Pre-training prevents context fear conditioning deficits produced by hippocampal NMDA receptor blockade

Neurobiology of Learning and Memory

Volumn 80, Issue 2, 2003, Pages 123-129

  Sanders, Matthew J ^a   Fanselow, Michael S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

APV; Context fear; Hippocampus; Learning and memory; Pavlovian conditioning

Indexed keywords

5 AMINOPHOSPHONOVALERIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE; WATER;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONDITIONING; CONTROLLED STUDY; FEAR; FEMALE; HIPPOCAMPUS; INFUSION; LEARNING; LEARNING DISORDER; MALE; MAZE TEST; NEUROBIOLOGY; NONHUMAN; PREVENTION; RAT; RECEPTOR BLOCKING; SHOCK; SPATIAL MEMORY; TRAINING;

EID: 0042160187     PISSN: 10747427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7427(03)00040-6     Document Type: Article

References (19)

1. Bannerman D.M., Good M.A., Butcher S.P., Ramsay M., Morris R.G.M. Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature. 378:1995;182-186.
2. Cain D.P., Saucier D., Hall J., Hargreaves E.L., Boon F. Detailed behavioral analysis of water maze acquisition under APV or CNQX: Contribution of sensorimotor disturbances to drug-induced acquisition deficits. Behavioral Neuroscience. 110:1996;86-102.
3. Fanselow M.S. Conditional and unconditional components of postshock freezing. Pavlovian Journal of Biological Sciences. 15:1980;177-182.
4. Fanselow M.S., Kim J.J., Yipp J., DeOca B. Differential effects of N-methyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues. Behavioral Neuroscience. 108:1994;235-240.
5. Kim J.J., DeCola J.P., Landeira-Fernandez J., Fanselow M.S. N-Methyl-D-aspartate receptor antagonist APV blocks acquisition but not expression of fear conditioning. Behavioral Neuroscience. 105:1991;126-133.
6. Kim J.J., Rison R.A., Fanselow M.S. Effects of amygdala, hippocampus, and periacqueductal gray lesions on short- and long-term contextual fear. Behavioral Neuroscience. 107:1993;1093-1098.
7. Lee H., Kim J.J. Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats. Journal of Neuroscience. 18:1998;8444-8454.
8. Morris R.G.M. Synaptic plasticity and learning: Selective impairment of learning in rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. Journal of Neuroscience. 9:1989;3040-3057.
9. Morris G.G.M., Anderson E., Lynch G.S., Baudry M. Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature. 319:1986;774-776.
10. Morris R.G.M., Garrud P., Rawlins J., O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature. 297:1982;681-683.
11. O'Keefe J., Dostrovsky J. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely moving rat. Brain Research. 34:1971;171-175.
12. O'Keefe J., Nadel L. The hippocampus as a cognitive map. 1978;Clarendon, Oxford.
13. O'Keefe J., Nadel L., Keightley S., Kill D. Fornix lesions selectively abolish place learning in the rat. Experimental Neurology. 48:1975;152-166.
14. Owen E.H., Logue S.F., Rasmussen D.L., Wehner J.M. Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: Implications of genetic background for single gene mutations and quantitative trait loci analyses. Neuroscience. 80:1997;1087-1099.
15. Phillips R.G., LeDoux J.E. Differential contributions of amygdala and hippocampus to cued and contextual fear conditioning. Behavioral Neuroscience. 106:1992;274-285.
16. Saucier D., Hargreaves E.L., Boon F., Vanderwolf C.H., Cain D.P. Detailed behavioral analysis of water maze acquisition under systemic NMDA or muscarinic antagonism: Nonspatial pretraining eliminates spatial learning deficits. Behavioral Neuroscience. 110:1996;103-116.
17. Whishaw I.Q., Petrie B.F. Cholinergic blockade in the rat impairs strategy selection but not learning and retention of nonspatial visual discrimination problems in a swimming pool. Behavioral Neuroscience. 102:1988;662-677.
18. Whishaw I.Q., Tomie J. Cholinergic receptor blockade produces impairments in a sensorimotor subsystem for place navigation in the rat: Evidence from sensory, motor, and acquisition tests in a swimming pool. Behavioral Neuroscience. 101:1987;603-616.
19. Young S.L., Bohenek D.L., Fanselow M.S. NMDA processes mediate anterograde amnesia of contextual fear conditioning induced by hippocampal damage: Immunization against amnesia by context preexposure. Behavioral Neuroscience. 108:1994;19-29.