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Volumn 193, Issue 4, 2008, Pages 311-323

The role of serotonin in intestinal luminal sensing and secretion

Author keywords

Enteric neurones; Enterochromaffin cells; Epithelial ion transport; Intestinal secretion; Serotonin; Transient receptor potential vanilloid type 1

Indexed keywords

ION CHANNEL; NEUROTRANSMITTER; SEROTONIN; SEROTONIN 1P RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL; VANILLOID RECEPTOR 1;

EID: 48449088875     PISSN: 17481708     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2008.01870.x     Document Type: Review
Times cited : (115)

References (112)
  • 1
    • 0035162772 scopus 로고    scopus 로고
    • The gut as the largest endocrine organ in the body
    • Ahlman, H. Nilsson, O. 2001. The gut as the largest endocrine organ in the body. Ann Oncol 12 (Suppl. 2 S63 S68.
    • (2001) Ann Oncol , vol.12 , Issue.2
    • Ahlman, H.1    Nilsson, O.2
  • 2
    • 10644261336 scopus 로고    scopus 로고
    • Gastroduodenal mucus bicarbonate barrier: Protection against acid and pepsin
    • Allen, A. Flemstrom, G. 2005. Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin. Am J Physiol Cell Physiol 288, C1 C19.
    • (2005) Am J Physiol Cell Physiol , vol.288
    • Allen, A.1    Flemstrom, G.2
  • 3
    • 0029964719 scopus 로고    scopus 로고
    • 5-hydroxytryptamine release into human jejunum by cholera toxin
    • Bearcroft, C.P., Perrett, D. Farthing, M.J. 1996. 5-hydroxytryptamine release into human jejunum by cholera toxin. Gut 39, 528 531.
    • (1996) Gut , vol.39 , pp. 528-531
    • Bearcroft, C.P.1    Perrett, D.2    Farthing, M.J.3
  • 4
    • 0030833013 scopus 로고    scopus 로고
    • In vivo effects of the 5-HT3 antagonist alosetron on basal and cholera toxin-induced secretion in the human jejunum: A segmental perfusion study
    • Bearcroft, C.P., Andre, E.A. Farthing, M.J. 1997. In vivo effects of the 5-HT3 antagonist alosetron on basal and cholera toxin-induced secretion in the human jejunum: a segmental perfusion study. Aliment Pharmacol Ther 11, 1109 1114.
    • (1997) Aliment Pharmacol Ther , vol.11 , pp. 1109-1114
    • Bearcroft, C.P.1    Andre, E.A.2    Farthing, M.J.3
  • 5
    • 0031980886 scopus 로고    scopus 로고
    • Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: A pilot study
    • Bearcroft, C.P., Perrett, D. Farthing, M.J. 1998. Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut 42, 42 46.
    • (1998) Gut , vol.42 , pp. 42-46
    • Bearcroft, C.P.1    Perrett, D.2    Farthing, M.J.3
  • 6
    • 0031007901 scopus 로고    scopus 로고
    • Nitric oxide counteracts 5-hydroxytryptamine- and cholera toxin-induced fluid secretion and enhances the effect of oral rehydration solution
    • Beubler, E. Schirgi-Degen, A. 1997. Nitric oxide counteracts 5-hydroxytryptamine- and cholera toxin-induced fluid secretion and enhances the effect of oral rehydration solution. Eur J Pharmacol 326, 223 228.
    • (1997) Eur J Pharmacol , vol.326 , pp. 223-228
    • Beubler, E.1    Schirgi-Degen, A.2
  • 7
    • 0036902286 scopus 로고    scopus 로고
    • The pharmacology of gastrointestinal nociceptive pathways
    • Blackshaw, L.A. Gebhart, G.F. 2002. The pharmacology of gastrointestinal nociceptive pathways. Curr Opin Pharmacol 2, 642 649.
    • (2002) Curr Opin Pharmacol , vol.2 , pp. 642-649
    • Blackshaw, L.A.1    Gebhart, G.F.2
  • 9
    • 0035199870 scopus 로고    scopus 로고
    • Localization, physiological significance and possible clinical implication of gastrointestinal melatonin
    • Bubenik, G.A. 2001. Localization, physiological significance and possible clinical implication of gastrointestinal melatonin. Biol Signals Recept 10, 350 366.
    • (2001) Biol Signals Recept , vol.10 , pp. 350-366
    • Bubenik, G.A.1
  • 10
    • 0028170524 scopus 로고
    • The 5-HT4 receptor mediates 5-hydroxytryptamine-induced rise in short circuit current in the human jejunum in vitro
    • Budhoo, M.R. Kellum, J.M. 1994. The 5-HT4 receptor mediates 5-hydroxytryptamine-induced rise in short circuit current in the human jejunum in vitro. Surgery 116, 396 400.
    • (1994) Surgery , vol.116 , pp. 396-400
    • Budhoo, M.R.1    Kellum, J.M.2
  • 11
    • 0029670467 scopus 로고    scopus 로고
    • - transport is mediated by 5-HT3 and 5-HT4 receptors in the rat distal colon
    • - transport is mediated by 5-HT3 and 5-HT4 receptors in the rat distal colon. Eur J Pharmacol 298, 137 144.
    • (1996) Eur J Pharmacol , vol.298 , pp. 137-144
    • Budhoo, M.R.1    Harris, R.P.2    Kellum, J.M.3
  • 13
    • 0027169234 scopus 로고
    • Short-circuit current responses to 5-hydroxytryptamine in human ileal mucosa are mediated by a 5-HT4 receptor
    • Burleigh, D.E. Borman, R.A. 1993. Short-circuit current responses to 5-hydroxytryptamine in human ileal mucosa are mediated by a 5-HT4 receptor. Eur J Pharmacol 241, 125 128.
