Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists

Neuropsychopharmacology

Volumn 30, Issue 7, 2005, Pages 1324-1333

  Chartoff, Elena H ^a,c   Heusner, Carrie L ^b,c   Palmiter, Richard D ^b,c  

^a MCLEAN HOSPITAL   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

c fos; Dopamine deficient mice; Glutamate; Locomotion; MK 801; Phencyclidine

Indexed keywords

4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; DIZOCILPINE; DIZOCILPINE MALEATE; DOPAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; PROTEIN C FOS; TYROSINE 3 MONOOXYGENASE;

ANIMAL BEHAVIOR; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOPAMINERGIC SYSTEM; DRUG EFFECT; HYPERLOCOMOTION; LOCOMOTION; MOUSE; MOUSE STRAIN; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; STEREOTYPY;

(R)-2,3,4,5-TETRAHYDRO-8-CHLORO-3-METHYL-5-PHENYL-1H-3-BENZAZEPIN-7-OL; ANIMALS; CELL COUNT; DIZOCILPINE MALEATE; DOPAMINE; DOPAMINE ANTAGONISTS; DOPAMINE BETA-HYDROXYLASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION; GENES, FOS; HALOPERIDOL; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; PHENCYCLIDINE; RNA, MESSENGER; TIME FACTORS; TYROSINE 3-MONOOXYGENASE;

EID: 20544444984     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300678     Document Type: Article

References (60)

