메뉴 건너뛰기




Volumn 17, Issue 1, 2011, Pages 28-34

Basic and translational understandings of microbial recognition by Toll-like receptors in the intestine

Author keywords

Flagellin; Immunity; Innate; Toll like receptor

Indexed keywords


EID: 80051788176     PISSN: 20930879     EISSN: 20930887     Source Type: Journal    
DOI: 10.5056/jnm.2011.17.1.28     Document Type: Review
Times cited : (29)

References (62)
  • 1
    • 67650333217 scopus 로고    scopus 로고
    • Principles and clinical implications of the brain-gut-enteric microbiota axis
    • Rhee SH, Pothoulakis C, Mayer EA. Principles and clinical implications of the brain-gut-enteric microbiota axis. Nat Rev Gastroenterol Hepatol 2009;6:306-314.
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , pp. 306-314
    • Rhee, S.H.1    Pothoulakis, C.2    Mayer, E.A.3
  • 2
    • 77956569409 scopus 로고    scopus 로고
    • Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis
    • Garrett WS, Gallini CA, Yatsunenko T, et al. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe 2010;8:292-300.
    • (2010) Cell Host Microbe , vol.8 , pp. 292-300
    • Garrett, W.S.1    Gallini, C.A.2    Yatsunenko, T.3
  • 4
    • 26444440067 scopus 로고    scopus 로고
    • Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation
    • Rhee SH, Im E, Riegler M, Kokkotou E, O'brien M, Pothoulakis C. Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci USA 2005;102:13610-13615.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 13610-13615
    • Rhee, S.H.1    Im, E.2    Riegler, M.3    Kokkotou, E.4    O'brien, M.5    Pothoulakis, C.6
  • 5
    • 33746110481 scopus 로고    scopus 로고
    • Lactobacillus farciminis treatment suppresses stress induced visceral hypersensitivity: a possible action through interaction with epithelial cell cytoskeleton contraction
    • Ait-Belgnaoui A, Han W, Lamine F. Lactobacillus farciminis treatment suppresses stress induced visceral hypersensitivity: a possible action through interaction with epithelial cell cytoskeleton contraction. Gut 2006;55:1090-1094.
    • (2006) Gut , vol.55 , pp. 1090-1094
    • Ait-Belgnaoui, A.1    Han, W.2    Lamine, F.3
  • 6
    • 58049220365 scopus 로고    scopus 로고
    • Pattern recognition receptors and control of adaptive immunity
    • Palm NW, Medzhitov R. Pattern recognition receptors and control of adaptive immunity. Immunol Rev 2009;227:221-233.
    • (2009) Immunol Rev , vol.227 , pp. 221-233
    • Palm, N.W.1    Medzhitov, R.2
  • 7
    • 78649686679 scopus 로고    scopus 로고
    • A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes
    • Willing BP, Dicksved J, Halfvarson J, et al. A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes. Gastroenterology 2010;139: 1844-1854.e1.
    • (2010) Gastroenterology , vol.139
    • Willing, B.P.1    Dicksved, J.2    Halfvarson, J.3
  • 8
    • 2342646956 scopus 로고    scopus 로고
    • Bacterial flagellin is a dominant antigen in Crohn disease
    • Lodes MJ, Cong Y, Elson CO, et al. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 2004;113:1296-1306.
    • (2004) J Clin Invest , vol.113 , pp. 1296-1306
    • Lodes, M.J.1    Cong, Y.2    Elson, C.O.3
  • 9
    • 40749161012 scopus 로고    scopus 로고
    • A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair
    • Leaphart CL, Cavallo J, Gribar SC, et al. A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair. J Immunol 2007;179:4808-4820.
    • (2007) J Immunol , vol.179 , pp. 4808-4820
    • Leaphart, C.L.1    Cavallo, J.2    Gribar, S.C.3
  • 10
    • 72249112519 scopus 로고    scopus 로고
    • Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis: pathogenesis and therapeutic implications
    • Chan KL, Wong KF, Luk JM. Role of LPS/CD14/TLR4-mediated inflammation in necrotizing enterocolitis: pathogenesis and therapeutic implications. World J Gastroenterol 2009;15:4745-4752.