    • (1993) Eur J Pharmacol , vol.241 , pp. 125-128
    • Burleigh, D.E.1    Borman, R.A.2
  • 14
    • 1642451914 scopus 로고    scopus 로고
    • Management of infectious diarrhoea
    • Casburn-Jones, A.C. Farthing, M.J. 2004. Management of infectious diarrhoea. Gut 53, 296 305.
    • (2004) Gut , vol.53 , pp. 296-305
    • Casburn-Jones, A.C.1    Farthing, M.J.2
  • 17
    • 0026737317 scopus 로고
    • Gastrointestinal food hypersensitivity: Basic mechanisms of pathophysiology
    • Crowe, S.E. Perdue, M.H. 1992. Gastrointestinal food hypersensitivity: basic mechanisms of pathophysiology. Gastroenterology 103, 1075 1095.
    • (1992) Gastroenterology , vol.103 , pp. 1075-1095
    • Crowe, S.E.1    Perdue, M.H.2
  • 18
    • 26844502132 scopus 로고    scopus 로고
    • A nonneuronal 5-hydroxytryptamine receptor 3 induces chloride secretion in the rat distal colonic mucosa
    • Day, J., King, B., Haque, S.M. Kellum, J.M. 2005. A nonneuronal 5-hydroxytryptamine receptor 3 induces chloride secretion in the rat distal colonic mucosa. Am J Surg 190, 736 738.
    • (2005) Am J Surg , vol.190 , pp. 736-738
    • Day, J.1    King, B.2    Haque, S.M.3    Kellum, J.M.4
  • 19
    • 0014604465 scopus 로고
    • Recent concepts in the dumping syndrome
    • Drapanas, T. 1969. Recent concepts in the dumping syndrome. J Miss State Med Assoc 10, 493 498.
    • (1969) J Miss State Med Assoc , vol.10 , pp. 493-498
    • Drapanas, T.1
  • 22
    • 0037380607 scopus 로고    scopus 로고
    • Intestinal ion transport and the pathophysiology of diarrhea
    • Field, M. 2003. Intestinal ion transport and the pathophysiology of diarrhea. J Clin Invest 111, 931 943.
    • (2003) J Clin Invest , vol.111 , pp. 931-943
    • Field, M.1
  • 23
    • 0035258047 scopus 로고    scopus 로고
    • Gastroduodenal mucosal alkaline secretion and mucosal protection
    • Flemstrom, G. Isenberg, J.I. 2001. Gastroduodenal mucosal alkaline secretion and mucosal protection. News Physiol Sci 16, 23 28.
    • (2001) News Physiol Sci , vol.16 , pp. 23-28
    • Flemstrom, G.1    Isenberg, J.I.2
  • 24
    • 24044445790 scopus 로고    scopus 로고
    • Epithelial cells and their neighbors. II. New perspectives on efferent signaling between brain, neuroendocrine cells, and gut epithelial cells
    • Flemstrom, G. Sjoblom, M. 2005. Epithelial cells and their neighbors. II. New perspectives on efferent signaling between brain, neuroendocrine cells, and gut epithelial cells. Am J Physiol Gastrointest Liver Physiol 289, G377 G380.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.289
    • Flemstrom, G.1    Sjoblom, M.2
  • 27
    • 0034524493 scopus 로고    scopus 로고
    • Inflammatory mediators influencing submucosal secretory reflexes
    • Frieling, T., Weber, E. Schemann, M. 2000. Inflammatory mediators influencing submucosal secretory reflexes. Ann N Y Acad Sci 915, 98 101.
    • (2000) Ann N Y Acad Sci , vol.915 , pp. 98-101
    • Frieling, T.1    Weber, E.2    Schemann, M.3
  • 28
    • 0026027674 scopus 로고
    • Serotonin-containing epithelial cells in rat duodenum. I. Quantitative morphometric study of the distribution density
    • Fujimiya, M., Maeda, T. Kimura, H. 1991. Serotonin-containing epithelial cells in rat duodenum. I. Quantitative morphometric study of the distribution density. Histochemistry 95, 217 224.
    • (1991) Histochemistry , vol.95 , pp. 217-224
    • Fujimiya, M.1    Maeda, T.2    Kimura, H.3
  • 29
    • 0031751819 scopus 로고    scopus 로고
    • Effect of VIP and PACAP on basal release of serotonin from isolated vascularly and luminally perfused rat duodenum
    • Fujimiya, M., Yamamoto, H. Kuwahara, A. 1998. Effect of VIP and PACAP on basal release of serotonin from isolated vascularly and luminally perfused rat duodenum. Am J Physiol 275, G731 G739.
    • (1998) Am J Physiol , vol.275
    • Fujimiya, M.1    Yamamoto, H.2    Kuwahara, A.3
  • 31
    • 0027339690 scopus 로고
    • Modulation by 5-HT3 and 5-HT4 receptors of the release of 5-hydroxytryptamine from the guinea-pig small intestine
    • Gebauer, A., Merger, M. Kilbinger, H. 1993. Modulation by 5-HT3 and 5-HT4 receptors of the release of 5-hydroxytryptamine from the guinea-pig small intestine. Naunyn Schmiedebergs Arch Pharmacol 347, 137 140.
    • (1993) Naunyn Schmiedebergs Arch Pharmacol , vol.347 , pp. 137-140
    • Gebauer, A.1    Merger, M.2    Kilbinger, H.3
  • 32
    • 0032919084 scopus 로고    scopus 로고
    • Review article: Roles played by 5-hydroxytryptamine in the physiology of the bowel
    • Gershon, M.D. 1999. Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment Pharmacol Ther 13 (Suppl. 2 15 30.
