The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide

Nitric Oxide

Volumn , Issue , 2010, Pages 441-482

  Boveris, Alberto ^a   Carreras, Maria Cecilia ^a   Poderoso, Juan Jose ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80051784790     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-373866-0.00013-7     Document Type: Chapter

References (195)

1. Adams D.O., Hamilton T.A. The cell biology of macrophage activation. Annu. Rev. Immunol. 1984, 2:283-318.
2. Alonso M., Melani M., Jaitovich A., Converso D.P., Carreras M.C., Medina J.H., Poderoso J.J. Mitochondrial extracellular signal-regulated kinases (ERK1/2) are modulated during brain development. J. Neurochem. 2004, 89:248-256.
3. Alvarez S., Valdez L.B., Zaobornij T., Boveris A. Oxygen dependence of mitochondrial nitric oxide synthase activity. Biochem. Biophys. Res. Commun. 2003, 305:771-775.
4. Ambs S., Hussain S.P., Harris C.C. Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J. 1997, 11:443-448.
5. Antunes F., Cadenas E. The mechanism of cytochrome c inhibition by nitric oxide. Front. Biosci. 2007, 12:975-985.
6. Antunes F., Boveris A., Cadena E. On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide. Proc. Natl. Acad. Sci. USA, 2004, 101:16774-16779.
7. Baker J.E. Oxidative stress and adaptation of the infant heart to hypoxia and ischemia. Antioxid. Redox Signal. 2004, 6:423-429.
8. Barouch L.A., Harrison R.W., Skaf M.W., Rosas G.O., Cappola T.P., Kobeissi Z.A., Hobai I.A., Lemmon C.A., Burnett A.L., O'Rourke B., Rodriguez E.R., Huang P.L., Lima J.A., Berkowitz D.E., Hare J.M. Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. Nature 2002, 416:337-339.
9. Basu S., Azarova N.A., Font M.D., King S.B., Hogg N., Gladwin M.T., Shiva S., Kim-Shapiro D.B. Nitrite reductase activity of cytochrome c. J. Biol. Chem. 2008, 283:32590-32597.
10. Beckman J.S. Ischemic injury mediator. Nature 1990, 345:27-28.
11. Beckman K.B., Ames B.N. Mitochondrial aging: open questions. Physiol. Rev. 1998, 78:547-581.
12. Boczkowski J., Lisdero C., Lanone S., Carreras M.C., Boveris A., Aubier M., Poderoso J.J. Endogenous peroxynitrite mediates mitochondrial dysfunction in rat diaphram during endotoxemia. FASEB J. 1999, 13:1637-1646.
13. Bonfoco E., Krainc D., Ankarcrona M., Nicotera P., Lipton S.A. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. USA 1995, 92:7162-7166.
14. Borutaite V., Brown G.C. Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide. Biochem. J. 1996, 315:295-299.
15. Boveris D.L., Boveris A. Oxygen delivery to the tissues and mitochondrial respiration. Front. Biosci. 2007, 12:1014-1023.
16. Boveris A., Cadenas E. Mitochondrial production of superoxide anions and its relationship to the antimycin-insensitive respiration. FEBS Lett. 1975, 54:311-314.
17. Boveris A., Cadenas E. Mitochondrial production of hydrogen peroxide. Regulation by nitric oxide and the role of ubisemiquinone. IUBMB Life 2001, 50:1-6.
18. Boveris A., Chance B. The mitochondrial production of hydrogen peroxide. Biochem. J. 1973, 134:707-716.
19. Boveris A., Oshino N., Chance B. The cellular production of hydrogen peroxide. Biochem J. 1972, 128:617-630.
20. Boveris A., Cadenas E., Stoppani A.O.M. Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. Biochem. J. 1976, 156:435-444.
21. Boveris A., Costa L.E., Cadenas E., Poderoso J.J. Regulation of mitochondrial respiration by adenosine diphosphate, oxygen, and nitric oxide. Methods Enzymol. 1999, 301:188-198.
22. Boveris A., Costa L.E., Poderoso J.J., Cadenas E. Regulation of mitochondrial respiration by oxygen and nitric oxide. Ann. NY Acad. Sci. 2000, 899:121-135.
23. Boveris A., Lores Arnaiz S., Bustamante J., Alvarez S., Valdez L.B., Boveris A.D., Navarro A. Pharmacological regulation of mitochondrial nitric oxide synthase. Methods Enzymol. 2002, 359:328-339.
24. Boveris A., Alvarez S., Navarro A. The role of mitochondrial nitric oxide synthase in inflammation and septic shock. Free Radic. Biol. Med. 2002, 33:1186-1193.
25. Boveris A., Valdez L.B., Zaobornyj T., Bustamante J. Mitochondrial metabolic states and membrane potential regulate nitric oxide and hydrogen peroxide diffusion to the cytosol. Biochim. Biophys. Acta, 2006, 1757:535-542.
26. Brealey D., Brand M., Hargreaves I., Heales S., Land J., Smolenski R., Davies N.A., Cooper C.E., Singer M. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002, 360:219-223.