    • (2009) World J Gastroenterol , vol.15 , pp. 4745-4752
    • Chan, K.L.1    Wong, K.F.2    Luk, J.M.3
  • 11
    • 49749149169 scopus 로고    scopus 로고
    • Crohn's disease-associated Escherichia coli LF82 aggravates colitis in injured mouse colon via signaling by flagellin
    • Carvalho FA, Barnich N, Sauvanet P, Darcha C, Gelot A, Darfeuille-Michaud A. Crohn's disease-associated Escherichia coli LF82 aggravates colitis in injured mouse colon via signaling by flagellin. Inflamm Bowel Dis 2008;14:1051-1060.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 1051-1060
    • Carvalho, F.A.1    Barnich, N.2    Sauvanet, P.3    Darcha, C.4    Gelot, A.5    Darfeuille-Michaud, A.6
  • 12
    • 80053601764 scopus 로고    scopus 로고
    • From cytokines to toll-like receptors and beyond - current knowledge and future research needs in irritable bowel syndrome
    • Rodríguez-Fandiño O, Hernández-Ruiz J, Schmulson M. From cytokines to toll-like receptors and beyond - current knowledge and future research needs in irritable bowel syndrome. J Neurogastroenterol Motil 2010;16:363-373.
    • (2010) J Neurogastroenterol Motil , vol.16 , pp. 363-373
    • Rodríguez-Fandiño, O.1    Hernández-Ruiz, J.2    Schmulson, M.3
  • 13
    • 33644514222 scopus 로고    scopus 로고
    • Interactions between commensal bacteria and gut sensorimotor function in health and disease
    • Barbara G, Stanghellini V, Brandi G, et al. Interactions between commensal bacteria and gut sensorimotor function in health and disease. Am J Gastroenterol 2005;100:2560-2568.
    • (2005) Am J Gastroenterol , vol.100 , pp. 2560-2568
    • Barbara, G.1    Stanghellini, V.2    Brandi, G.3
  • 14
    • 0035793372 scopus 로고    scopus 로고
    • Molecular analysis of commensal host-microbial relationships in the intestine
    • Hooper LV, Wong MH, Thelin A, Hansson L, Falk PG, Gordon JI. Molecular analysis of commensal host-microbial relationships in the intestine. Science 2001;291:881-884.
    • (2001) Science , vol.291 , pp. 881-884
    • Hooper, L.V.1    Wong, M.H.2    Thelin, A.3    Hansson, L.4    Falk, P.G.5    Gordon, J.I.6
  • 15
    • 58149132139 scopus 로고    scopus 로고
    • Effect of acute mucosal exposure to Lactobacillus rhamnosus GG on human colonic smooth muscle cells
    • Guarino MP, Altomare A, Stasi E, et al. Effect of acute mucosal exposure to Lactobacillus rhamnosus GG on human colonic smooth muscle cells. J Clin Gastroenterol 2008;42(suppl 3 Pt 2):S185-S190.
    • (2008) J Clin Gastroenterol , vol.42 , Issue.SUPPL. 3 PART 2
    • Guarino, M.P.1    Altomare, A.2    Stasi, E.3
  • 16
    • 77957848189 scopus 로고    scopus 로고
    • Luminal administration ex vivo of a live Lactobacillus species moderates mouse jejunal motility within minutes
    • Wang B, Mao YK, Diorio C, et al. Luminal administration ex vivo of a live Lactobacillus species moderates mouse jejunal motility within minutes. FASEB J 2010;24:4078-4088.
    • (2010) FASEB J , vol.24 , pp. 4078-4088
    • Wang, B.1    Mao, Y.K.2    Diorio, C.3
  • 17
    • 33845663225 scopus 로고    scopus 로고
    • The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation
    • Dass NB, John AK, Bassil AK, et al. The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation. Neurogastroenterol Motil 2007;19:66-74.
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 66-74
    • Dass, N.B.1    John, A.K.2    Bassil, A.K.3
  • 18
    • 19944399750 scopus 로고    scopus 로고
    • The ileocolonic sphincter
    • Malbert CH. The ileocolonic sphincter. Neurogastroenterol Motil 2005;17(suppl 1):41-49.
    • (2005) Neurogastroenterol Motil , vol.17 , Issue.SUPPL. 1 , pp. 41-49
    • Malbert, C.H.1
  • 19
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 20
    • 0034602150 scopus 로고    scopus 로고
    • Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase
    • Rhee SH, Hwang D. Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase. J Biol Chem 2000;275:34035-34040.
    • (2000) J Biol Chem , vol.275 , pp. 34035-34040
    • Rhee, S.H.1    Hwang, D.2
  • 22
    • 35349016235 scopus 로고    scopus 로고
    • Recognition of microorganisms and activation of the immune response
    • Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature 2007;449:819-826.
    • (2007) Nature , vol.449 , pp. 819-826
    • Medzhitov, R.1
  • 23
    • 33750070631 scopus 로고    scopus 로고
    • Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting
    • Triantafilou M, Gamper FG, Haston RM, et al. Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J Biol Chem 2006;281:31002-31011.