    • (1999) Aliment Pharmacol Ther , vol.13 , Issue.2 , pp. 15-30
    • Gershon, M.D.1
  • 33
    • 0037808968 scopus 로고    scopus 로고
    • Importance of serotonergic mechanisms in gastrointestinal motility and sensation
    • In: M. Camilleri. R.C. Spiller (. eds). pp. WB Saunders, Elsevier Science Limited, Edinburgh.
    • Gershon, M.D. 2002. Importance of serotonergic mechanisms in gastrointestinal motility and sensation. In : M. Camilleri R.C. Spiller (eds) Irritable Bowel Syndrome, pp. 95 116. WB Saunders, Elsevier Science Limited, Edinburgh.
    • (2002) Irritable Bowel Syndrome , pp. 95-116
    • Gershon, M.D.1
  • 34
    • 0038107287 scopus 로고    scopus 로고
    • Serotonin and its implication for the management of irritable bowel syndrome
    • Gershon, M.D. 2003. Serotonin and its implication for the management of irritable bowel syndrome. Rev Gastroenterol Disord 3 (Suppl. 2 S25 S34.
    • (2003) Rev Gastroenterol Disord , vol.3 , Issue.2
    • Gershon, M.D.1
  • 35
    • 33846347644 scopus 로고    scopus 로고
    • The serotonin signaling system: From basic understanding to drug development for functional GI disorders
    • Gershon, M.D. Tack, J. 2007. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 132, 397 414.
    • (2007) Gastroenterology , vol.132 , pp. 397-414
    • Gershon, M.D.1    Tack, J.2
  • 37
    • 33747378241 scopus 로고    scopus 로고
    • Serotonin-producing enterochromaffin (EC) cells of gastrointestinal mucosa in dexamethasone-treated rats
    • Glisic, R., Koko, V., Todorovic, V., Drndarevic, N. Cvijic, G. 2006. Serotonin-producing enterochromaffin (EC) cells of gastrointestinal mucosa in dexamethasone-treated rats. Regul Pept 136, 30 39.
    • (2006) Regul Pept , vol.136 , pp. 30-39
    • Glisic, R.1    Koko, V.2    Todorovic, V.3    Drndarevic, N.4    Cvijic, G.5
  • 38
    • 0030039516 scopus 로고    scopus 로고
    • Age and segmental differences in 5-hydroxytryptamine-induced hypersecretion in the pig small intestine
    • Grondahl, M.L., Hansen, M.B., Larsen, I.E. Skadhauge, E. 1996. Age and segmental differences in 5-hydroxytryptamine-induced hypersecretion in the pig small intestine. J Comp Physiol [B] 166, 21 29.
    • (1996) J Comp Physiol [B] , vol.166 , pp. 21-29
    • Grondahl, M.L.1    Hansen, M.B.2    Larsen, I.E.3    Skadhauge, E.4
  • 39
    • 2542589350 scopus 로고    scopus 로고
    • Regional differences in the effect of cholera toxin and enterotoxigenic Escherichia coli infection on electrolyte and fluid transport in the porcine small intestine
    • Grondahl, M.L., Thorboll, J.E., Hansen, M.B. Skadhauge, E. 1998. Regional differences in the effect of cholera toxin and enterotoxigenic Escherichia coli infection on electrolyte and fluid transport in the porcine small intestine. Zentralbl Veterinarmed A 45, 369 381.
    • (1998) Zentralbl Veterinarmed a , vol.45 , pp. 369-381
    • Grondahl, M.L.1    Thorboll, J.E.2    Hansen, M.B.3    Skadhauge, E.4
  • 40
    • 24044467418 scopus 로고    scopus 로고
    • Effects of nitric oxide in 5-hydroxytryptamine-, cholera toxin-, enterotoxigenic Escherichia coli- and Salmonella Typhimurium-induced secretion in the porcine small intestine
    • Grondahl, M.L., Unmack, M.A., Ragnarsdottir, H.B., Hansen, M.B., Olsen, J.E. Skadhauge, E. 2005. Effects of nitric oxide in 5-hydroxytryptamine-, cholera toxin-, enterotoxigenic Escherichia coli- and Salmonella Typhimurium-induced secretion in the porcine small intestine. Comp Biochem Physiol A Mol Integr Physiol 141, 476 484.
    • (2005) Comp Biochem Physiol a Mol Integr Physiol , vol.141 , pp. 476-484
    • Grondahl, M.L.1    Unmack, M.A.2    Ragnarsdottir, H.B.3    Hansen, M.B.4    Olsen, J.E.5    Skadhauge, E.6
  • 41
    • 33646390403 scopus 로고    scopus 로고
    • A new method for visualization of gut mucosal cells, describing the enterochromaffin cell in the rat gastrointestinal tract
    • Gustafsson, B.I., Bakke, I., Tommeras, K. Waldum, H.L. 2006. A new method for visualization of gut mucosal cells, describing the enterochromaffin cell in the rat gastrointestinal tract. Scand J Gastroenterol 41, 390 395.
    • (2006) Scand J Gastroenterol , vol.41 , pp. 390-395
    • Gustafsson, B.I.1    Bakke, I.2    Tommeras, K.3    Waldum, H.L.4
  • 42
    • 38149050708 scopus 로고    scopus 로고
    • Hypersensitivity for capsaicin in patients with functional dyspepsia
    • Hammer, J., Führer, M., Pipal, L. Matiasek, J. 2008. Hypersensitivity for capsaicin in patients with functional dyspepsia. Neurogastroenterol Motil 20, 125 133.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 125-133
    • Hammer, J.1    Führer, M.2    Pipal, L.3    Matiasek, J.4
  • 43
    • 0028816157 scopus 로고
    • Tropisetron and octreotide reduce serotonin-induced fluid hypersecretion in pig jejunum
    • Hansen, M.B. 1995. Tropisetron and octreotide reduce serotonin-induced fluid hypersecretion in pig jejunum. Pharmacol Toxicol 76, 136 140.