1. Adams B, Moghaddam B (1998). Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine. J Neurosci 18: 5545-5554.
2. Adams MR, Brandon EP, Chartoff EH, Idzerda RL, Dorsa DM, McKnight GS (1997). Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice. Proc Natl Acad Sci USA 94: 12157-12161.
3. Andine P, Widermark N, Axelsson R, Nyberg G, Olofsson U, Martensson E et al (1999). Characterization of MK-801-induced behavior as a putative rat model of psychosis. J Pharmacol Exp Ther 290: 1393-1408.
4. Bakshi VP, Swerdlow NR, Geyer MA (1994). Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. J Pharmacol Exp Ther 271: 787-794.
5. Bamford NS, Robinson S, Palmiter RD, Joyce JA, Moore C, Meshul CK (2004). Dopamine modulates release from corticostriatal terminals. J Neurosci 24: 9541-9552.
6. Carlezon Jr WA, Wise RA (1996). Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex. J Neurosci 16: 3112-3122.
7. Carlsson M, Carlsson A (1989a). The NMDA antagonist MK-801 causes marked locomotor stimulation in monoamine-depleted mice. J Neural Transm 75: 221-226.
8. Carlsson M, Carlsson A (1989b). Dramatic synergism between MK-801 and clonidine with respect to locomotor stimulatory effect in monoamine-depleted mice. J Neural Transm 77: 65-71.
9. Chartoff EH, Marck BT, Matsumoto AM, Dorsa DM, Palmiter RD (2001). Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation. Proc Natl Acad Sci USA 98: 10451-10456.
10. Chartoff EH, Ward RP, Dorsa DM (1999). Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsy. J Pharmacol Exp Ther 291: 531-537.
11. Cornish JL, Nakamura M, Kalivas PW (2001). Dopamine-independent locomotion following blockade of AT-methyl-D-aspartate receptors in the ventral tegmental area. J Pharmacol Exp Ther 298: 226-233.
12. Coyle JT (1996). The glutamatergic dysfunction hypothesis for schizophrenia. Harvard Rev Psychiatry 3: 241-253.
13. Creese I, Iversen SD (1973). Blockage of amphetamine induced motor stimulation and stereotypy in the adult rat following neonatal treatment with 6-hydroxydopamine. Brain Res 55: 369-382.
14. Davis KL, Kahn RS, Ko G, Davidson M (1991). Dopamine in schizophrenia: a review and reconceptualization. Am J Psychiatry 148: 1474-1486.
15. Druhan JP, Rajabi H, Stewart J (1996). MK-801 increases locomotor activity without elevating extracellular dopamine levels in the nucleus accumbens. Synapse 24: 135-146.
16. Freed WJ, Bing LA, Wyatt RJ (1984). Effects of neuroleptics on phencyclidine (PCP)-induced locomotor stimulation in mice. Neuropharmacology 23: 175-181.
17. Freeman AS, Bunney BS (1984). The effects of phencyclidine and AT-allylnormetazocine on midbrain dopamine neuronal activity. Eur J Pharmacol 104: 287-293.
18. Freneh ED, Mura A, Wang T (1993). MK-801, phencyclidine (PCP), and PCP-like drugs increase burst firing in rat A10 dopamine neurons: comparison to competitive NMDA antagonists. Synapse 13: 108-116.
19. French ED, Pilapil C, Quirion R (1985). Phencyclidine binding sites in the nucleus accumbens and phencyclidine-induced hyperactivity are decreased following lesions of the mesolimbic dopamine system. Eur J Pharmacol 116: 1-9.
20. French ED, Vantini G (1984). Phencyclidine-induced locomotor activity in the rat is blocked by 6-hydroxydopamine lesion of the nucleus accumbens: comparisons to other psychomotor stimulants. Psychopharmacology (Berl) 82: 83-88.
21. Gerhardt GA, Pang K, Rose GM (1987). In vivo electrochemical demonstration of the presynaptic actions of phencyclidine in rat caudate nucleus. J Pharmacol Exp Ther 241: 714-721.
22. Graybiel AM, Hirsch EC, Agid Y (1990). The nigrostriatal system in Parkinson's disease. Adv Neurol 53: 17-29.
23. Greenberg BD, Segal DS (1985). Acute and chronic behavioral interactions between phencyclidine (PCP) and amphetamine: evidence for a dopaminergic role in some PCP-induced behaviors. Pharmacol Biochem Behav 23: 99-105.
24. Grunze HC, Rainnie DG, Hasselmo ME, Barkai E, Hearn EF, McCarley RW et al (1996). NMDA-dependent modulation of CA1 local circuit inhibition. J Neurosci 16: 2034-2043.
25. Heusner CL, Hnasko TS, Szczypka MS, Liu Y, During MJ, Palmiter RD (2003). Viral restoration of dopamine to the nucleus accumbens is sufficient to induce a locomotor response to amphetamine. Brain Res 980: 266-274.
26. Imperato A, Scrocco MG, Bacchi S, Angelucci L (1990). NMDA receptors and in vivo dopamine release in the nucleus accumbens and caudatus. Eur J Pharmacol 187: 555-556.
27. Javitt DC, Zukin SR (1991). Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 148: 1301-1308.
28. Jokel ES, Garduno ER, Ariano MA, Levine MS (2001). Metabotropic glutamate receptors mGluR1alpha and mGluR2/3 display dynamic expression patterns in developing rat striatum. Dev Neurosci 23: 1-6.
29. Kelly PH, Seviour PW, Iversen SD (1975). Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum. Brain Res 94: 507-522.
30. Kim DS, Froelick GJ, Palmiter RD (2002). Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum. J Neurosci 22: 9841-9849.