27. Brookes P.S., Bolanos J.P., Heales S.J. The assumption that nitric oxide inhibits mitochondrial ATP production is correct. FEBS Lett. 1999, 446:261-263.
28. Brookes P.S., Kraus D.W., Shiva S., Doeller J.E., Barone M.C., Patel R.P., Lancaster J., Darley-Usmar V. Control of mitochondrial respiration by NO, effects of low oxygen and respiratory state. J. Biol. Chem. 2003, 278:31603-31609.
29. Brown G.C. Nitric oxide inhibition of cytochrome oxidase and mitochondrial respiration: Implications for inflammatory, neurodegenerative and ischemic pathologies. Mol. Cell. Biochem. 1997, 174:189-192.
30. Brown G.C., Borutaite V. Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols. Biochim. Biophys. Acta 2004, 1658:44-49.
31. Brown G.C., Cooper C.E. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett. 1994, 356:295-298.
32. Burch P.M., Heintz N.H. Redox regulation of cell-cycle re-entry: cyclin D1 as a primary target for the mitogenic effects of reactive oxygen and nitrogen species. Antioxid. Redox Signal. 2005, 7:741-751.
33. Burdon R.H. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic. Biol. Med. 1995, 18:775-794.
34. Busija D.W., Gaspar T., Domoki F., Katakam P.V., Bari F. Mitochondrial-mediated suppression of ROS production upon exposure of neurons to lethal stress: mitochondrial targeted preconditioning. Adv. Drug Deliv. 2008, 60:1471-1477.
35. Bustamante J., Bersier G., Romero M., Badin R.A., Boveris A. Nitric oxide production and mitochondrial dysfunction during rat thymocyte apoptosis. Arch. Biochem. Biophys. 2000, 376:239-247.
36. Cadenas E., Boveris A., Ragan C., Stoppani A.O.M. Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef heart mitochondria. Arch. Biochem. Biophys. 1977, 180:248-257.
37. Carreras M.C., Poderoso J.J. Mitochondrial nitric oxide in the signaling of cell integrated responses. Am. J. Physiol. 2007, 292:C1569-C1580.
38. Carreras M.C., Peralta J.G., Converso D.P., Finocchietto PV., Rebagliati I., Zaninovich A.A., Poderoso J.J. Mitochondrial nitric oxide synthase is a final effector in the thyroid-dependent modulation of oxygen uptake. Am. J. Physiol. 2001, 281:H2282-H2288.
39. Carreras M.C., Franco M.C., Peralta J.G., Poderoso J.J. Nitric oxide, complex I, and the modulation of mitochondrial reactive species in biology and disease. Mol. Aspects Med. 2004, 25:125-139.
40. Carreras M.C., Converso D.P., Lorente A.S., Barbich M.R., Levisman D.M., Jaitovich A., Antico Arciuch V.G., Galli S., Poderoso J.J. Mitochondrial nitric oxide synthase drives redox signals from proliferation and quiescence in rat liver development. Hepatology 2004, 40:157-166.
41. Carreras M.C., Franco M.C., Molinas M.F., González A.S., Finocchietto P.V., Converso D.P., Poderoso J.J. Neuronal nitric oxide synthase trafficking into mitochondria. Free Radic. Biol. Med. 2008, 45(S1):S111.
42. Cassarino D.S., Halvorsen E.M., Swerdlow R.H., Abramova N.N., Parker W.D., Sturgill T.W., Bennett J.P. Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factorκB in cellular models of Parkinson's disease. J. Neurochem. 2000, 74:1384-1392.
43. Cassina A., Radi R. Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport. Arch. Biochem. Biophys, 1996, 328:309-316.
44. Cassina A.M., Hodara R., Souza J.M., Thomson L., Castro L., Ischiropoulos H., Freeman B.A., Radi R. Cytochrome c nitration by peroxynitrite. J. Biol. Chem. 2000, 275:21409-21415.
45. Castello P.R., David P.S., McClure T., Crook Z., Poyton R.O. Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes. Cell Metab. 2006, 3:277-287.
46. Chance B., Williams G.R. A simple and rapid assay of oxidative phosphorylation. Nature 1955, 175:1120-1121.
47. Chance B., Williams G.R. The respiratory chain and oxidative phosphorylation. Adv. Enzymol. 1956, 17:65-134.
48. Chance B., Sies H., Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 1979, 59:527-605.
49. Chang L., Karin M. Mammalian MAP kinase signaling cascades. Nature 2001, 410:37-40.
50. Chen F., Castranova V., Shi X., Demers L.M. New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin. Chem. 1999, 45:7-17.
51. Chen H., Chan D.C. Emerging functions of mammalian mitochondrial fusion and fission. Hum. Mol. Genet. 2005, 14:R283-R289.
52. Choi B.M., Pae H.O., Jang S.I., Kim Y.M., Chung H.T. Nitric oxide as a pro-apoptotic as well as anti-apoptotic modulator. J. Biochem. Mol. Biol. 2002, 35:116-126.
53. Chung H-T., Pae H-O., Choi B-M., Billiar T.R., Kim Y-M. Nitric oxide as a bioregulator of apoptosis. Biochem. Biophys. Res. Commun. 2001, 282:1075-1079.