    • (1995) Pharmacol Toxicol , vol.76 , pp. 136-140
    • Hansen, M.B.1
  • 44
    • 0037233610 scopus 로고    scopus 로고
    • Neurohumoral control of gastrointestinal motility
    • Hansen, M.B. 2003a. Neurohumoral control of gastrointestinal motility. Physiol Res 52, 1 30.
    • (2003) Physiol Res , vol.52 , pp. 1-30
    • Hansen, M.B.1
  • 45
    • 0037354685 scopus 로고    scopus 로고
    • The enteric nervous system I: Organisation and classification
    • Hansen, M.B. 2003b. The enteric nervous system I: organisation and classification. Pharmacol Toxicol 92, 105 113.
    • (2003) Pharmacol Toxicol , vol.92 , pp. 105-113
    • Hansen, M.B.1
  • 46
    • 0037903143 scopus 로고    scopus 로고
    • The enteric nervous system II: Gastrointestinal functions
    • Hansen, M.B. 2003c. The enteric nervous system II: gastrointestinal functions. Pharmacol Toxicol 92, 249 257.
    • (2003) Pharmacol Toxicol , vol.92 , pp. 249-257
    • Hansen, M.B.1
  • 47
    • 84882923418 scopus 로고    scopus 로고
    • BookPartner A/S, Denmark. ISNB 87-989118-1-3.
    • Hansen, M.B. 2004. Neurogastroenterology, 1 145. BookPartner A/S, Denmark. ISNB 87-989118-1-3.
    • (2004) Neurogastroenterology , pp. 1-145
    • Hansen, M.B.1
  • 48
    • 0024841178 scopus 로고
    • Serotonin receptors for chloride secretion in hen colon
    • Hansen, M.B. Bindslev, N. 1989. Serotonin receptors for chloride secretion in hen colon. Comp Biochem Physiol C 94, 189 197.
    • (1989) Comp Biochem Physiol C , vol.94 , pp. 189-197
    • Hansen, M.B.1    Bindslev, N.2
  • 49
    • 0029027208 scopus 로고
    • New aspects of the pathophysiology and treatment of secretory diarrhoea
    • Hansen, M.B. Skadhauge, E. 1995. New aspects of the pathophysiology and treatment of secretory diarrhoea. Physiol Res 44, 61 78.
    • (1995) Physiol Res , vol.44 , pp. 61-78
    • Hansen, M.B.1    Skadhauge, E.2
  • 50
    • 0031260218 scopus 로고    scopus 로고
    • Signal transduction pathways for serotonin as an intestinal secretagogue
    • Hansen, M.B. Skadhauge, E. 1997. Signal transduction pathways for serotonin as an intestinal secretagogue. Comp Biochem Physiol A Physiol 118, 283 290.
    • (1997) Comp Biochem Physiol a Physiol , vol.118 , pp. 283-290
    • Hansen, M.B.1    Skadhauge, E.2
  • 52
    • 0030723785 scopus 로고    scopus 로고
    • Comparison of the intestinal secretory response to 5-hydroxytryptamine in the rat jejunum and ileum in-vitro
    • Hardcastle, J. Hardcastle, P.T. 1997. Comparison of the intestinal secretory response to 5-hydroxytryptamine in the rat jejunum and ileum in-vitro. J Pharm Pharmacol 49, 1126 1131.
    • (1997) J Pharm Pharmacol , vol.49 , pp. 1126-1131
    • Hardcastle, J.1    Hardcastle, P.T.2
  • 53
    • 33746080459 scopus 로고    scopus 로고
    • TRP channels as therapeutic targets: Hot property, or time to cool down?
    • Hicks, G.A. 2006. TRP channels as therapeutic targets: hot property, or time to cool down? Neurogastroenterol Motil 18, 590 594.
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 590-594
    • Hicks, G.A.1
  • 55
    • 1842843657 scopus 로고    scopus 로고
    • Gastrointestinal pain in functional bowel disorders: Sensory neurons as novel drug targets
    • Holzer, P. 2004. Gastrointestinal pain in functional bowel disorders: sensory neurons as novel drug targets. Expert Opin Ther Targets 8, 107 123.
    • (2004) Expert Opin Ther Targets , vol.8 , pp. 107-123
    • Holzer, P.1
  • 56
    • 0030961840 scopus 로고    scopus 로고
    • 5-HT receptor classification and nomenclature: Towards a harmonization with the human genome
    • Hoyer, D. Martin, G. 1997. 5-HT receptor classification and nomenclature: towards a harmonization with the human genome. Neuropharmacology 36, 419 428.
    • (1997) Neuropharmacology , vol.36 , pp. 419-428
    • Hoyer, D.1    Martin, G.2
  • 57
    • 0023139121 scopus 로고
    • Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer
    • Isenberg, J.I., Selling, J.A., Hogan, D.L. Koss, M.A. 1987. Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. N Engl J Med 316, 374 379.