    • (2006) J Biol Chem , vol.281 , pp. 31002-31011
    • Triantafilou, M.1    Gamper, F.G.2    Haston, R.M.3
  • 24
    • 51349158231 scopus 로고    scopus 로고
    • Signalling adaptors used by Toll-like receptors: an update
    • Kenny EF, O'Neill LA. Signalling adaptors used by Toll-like receptors: an update. Cytokine 2008;43:342-349.
    • (2008) Cytokine , vol.43 , pp. 342-349
    • Kenny, E.F.1    O'Neill, L.A.2
  • 25
    • 56549116047 scopus 로고    scopus 로고
    • Toll-like receptor and RIG-I-like receptor signaling
    • Kawai T, Akira S. Toll-like receptor and RIG-I-like receptor signaling. Ann N Y Acad Sci 2008;1143:1-20.
    • (2008) Ann N Y Acad Sci , vol.1143 , pp. 1-20
    • Kawai, T.1    Akira, S.2
  • 26
    • 0038605053 scopus 로고    scopus 로고
    • Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophages
    • Rhee SH, Jones BW, Toshchakov V, Vogel SN, Fenton MJ. Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophages. J Biol Chem 2003;278:22506-22512.
    • (2003) J Biol Chem , vol.278 , pp. 22506-22512
    • Rhee, S.H.1    Jones, B.W.2    Toshchakov, V.3    Vogel, S.N.4    Fenton, M.J.5
  • 27
    • 24644442139 scopus 로고    scopus 로고
    • Effects of flagellin on innate and adaptive immunity
    • Honko AN, Mizel SB. Effects of flagellin on innate and adaptive immunity. Immunol Res 2005;33:83-101.
    • (2005) Immunol Res , vol.33 , pp. 83-101
    • Honko, A.N.1    Mizel, S.B.2
  • 28
    • 0037036469 scopus 로고    scopus 로고
    • TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells
    • Abreu MT, Arnold ET, Thomas LS, et al. TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J Biol Chem 2002;277:20431-20437.
    • (2002) J Biol Chem , vol.277 , pp. 20431-20437
    • Abreu, M.T.1    Arnold, E.T.2    Thomas, L.S.3
  • 29
    • 0035424901 scopus 로고    scopus 로고
    • Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide
    • Abreu MT, Vora P, Faure E, Thomas LS, Arnold ET, Arditi M. Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J Immunol 2001;167:1609-1616.
    • (2001) J Immunol , vol.167 , pp. 1609-1616
    • Abreu, M.T.1    Vora, P.2    Faure, E.3    Thomas, L.S.4    Arnold, E.T.5    Arditi, M.6
  • 30
    • 59849091829 scopus 로고    scopus 로고
    • Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis
    • Gribar SC, Sodhi CP, Richardson WM, et al. Reciprocal expression and signaling of TLR4 and TLR9 in the pathogenesis and treatment of necrotizing enterocolitis. J Immunol 2009;182:636-646.
    • (2009) J Immunol , vol.182 , pp. 636-646
    • Gribar, S.C.1    Sodhi, C.P.2    Richardson, W.M.3
  • 31
    • 74049093945 scopus 로고    scopus 로고
    • Localization of the lipopolysaccharide recognition complex in the human healthy and inflamed premature and adult gut
    • Wolfs TG, Derikx JP, Hodin CM, et al. Localization of the lipopolysaccharide recognition complex in the human healthy and inflamed premature and adult gut. Inflamm Bowel Dis 2010;16:68-75.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 68-75
    • Wolfs, T.G.1    Derikx, J.P.2    Hodin, C.M.3
  • 32
    • 33644844631 scopus 로고    scopus 로고
    • Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk
    • LeBouder E, Rey-Nores JE, Raby AC, et al. Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk. J Immunol 2006;176:3742-3752.
    • (2006) J Immunol , vol.176 , pp. 3742-3752
    • LeBouder, E.1    Rey-Nores, J.E.2    Raby, A.C.3
  • 33
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004;118:229- 241.
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 34
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
    • Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol 2001; 167:1882-1885.
    • (2001) J Immunol , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3    Godowski, P.J.4    Madara, J.L.5
  • 36
    • 77149142027 scopus 로고    scopus 로고
    • TLR5 is not required for flagellin-mediated exacerbation of DSS colitis
    • Ivison SM, Himmel ME, Hardenberg G, et al. TLR5 is not required for flagellin-mediated exacerbation of DSS colitis. Inflamm Bowel Dis 2010;16:401-409.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 401-409
    • Ivison, S.M.1    Himmel, M.E.2    Hardenberg, G.3
  • 37
    • 20444441016 scopus 로고    scopus 로고
    • Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease
    • Targan SR, Landers CJ, Yang H, et al. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology 2005;128:2020-2028.