54. Clarke K., Willis R.J. Energy metabolism and contractile function in rat heart during graded, isovolumic perfusion using P nuclear magnetic resonance spectroscopy. J. Mol. Cell. Cardiol. 1987, 19:1153-1160.
55. Cleeter M.W.J., Cooper J.M., Darley-Usmar V.M., Moncada S., Schapira A.H.V. Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. FEBS Lett. 1994, 345:50-54.
56. Costa L.E., Mendez G., Boveris A. Oxygen dependence of mitochondrial function measured by high-resolution respirometry in long-term hypoxic rats. Am. J. Physiol. 1997, 273:C852-C858.
57. Davies K.J.A. The broad spectrum of responses to oxidants in proliferating cells: a new paradigm for oxidative stress. IUBMB Life 2000, 48:41-47.
58. de Groot H., Noll T., Sies H. Oxygen dependence of mitochondrial cellular partitioning of hepatic menadione-mediated oxygen uptake. Studies with isolated hepatocytes, mitochondria, and microsomes in an oxystat system. Arch. Biochem. Biophys. 1985, 243:556-562.
59. Dedkova E.N., Blatter L.A. Characteristics and function of cardiac mitochondrial nitric oxide synthase. J. Physiol. 2009, 587:851-872.
60. Dedkova E.N., Ji X., Wang Y.G., Blatter L.A., Lipsius S.L. Signaling mechanisms that mediate nitric oxide production induced by acetylcholine exposure and withdrawl in cat atrial myocytes. Circ. Res. 2004, 93:1233-1240.
61. Denicola A., Souza J.M., Radi R., Lissi E. Nitric oxide diffusion in membranes determined by fluorescence quenching. Arch. Biochem. Biophys. 1996, 328:208-212.
62. Dennis J., Bennett J.P. Interactions among nitric oxide and Bcl-family proteins after MPP+ exposure of SH-SY5Y neural cells I: MPP+ increases mitochondrial NO and Bax protein. J. Neurosci. Res. 2003, 72:76-88.
63. Dionisi O., Galeotti T., Terranova T., Azzi A. Superoxide radicals and hydrogen peroxide production in mitochondria from normal and neoplastic tissues. Biochim. Biophys. Acta 1975, 403:292-300.
64. Drew B., Leeuwenburg C. Aging and the role of reactive nitrogen apecies. Ann. NY Acad. Sci. 2002, 959:66-81.
65. Elfering S.L., Sarkela T.M., Giulivi C. Biochemistry of mitochondrial nitric-oxide synthase. J. Biol. Chem. 2002, 277:38079-38086.
66. Estévez A.G., Crow J.P., Sampson J.B., Reiter C., Zhuang V., Richardson G.J., Tarpey M.M., Barbeito L., Beckman J.S. Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. Science 1999, 286:2498-2500.
67. Eve D.J., Nisbet A.P., Kingsbury A.E., Hewson E.L., Daniel S.E., Lees A.J., Marsden C.D., Forster O.J. Basal ganglia neuronal nitric oxide synthase mRNA expression in Parkinson's disease. Brain Res. Mol. Biol. 1998, 63:62-71.
68. Finocchietto P.V., Barreyro F., Holod S., Peralta J.G., Franco M.C., Méndez C., Converso D.P., Estévez A.G., Carreras M.C., Poderoso J.J. Control of muscle mitochondria by insulin entails activation of Akt2-mtNOS pathway: implications for the metabolic syndrome. PLoS ONE 2008, 3:e1749.
69. Franco M.C., Antico Arciuch V.G., Peralta J.G., Galli S., Levisman D., López L.M., Romorini L., Poderoso J.J., Carreras M.C. Hypothyroid phenotype is contributed by mitochondrial complex I inactivation due to translocated neuronal nitric oxide synthase. J. Biol. Chem. 2006, 281:4779-4786.
70. Fridovich I. The biology of oxygen radicals. Science 1978, 201:875-880.
71. Galli S., Labato M., Bal de Kier Joffè E., Carreras M.C., Poderoso J.J. Decreased mitochondrial nitric oxide synthase activity and hydrogen peroxide relate persistent tumoral proliferation to embryonic behavior. Cancer Res. 2003, 60:6073-6077.
72. Gatto E.M., Riobó N.A., Carreras M.C., Cherñavsky A., Rubio A., Satz L., Poderoso J.J. Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson's disease. Nitric Oxide 2000, 4:534-539.
73. 2 in individual cardiac myocytes in dogs, cats, rabbits, ferrets, and rats. Am. J. Physiol. 1991, 260:522-531.
74. García-Ruiz I., Rodríguez-Juan P., del Hoyo P., Colina F., Muñoz-Yagüe T., Solis-Herruzo J.A. Uric acid and anti-TNF antibody improve mitochondrial dysfunction in ob/ob mice. Hepatology 2006, 44:581-591.
75. Gerschman R., Gilbert D.L., Nye S.W., Fenn W.O. Influence of x-irradiation on oxygen poisoning in mice. Proc. Soc. Exp. Biol. Med. 1954, 86:27-29.