    • (1987) N Engl J Med , vol.316 , pp. 374-379
    • Isenberg, J.I.1    Selling, J.A.2    Hogan, D.L.3    Koss, M.A.4
  • 58
    • 0028286894 scopus 로고
    • Characterization of 5-hydroxytryptamine receptors mediating mucosal secretion in guinea-pig ileum
    • Johnson, P.J., Bornstein, J.C., Furness, J.B., Woollard, D.J. Orrman-Rossiter, S.L. 1994. Characterization of 5-hydroxytryptamine receptors mediating mucosal secretion in guinea-pig ileum. Br J Pharmacol 111, 1240 1244.
    • (1994) Br J Pharmacol , vol.111 , pp. 1240-1244
    • Johnson, P.J.1    Bornstein, J.C.2    Furness, J.B.3    Woollard, D.J.4    Orrman-Rossiter, S.L.5
  • 59
    • 13344278717 scopus 로고    scopus 로고
    • Is nitric oxide involved in 5-HT-induced fluid secretion in the gut?
    • Kadowaki, M., Gershon, M.D. Kuwahara, A. 1996. Is nitric oxide involved in 5-HT-induced fluid secretion in the gut? Behav Brain Res 73, 293 296.
    • (1996) Behav Brain Res , vol.73 , pp. 293-296
    • Kadowaki, M.1    Gershon, M.D.2    Kuwahara, A.3
  • 60
    • 33846353776 scopus 로고    scopus 로고
    • Involvement of a 5-HT3 receptor in the capsaicin-induced inhibitory duodeno-gastric reflex in man
    • Suppl. 2)
    • Karamanolis, G., Vos, R., Janssens, J. Tack, J. 2006. Involvement of a 5-HT3 receptor in the capsaicin-induced inhibitory duodeno-gastric reflex in man. Gastroenterology 130 (Suppl. 2) A-250.
    • (2006) Gastroenterology , vol.130
    • Karamanolis, G.1    Vos, R.2    Janssens, J.3    Tack, J.4
  • 61
    • 0029055473 scopus 로고
    • Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
    • Kararli, T.T. 1995. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm Drug Dispos 16, 351 380.
    • (1995) Biopharm Drug Dispos , vol.16 , pp. 351-380
    • Kararli, T.T.1
  • 62
    • 33846070748 scopus 로고    scopus 로고
    • Review article: Duodenal bicarbonate - Mucosal protection, luminal chemosensing and acid-base balance
    • Kaunitz, J.D. Akiba, Y. 2006. Review article: duodenal bicarbonate - mucosal protection, luminal chemosensing and acid-base balance. Aliment Pharmacol Ther 24 (Suppl. 4 169 176.
    • (2006) Aliment Pharmacol Ther , vol.24 , Issue.4 , pp. 169-176
    • Kaunitz, J.D.1    Akiba, Y.2
  • 64
    • 0017173941 scopus 로고
    • Release of immunoreactive serotonin following acid perfusion of the duodenum
    • Kellum, J.M., Jr Jaffe, B.M. 1976. Release of immunoreactive serotonin following acid perfusion of the duodenum. Ann Surg 184, 633 636.
    • (1976) Ann Surg , vol.184 , pp. 633-636
    • Kellum, J.M.1    Jr2    Jaffe, B.M.3
  • 66
    • 0037251439 scopus 로고    scopus 로고
    • Systematic review: Serotonergic modulators in the treatment of irritable bowel syndrome - Influence on psychiatric and gastrointestinal symptoms
    • Kilkens, T.O., Honig, A., Rozendaal, N., van Nieuwenhoven, M.A. Brummer, R.J. 2003. Systematic review: serotonergic modulators in the treatment of irritable bowel syndrome - influence on psychiatric and gastrointestinal symptoms. Aliment Pharmacol Ther 17, 43 51.
    • (2003) Aliment Pharmacol Ther , vol.17 , pp. 43-51
    • Kilkens, T.O.1    Honig, A.2    Rozendaal, N.3    Van Nieuwenhoven, M.A.4    Brummer, R.J.5
  • 67
    • 0035207186 scopus 로고    scopus 로고
    • D-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells
    • Kim, M., Cooke, H.J., Javed, N.H., Carey, H.V., Christofi, F. Raybould, H.E. 2001. d-glucose releases 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells. Gastroenterology 121, 1400 1406.
    • (2001) Gastroenterology , vol.121 , pp. 1400-1406
    • Kim, M.1    Cooke, H.J.2    Javed, N.H.3    Carey, H.V.4    Christofi, F.5    Raybould, H.E.6
  • 68
    • 0035041595 scopus 로고    scopus 로고
    • Receptors and transmission in the brain-gut axis: Potential for novel therapies. I. Receptors on visceral afferents
    • Kirkup, A.J., Brunsden, A.M. Grundy, D. 2001. Receptors and transmission in the brain-gut axis: potential for novel therapies. I. Receptors on visceral afferents. Am J Physiol Gastrointest Liver Physiol 280, G787 G794.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280
    • Kirkup, A.J.1    Brunsden, A.M.2    Grundy, D.3
  • 69
    • 0020965188 scopus 로고
    • Immunocytochemistry of serotonin-containing nerves in the human gut
    • Kurian, S.S., Ferri, G.L., De Mey, J. Polak, J.M. 1983. Immunocytochemistry of serotonin-containing nerves in the human gut. Histochemistry 78, 523 529.