    • (2005) Gastroenterology , vol.128 , pp. 2020-2028
    • Targan, S.R.1    Landers, C.J.2    Yang, H.3
  • 40
    • 42049095095 scopus 로고    scopus 로고
    • An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models
    • Burdelya LG, Krivokrysenko VI, Tallant TC, et al. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 2008;320:226-230.
    • (2008) Science , vol.320 , pp. 226-230
    • Burdelya, L.G.1    Krivokrysenko, V.I.2    Tallant, T.C.3
  • 41
    • 48549085489 scopus 로고    scopus 로고
    • Flagellin treatment protects against chemicals, bacteria, viruses, and radiation
    • Vijay-Kumar M, Aitken JD, Sanders CJ, et al. Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. J Immunol 2008;180:8280-8285.
    • (2008) J Immunol , vol.180 , pp. 8280-8285
    • Vijay-Kumar, M.1    Aitken, J.D.2    Sanders, C.J.3
  • 42
    • 36849000520 scopus 로고    scopus 로고
    • Deletion of TLR5 results in spontaneous colitis in mice
    • Vijay-Kumar M, Sanders CJ, Taylor RT, et al. Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest 2007;117:3909-3921.
    • (2007) J Clin Invest , vol.117 , pp. 3909-3921
    • Vijay-Kumar, M.1    Sanders, C.J.2    Taylor, R.T.3
  • 43
    • 77950250064 scopus 로고    scopus 로고
    • Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
    • Vijay-Kumar M, Aitken JD, Carvalho FA, et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010;328:228-231.
    • (2010) Science , vol.328 , pp. 228-231
    • Vijay-Kumar, M.1    Aitken, J.D.2    Carvalho, F.A.3
  • 44
    • 33747769371 scopus 로고    scopus 로고
    • Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria
    • Feuillet V, Medjane S, Mondor I, et al. Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci USA 2006;103:12487-12492.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 12487-12492
    • Feuillet, V.1    Medjane, S.2    Mondor, I.3
  • 45
    • 48549106083 scopus 로고    scopus 로고
    • Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer
    • Rhee SH, Im E, Pothoulakis C. Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Gastroenterology 2008;135:518-528.
    • (2008) Gastroenterology , vol.135 , pp. 518-528
    • Rhee, S.H.1    Im, E.2    Pothoulakis, C.3
  • 46
    • 33744473038 scopus 로고    scopus 로고
    • Expression of Toll-like receptors and their association with cytokine responses in peripheral blood mononuclear cells of children with acute rotavirus diarrhoea
    • Xu J, Yang Y, Sun J, et al. Expression of Toll-like receptors and their association with cytokine responses in peripheral blood mononuclear cells of children with acute rotavirus diarrhoea. Clin Exp Immunol 2006;144:376-381.
    • (2006) Clin Exp Immunol , vol.144 , pp. 376-381
    • Xu, J.1    Yang, Y.2    Sun, J.3
  • 48
    • 22744453319 scopus 로고    scopus 로고
    • Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria
    • Furrie E, Macfarlane S, Thomson G. Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria. Immunology 2005;115:565-574.
    • (2005) Immunology , vol.115 , pp. 565-574
    • Furrie, E.1    Macfarlane, S.2    Thomson, G.3
  • 49
    • 0038781673 scopus 로고    scopus 로고
    • Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated upregulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex
    • Suzuki M, Hisamatsu T, Podolsky DK. Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated upregulation of LPS uptake and expression of the intracellular Toll-like receptor 4-MD-2 complex. Infect Immun 2003;71:3503-3511.
    • (2003) Infect Immun , vol.71 , pp. 3503-3511
    • Suzuki, M.1    Hisamatsu, T.2    Podolsky, D.K.3
  • 50
    • 34248397191 scopus 로고    scopus 로고
    • Surface expression of Toll-like receptor 9 is upregulated on intestinal epithelial cells in response to pathogenic bacterial DNA
    • Ewaschuk JB, Backer JL, Churchill TA, Obermeier F, Krause DO, Madsen KL. Surface expression of Toll-like receptor 9 is upregulated on intestinal epithelial cells in response to pathogenic bacterial DNA. Infect Immun 2007;75:2572-2579.
    • (2007) Infect Immun , vol.75 , pp. 2572-2579
    • Ewaschuk, J.B.1    Backer, J.L.2    Churchill, T.A.3    Obermeier, F.4    Krause, D.O.5    Madsen, K.L.6
  • 51
    • 33646908228 scopus 로고    scopus 로고
    • Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
    • Kagan JC, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 2006;125:943-955.