76. Ghafourifar P., Cadenas E. Mitochondrial nitric oxide synthase. Trends Pharmacol. Sci. 2005, 26:190-195.
77. Ghafourifar P., Richter C. Nitric oxide synthase activity in mitochondria. FEBS Lett. 1997, 418:291-296.
78. Ghafourifar P., Schenk U., Klein S.D., Richter C. Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation. J. Biol. Chem. 1999, 274:31185-31188.
79. Giuffre A., Sarti P., D'Itri E., Buse G., Soulimane T., Brunori M. On the mechanism of inhibition of cytochrome oxidase by nitric oxide. J. Biol. Chem. 1996, 271:33404-33408.
80. Giulivi C., Poderoso J.J., Boveris A. Production of nitric oxide by mitochondria. J. Biol. Chem. 1998, 273:11038-11043.
81. Gonzales G.F., Chung F.A., Miranda S., Valdez L.B., Zaobornyj T., Bustamante J., Boveris A. Heart mitochondrial nitric oxide synthase is up-regulated in male rats exposed to high altitude (4340m). Am. J. Physiol. Heart 2005, 28:H2568-H2573.
82. Good P.F., Hsu A., Werner P., Perl D.P., Olanow C.W. Protein nitration in Parkinson's disease. J. Neuropathol. Exp. Neurol. 1998, 57:338-342.
83. Granger D.L., Lehninger A.L. Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells. J. Cell Biol. 1982, 95:527-535.
84. Greenwood C., Gibson G. The reaction of reduced cytochrome oxidase with oxygen. J. Biol. Chem. 1967, 242:1782-1787.
85. Gutsaeva D.R., Suliman H.B., Carraway M.S., Demchenko I.T., Piantadosi C.A. Oxygen-induced mitochondrial biogenesis in the rat hippocampus. Neuroscience 2006, 137:493-504.
86. Hajri A., Metzger E., Vallat F., Coffy S., Flatter E., Evrard S., Marescaux J., Aprahamian M. Role of nitric oxide in pancreatic tumour growth: in vivo and in vitro studies. Br. J. Cancer 1998, 78:841-849.
87. Harman D. Aging: a theory based on free radical and radiation. J. Gerontol. 1956, 11:298-300.
88. Hassinen I.E., Hiltunen J.K., Takala T.E.S. Reflectance spectrophotometric monitoring of the isolated perfused heart as a method of measuring the oxidation-reduction state of cytochromes and oxygenation of myoglobin. Cardiovasc. Res. 1981, 15:86-91.
89. Herzig S., Long F., Jhala U.S., Hedrick S., Quinn R., Bauer A., Rudolph D., Schutz G., Yoon C., Puigserver P., et al. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 2001, 413:179-183.
90. Hoppins S., Lackner L., Nunnari J. The machines that divide and fuse mitochondria. Annu. Rev. Biochem. 2007, 76:751-780.
91. Hortelano S., Alvarez A.M., Bosca L. Nitric oxide induces tyrosine nitration and release of cytochrome c preceding an increrase of mitochondrial transmembrane potential in macrophages. FASEB J. 1999, 13:2311-2317.
92. Huang J.S., Chuang L.Y., Guh J.Y., Chen C.J., Yang Y.L., Chiang T.A., Hung M.Y., Liao T.N. Effect of nitric oxide-cGMP-dependent protein kinase activation on advanced glycation end-product-induced proliferation in renal fibroblasts. J. Am. Soc. Nephrol. 2005, 16:2318-2329.
93. Ignarro L.J. Introduction and overview. Nitric Oxide: Biology and Pathobiology 2000, 3-19. Academic Press, San Diego. L.J. Ignarro (Ed.).
94. Ignarro L.J. Heart mtNOS, a key mediator of oxidative injury in ischemia-reperfusion. J. Mol. Cell Cardiol. 2007, 43:409-410.
95. Ignarro L.J., Buga G.M., Wood K.S., Byrns R.E., Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. U.S.A. 1987, 84:9265-9269.
96. Imlay J.A., Fridovich I. Assay of metabolic superoxide production in Escherichia coli. J. Biol. Chem. 1991, 266:6957-6965.
97. Inoue M., Nishikawa M., Sato E.F., Ah-Mee P., Kashiba M., Takehara Y., Utsumi K. Cross-talk of NO, superoxide and molecular oxygen, a majesty of aerobic life. Free Radic. Res. 1999, 31:251-260.
98. Ischiropoulos H. Protein tyrosine nitration - An update. Arch. Biochem. Biophys. 2009, 484:117-121.
99. Sdi1Cip1/Waf1 by nitric oxide-generating vasodilator in vascular smooth muscle cells. J. Biol. Chem. 1997, 272:10050-10057.
100. Kanai A.J., Pearce L.L., Clemens P.R., Birder L.A., VanBibber M.M., Choi S.Y., de Groat W.C., Peterson J. Identification of a neuronal nitric oxide synthase in isolated cardiac mitochondria using electrochemical detection. Proc. Natl. Acad. Sci. USA 2001, 98:14126-14131.
