Control of muscle mitochondria by insulin entails activation of Akt2-mtNOS pathway: Imlpications for the metabolic syndrome

PLoS ONE

Volumn 3, Issue 3, 2008, Pages

  Finocchietto, Paola ^a,b   Barreyro, Fernando ^a,b   Holod, Silvia ^a,b   Peralta, Jorge ^a,b   Franco, María C ^a   Méndez, Carlos ^b   Converso, Daniela P ^a   Estévez, Alvaro ^c   Carreras, Maria C ^a,b   Poderoso, Juan J ^a,b  

^a HOSPITAL DE CLÍNICAS JOSÉ DE SAN MARTÍN   (Argentina)

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; GLUCOSE; GLYCOGEN; INSULIN; INSULIN GLARGINE; LONG ACTING DRUG; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN; PROTEIN KINASE B BETA; SMALL INTERFERING RNA; WATER; AKT2 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTROPORATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GASTROCNEMIUS MUSCLE; GENE SILENCING; GLUCONEOGENESIS; GLUCOSE OXIDATION; GLYCOGEN SYNTHESIS; HYPERINSULINEMIA; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MACROMOLECULE; MALE; METABOLIC RATE; METABOLIC SYNDROME X; MITOCHONDRIAL RESPIRATION; MUSCLE MITOCHONDRION; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ENZYMOLOGY; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALIA; RATTUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ENZYME ACTIVATION; HUMANS; INSULIN; METABOLIC SYNDROME X; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; NITRIC OXIDE SYNTHASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 46149115394     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001749     Document Type: Article

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