    • (2006) Cell , vol.125 , pp. 943-955
    • Kagan, J.C.1    Medzhitov, R.2
  • 52
    • 40949134086 scopus 로고    scopus 로고
    • TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
    • Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol 2008;9:361-368.
    • (2008) Nat Immunol , vol.9 , pp. 361-368
    • Kagan, J.C.1    Su, T.2    Horng, T.3    Chow, A.4    Akira, S.5    Medzhitov, R.6
  • 53
    • 2942560322 scopus 로고    scopus 로고
    • MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells
    • Rhee SH, Keates AC, Moyer MP, Pothoulakis C. MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. J Biol Chem 2004;279:25179-25188.
    • (2004) J Biol Chem , vol.279 , pp. 25179-25188
    • Rhee, S.H.1    Keates, A.C.2    Moyer, M.P.3    Pothoulakis, C.4
  • 54
    • 33745868678 scopus 로고    scopus 로고
    • Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells
    • Rhee SH, Kim H, Moyer MP, Pothoulakis C. Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. J Biol Chem 2006;281: 18560-18568.
    • (2006) J Biol Chem , vol.281 , pp. 18560-18568
    • Rhee, S.H.1    Kim, H.2    Moyer, M.P.3    Pothoulakis, C.4
  • 55
    • 78549284013 scopus 로고    scopus 로고
    • TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells
    • Choi YJ, Im E, Chung HK, Pothoulakis C, Rhee SH. TRIF mediates Toll-like receptor 5-induced signaling in intestinal epithelial cells. J Biol Chem 2010;285:37570-37578.
    • (2010) J Biol Chem , vol.285 , pp. 37570-37578
    • Choi, Y.J.1    Im, E.2    Chung, H.K.3    Pothoulakis, C.4    Rhee, S.H.5
  • 56
    • 77954381441 scopus 로고    scopus 로고
    • TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5
    • Choi YJ, Im E, Pothoulakis C, Rhee SH. TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5. J Biol Chem 2010;285:21382-21390.
    • (2010) J Biol Chem , vol.285 , pp. 21382-21390
    • Choi, Y.J.1    Im, E.2    Pothoulakis, C.3    Rhee, S.H.4
  • 57
    • 48449088875 scopus 로고    scopus 로고
    • The role of serotonin in intestinal luminal sensing and secretion
    • Hansen MB, Witte AB. The role of serotonin in intestinal luminal sensing and secretion. Acta Physiol (Oxf) 2008;193:311-323.
    • (2008) Acta Physiol (Oxf) , vol.193 , pp. 311-323
    • Hansen, M.B.1    Witte, A.B.2
  • 59
    • 0029976793 scopus 로고    scopus 로고
    • 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons
    • Grider JR, Kuemmerle JF, Jin JG. 5-HT released by mucosal stimuli initiates peristalsis by activating 5-HT4/5-HT1p receptors on sensory CGRP neurons. Am J Physiol 1996;270(5 Pt 1):G778-G782.
    • (1996) Am J Physiol , vol.270 , Issue.5 PART 1
    • Grider, J.R.1    Kuemmerle, J.F.2    Jin, J.G.3
  • 60
    • 0032982972 scopus 로고    scopus 로고
    • Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin
    • Peregrin AT, Ahlman H, Jodal M, Lundgren O. Involvement of serotonin and calcium channels in the intestinal fluid secretion evoked by bile salt and cholera toxin. Br J Pharmacol 1999;127:887-894.
    • (1999) Br J Pharmacol , vol.127 , pp. 887-894
    • Peregrin, A.T.1    Ahlman, H.2    Jodal, M.3    Lundgren, O.4
  • 61
    • 0036293574 scopus 로고    scopus 로고
    • Visceral perception: sensory transduction in visceral afferents and nutrients
    • Raybould HE. Visceral perception: sensory transduction in visceral afferents and nutrients. Gut 2002;51(suppl 1):i11-i14.
    • (2002) Gut , vol.51 , Issue.SUPPL. 1
    • Raybould, H.E.1
  • 62
    • 34247631654 scopus 로고    scopus 로고
    • Enterochromaffin cells of the human gut: sensors for spices and odorants
    • Braun T, Voland P, Kunz L, Prinz C, Gratzl M. Enterochromaffin cells of the human gut: sensors for spices and odorants. Gastroenterology 2007;132:1890-1901.
    • (2007) Gastroenterology , vol.132 , pp. 1890-1901
    • Braun, T.1    Voland, P.2    Kunz, L.3    Prinz, C.4    Gratzl, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.