101. Kashiwakura I., Kuwabara M., Murakami M., Hayase Y., Takagi Y. Effect of carboxy-PTIO, a nitric oxide scavenger, on the proliferation of murine hematopoietic progenitor cells in vitro. Res. Commun. Mol. Pathol. Pharmacol. 1998, 99:329-337.
102. Kelly D., Scarpulla R.C. Transcriptional regulatory circuits controlling mitochondrial biogenesis and functions. Genes Dev. 2004, 15:357-368.
103. Kennedy F.G., Jones D.P. Oxygen dependence of mitochondrial function in isolated rat cardiac myocytes. Am. J. Physiol. 1986, 250:374-383.
104. Knowles R.G., lter M., Moncada S. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat. Biochem. J. 1990, 270:833-836.
105. Koivisto A., Matthias A., Bronnkov G., Nedergaard J. Kinetics of the inhibition of mitochondrial respiration by NO. FEBS Lett. 1997, 417:75-80.
106. Konorev E.A., Joseph J., Kalanyanaranam B. S-nitrosoglutathione induces formation of nitrosyl myoglobin in isolated hearts during cardioplegic ischemia. An electron spin resonance study. FEBS Lett. 1996, 378:111-114.
107. Koppenol W.H. The basic chemistry of nitrogen monoxide and peroxynitrite. Free Radic. Biol. Med. 1998, 25:385-391.
108. Koteish A., Diehl A.M. Animal models of steatosis. Semin. Liver Dis. 2001, 21:89-104.
109. Lacza Z., Kozlov A.V., Pankotai E., Csordás A., Wolf G., Redl H., Kollai M., Szabó C., Busija D.W., Horn T.F. Mitochondria produce reactive nitrogen species via a arginine-independent pathway. Free Radic. Res. 2006, 40:369-378.
110. Lanone S., Mebazaa A., Heymes C., Henin D., Poderoso J.J., Panis Y., Zedda C., Billiar T., Payen D., Aubier M., Boczkowski J. Muscular contractile failure in septic patients: role of the inducible nitric oxide synthase pathway. Am. J. Respir. Crit. Care Med. 2000, 162:2308-2315.
111. LaNoue K.F., Jefferies F.M., Radda G.K. Kinetic control of mitochondrial ATP synthesis. Biochemistry 1986, 25:7667-7675.
112. Laranjinha J., Ledo A. Coordination of physiologic and toxic pathways in hippocampus by nitric oxide and mitochondria. Front. Biosci. 2007, 12:1094-1106.
113. Lin J., Wu H., Tarr P.T., Zhang C.Y., Wu Z., Boss O., Michael L.F., Puigserver P., Isotani E., Olson E.N., et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 2002, 418:797-801.
114. Lisdero C.L., Carreras M.C., Meulemans A., Melani M., Aubier M., Boczkowski J., Poderoso J.J. The mitochondrial interplay of ubiquinol and nitric oxide in endotoxemia. Methods Enzymol. 2004, 382:67-81.
115. Lizasoain I., Moro M., Knowles R.G., Darley-Usmar V., Moncada S. Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose. J. Biochem. (Tokyo) 1996, 314:877-880.
116. López-LLuch G., Irusta P.M., Navas P., de Cabo R. Mitochondrial biogenesis and healthy aging. Exp. Gerontol. 2008, 43:813-819.
117. Lu Z., Tao Y., Zhou Z., Zhang J., Li C., Ou L., Zhao B. Mitochondrial reactive oxygen species and nitric oxide-mediated cancer cell apoptosis in 2-butylamino-2-demethoxyhypocrellin B photodynamic treatment. Free Radic. Biol. Med. 2006, 41:1590-1605.
118. Lu Q., Jourd'Heuil L., Jourd'Heuil D. Redox control of G1/S cell cycle regulators during nitric oxide-mediated cell cycle arrest. J. Cell Physiol. 2007, 212:827-839.
119. McCord J.M., Fridovich I. Superoxide dismutase. An enzymic function for erytrocuprein (hemocuprein). J. Biol. Chem. 1969, 244:6049-6055.
120. Meini A., Garcia J.B., Pessina G.P., Aldinucci C., Frosin M., Palmi M. Role of intracellular Ca2+ and calmodulin/MAP kinase kinase/extracellular signal-regulated protein kinase signalling pathway in the mitogenic and antimitogenic effect of nitric oxide in glia- and neurone-derived cell lines. Eur. J. Neurosci. 2006, 23:1690-1700.
121. Millar A.H., Day D.A. Nitric oxide inhibits the cytochrome oxidase but not the alternative oxidase of plant mitochondria. FEBS Lett. 1996, 398:155-158.
122. Mitchell P. Vectorial chemiosmotic processes. Annu. Rev. Biochem. 1977, 46:996-1005.
123. Mitchell P. Keilin's respiratory chain concept and its chemiosmotic consequences. Science 1979, 206:1148-1159.
124. Murphy E., Steenbergen C. Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol. Rev. 2008, 88:581-609.
125. Natal C., Modol T., Osés-Prieto J.A., López-Moratalla N., Iraburu M.J., López-Zabalza M,J. Specific protein nitration in nitric oxide-induced apoptosis of human monocytes. Apoptosis 2008, 13:1356-1367.