    • (1983) Histochemistry , vol.78 , pp. 523-529
    • Kurian, S.S.1    Ferri, G.L.2    De Mey, J.3    Polak, J.M.4
  • 70
    • 4544388553 scopus 로고    scopus 로고
    • A pilot study on duodenal acid exposure and its relationship to symptoms in functional dyspepsia with prominent nausea
    • Lee, K.J., Demarchi, B., Demedts, I., Sifrim, D., Raeymaekers, P. Tack, J. 2004. A pilot study on duodenal acid exposure and its relationship to symptoms in functional dyspepsia with prominent nausea. Am J Gastroenterol 99, 1765 1773.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1765-1773
    • Lee, K.J.1    Demarchi, B.2    Demedts, I.3    Sifrim, D.4    Raeymaekers, P.5    Tack, J.6
  • 71
    • 77954408263 scopus 로고    scopus 로고
    • Mechanisms of glucose sensing in enteric neurons
    • Ma, J. Kirchgessner, A. 2003. Mechanisms of glucose sensing in enteric neurons. Gastroenterology 124 (Suppl. 1 A63.
    • (2003) Gastroenterology , vol.124 , Issue.1
    • Ma, J.1    Kirchgessner, A.2
  • 72
    • 0036149120 scopus 로고    scopus 로고
    • Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5-hydroxytryptamine in human inflammatory bowel disease
    • Magro, F., Vieira-Coelho, M.A., Fraga, S., Serrao, M.P., Veloso, F.T., Ribeiro, T. Soares-da-Silva, P. 2002. Impaired synthesis or cellular storage of norepinephrine, dopamine, and 5-hydroxytryptamine in human inflammatory bowel disease. Dig Dis Sci 47, 216 224.
    • (2002) Dig Dis Sci , vol.47 , pp. 216-224
    • Magro, F.1    Vieira-Coelho, M.A.2    Fraga, S.3    Serrao, M.P.4    Veloso, F.T.5    Ribeiro, T.6    Soares-Da-Silva, P.7
  • 73
    • 33645874190 scopus 로고    scopus 로고
    • Intestinal 5-hydroxytryptamine and mast cell infiltration in rat experimental colitis
    • Magro, F., Fraga, S., Azevedo, I. Soares-da-Silva, P. 2006. Intestinal 5-hydroxytryptamine and mast cell infiltration in rat experimental colitis. Dig Dis Sci 51, 495 501.
    • (2006) Dig Dis Sci , vol.51 , pp. 495-501
    • Magro, F.1    Fraga, S.2    Azevedo, I.3    Soares-Da-Silva, P.4
  • 74
    • 33646870356 scopus 로고    scopus 로고
    • Review article: Intestinal serotonin signalling in irritable bowel syndrome
    • Mawe, G.M., Coates, M.D. Moses, P.L. 2006. Review article: intestinal serotonin signalling in irritable bowel syndrome. Aliment Pharmacol Ther 23, 1067 1076.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1067-1076
    • Mawe, G.M.1    Coates, M.D.2    Moses, P.L.3
  • 75
    • 0032919616 scopus 로고    scopus 로고
    • Differential distribution of serotonin and tryptophan hydroxylase in the human gastrointestinal tract
    • Meyer, T. Brinck, U. 1999. Differential distribution of serotonin and tryptophan hydroxylase in the human gastrointestinal tract. Digestion 60, 63 68.
    • (1999) Digestion , vol.60 , pp. 63-68
    • Meyer, T.1    Brinck, U.2
  • 76
  • 78
    • 0035020937 scopus 로고    scopus 로고
    • Patients with constipation-predominant irritable bowel syndrome (IBS) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea-predominant patients and subjects with normal bowel habits
    • Miwa, J., Echizen, H., Matsueda, K. Umeda, N. 2001. Patients with constipation-predominant irritable bowel syndrome (IBS) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea-predominant patients and subjects with normal bowel habits. Digestion 63, 188 194.
    • (2001) Digestion , vol.63 , pp. 188-194
    • Miwa, J.1    Echizen, H.2    Matsueda, K.3    Umeda, N.4
  • 79
    • 33744965572 scopus 로고    scopus 로고
    • The functional characterization of normal and neoplastic human enterochromaffin cells
    • Modlin, I.M., Kidd, M., Pfragner, R., Eick, G.N. Champaneria, M.C. 2006. The functional characterization of normal and neoplastic human enterochromaffin cells. J Clin Endocrinol Metab 91, 2340 2348.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2340-2348
    • Modlin, I.M.1    Kidd, M.2    Pfragner, R.3    Eick, G.N.4    Champaneria, M.C.5
  • 81
    • 0028235075 scopus 로고
    • Failure of tropisetron to inhibit jejunal water and electrolyte secretion induced by 5-hydroxytryptamine in healthy volunteers
    • Munck, L.K., Eskerod, O., Hansen, M.B., Bukhave, K. Rask-Madsen, J. 1994. Failure of tropisetron to inhibit jejunal water and electrolyte secretion induced by 5-hydroxytryptamine in healthy volunteers. Gut 35, 637 640.
    • (1994) Gut , vol.35 , pp. 637-640
    • Munck, L.K.1    Eskerod, O.2    Hansen, M.B.3    Bukhave, K.4    Rask-Madsen, J.5
  • 82
    • 33750399000 scopus 로고    scopus 로고
    • Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons
    • Ohta, T., Ikemi, Y., Murakami, M., Imagawa, T., Otsuguro, K. Ito, S. 2006. Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons. J Physiol 576, 809 822.
    • (2006) J Physiol , vol.576 , pp. 809-822
    • Ohta, T.1    Ikemi, Y.2    Murakami, M.3    Imagawa, T.4    Otsuguro, K.5    Ito, S.6
  • 83
    • 0026074355 scopus 로고
    • Regulation of serotonin release from the intestinal mucosa
    • Racke, K. Schworer, H. 1991. Regulation of serotonin release from the intestinal mucosa. Pharmacol Res 23, 13 25.