31. Kim DS, Szczypka MS, Palmiter RD (2000). Dopamine-deficient mice are hypersensitive to dopamine receptor agonists. J Neurosci 20: 4405-4413.
32. Kim JS, Kornhuber HH, Schmid-Burgk W, Holzmuller B (1980). Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia. Neurosci Lett 20: 379-382.
33. Lapin IP, Rogawski MA (1995). Effects of D1 and D2 dopamine receptor antagonists and catecholamine depleting agents on the locomotor stimulation induced by dizocilpine in mice. Behav Brain Res 70: 145-151.
34. Miller DW, Abercrombie ED (1996). Effects of MK-801 on spontaneous and amphetamine-stimulated dopamine release in striatum measured with in vivo microdialysis in awake rats. Brain Res Bull 40: 57-62.
35. Moghaddam B, Adams BW (1998). Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science 281: 1349-1352.
36. Moy SS, Breese GR (2002). Phencyclidine supersensitivity in rats with neonatal dopamine loss. Psychopharmacology (Berl) 161: 255-262.
37. O'Neill MF, Heron-Maxwell C, Conway MW, Monn JA, Ornstein P (2003). Group II metabotropic glutamate receptor antagonists LY341495 and LY366457 increase locomotor activity in mice. Neuropharmacology 45: 565-574.
38. Olney JW, Farber NB (1995). Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 52: 998-1007.
39. Olszewski RT, Bukhari N, Zhou J, Kozikowski AP, Wroblewski JT, Shamimi-Noori S et al (2004). NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J Neurochem 89: 876-885.
40. Pierce RC, Meil WM, Kalivas PW (1997). The NMDA antagonist, dizocilpine, enhances cocaine reinforcement without influencing mesoaccumbens dopamine transmission. Psychopharmacology (Berl) 133: 188-195.
41. Rios M, Habecker B, Sasaoka T, Eisenhofer G, Tian H, Landis S et al (1999). Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. J Neurosci 19: 3519-3526.
42. 2+ channels in metabotropic glutamate receptor 2/3-dependent presynaptic long-term depression at nucleus accumbens synapses. J Neurosci 22: 4346-4356.
43. Robinson S, Smith DM, Mizumori SJ, Palmiter RD (2004). Firing properties of dopamine neurons in freely moving dopamine-deficient mice: effects of dopamine receptor activation and anesthesia. Proc Natl Acad Sci USA 101: 13329-13334.
44. Segal DS, Mandell AJ (1974). Long-term administration of d-amphetamine: progressive augmentation of motor activity and stereotypy. Pharmacol Biochem Behav 2: 249-255.
45. Sesack SR, Deutch AY, Roth RH, Bunney BS (1989). Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin. J Comp Neurol 290: 213-242.
46. Snyder SH (1976). The dopamine hypothesis of schizophrenia: focus on the dopamine receptor. Am J Psychiatry 133: 197-202.
47. Steinpreis RE, Salamone JD (1993). The role of nucleus accumbens dopamine in the neurochemical and behavioral effects of phencyclidine: a microdialysis and behavioral study. Brain Res 612: 263-270.
48. Sturgeon RD, Fessler RG, London SF, Meltzer HY (1981). A comparison of the effects of neuroleptics on phencyclidine-induced behaviors in the rat. Eur J Pharmacol 76: 37-53.
49. Sturgeon RD, Fessler RG, Meltzer HY (1979). Behavioral rating scales for assessing phencyclidine-induced locomotor activity, stereotyped behavior and ataxia in rats. Eur J Pharmacol 59: 169-179.
50. Svenningsson P, Tzavara ET, Carruthers R, Rachleff I, Wattler S, Nehls M et al (2003). Diverse psychotomimetics act through a common signaling pathway. Science 302: 1412-1415.
51. Swanson CJ, Schoepp DD (2002). The group II metabotropic glutamate receptor agonist (-)-2-oxa-4-aminobicyclo[3.1.0.]-hexane-4, 6-dicarboxylate (LY379268) and clozapine reverse phencyclidine-induced behaviors in monoamine-depleted rats. J Pharmacol Exp Ther 303: 919-927.
52. Szczypka MS, Rainey MA, Kim DS, Alaynick WA, Marck BT, Matsumoto AM et al (1999). Feeding behavior in dopamine-deficient mice. Proc Natl Acad Sci USA 96: 12138-12143.
53. Takahata R, Moghaddam B (2003). Activation of glutamate neurotransmission in the prefrontal cortex sustains the motoric and dopaminergic effects of phencyclidine. Neuropsychopharmacology 28: 1117-1124.
54. Thomas SA, Marck BT, Palmiter RD, Matsumoto AM (1998). Restoration of norepinephrine and reversal of phenotypes in mice lacking dopamine beta-hydroxylase. J Neurochem 70: 2468-2476.
55. Ungerstedt U (1971). Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol Scand Suppl 367: 95-122.
56. Ungerstedt U, Ljungberg T, Steg G (1974). Behavioral, physiological, and neurochemical changes after 6-hydroxydopamine-induced degeneration of the nigro-striatal dopamine neurons. Adv Neurol 5: 421-426.
57. Verma A, Moghaddam B (1996). NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine. J Neurosci 16: 373-379.
58. Winter JC, Eckler JR, Rabin RA (2004). Serotonergic/glutamatergic interactions: the effects of mGlu2/3 receptor ligands in rats trained with LSD and PCP as discriminative stimuli. Psychopharmacology (Berl) 172: 233-240.
59. Zhou QY, Palmiter RD (1995). Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic. Cell 83: 1197-1209.
60. Zigmond MJ, Stricker EM (1984). Parkinson's disease: studies with an animal model. Life Sci 35: 5-18.