126. Navarro A., Boveris A. The mitochondrial energy transduction system and the aging process. Am. J. Physiol. Cell Physiol. 2007, 292:C670-C686.
127. Navarro A., Boveris A. Mitochondrial nitric oxide synthase, mitochondrial brain dysfunction in aging, and mitochondria-targeted antioxidants. Adv. Drug Deliv. Release 2008, 60:1534-1544.
128. Navarro A., Torrejon R. Role of nitric oxide on mitochondrial biogenesis during the ovarian cycle. Front. Biosci. 2007, 12:1164-1173.
129. Navarro A., Torrejon R., Bandez M.J., Lopez-Cepero J.M., Boveris A. Mitochondrial function and mitochondria-induced apoptosis in an over-stimulated ovarian cycle. Am. J. Physiol. Endocrinol. 2005, 289:E1101-E1109.
130. Navarro A., Lopez-Cepero J.M., Bandez M.J., Sanchez-Pino M.J., Gomez C., Cadenas E., Boveris A. Hippocampal mitochondrial dysfunction in rat aging. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2008, 294:501-509.
131. Nazarewicz R.R., Zeneb W.J., Parihar A., Larson S.K., Alidema E., Choi J., Ghafourifar P. Tamoxifen induces oxidative stress and mitochondrial apoptosis via stimulating mitochondrial nitric oxide synthase. Cancer Res. 2007, 67:1282-1290.
132. Nazarewicz R.R., Zenebe W.J., Parihar A., Parihar M.S., Vaccaro M., Rink C., Sen C.K., Ghafourifar P. 12(S)-hydroperoxyeicosatetraenoic acid (12-HETE) increases mitochondrial nitric oxide by increasing intramitochondrial calcium. Arch. Biochem. Biophys. 2007, 468:114-120.
133. Nisoli E., Carruba M.O. Nitric oxide and mitochondrial biogenesis. J. Cell Sci. 2006, 119:2855-2862.
134. Nisoli E., Falcone S., Tonello C., Cozzi V., Palomba L., Fiorani M., Pisconti A., Brunelli S., Cardile A., Francolini M., Cantoni O., Carruba M.O., Moncada S., Clementi E. Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals. Proc. Natl. Acad. Sci. USA 2004, 101:16507-16512.
135. Nohl H., Staniek K., Kozlov A.V. The existence and significance of a mitochondrial nitrite reductase. Redox Rep. 2005, 10:281-286.
136. Pacher P., Beckman J.S., Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol. Rev. 2007, 87:315-424.
137. Packer M.A., Porteous C.M., Murphy M.P. Superoxide production by mitochondria in the presence of nitric oxide forms peroxynitrite. Biochem. Mol. Biol. Int. 1996, 40:527-534.
138. Peng H.B., Spiecker M., Liao J.K. Inducible nitric oxide: an autoregulatory feedback inhibitor of vascular inflammation. J. Immunol. 1998, 161:1970-1976.
139. Peralta J.G., Llesuy S., Evelson P., Carreras M.C., González Flecha B., Poderoso J.J. Oxidative stress in skeletal muscle during sepsis in rats. Circ. Shock 1993, 39:153-159.
140. Persichini T., Mazzone V., Polticelli F., Moreno S., Venturini G., Clementi E., Colasanti M. Mitochondrial type I nitric oxide synthase physically interacts with cytochrome c oxidase. Neurosci. Lett. 2005, 384:254-259.
141. Pervin S., Singh R., Chaudhuri G. Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): Potential role of cyclin D1. Proc. Natl. Acad. Sci. USA 2001, 98:3583-3588.
142. Petersen K.F., Dufour S., Befroy D., Garcia R., Shulman G.I. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes N. Engl. J. Med. 2004, 350:664-671.
143. Poderoso J.J. The formation of peroxynitrite in the applied physiology of mitochondrial nitric oxide. Arch. Biochem. Biophys. 2009, 484:214-220.
144. Poderoso J.J., Boveris A., Jorge M.A., Gherardi C.R., Caprile A.W., Turrens J., Stoppani A.O. Mitochondrial function in septic shock. Medicina 1978, 38:371-377.
145. Poderoso J.J., Carreras M.C., Lisdero C., Riobó N., Schöpfer F., Boveri A. Nitric oxide inhibits electron transfer and increases superoxide radical production in rat heart mitochondria and submitochondrial particles. Arch. Biochem. Biophys. 1996, 328:85-92.
146. Poderoso J.J., Peralta J.G., Lisdero C., Carreras M.C., Radisic M., Schöpfer F., Cadenas E., Boveris A. Nitric oxide regulates oxygen uptake and hydrogen peroxide release by the isolated beating rat heart. Am. J. Physiol. 1998, 274:112-119.
147. Poderoso J.J., Carreras M.C., Schöpfer F., Lisdero C., Riobó N., Giulivi C., Boveris A., Boveris A.A., Cadenas E. The reaction of nitric oxide with ubiquinol: kinetic properties and biological significance. Free Radic. Biol. Med. 1999, 26:925-935.
