Spectral modification and catalytic inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2A6, and 2A13 by four chemopreventive organoselenium compounds

Chemical Research in Toxicology

Volumn 24, Issue 8, 2011, Pages 1327-1337

  Shimada, Tsutomu ^a   Murayama, Norie ^b   Tanaka, Katsuhiro ^a   Takenaka, Shigeo ^a   Guengerich, F Peter ^c   Yamazaki, Hiroshi ^b   Komori, Masayuki ^a  

^a Osaka Prefecture University   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 PHENYLENEBIS(METHYLENE)SELENOCYANATE; 1,3 PHENYLENEBIS(METHYLENE)SELENOCYANATE; 1,4 PHENYLENEBIS(METHYLENE)SELENOCYANATE; 4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; BENZYL SELENOCYANATE; COUMARIN; COUMARIN 7; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; CYTOCHROME P450 2A; CYTOCHROME P450 2A13; CYTOCHROME P450 2A6; ORGANOSELENIUM DERIVATIVE; POLYCYCLIC HYDROCARBON; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; ENZYME INHIBITION; PROTEIN BINDING;

ANIMALS; ANTINEOPLASTIC AGENTS; ARYL HYDROCARBON HYDROXYLASES; BINDING SITES; BIOCATALYSIS; CATALYTIC DOMAIN; COMPUTER SIMULATION; CYANATES; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; NEOPLASMS; ORGANOSELENIUM COMPOUNDS; PROTEIN BINDING; RATS;

ANIMALIA;

EID: 80051739998     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200218u     Document Type: Article

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