graap K., Zimand E., et al. Cognitive enhancers as adjuncts to psychotherapy: Use of D-cycloserine in phobic individuals to facilitate extinction of fear. Archive of General Psychiatry 61 (2004) 1136-1144
21. Roesler R., Vianna M., Sant'Anna M.K., Kuyven C.R., Kruel A.V., Quevedo J., et al. Intrahippocampal infusion of the NMDA receptor antagonist AP5 impairs retention of an inhibitory avoidance task: Protection from impairment by pretraining or preexposure to the task apparatus. Neurobiology of Learning and Memory 69 (1998) 87-91
22. Sanders M.J., and Fanselow M.S. Pre-training prevents context fear conditioning deficits produced by hippocampal NMDA receptor blockade. Neurobiology of Learning and Memory 80 (2003) 123-129
23. Saucier D., and Cain D.P. Spatial learning without NMDA receptor-dependent long-term potentiation. Nature 378 (1995) 186-189
24. Saucier D., Hargreaves E.L., Boon F., Vanderwolf C.H., and Cain D.P. Detailed behavioral analysis of water maze acquisition under systemic NMDA or muscarinic antagonism: Nonspatial pretraining eliminates spatial learning deficits. Behavioral Neuroscience 110 (1996) 103-116
25. Sotres-Bayon F., Bush D.E., and LeDoux J.E. Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. Neuropsychopharmacology 32 (2007) 1929-1940
26. Wagner A.R. SOP: A model of automatic memory processing in animal behavior. In: Spear N.E., and Miller R.R. (Eds). Information processing in animals: Memory mechanisms (1981), Erlbaum, Hillsdale, NJ 5-47
27. Walker D.L., Ressler K.J., Lu K.T., and Davis M. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. Journal of Neuroscience 22 (2002) 2343-2351
28. Westbrook R.F., Iordanova M., McNally G., Richardson R., and Harris J.A. Reinstatement of fear to an extinguished conditioned stimulus: Two roles for context. Journal of Experimental Psychology: Animal Behavior Processes 28 (2002) 97-110