148. Poderoso J.J., Lisdero C., Schöpfer F., Riobó N., Carreras M.C., Cadenas E., Boveris A. The regulation of mitochondrial oxygen uptake by redox reactions involving nitric oxide and ubiquinol. J. Biol. Chem. 1999, 274:37709-37716.
149. Puigserver P., Wu Z., Park C.W., Graves R., Wright M., Spiegelman B.M. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 1998, 92:829-839.
150. Protti A., Carré J., Frost M.T., Taylor V., Stidwill R., Rudiger A., Singer M. Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle. Crit. Care Med. 2007, 35:2150-2155.
151. Raha S., Robinson B.H. Mitochondria, oxygen free radicals, disease and ageing. Trends Biochem. Sci. 2000, 25:502-508.
152. Reed J.C. Mechanisms of apoptosis. Am. J. Pathol. 2000, 157:1415-1430.
153. 2+ homeostasis and respiration. Biosci. Rep. 1997, 17:53-66.
154. Riobó N.A., Schöpfer F., Boveris A., Cadenas E., Poderoso J.J. The reaction of nitric oxide with 6-hydroxydopamine: implications for Parkinson's disease. Free Radic. Biol. Med. 2001, 32:115-121.
155. Riobó N., Melani M., Sanjuán N., Carreras M.C., Cadenas E., Poderoso J.J. The modulation of mitochondrial nitric oxide synthase activity in rat brain development. J. Biol. Chem. 2002, 277:42447-42455.
156. Sarti P., Giuffre A., Forte E., Matronicola D., Barone M.C., Brunori M. Nitric oxide and cytochrome oxidase: mechanism of inhibition and of NO degradation. Biochem. Biophys. Res. Commun. 2000, 274:183-187.
157. Schäfer E., Seelert H., Reifschneider N.H., Krause F., Decher N.A., Vonck J. Architecture of active mammalian respiratory chain supercomplexes. J. Biol. Chem. 2006, 281:15370-15375.
158. Schonhoff C.M., Matsuoka M., Tummala H., Johnson M.A., Estevéz A.G., Wu R., Kamaid A., Ricart K.C., Hashimoto Y., Gaston B., Macdonald T.L., Xu Z., Mannick J.B. S-nitrosothiol depletion in amyotrophic lateral sclerosis. Proc. Natl. Acad. Sci. USA 2006, 103:2404-2409.
159. Sharpe M.A., Cooper C.E. Reactions of nitric oxide with mitochondrial cytochrome c: A novel mechanism for the formation of nitroxyl anion and peroxynitrite. J. Biochem. 1998, 332:9-19.
160. Shen W., Xu X., Ochoa M., Zhao G., Wolin M., Hintze T.H. Role of nitric oxide in the regulation of oxygen consumption in conscious dogs. Circ. Res. 1994, 75:1086-1095.
161. Shen W., Hintze T.H., Wolin M.S. Nitric oxide. An important signaling mechanism between vascular endothelium and parenchymal cells in the regulation of oxygen consumption. Circulation 1995, 92:3505-3512.
162. Shiva S., Brookes P.S., Patel R.P., Anderson P.G., Darley-Usmar V.M. Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase. Proc. Natl. Acad. Sci. USA 2001, 98:7212-7217.
163. Shiva S., Oh J.Y., Landar A.L., Ulasova E., Venkatraman A., Bailey S.M., Darley-Usmar V.M. Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway. Free Radic. Biol. Med. 2005, 38:297-306.
164. Simonnet H., Alazard N., Pfeiffer K., Gallou C., Beroud C., Demont J., Bouvier R., Schagger H., Godinot C. Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma. Carcinogenesis 2002, 23:759-768.
165. Solenski N.J., Kosteki V.K., Dovey S., Periasamy A. Nitric oxide-induced depolarization of neuronal mitochondria: implications for neuronal cell death. Mol. Cell Neurochem. 2003, 24:1151-1169.
166. St-Pierre J., Drori S., Uldry M., Silvaggi J.M., Rhee J., Jager S., Handschin C., Zheng K., Lin J., Yang W., Simon D.K., Bachoo R., Spiegelman B.M. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006, 127:397-408.
167. Steinman R.M., North R.J. Mechanisms of Host Resistance to Infective Agents, Tumor and Allografts 1986, The Rockefeller University Press, New York.
168. Stubauer G., Giuffré A., Brunori M., Sarti P. Cytochrome c oxidase does not catalyze the anaerobic reduction of NO. Biochem. Biophys. Res. Commun. 1998, 245:459-465.
169. Sugano T., Oshino N., Chance B. Mitochondrial function under hypoxic conditions. The steady states of cytochrome c reduction and of energy metabolism. Biochim. Biophys. Acta 1974, 347:340-358.
170. Szabó C., Day B.J., Salzman A.L. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphirin superoxide dismutase mimetic and peroxynitrite scavenger. FEBS Lett. 1996, 381:82-86.
171. Szabó C., Ischiropoulos H., Radi R. Peroxynitrite: biochemistry, pathophysiology and developmet of therapeutics. Nat. Rev. Drug Discov. 2007, 6:662-680.
