Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes

Journal of Chromatography B: Biomedical Applications

Volumn 721, Issue 1, 1999, Pages 13-19

  Yamazaki, Hiroshi ^a   Tanaka, Masaaki ^a   Shimada, Tsutomu ^a  

^a OSAKA PREFECTURAL INSTITUTE OF PUBLIC HEALTH   (Japan)

Author keywords

Coumarin; Cytochromes; Enzymes

Indexed keywords

7 ETHOXYCOUMARIN; COUMARIN; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE DEMETHYLASE; OXYGENASE; PHENACETIN O DEETHYLASE; UMBELLIFERONE;

ACCURACY; ARTICLE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LIVER METABOLISM; LIVER MICROSOME; NORMAL HUMAN; PRIORITY JOURNAL; TECHNIQUE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COUMARINS; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; ISOENZYMES; KINETICS; MICROSOMES, LIVER; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE;

EID: 0032908959     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(98)00472-1     Document Type: Article

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