    • (1991) Pharmacol Res , vol.23 , pp. 13-25
    • Racke, K.1    Schworer, H.2
  • 84
    • 0028168619 scopus 로고
    • Distribution of serotonin-immunoreactive gut endocrine cells in chicks at hatching. Examination of possible co-localisation with peptides reveals unexpected cross-reactivity of substance P antiserum with serotonin
    • Rawdon, B.B. Andrew, A. 1994. Distribution of serotonin-immunoreactive gut endocrine cells in chicks at hatching. Examination of possible co-localisation with peptides reveals unexpected cross-reactivity of substance P antiserum with serotonin. Histochemistry 102, 93 100.
    • (1994) Histochemistry , vol.102 , pp. 93-100
    • Rawdon, B.B.1    Andrew, A.2
  • 85
    • 0037572089 scopus 로고    scopus 로고
    • The future of GI and liver research: Editorial perspectives. IV. Visceral afferents: An update
    • Raybould, H.E. 2003. The future of GI and liver research: editorial perspectives. IV. Visceral afferents: an update. Am J Physiol Gastrointest Liver Physiol 284, G880 G882.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.284
    • Raybould, H.E.1
  • 86
    • 2342481083 scopus 로고    scopus 로고
    • Sensory mechanisms: Transmitters, modulators and reflexes
    • Raybould, H.E., Cooke, H.J. Christofi, F.L. 2004. Sensory mechanisms: transmitters, modulators and reflexes. Neurogastroenterol Motil 16 (Suppl. 1 60 63.
    • (2004) Neurogastroenterol Motil , vol.16 , Issue.1 , pp. 60-63
    • Raybould, H.E.1    Cooke, H.J.2    Christofi, F.L.3
  • 87
    • 33750402652 scopus 로고    scopus 로고
    • Serotonin increases protective duodenal bicarbonate secretion via enteric ganglia and a 5-HT4-dependent pathway
    • Safsten, B., Sjoblom, M. Flemstrom, G. 2006. Serotonin increases protective duodenal bicarbonate secretion via enteric ganglia and a 5-HT4-dependent pathway. Scand J Gastroenterol 41, 1279 1289.
    • (2006) Scand J Gastroenterol , vol.41 , pp. 1279-1289
    • Safsten, B.1    Sjoblom, M.2    Flemstrom, G.3
  • 88
    • 0031801939 scopus 로고    scopus 로고
    • Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro
    • Schworer, H. Ramadori, G. 1998. Autoreceptors can modulate 5-hydroxytryptamine release from porcine and human small intestine in vitro. Naunyn Schmiedebergs Arch Pharmacol 357, 548 552.
    • (1998) Naunyn Schmiedebergs Arch Pharmacol , vol.357 , pp. 548-552
    • Schworer, H.1    Ramadori, G.2
  • 89
    • 0027340595 scopus 로고
    • A 5-HT2 receptor mediates serotonin-induced electrolyte transport in rat left colon
    • Siriwardena, A. Kellum, J.M., Jr 1993. A 5-HT2 receptor mediates serotonin-induced electrolyte transport in rat left colon. J Surg Res 55, 323 329.
    • (1993) J Surg Res , vol.55 , pp. 323-329
    • Siriwardena, A.1    Kellum, J.M.2    Jr3
  • 90
    • 0020501561 scopus 로고
    • Endocrine cells in human intestine: An immunocytochemical study
    • Sjolund, K., Sanden, G., Hakanson, R. Sundler, F. 1983. Endocrine cells in human intestine: an immunocytochemical study. Gastroenterology 85, 1120 1130.
    • (1983) Gastroenterology , vol.85 , pp. 1120-1130
    • Sjolund, K.1    Sanden, G.2    Hakanson, R.3    Sundler, F.4
  • 91
    • 33845608434 scopus 로고    scopus 로고
    • 5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury
    • Smith, A.J., Chappell, A.E., Buret, A.G., Barrett, K.E. Dong, H. 2006. 5-Hydroxytryptamine contributes significantly to a reflex pathway by which the duodenal mucosa protects itself from gastric acid injury. FASEB J 20, 2486 2495.
    • (2006) FASEB J , vol.20 , pp. 2486-2495
    • Smith, A.J.1    Chappell, A.E.2    Buret, A.G.3    Barrett, K.E.4    Dong, H.5
  • 92
    • 12844265450 scopus 로고    scopus 로고
    • Polymodal sensory function of the Caenorhabditis elegans OCR-2 channel arises from distinct intrinsic determinants within the protein and is selectively conserved in mammalian TRPV proteins
    • Sokolchik, I., Tanabe, T., Baldi, P.F. Sze, J.Y. 2005. Polymodal sensory function of the Caenorhabditis elegans OCR-2 channel arises from distinct intrinsic determinants within the protein and is selectively conserved in mammalian TRPV proteins. J Neurosci 25, 1015 1023.
    • (2005) J Neurosci , vol.25 , pp. 1015-1023
    • Sokolchik, I.1    Tanabe, T.2    Baldi, P.F.3    Sze, J.Y.4
  • 93
    • 0036893824 scopus 로고    scopus 로고
    • Role of nerves in enteric infection
    • Spiller, R.C. 2002. Role of nerves in enteric infection. Gut 51, 759 762.
    • (2002) Gut , vol.51 , pp. 759-762
    • Spiller, R.C.1
  • 94
    • 0033665517 scopus 로고    scopus 로고
    • Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
    • Spiller, R.C., Jenkins, D., Thornley, J.P., Hebden, J.M., Wright, T., Skinner, M. Neal, K.R. 2000. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 47, 804 811.