172. Takabayashi A., Kawai Y., Iwata S., Kanai M., Denno R., Kawada K., Obam
173. Takehara Y., Kanno T., Yoshioka T., Inoue M., Utsumi K. Oxygen-dependent regulation of mitochondrial energy metabolism by nitric oxide. Arch. Biochem. Biophys. 1995, 323:27-32.
174. Tatoyan A., Giulivi C. Purification and characterization of a nitric-oxide synthase from rat liver mitochondria. J. Biol. Chem. 1998, 273:11044-11048.
175. Tay Y.M., Lim K.S., Sheu F.S., Jenner A., Whiteman M., Wong K.P., Halliwell B. Do mitochondria make nitric oxide? no?. Free Radic. Res. 2004, 38:591-599.
176. 2. Proc. Natl. Acad. Sci. USA 2001, 98:355-360.
177. Thomas G.D., Shaul P.W., Yuhanna I.S., Froehner S.C., Madams E. Vasomodulation by skeletal muscle-derived nitric oxide requires alpha-syntrophin-mediated sarcolemmal localization of neuronal nitric oxide synthase. Circ. Res. 2003, 92:554-560.
178. Torres J., Darley-Usmar V., Wilson M.T. Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration. Biochem. J. 1995, 312:169-173.
179. Turrens J.F. Mitochondrial formation of reactive oxygen species. J. Physiol. 2003, 552:335-344.
180. Valdez L.B., Zaobornyj T., Boveris A. Functional activity of mitochondrial nitric oxide synthase. Methods Enzymol. 2005, 396:444-455.
181. Valdez L.B., Zaobornyj T., Boveris A. Mitochondrial metabolic states and membrane potential modulate mtNOS activity. Biochim. Biophys. Acta 2006, 1757:166-172.
182. Verkhovsky M.I., Morgan J.E., Wikstrom M. Oxygen binding and activation: early steps in the reaction of oxygen and cytochrome oxidase. Biochemistry 1994, 33:3079-3086.
183. Villalobo A. Nitric oxide and cell proliferation. FEBS J. 2006, 273:2329-2344.
184. Walker J.E. The NADH-ubiquinone reductase (complex I) of the respiratory chain. Q. Rev. Biophys. 1992, 25:253-324.
185. Wright T.L., Li C.Q., Trudel L.J., Wogan G.N., Tannenbaum S.R. Determination of nitric oxide-induced effects on tissue levels of glutathione and mitochondrial membrana potential. Methods Enzymol. 2002, 35:319-328.
186. Xie Y.W., Kaminski M., Wolin M.S. Inhibition of rat cardiac muscle contraction and mitochondrial respiration by endogenous peroxynitrite formation during posthypoxic reoxygenation. Circ. Res. 1998, 82:891-897.
187. Yamamoto Y., Gaynor R.B. Therapeutic potential of inhibition of the NFκB pathway in the treatment of inflammation and cancer. J. Clin. Invest. 2001, 107:135-142.
188. Yamakura F., Taka H., Fujimura T., Murayama K. Inactivation of human manganese-superoxide dismutase is caused by exclusive nitration of tyrosine 34 to 3-nitrotyrosine. J. Biol. Chem. 1998, 273:14085-14089.
189. Yamamoto T., Maruyama W., Kato Y., Yi H., Shamoto-Nagai M., Tanaka M., Sato Y., Naoi M. Selective nitration of mitochondrial complex I by peroxynitrite: involvement in mitochondria dysfunction and cell death of dopaminergic SH-SY5Y cells. J. Neural Transm. 2002, 109:1-13.
190. Yuan H., Gerencser A.A., Liot G., Lipton S.A., Ellisman M., Perkins G.A., Bossy-Wetzel E. Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons. Cell Death Differ. 2007, 14:462-471.
191. Zaobornyj T., Valdez L.B., La Padula P., Costa L.E., Boveris A. Effect of sustained hypobaric hypoxia during maturation and aging on rat myocardium.II. mtNOS activity. J. Appl. Physiol. 2005, 98:2370-2375.
192. Zemojtel T., Kolanczyk M., Kossler N., Stricker S., Lurz R., Mikula I., Duchniewicz M., Schuelke M., Ghafourifar P., Martasek P., Vingron M., Mundlos S.M. Mammalian mitochondrial nitric oxide synthase: characterization of a novel candidate. FEBS Lett. 2006, 580:455-462.
193. Zenebe W.J., Nazarewicz R.R., Parihar M.S., Ghafourifar P. Hypoxia/reoxygenation of isolated rat heart mitochondria causes cytochrome c release and oxidative stress; evidence for involvement of mitochondrial nitric oxide synthase. J Mol. Cell Cardiol. 2007, 43:411-419.
194. Zhang X., Xie Y., Nasjletti X., Xu X., Wolin M.S., Hitze T.H. ACE inhibitors promote nitric oxide accumulation to modulate myocardial oxygen consumption. Circulation 1996, 95:176-182.
195. Zhao X.J., Sampath V., Caughey W.S. Cytochrome c oxidase catalysis of the reduction of nitric oxide to nitrous oxide. Biochem. Biophys. Res. Commun. 1995, 212:1054-1060.