Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity

Chemical Research in Toxicology

Volumn 21, Issue 12, 2008, Pages 2313-2323

  Shimada, Tsutomu ^a   Murayama, Norie ^b   Tanaka, Katsuhiro ^a   Takenaka, Shigeo ^a   Imai, Yoshio ^a   Hopkins, Nancy E ^c   Foroozesh, Maryam K ^d   Alworth, Willam L ^c   Yamazaki, Hiroshi ^b   Guengerich, F Peter ^e   Komori, Masayuki ^a  

^a Osaka Prefecture University   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^c TULANE UNIVERSITY   (United States)

^d XAVIER UNIVERSITY OF LOUISIANA   (United States)

^e VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 PROPYNYL)PHENANTHRENE; 1 (1 PROPYNYL)PYRENE; 4 (1 PROPYNYL)BIPHENYL; BENZO[A]PYRENE; BIPHENYL DERIVATIVE; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; ETHOXYRESORUFIN DEETHYLASE; POLYCYCLIC AROMATIC HYDROCARBON; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME STRUCTURE; FLUORESCENCE; INCUBATION TIME; MOLECULAR DOCKING; MOLECULAR MODEL; PHOTOCHEMICAL QUENCHING; PROTEIN INTERACTION;

ARYL HYDROCARBON HYDROXYLASES; COMPUTER SIMULATION; CYTOCHROME P-450 CYP1A1; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; POLYCYCLIC HYDROCARBONS, AROMATIC; PROTEIN CONFORMATION;

EID: 58149085978     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx8002998     Document Type: Article

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