    • (2000) Gut , vol.47 , pp. 804-811
    • Spiller, R.C.1    Jenkins, D.2    Thornley, J.P.3    Hebden, J.M.4    Wright, T.5    Skinner, M.6    Neal, K.R.7
  • 95
    • 0033862394 scopus 로고    scopus 로고
    • Nitric oxide is a neurotransmitter in the chloride secretory response to serotonin in rat colon
    • Stoner, M.C., Scherr, A.M., Lee, J.A., Wolfe, L.G. Kellum, J.M. 2000. Nitric oxide is a neurotransmitter in the chloride secretory response to serotonin in rat colon. Surgery 128, 240 245.
    • (2000) Surgery , vol.128 , pp. 240-245
    • Stoner, M.C.1    Scherr, A.M.2    Lee, J.A.3    Wolfe, L.G.4    Kellum, J.M.5
  • 96
    • 7444235361 scopus 로고    scopus 로고
    • TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation
    • Sugiuar, T., Bielefeldt, K. Gebhart, G.F. 2004. TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation. J Neurosci 24, 9521 9530.
    • (2004) J Neurosci , vol.24 , pp. 9521-9530
    • Sugiuar, T.1    Bielefeldt, K.2    Gebhart, G.F.3
  • 98
    • 33947509947 scopus 로고    scopus 로고
    • Chemosensitivity of the human gastrointestinal tract in health and in disease
    • Tack, J. 2007. Chemosensitivity of the human gastrointestinal tract in health and in disease. Neurogastroenterol Motil 19, 241 244.
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 241-244
    • Tack, J.1
  • 99
    • 24644510190 scopus 로고    scopus 로고
    • Mediation of neurogenic ion transport by acetylcholine, prostanoids and 5-hydroxytryptamine in porcine ileum
    • Townsend, D., Casey, M.A. Brown, D.R. 2005. Mediation of neurogenic ion transport by acetylcholine, prostanoids and 5-hydroxytryptamine in porcine ileum. Eur J Pharmacol 519, 285 289.
    • (2005) Eur J Pharmacol , vol.519 , pp. 285-289
    • Townsend, D.1    Casey, M.A.2    Brown, D.R.3
  • 100
    • 0042825763 scopus 로고    scopus 로고
    • Effect of 5-hydroxytryptamine on duodenal mucosal bicarbonate secretion in mice
    • Tuo, B.G. Isenberg, J.I. 2003. Effect of 5-hydroxytryptamine on duodenal mucosal bicarbonate secretion in mice. Gastroenterology 125, 805 814.
    • (2003) Gastroenterology , vol.125 , pp. 805-814
    • Tuo, B.G.1    Isenberg, J.I.2
  • 101
    • 1942519787 scopus 로고    scopus 로고
    • Protein kinase C potentiates cAMP-stimulated mouse duodenal mucosal bicarbonate secretion in vitro
    • Tuo, B.G., Chow, J.Y., Barrett, K.E. Isenberg, J.I. 2004. Protein kinase C potentiates cAMP-stimulated mouse duodenal mucosal bicarbonate secretion in vitro. Am J Physiol Gastrointest Liver Physiol 286, G814 G821.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.286
    • Tuo, B.G.1    Chow, J.Y.2    Barrett, K.E.3    Isenberg, J.I.4
  • 104
    • 34248547292 scopus 로고    scopus 로고
    • Regional differences in expression of TPH-1, SERT, 5-HT(3) and 5-HT(4) receptors in the human stomach and duodenum
    • Van Lelyveld, N., Ter, L.J., Schipper, M.E. Samsom, M. 2007. Regional differences in expression of TPH-1, SERT, 5-HT(3) and 5-HT(4) receptors in the human stomach and duodenum. Neurogastroenterol Motil 19, 342 348.
    • (2007) Neurogastroenterol Motil , vol.19 , pp. 342-348
    • Van Lelyveld, N.1    Ter, L.J.2    Schipper, M.E.3    Samsom, M.4
  • 108
    • 28644450976 scopus 로고    scopus 로고
    • Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction
    • Wheatcroft, J., Wakelin, D., Smith, A., Mahoney, C.R., Mawe, G. Spiller, R. 2005. Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction. Neurogastroenterol Motil 17, 863 870.
    • (2005) Neurogastroenterol Motil , vol.17 , pp. 863-870
    • Wheatcroft, J.1    Wakelin, D.2    Smith, A.3    Mahoney, C.R.4    Mawe, G.5    Spiller, R.6
  • 109
    • 0003096661 scopus 로고    scopus 로고
    • Fundamentals of neurogastroenterology
    • Wood, J.D., Alpers, D.H. Andrews, P.L. 1999. Fundamentals of neurogastroenterology. Gut 45 (Suppl. 2 II6 II16.
    • (1999) Gut , vol.45 , Issue.2
    • Wood, J.D.1    Alpers, D.H.2    Andrews, P.L.3
  • 111
    • 2342430835 scopus 로고    scopus 로고
    • Caenorhabditis elegans TRPV ion channel regulates 5-HT biosynthesis in chemosensory neurons
    • Zhang, S., Sokolchik, I., Blanco, G. Sze, J.Y. 2004. Caenorhabditis elegans TRPV ion channel regulates 5-HT biosynthesis in chemosensory neurons. Development 131, 1629 1638.
    • (2004) Development , vol.131 , pp. 1629-1638
    • Zhang, S.1    Sokolchik, I.2    Blanco, G.3    Sze, J.Y.4
  • 112
    • 0035252792 scopus 로고    scopus 로고
    • Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat
    • Zhu, J.X., Zhu, X.Y., Owyang, C. Li, Y. 2001. Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat. J Physiol 530, 431 442.
    • (2001) J Physiol , vol.530 , pp. 431-442
    • Zhu, J.X.1    Zhu, X.Y.2    Owyang, C.3    Li, Y.4


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